High‐Frequency Continuous Pulsed Magnetic Stimulation Does Not Adversely Affect Development on Whole Body Organs in Female Sprague–Dawley Rats
ConclusionsPulsed magnetic stimulation exerted no apparent adverse effect on the various organs, hormone levels, body weight, and daily behaviors in female rats. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - September 1, 2015 Category: Urology & Nephrology Authors: Eiichi SATO, Tomonori YAMANISHI, Yasuo IMAI, Masashi KOBAYASHI, Taku SAKAMOTO, Yuko ONO, Akiko FUJII, Takehiko YAMAGUCHI, Tsukasa NAKAMURA, Yoshihiko UEDA Tags: ORIGINAL ARTICLE Source Type: research

Treatment Patterns and Patient Reported Outcomes in Benign Prostatic Hyperplasia Patients with Overactive Bladder Symptoms
ConclusionsAbout one‐third of patients received α‐blocker monotherapy, one‐third received combination therapy with anticholinergics, and another one‐third received subsequent anticholinergics in addition to α‐blocker. Storage subscore was higher in patients with anticholinergics than those without it, but vice‐versa for voiding subscore. Similar improvement on clinical outcomes and PROs was observed in all treatment groups. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - September 1, 2015 Category: Urology & Nephrology Authors: Yong Hyun PARK, Tae Hyo KIM, Seung Wook LEE, Byung Ha CHUNG, Jin Seon CHO, Ji Youl LEE Tags: ORIGINAL ARTICLE Source Type: research

Degarelix Versus Goserelin Plus Bicalutamide in the Short‐Term Relief of Lower Urinary Tract Symptoms in Prostate Cancer Patients: Results of a Pooled Analysis
ConclusionAn early, significant and clinically more pronounced improvement of LUTS, especially in patients with moderate‐to‐severe LUTS or advanced PCa, was seen with degarelix vs. goserelin plus bicalutamide. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - September 1, 2015 Category: Urology & Nephrology Authors: Malcolm MASON, Pierre RICHAUD, Zsolt BOSNYAK, Anders MALMBERG, Anders NEIJBER Tags: ORIGINAL ARTICLE Source Type: research

Naftopidil Improves Symptoms in a Rat Model of Tranilast‐Induced Interstitial Cystitis
ConclusionNaftopidil improved the symptoms of tranilast‐induced IC, such as reduced locomotor activity due to pelvic pain and a shortened interval between bladder contractions. Therefore, naftopidil may be a potential treatment for IC. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - September 1, 2015 Category: Urology & Nephrology Authors: Kimio SUGAYA, Saori NISHIJIMA, Katsumi KADEKAWA, Katsuhiro ASHITOMI, Tomoyuki UEDA, Hideyuki YAMAMOTO Tags: ORIGINAL ARTICLE Source Type: research

Synergic Suppressive Effect of Silodosin and Imidafenacin on Non‐Voiding Bladder Contractions in Male Rats with Subacute Bladder Outlet Obstruction
ConclusionsThe present results indicate a suppressive effect of silodosin or imidafenacin alone and a synergic effect of the combination of these two drugs on NVCs in a subacute BOO model of male rats. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - July 27, 2015 Category: Urology & Nephrology Authors: Rino SUGIYAMA, Naoki AIZAWA, Hiroki ITO, Tetsuya FUJIMURA, Motofumi SUZUKI, Tohru NAKAGAWA, Hiroshi FUKUHARA, Haruki KUME, Yukio HOMMA, Yasuhiko IGAWA Tags: ORIGINAL ARTICLE Source Type: research

Synergic Suppressive Effect of Silodosin and Imidafenacin on Non ‐Voiding Bladder Contractions in Male Rats with Subacute Bladder Outlet Obstruction
ConclusionsThe present results indicate a suppressive effect of silodosin or imidafenacin alone and a synergic effect of the combination of these two drugs on NVCs in a subacute BOO model of male rats. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - July 27, 2015 Category: Urology & Nephrology Authors: Rino SUGIYAMA, Naoki AIZAWA, Hiroki ITO, Tetsuya FUJIMURA, Motofumi SUZUKI, Tohru NAKAGAWA, Hiroshi FUKUHARA, Haruki KUME, Yukio HOMMA, Yasuhiko IGAWA Tags: ORIGINAL ARTICLE Source Type: research

Effect of Voided Volume on Voiding Patterns and Reliability of Uroflowmetry ‐Electromyography Results in Children with Lower Urinary Tract Dysfunction
ConclusionsIn case of exceeding the EBC, the test should be repeated with normal VV when UF results are being evaluated. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - July 22, 2015 Category: Urology & Nephrology Authors: M. Murat DAYANC, Yusuf KIBAR, H. Cem IRKILATA, Ahmet A. SANCAKTUTAR, Turgay EBILOGLU, Ahmet GUR, Giray ERGIN, Bilal F. ALP, Faysal GOK Tags: ORIGINAL ARTICLE Source Type: research

