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Frailty – A promising concept to evaluate disease vulnerability
We describe how high levels of frailty in such disorders predict worse outcomes and play a direct role in disease progression and in prognostic prediction. Overall, the potential for frailty to predict adverse health outcomes among young people as well as in non-age-related diseases is an evolving topic. Understanding how frailty contributes to poor health and how it can be modified to prevent or delay disease progression will ultimately enhance quality of life in affected individuals. (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 22, 2020 Category: Geriatrics Source Type: research

SIRT1 and aging related signaling pathways
Publication date: Available online 19 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Cui Chen, Min Zhou, Yuchen Ge, Xiaobo WangAbstractAging is a biological phenomenon in which the structure and function of organisms declining with the increasing of age. It has become a major risk factor of human diseases, including diabetes, cancers, cardiovascular diseases and neurodegenerative diseases. Silencing information regulator 2 related enzyme 1(sirtuin1, SIRT1) is an NAD+-dependent deacetylase, which has been reported to be involved in the regulation of cellular senescence and aging. The expression of SIRT1...
Source: Mechanisms of Ageing and Development - February 19, 2020 Category: Geriatrics Source Type: research

Regulation and roles of mitophagy at synapses
Publication date: Available online 19 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Konstantinos Palikaras, Nektarios TavernarakisAbstractMaintenance of synaptic homeostasis is a challenging task, due to the intricate spatial organization and intense activity of synapses. Typically, synapses are located far away from the neuronal cell body, where they orchestrate neuronal signalling and communication, through neurotransmitter release. Stationary mitochondria provide energy required for synaptic vesicle cycling, and preserve ionic balance by buffering intercellular calcium at synapses. Thus, synaptic h...
Source: Mechanisms of Ageing and Development - February 19, 2020 Category: Geriatrics Source Type: research

Corrigendum to “Endurance training improves plasma superoxide dismutase activity in healthy elderly” [Mechanisms of Ageing and Development 185 (2020) 111190]
Publication date: Available online 17 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Roberta Ceci, Guglielmo Duranti, Ester Sara Di Filippo, Danilo Bondi, Vittore Verratti, Christian Doria, Daniela Caporossi, Stefania Sabatini, Ivan Dimauro, Tiziana Pietrangelo (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - February 18, 2020 Category: Geriatrics Source Type: research

Physical exercise increases ROCK activity in the skeletal muscle of middle-aged rats
Publication date: Available online 4 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Vitor Rosetto Muñoz, Rafael Calais Gaspar, Marcos Vinicius Esteca, Igor Luchini Baptista, Renan Fudoli Lins Vieira, Adelino Sanchez Ramos da Silva, Leandro Pereira de Moura, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo PauliAbstractThe physical exercise is a potential strategy to control age-related metabolic disorders, such as insulin resistance, impaired glucose homeostasis, and type 2 diabetes. Rho-kinase (ROCK) increases skeletal muscle glucose uptake through Insulin Receptor Substrate 1 (IRS1) phosp...
Source: Mechanisms of Ageing and Development - February 5, 2020 Category: Geriatrics Source Type: research

Mitochondrial fission and fusion: a dynamic role in aging and potential target for age-related disease
Publication date: Available online 1 February 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Yasmine J. Liu, Rebecca L. McIntyre, Georges E. Janssens, Riekelt H. HoutkooperAbstractThe mitochondria is the major hub to convert energy for cellular processes. Dysregulation of mitochondrial function is one of the classical hallmarks of aging, and mitochondrial interventions have repeatedly been shown to improve outcomes in age-related diseases. Crucial to mitochondrial regulation is the dynamic nature of their network structure. Mitochondria separate and merge using fission and fusion processes in response to change...
Source: Mechanisms of Ageing and Development - February 1, 2020 Category: Geriatrics Source Type: research

Role of sorting nexin PaATG24 in autophagy, aging and development of Podospora anserina
Publication date: Available online 30 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Vanessa Henkel, Lea Schürmanns, Miriam Brunner, Andrea Hamann, Heinz D. OsiewaczAbstractSorting nexins are a conserved protein family involved in vesicle transport, membrane trafficking and protein sorting. The sorting nexin ATG24/SNX4 has been demonstrated to be involved in different autophagy pathways and in endosomal trafficking. However, its impact on cellular quality control and on aging and development is still elusive. Here we report studies analyzing the function of PaATG24 in the aging model Podospora anserina...
Source: Mechanisms of Ageing and Development - January 31, 2020 Category: Geriatrics Source Type: research

Molecular mechanisms in Cognitive Frailty: potential therapeutic targets for oxygen-ozone treatment
Publication date: Available online 23 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Catia Scassellati, Miriam Ciani, Antonio Carlo Galoforo, Roberta Zanardini, Cristian Bonvicini, Cristina GeroldiAbstractIn the last decade, cognitive frailty has gained great attention from the scientific community. It is characterized by high inflammation and oxidant state, endocrine and metabolic alterations, mitochondria dysfunctions and slowdown in regenerative processes and immune system, with a complex and multifactorial aetiology. Although several treatments are available, challenges regarding the efficacy and th...
Source: Mechanisms of Ageing and Development - January 23, 2020 Category: Geriatrics Source Type: research

Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease
Publication date: Available online 15 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Pratishtha Chatterjee, Malika Fernando, Binosha Fenando, Cintia B Dias, Tejal Shah, Renuka Silva, Shehan Williams, Steve Pedrini, Heidi Hillebrandt, Kathryn Goozee, Edward Barin, Hamid R Sohrabi, Manohar Garg, Stephen Cunnane, Ralph N MartinsAbstractAlzheimer’s disease (AD) is the most common form of dementia. Currently, there is no effective medication for the prevention or treatment of AD. This has led to the search for alternative therapeutic strategies. Coconut oil(CO) has a unique fatty acid composition that is r...
Source: Mechanisms of Ageing and Development - January 15, 2020 Category: Geriatrics Source Type: research

Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing
Publication date: Available online 15 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Brian C. Gilmour, Ruben Gudmundsrud, Johannes Frank, Amund Hov, Sofie Hindkjær Lautrup, Yahyah Aman, Helge Røsjø, Charles Brenner, Mathias Ziegler, Ole-Bjørn Tysnes, Charalampos Tzoulis, Torbjørn Omland, Arne Søraas, Trygve Holmøy, Linda H. Bergersen, Jon Storm-Mathisen, Hilde Nilsen, Evandro F. FangAbstractNicotinamide adenine dinucleotide (NAD+) plays a fundamental role in life and health through the regulation of energy biogenesis, redox homeostasis, cell metabolism, and the arbitration of cell survival via li...
Source: Mechanisms of Ageing and Development - January 15, 2020 Category: Geriatrics Source Type: research

Mitophagy and DNA Damage Signaling in Human Aging
Publication date: Available online 7 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Mansi Babbar, Sambuddha Basu, Beimeng Yang, Deborah L. Croteau, Vilhelm A. BohrAbstractAging is associated with multiple human pathologies. In the past few years mitochondrial homeostasis has been well corelated with age-related disorders and longevity. Mitochondrial homeostasis involves generation, biogenesis and removal of dysfunctional mitochondria via mitophagy. Mitophagy is regulated by various mitochondrial and extra-mitochondrial factors including morphology, oxidative stress and DNA damage. For decades, DNA damag...
Source: Mechanisms of Ageing and Development - January 9, 2020 Category: Geriatrics Source Type: research

Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines
Publication date: Available online 2 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Zeinab Farhadi, Mohammad Khaksari, Hossein Azizian, Shahriar Dabiri, Hossein Fallah, Masoumeh NozariAbstractAging causes changes in body composition and energy balance. Estrogen plays an important role in body’s metabolism. The aim of this study was to determine whether estrogen has beneficial effects on leptin responsiveness in aged mice. Young 4 months and aged 19-21 female mice fed High Fat Diet (HFD) or Standard Diet (SD) for 12 weeks and following received estrogen for 4 weeks. Responsiveness to leptin was compare...
Source: Mechanisms of Ageing and Development - January 3, 2020 Category: Geriatrics Source Type: research

AISA can control the inflammatory facet of SASP
Publication date: Available online 2 January 2020Source: Mechanisms of Ageing and DevelopmentAuthor(s): Patrizia A. d’Alessio, Marie C. BénéAbstractSenescent cells have been suspected, because of their secretory phenotype (SASP or senescence associated secretory profile), to contribute to the extension of the chronic inflammatory condition leading to unhealthy aging processes. AISA (Anti-Inflammatory Senescence Actives). AISA monoterpens have been characterized as possessing anti-inflammatory capacities in young cells submitted to pro-inflammatory cytokine stimulation. They have also been demonstrated to have the abili...
Source: Mechanisms of Ageing and Development - January 3, 2020 Category: Geriatrics Source Type: research

Centenarians: An excellent example of resilience for successful ageing
Publication date: Available online 31 December 2019Source: Mechanisms of Ageing and DevelopmentAuthor(s): C. Borras, M. Ingles, C. Mas-Bargues, M. Dromant, J. Sanz-Ros, A. Román-Domínguez, L. Mallench-Gimeno, J. Gambini, J. ViñaAbstractCentenarians are remarkable not only because of their prolonged life, but also because they compress morbidity until the very last moments of their lives, thus being proposed as a model of successful, extraordinary ageing. From the medical viewpoint, centenarians do not escape the physiological decline or the age-related diseases or syndromes (i.e. frailty), but the rate of such processes...
Source: Mechanisms of Ageing and Development - January 1, 2020 Category: Geriatrics Source Type: research

Editorial Board
Publication date: January 2020Source: Mechanisms of Ageing and Development, Volume 185Author(s): (Source: Mechanisms of Ageing and Development)
Source: Mechanisms of Ageing and Development - December 28, 2019 Category: Geriatrics Source Type: research