Phase III Study to Assess Long ‐Term (52‐Week) Safety and Efficacy of Mirabegron, a β3‐Adrenoceptor Agonist, in Japanese Patients with Overactive Bladder
ConclusionsThere were no safety or tolerability concerns associated with mirabegron 50 mg (with an optional dose increase to 100 mg) over 52 weeks. Improvement in micturition variables was maintained with mirabegron 50 mg from weeks 8 to 52. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - July 7, 2015 Category: Urology & Nephrology Authors: Osamu YAMAGUCHI, Yasushi IKEDA, Sumito OHKAWA Tags: ORIGINAL ARTICLE Source Type: research

Evaluation of Sacrospinous Hysteropexy vs. Uterosacral Suspension for the Treatment of Uterine Prolapse: A Retrospective Assessment
ConclusionThe findings of this retrospective study indicate that SSHP appears to be associated with less anatomical objective success and an increased risk of recurrent anterior prolapse in comparison to VH/USS. Further validation of our observations by independent investigators is required. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - July 2, 2015 Category: Urology & Nephrology Authors: Ahmed AL‐BADR, Kauser PERVEEN, Ghadeer AL‐SHAIKH Tags: ORIGINAL ARTICLE Source Type: research

Efficacy and Adherence of Flexibly Adding on a Second Antimuscarinic Agent for Patients with Refractory Overactive Bladder
ConclusionsFlexibly adding on a second antimuscarinic agent is effective and safe for only some OAB patients dissatisfied with the first antimuscarinic treatment in the short‐term period. The patients' dropout rate is high and the long‐term efficacy of the combination of two antimuscarinic agents is limited. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - July 2, 2015 Category: Urology & Nephrology Authors: Chung‐Cheng WANG, Yuan‐Hong JIANG, Hann‐Chorng KUO Tags: ORIGINAL ARTICLE Source Type: research

An Investigation of Lower Urinary Tract Symptoms in Women Aged 40 and Over
ConclusionThe most common LUTS was urgency in women aged 40 years and older. Recurrent urinary tract infection was determined as the most significant risk factor for LUTS, followed by chronic illness, chronic constipation, higher BMI and parity. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - July 2, 2015 Category: Urology & Nephrology Authors: Neziha SEVER, Umran OSKAY Tags: ORIGINAL ARTICLE Source Type: research

Correlation Between Advanced Glycation End ‐Products, Lower Urinary Tract Symptoms and Bladder Dysfunctions in Patients with type 2 Diabetes Mellitus
ObjectivesTo explore whether serum and urinary advanced glycation end‐products (AGEs) are related to urinary symptoms and bladder dysfunctions in diabetic patients. MethodsForty‐seven patients with type 2 Diabetes mellitus (T2DM) and lower urinary tract symptoms (LUTS) were enrolled. LUTS evaluation was performed by IPSS (International Prostatic Symptoms Score), QoL (quality of life), OAB (overactive bladder). ICI‐SF (International Consultation on Incontinence – short form) quaestionneires; ultrasound examination, evaluation of postvoid residual (PVR), uroflowmetry, cystometry with pressure‐flow stu...
Source: LUTS: Lower Urinary Tract Symptoms - June 5, 2015 Category: Urology & Nephrology Authors: Alessandro GAL Ì, Giuseppe MUCCIARDI, Salvatore BUTTICÈ, Enrica SUBBA, Carmela D'AMICO, Francesco LEMBO, Carlo MAGNO Tags: ORIGINAL ARTICLE Source Type: research

Change of Ultrasound Estimated Bladder Weight and Bladder Wall Thickness After Treatment of Bladder Outlet Obstruction With Dutasteride
ConclusionsThere was no change in UEBW, UEBW/BSA and BWT despite improving most clinical parameters suggesting BOO. The changes of bladder wall hypertrophy parameters still have limitations to directly reflect the relief of BOO. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - May 1, 2015 Category: Urology & Nephrology Authors: Ha Na LEE, Young‐Suk LEE, Deok Hyun HAN, Kyu‐Sung LEE Tags: ORIGINAL ARTICLE Source Type: research

Effect of Voided Volume on Voiding Patterns and Reliability of Uroflowmetry‐Electromyography Results in Children with Lower Urinary Tract Dysfunction
ConclusionsIn case of exceeding the EBC, the test should be repeated with normal VV when UF results are being evaluated. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - May 1, 2015 Category: Urology & Nephrology Authors: M. Murat DAYANC, Yusuf KIBAR, H. Cem IRKILATA, Ahmet A. SANCAKTUTAR, Turgay EBILOGLU, Ahmet GUR, Giray ERGIN, Bilal F. ALP, Faysal GOK Tags: ORIGINAL ARTICLE Source Type: research

Phase III Study to Assess Long‐Term (52‐Week) Safety and Efficacy of Mirabegron, a β3‐Adrenoceptor Agonist, in Japanese Patients with Overactive Bladder
ConclusionsThere were no safety or tolerability concerns associated with mirabegron 50 mg (with an optional dose increase to 100 mg) over 52 weeks. Improvement in micturition variables was maintained with mirabegron 50 mg from weeks 8 to 52. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - May 1, 2015 Category: Urology & Nephrology Authors: Osamu YAMAGUCHI, Yasushi IKEDA, Sumito OHKAWA Tags: ORIGINAL ARTICLE Source Type: research

Randomized Crossover Comparison of the Short‐Term Efficacy and Safety of Single Half‐Dose Silodosin and Tamsulosin Hydrochoride in Men With Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia
ConclusionSingle half‐dose silodosin has a similar efficacy to full‐dose tamsulosin in Japanese men with LUTS/BPH and thus, may represent an effective, safe, and affordable treatment option. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - May 1, 2015 Category: Urology & Nephrology Authors: Hideki TAKESHITA, Shingo MORIYAMA, Yoshiaki ARAI, Satoshi WASHINO, Kimitoshi SAITO, Koji CHIBA, Susumu HORIUCHI, Akira NORO Tags: ORIGINAL ARTICLE Source Type: research

Correlation Between Advanced Glycation End‐Products, Lower Urinary Tract Symptoms and Bladder Dysfunctions in Patients with type 2 Diabetes Mellitus
ObjectivesTo explore whether serum and urinary advanced glycation end‐products (AGEs) are related to urinary symptoms and bladder dysfunctions in diabetic patients. MethodsForty‐seven patients with type 2 Diabetes mellitus (T2DM) and lower urinary tract symptoms (LUTS) were enrolled. LUTS evaluation was performed by IPSS (International Prostatic Symptoms Score), QoL (quality of life), OAB (overactive bladder). ICI‐SF (International Consultation on Incontinence – short form) quaestionneires; ultrasound examination, evaluation of postvoid residual (PVR), uroflowmetry, cystometry with pressure‐flow stu...
Source: LUTS: Lower Urinary Tract Symptoms - May 1, 2015 Category: Urology & Nephrology Authors: Alessandro GALÌ, Giuseppe MUCCIARDI, Salvatore BUTTICÈ, Enrica SUBBA, Carmela D'AMICO, Francesco LEMBO, Carlo MAGNO Tags: ORIGINAL ARTICLE Source Type: research

Crystallizing the Definition of Underactive Bladder Syndrome, a Common but Under‐recognized Clinical Entity
Detrusor underactivity (DU) is an important contributor to lower urinary tract symptoms (LUTS). While DU has been defined in the literature in urodynamic terms, current definitions lack specific parameters. In addition, the clinical syndrome associated with and manifesting itself as DU, underactive bladder (UAB), has not been well defined in the literature. In the absence of a precise definition of UAB, it is difficult to appreciate the true nature and burden of this condition. We review the evidence regarding the epidemiology, pathogenesis, diagnosis, and treatment of DU and UAB and discuss the challenges in gathering dat...
Source: LUTS: Lower Urinary Tract Symptoms - April 15, 2015 Category: Urology & Nephrology Authors: Christopher R. CHAPPLE, Nadir I. OSMAN Tags: REVIEW ARTICLE Source Type: research

Application of Tissue Engineering to Pelvic Organ Prolapse and Stress Urinary Incontinence
Synthetic or biological materials can be used for the surgical repair of pelvic organ prolapse (POP) or stress urinary incontinence (SUI). While non‐degradable synthetic mesh has a low failure rate, it is prone to complications such as infection and erosion, particularly in the urological/gynecological setting when subject to chronic influences of gravity and intermittent, repetitive strain. Biological materials have lower complication rates, although allografts and xenografts have a high risk of failure and the theoretical risk of infection. Autografts are used successfully for the treatment of SUI and are not associate...
Source: LUTS: Lower Urinary Tract Symptoms - April 15, 2015 Category: Urology & Nephrology Authors: Christopher R. CHAPPLE, Nadir I. OSMAN, Altaf MANGERA, Christopher HILLARY, Sabiniano ROMAN, Anthony BULLOCK, Sheila MACNEIL Tags: REVIEW ARTICLE Source Type: research

The Long ‐Term Outcomes of the Tension‐free Vaginal Tape Procedure for Treatment of Female Stress Urinary Incontinence: Data from Minimum 13 Years of Follow‐Up
ConclusionOur long‐term data, which illustrate the absence of long‐term adverse events secondary to TVT procedure and the high success rate both in subjective and objective goals regardless of any independent predictive factors, suggest the TVT procedure as a recommendable method for the management of female SUI. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - April 15, 2015 Category: Urology & Nephrology Authors: Phil Hyun SONG, Dae Hyeon KWON, Young Hwii KO, Hee Chang JUNG Tags: ORIGINAL ARTICLE Source Type: research

Prevalence of Lower Urinary Tract Symptoms Among Individuals Aged 50  Years and Over and Its Effect on the Quality of Life in a Semi‐Rural Area of Western Turkey
ConclusionThe prevalence of LUTS was found to be high in the men in this region of Turkey, and the degree of LUTS is inversely correlated with the quality of life. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - April 14, 2015 Category: Urology & Nephrology Authors: Didem ARSLANTAS, Mehmet E. GOKLER, Alaettin UNSAL, Barbaros BA ŞESKIOĞLU Tags: ORIGINAL ARTICLE Source Type: research

Effect on Sexual Function of Patients and Patients' Spouses After Midurethral Sling Procedure for Stress Urinary Incontinence: A Prospective Single Center Study
ObjectivesTo evaluate the effect on sexual function of patients and their spouses after transobturator tape (TOT) procedure, prospectively. Midurethral sling procedure has been widely performed for treatment of urinary incontinence; however, little has been reported regarding sexual function after surgery. MethodsBetween September 2012 and June 2013, 65 patients undergoing TOT and their sexual partners were enrolled. An investigation was conducted using validated, self‐administered questionnaires, Female Sexual Function Index (FSFI) and satisfaction domain on Male Sexual Health Questionnaire (MSHQ) for evaluation of coup...
Source: LUTS: Lower Urinary Tract Symptoms - March 19, 2015 Category: Urology & Nephrology Authors: Young Hwii KO, Chang‐Hyun SONG, Ji Woong CHOI, Hee Chang JUNG, Phil Hyun SONG Tags: ORIGINAL ARTICLE Source Type: research

Urodynamic Efficacy and Safety of Mirabegron Add‐on Treatment with Tamsulosin for Japanese Male Patients with Overactive Bladder
ObjectivesTo investigate urodynamic efficacy and safety of mirabegron add‐on treatment with tamsulosin for Japanese male patients with overactive bladder (OAB). MethodsA prospective study was conducted in 26 consecutive male patients with OAB who had been taking tamsulosin. OAB was diagnosed by overactive bladder symptom score (OABSS). Before and 8 weeks after mirabegron add‐on treatment with preceding tamsulosin, we assessed OABSS, International Prostate Symptom Score (IPSS), free uroflowmetry (UFM), filling cystometry and pressure‐flow study (PFS). ResultsMean age and prostate volume of the study patients we...
Source: LUTS: Lower Urinary Tract Symptoms - February 17, 2015 Category: Urology & Nephrology Authors: Naoki WADA, Hiromichi IUCHI, Masafumi KITA, Kazumi HASHIZUME, Seiji MATSUMOTO, Hidehiro KAKIZAKI Tags: ORIGINAL ARTICLE Source Type: research

Urodynamic Efficacy and Safety of Mirabegron Add ‐on Treatment with Tamsulosin for Japanese Male Patients with Overactive Bladder
ObjectivesTo investigate urodynamic efficacy and safety of mirabegron add‐on treatment with tamsulosin for Japanese male patients with overactive bladder (OAB). MethodsA prospective study was conducted in 26 consecutive male patients with OAB who had been taking tamsulosin. OAB was diagnosed by overactive bladder symptom score (OABSS). Before and 8 weeks after mirabegron add‐on treatment with preceding tamsulosin, we assessed OABSS, International Prostate Symptom Score (IPSS), free uroflowmetry (UFM), filling cystometry and pressure‐flow study (PFS). ResultsMean age and prostate volume of the study patients we...
Source: LUTS: Lower Urinary Tract Symptoms - February 17, 2015 Category: Urology & Nephrology Authors: Naoki WADA, Hiromichi IUCHI, Masafumi KITA, Kazumi HASHIZUME, Seiji MATSUMOTO, Hidehiro KAKIZAKI Tags: ORIGINAL ARTICLE Source Type: research

Mental Health Mediating the Relationship Between Symptom Severity and Health‐Related Quality of Life in Patients with Lower Urinary Tract Symptoms
ConclusionsIn order to enhance HRQOL, LUTS interventions should address the mental health of patients in addition to providing physical relief of symptoms. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - February 12, 2015 Category: Urology & Nephrology Authors: Edmond P. H. CHOI, Cindy L. K. LAM, Weng Yee CHIN Tags: ORIGINAL ARTICLE Source Type: research

Mental Health Mediating the Relationship Between Symptom Severity and Health ‐Related Quality of Life in Patients with Lower Urinary Tract Symptoms
ConclusionsIn order to enhance HRQOL, LUTS interventions should address the mental health of patients in addition to providing physical relief of symptoms. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - February 12, 2015 Category: Urology & Nephrology Authors: Edmond P. H. CHOI, Cindy L. K. LAM, Weng Yee CHIN Tags: ORIGINAL ARTICLE Source Type: research

Optimum Dose of Once ‐Daily Oxybutynin Patch in Japanese Patients with Overactive Bladder: A Randomized Double‐Blind Trial Versus Placebo
ConclusionThe efficacy of oxybutynin patch was confirmed, and the optimum dose for Japanese patients with overactive bladder was 73.5 mg. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - February 12, 2015 Category: Urology & Nephrology Authors: Osamu YAMAGUCHI, Eiji UCHIDA, Naruhito HIGO, Hidenao MINAMI, Shigeo KOBAYASHI, Hiroyuki SATO, Tags: ORIGINAL ARTICLE Source Type: research

Urethroplasty Using Diverticular Tissue for Hypospadias
ConclusionA urethral diverticulum is one of the often encountered complications of hypospadias surgery. However, there are only a few literature reports related to the treatment of urethral diverticulum. In addition, there are almost no reports on reconstructions using urethral diverticular tissue. In this report, we describe such a treatment experience. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - January 29, 2015 Category: Urology & Nephrology Authors: Nobuyuki MITSUKAWA, Yoshitaka KUBOTA, Shinsuke AKITA, Masakazu HASEGAWA, Atsuomi SAIGA, Kaneshige SATOH Tags: CASE REPORT Source Type: research

The Long‐Term Outcomes of the Tension‐free Vaginal Tape Procedure for Treatment of Female Stress Urinary Incontinence: Data from Minimum 13 Years of Follow‐Up
ConclusionOur long‐term data, which illustrate the absence of long‐term adverse events secondary to TVT procedure and the high success rate both in subjective and objective goals regardless of any independent predictive factors, suggest the TVT procedure as a recommendable method for the management of female SUI. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - January 1, 2015 Category: Urology & Nephrology Authors: Phil Hyun SONG, Dae Hyeon KWON, Young Hwii KO, Hee Chang JUNG Tags: ORIGINAL ARTICLE Source Type: research

Prevalence of Lower Urinary Tract Symptoms Among Individuals Aged 50 Years and Over and Its Effect on the Quality of Life in a Semi‐Rural Area of Western Turkey
ConclusionThe prevalence of LUTS was found to be high in the men in this region of Turkey, and the degree of LUTS is inversely correlated with the quality of life. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - January 1, 2015 Category: Urology & Nephrology Authors: Didem ARSLANTAS, Mehmet E. GOKLER, Alaettin UNSAL, Barbaros BAŞESKIOĞLU Tags: ORIGINAL ARTICLE Source Type: research

Diagnosis and Management of Bladder Outlet Obstruction in Women
Bladder outlet obstruction (BOO) should be considered when a woman complains of voiding difficulty, abdominal straining to void, or refractory storage symptoms. Diagnosis of female BOO is not straightforward and usually requires invasive (video)urodyanmic study. A diagnostic algorithm is recommended for making optimal diagnosis. Female BOO can be classified as having anatomical and functional origins, and each contains several sub‐classifications. Literatures published between 1988 and 2013 were reviewed and summarized for the diagnosis and therapy in each subtype of female BOO. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - January 1, 2015 Category: Urology & Nephrology Authors: Chia‐Da LIN, Hann‐Chorng KUO, Stephen S.‐D. YANG Tags: REVIEW ARTICLE Source Type: research

Effects of Sildenafil, a Phosphodiesterase Type 5 Inhibitor, on the Primary Single Afferent Activity of the Rat Bladder
ConclusionsThese results indicate that sildenafil can inhibit Aδ‐fibers (partly also C‐fibers) of the primary bladder mechanosensitive afferents of the rat although these effects may be partially influenced by systemic hypotension. The present results support the view that the NO/cGMP signaling pathway plays an inhibitory role in the bladder afferent transduction, and thus improves storage symptoms. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - January 1, 2015 Category: Urology & Nephrology Authors: Naoki AIZAWA, Hiroki ITO, Rino SUGIYAMA, Tetsuya FUJIMURA, Hiroshi FUKUHARA, Haruki KUME, Yukio HOMMA, Yasuhiko IGAWA Tags: ORIGINAL ARTICLE Source Type: research

Validating of a Novel Method for Electronically Recording Overactive Bladder Symptoms in Men
ConclusionsIn this study population, recording symptoms with EMC did not prove to be preferable compared to MC; however, EMC provided the same level of accuracy with the same or better adherence to the study protocol. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - January 1, 2015 Category: Urology & Nephrology Authors: Jan KRHUT, Marcel GÄRTNER, Katarína ZVAROVÁ, Michael DESARNO, Peter ZVARA Tags: ORIGINAL ARTICLE Source Type: research

Histopathologic and Urodynamic Effects of the Anticholinergic Drugs Oxybutynin, Tolterodine, and Trospium on the Bladder
ConclusionIntravesical oxybutynin treatment was observed to be safe; however, a single daily dose of oxybutynin may not be sufficient to increase bladder capacity. Intravesical use of trospium and tolterodine at high doses caused epithelial destruction and diffuse inflammation in the bladder mucosa. The irritation associated with epithelial destruction and inflammation prevented an increase in bladder capacity. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - January 1, 2015 Category: Urology & Nephrology Authors: Seyfettin ORGEN, Hasan DELIKTAS, Hayrettin SAHIN, Abdullah GEDIK, Yusuf NERGIS Tags: ORIGINAL ARTICLE Source Type: research

Safety and Efficacy of Thulium Laser Prostatectomy Versus Transurethral Resection of Prostate for Treatment of Benign Prostate Hyperplasia: A Meta‐Analysis
ConclusionsTmLRP is a safe and effective procedure for treatment of benign prostatic hyperplasia. Compared with TURP, TmLRP was not only associated with less decrease of serum sodium salt, less blood transfusion, shorter catheterization time and hospital time, but also may be superior to TURP in efficacy. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - January 1, 2015 Category: Urology & Nephrology Authors: HongJing JIANG, Yu ZHOU Tags: ORIGINAL ARTICLE Source Type: research

Neuromodulation for the Treatment of Lower Urinary Tract Symptoms
The objectives of this article are to review the mechanism of action, the type of neuromodulation, and the efficacy of neuromodulation mainly according to the results of randomized controlled trials. Neuromodulation includes pelvic floor electrical stimulation (ES) using vaginal, anal and surface electrodes, interferential therapy (IF), magnetic stimulation (MS), percutaneous tibial nerve stimulation, and sacral nerve stimulation (SNS). The former four stimulations are used for external periodic (short‐term) stimulation, and SNS are used for internal, chronic (long‐term) stimulation. All of these therapies have been re...
Source: LUTS: Lower Urinary Tract Symptoms - January 1, 2015 Category: Urology & Nephrology Authors: Tomonori YAMANISHI, Kanya KAGA, Miki FUSE, Chiharu SHIBATA, Tomoyuki UCHIYAMA Tags: REVIEW ARTICLE Source Type: research

Optimum Dose of Once‐Daily Oxybutynin Patch in Japanese Patients with Overactive Bladder: A Randomized Double‐Blind Trial Versus Placebo
ConclusionThe efficacy of oxybutynin patch was confirmed, and the optimum dose for Japanese patients with overactive bladder was 73.5 mg. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - January 1, 2015 Category: Urology & Nephrology Authors: Osamu YAMAGUCHI, Eiji UCHIDA, Naruhito HIGO, Hidenao MINAMI, Shigeo KOBAYASHI, Hiroyuki SATO, Tags: ORIGINAL ARTICLE Source Type: research

Anatomical and Functional Outcomes of Prolift Transvaginal Mesh for Treatment of Pelvic Organ Prolapse
ConclusionsPelvic organ prolapse repair using Prolift Transvaginal Mesh is an effective and safe procedure without significant complications. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - January 1, 2015 Category: Urology & Nephrology Authors: Wan SONG, Tae Heon KIM, Jin Woo CHUNG, Won Jin CHO, Ha Na LEE, Young Suk LEE, Kyu‐Sung LEE Tags: ORIGINAL ARTICLE Source Type: research

Survey and Risk Factors for Lower Urinary Tract Storage Symptoms in Middle ‐Aged and Older Stroke Patients in Urban China
ObjectivesTo evaluate the prevalence and associated risk factors of lower urinary tract symptoms (LUTS) in people with stroke. This was the first study that systematically surveyed the risk factors for LUTS in people with various lengths of stroke history in urban Chinese communities. MethodsA community‐based, cross‐sectional study was performed on 1404 residents aged over 40 years, randomly selected in the urban area of Zhengzhou, China. A questionnaire including the subjects' general health information, sociodemographic background, medical history, and the overactive bladder symptom score (OABSS) was filled by the su...
Source: LUTS: Lower Urinary Tract Symptoms - November 18, 2014 Category: Urology & Nephrology Authors: Yudong TIAN, Yanbin GUAN, Jianguo WEN, Xiaoping SHANG, Jinsheng LI, Yan WANG Tags: ORIGINAL ARTICLE Source Type: research

Influence of Naftopidil on Plasma Monoamine Levels and Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia
ConclusionsThe modulation of plasma adrenaline and serotonin levels by naftopidil in patients with increased sympathetic activity contributed to improvement of LUTS associated with BPH, in addition to its antagonistic effects of α1D/A‐adrenergic receptor on the detrusor and prostatic urethral smooth muscle, the urothelium, and the central nervous system. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - November 6, 2014 Category: Urology & Nephrology Authors: Katsumi KADEKAWA, Kimio SUGAYA, Hideki MUKOYAMA, Misao SAKUMOTO, Hiroichi SHIMABUKURO, Syuichi SHIMABUKURO, Yukihide MATAYOSHI, Tomohiro ONAGA, Katsuhiro ASHITOMI, Saori NISHIJIMA Tags: ORIGINAL ARTICLE Source Type: research

Effect of Selective Prostaglandin E2 EP2 Receptor Agonist CP ‐533,536 on Voiding Efficiency in Rats with Midodrine‐Induced Functional Urethral Obstruction
ConclusionsThese results suggest that a selective EP2 receptor agonist could ameliorate the elevation of RV and improve the reduction of VE in rats with functional urethral obstruction caused by stimulation of α1‐adrenoceptors. The mechanism of action might be not potentiation of bladder contraction but rather preferential relief of urethral constriction. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - November 6, 2014 Category: Urology & Nephrology Authors: Ryoko KURIHARA, Katsunori IMAZUMI, Hajime TAKAMATSU, Kenichiro ISHIZU, Taiji YOSHINO, Noriyuki MASUDA Tags: ORIGINAL ARTICLE Source Type: research

Correlation between Bladder Neck Mobility and Voiding Phase Urodynamic Parameters in Female Patients with Stress Urinary Incontinence
ConclusionsIn ISD patients, we found a positive correlation between BNM and flow rates. This is the first study to identify a close association between bladder neck mobility and voiding function in female SUI patients. Future studies are required to clarify the mechanism and to determine the significance of this finding. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - October 28, 2014 Category: Urology & Nephrology Authors: I‐Shen HUANG, Yu‐Hua FAN, Alex T. L. LIN, Kuang‐Kuo CHEN Tags: ORIGINAL ARTICLE Source Type: research

Effects of Silodosin and Tamsulosin on the Seminal Vesicle Contractile Response
ConclusionsThe initial contractions triggered by neuronal excitations were suppressed by silodosin and tamsulosin, suggesting that the ejaculation dysfunction may be attributed to the α1A‐AR antagonist‐mediated suppression of nerve‐evoked contractions in the seminal vesicle. The subsequent contractions may be induced by mechanical stimulation associated with the initial, nerve‐evoked contractions. Alternatively, other transmitters may be involved to various degrees in the neuromuscular transmission of the seminal vesicle. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - October 4, 2014 Category: Urology & Nephrology Authors: Tokumasa HAYASHI, Mitsue TAKEYA, Kei‐ichiro NAKAMURA, Kei MATSUOKA Tags: ORIGINAL ARTICLE Source Type: research

Efficacy of Transurethral Vesical Deafferentation with Mid ‐Urethral Sling Operation for Female Mixed Urinary Incontinence: Preliminary Results
ConclusionsThe transurethral vesical deafferentation procedure combined with MUS is effective for the treatment of MUI. The procedure is simple, safe and efficacious in treating urgency and UUI without affecting voiding function. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - October 4, 2014 Category: Urology & Nephrology Authors: Sang Jin KIM, Jung Soo PARK, Kyoung Taek LIM, Hong Sang MOON, Yong Tae KIM Tags: ORIGINAL ARTICLE Source Type: research

Effect of Work‐Related Factors on Lower Urinary Tract Symptoms in Nurses and Secretaries
ConclusionThere is a vicious circle between symptoms and work conditions. To prevent the working women from harmful effects of this circle, the employers should be aware of this health problem; working conditions should be improved; educational programs for LUTS should be organized and the working women should be encouraged to go to the health providers to seek treatment when the symptoms occurred. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - September 19, 2014 Category: Urology & Nephrology Authors: Yeliz KAYA, Coşkun KAYA, Barbaros BASESKIOGLU, Nebahat OZERDOĞAN, Aydın YENILMEZ, Canan DEMIRÜSTÜ Tags: ORIGINAL ARTICLE Source Type: research

Induction of Bladder Overactivity by Nerve Growth Factor in Testes in Rats: Possible Neural Crosstalk Between the Testes and Urinary Bladder
ConclusionsThe present study provides evidence of a possible new role of NGF in the testes regarding the activation of testicular primary afferent neurons mediated by capsaicin‐sensitive C‐fibers, which evokes bladder overactivity via neural crosstalk between the testes and the urinary bladder as well as testicular pain. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - September 18, 2014 Category: Urology & Nephrology Authors: Katsuro YOSHIOKA, Masayuki TANAHASHI, Masahiro TAKEDA, Noriyuki MASUDA Tags: ORIGINAL ARTICLE Source Type: research

Do Effects on Bowel Patterns Imposed by Solifenacin Always Have Negative Impacts on Treating Patients with Overactive Bladder (OAB)?
ConclusionsThis study shows that solifenacin treatment is effective for treating urinary incontinence but may lead to changes in bowel patterns and affects overall quality of life (QoL). Effects on bowel patterns imposed by solifenacin can be positive or negative, therefore, physicians should consider more holistic therapy by addressing overall bowel symptoms when treating OAB patients. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - September 1, 2014 Category: Urology & Nephrology Authors: Sung Yong CHO, Sohyun PARK, Seung Bae LEE, Jae‐Seung PAICK, Hwancheol SON Tags: ORIGINAL ARTICLE Source Type: research

Supraspinal Projection of Serotonergic and Noradrenergic Pathways Modulates Nociceptive Transmission in the Lower Urinary Tract of Rats
ObjectivesTo investigate the effect of descending serotonergic and noradrenergic pathways on nociception in the lower urinary tract (LUT). MethodsFemale Sprague–Dawley rats were used. Following intraperitoneal administration of Vehicle or Milnacipran (30 mg/kg), which is one of serotonin‐noradrenaline reuptake inhibitors (SNRI), 0.1% AA was infused into the bladder in normal (n = 4, each) and spinal cord injury (SCI) (n = 4, each) rats for 2 h on consciousness, and c‐Fos, 5‐HT and DβH were stained using immunohistochemistry at the L6 spinal cord as spinal areas ass...
Source: LUTS: Lower Urinary Tract Symptoms - September 1, 2014 Category: Urology & Nephrology Authors: Takahiko MITSUI, Yukiko KANNO, Takeya KITTA, Kimihiko MORIYA, Katsuya NONOMURA Tags: ORIGINAL ARTICLE Source Type: research

Lower Urinary Tract Symptoms and Urinary Incontinence During Pregnancy
ConclusionsLower urinary tract symptoms are commonly seen among pregnant women and these symptoms negatively affect the quality of life of pregnant women. Advanced age, smoking and multiparity were risk factors associated with urinary incontinence and LUTS. Obstetricians should be on the lookout for individual urological problems in pregnancy. Resolving any urological issues and cessation of smoking for the affected individuals will help alleviate the problem. (Source: LUTS: Lower Urinary Tract Symptoms)
Source: LUTS: Lower Urinary Tract Symptoms - September 1, 2014 Category: Urology & Nephrology Authors: Gülşah BALIK, Emine Seda G. GÜVEN, Yeşim B. TEKIN, Şenol ŞENTÜRK, Mehmet KAĞITCI, Işık ÜSTÜNER, Ülkü METE URAL, Figen K. ŞAHIN Tags: ORIGINAL ARTICLE Source Type: research

Structural Variation of Prostate Urethra Reflected by the Ratio Between Prostate Volume and Prostatic Urethral Length is Associated with the Degrees of Lower Urinary Tract Symptoms
ObjectivesBecause it is well known that the prostate volume is not directly associated with the degrees of lower urinary tract symptom (LUTS), we hypothesized that change of the prostatic urethra led by prostatic enlargement as missing links between them. To provide an integral description, we determined the ratio between prostate volume and prostatic urethral length (RPVL), and investigated its clinical implication. MethodsProstate volume, prostatic urethral length, RPVL was measured from transrectal ultrasonography for 213 consecutive patients. The degree of LUTS was investigated using the international prostate symptom ...
Source: LUTS: Lower Urinary Tract Symptoms - September 1, 2014 Category: Urology & Nephrology Authors: Young Hwii KO, Phil Hyun SONG Tags: ORIGINAL ARTICLE Source Type: research