MRI Features for Predicting Microvascular Invasion of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Conclusions: Seven MRI features including larger tumor size, rim arterial enhancement, arterial peritumoral enhancement, peritumoral hypointensity on HBP, nonsmooth margin, multifocality, and hypointensity on T1WI were significant predictors for MVI of HCC. These MRI features predictive of MVI can be useful in the management of HCC.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - March 11, 2021 Category: Cancer & Oncology Source Type: research

Reply to the Letter “Comment on Regarding Manuscript ‘Treatment of Intermediate Stage Hepatocellular Carcinoma in Japan: Position of Curative Therapies’”
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - March 11, 2021 Category: Cancer & Oncology Source Type: research

Clinical Outcomes with Multikinase Inhibitors after Progression on First-Line Atezolizumab plus Bevacizumab in Patients with Advanced Hepatocellular Carcinoma: A Multinational Multicenter Retrospective Study
Conclusion: Second-line treatment with MKIs, mostly sorafenib and lenvatinib, showed comparable efficacy and manageable toxicities in patients with advanced HCC after disease progression on atezolizumab-bevacizumab.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - March 3, 2021 Category: Cancer & Oncology Source Type: research

What Can Be Done to Solve the Unmet Clinical Need of Hepatocellular Carcinoma Patients following Lenvatinib Failure?
Conclusion: When ECOG PS and hepatic reserve function permit, continuing LEN treatment beyond PD, especially in u-HCC patients showed HFSR during LEN treatment, might be a good therapeutic option, at least until a more effective drug as a postprogression treatment after LEN failure is developed.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - February 25, 2021 Category: Cancer & Oncology Source Type: research

Hepatic Arterial Infusion Chemotherapy Combined with Radiation Therapy for Advanced Hepatocellular Carcinoma with Tumor Thrombosis of the Main Trunk or Bilobar of the Portal Vein
Conclusion: Combination therapies of HAIC and RT might be good therapy for advanced HCC with Vp4.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - February 24, 2021 Category: Cancer & Oncology Source Type: research

APPLE News
Liver Cancer 2021;10:82 –84 (Source: Liver Cancer)
Source: Liver Cancer - February 16, 2021 Category: Cancer & Oncology Source Type: research

Comment on the Manuscript “Treatment of Intermediate-Stage Hepatocellular Carcinoma in Japan: Position of Curative Therapies”
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - February 16, 2021 Category: Cancer & Oncology Source Type: research

Sequential Therapy for Hepatocellular Carcinoma after Failure of Atezolizumab plus Bevacizumab Combination Therapy
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - February 15, 2021 Category: Cancer & Oncology Source Type: research

Evolutions in the Management of Hepatocellular Carcinoma over Last 4 Decades: An Analysis from the 100 Most Influential Articles in the Field
Conclusions: Based on bibliometric analysis of the literature over the last 40 years, a comprehensive analysis of the most historically significant HCC management articles highlighted the key contributions made to the evolution and advancement of this specialist field. The data should provide clinicians and researchers insight into future directions relative to the advancement of HCC management.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - February 2, 2021 Category: Cancer & Oncology Source Type: research

Impact of Multi-Drug Sequential Therapy on Survival in Patients with Unresectable Hepatocellular Carcinoma
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 28, 2021 Category: Cancer & Oncology Source Type: research

Diffusion-Weighted Imaging Reflects Tumor Grading and Microvascular Invasion in Hepatocellular Carcinoma
Conclusion: ADCmin reflects tumor grading, and ADCmin andD predict MVI in HCC. Therefore, these DWI parameters should be estimated for every HCC lesion for pretreatment tumor stratification. ADCmean cannot predict tumor grading/MVI in HCC.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 27, 2021 Category: Cancer & Oncology Source Type: research

Comparison of Tenofovir and Entecavir in the Prevention of Hepatocellular Carcinoma Occurrence in Patients with Chronic Hepatitis B
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 18, 2021 Category: Cancer & Oncology Source Type: research

Laparoscopic Liver Resection versus Percutaneous Radiofrequency Ablation for Small Single Nodular Hepatocellular Carcinoma: Comparison of Treatment Outcomes
Conclusions: LLR can provide significantly better local tumor control than p-RFA for small single HCCs in subcapsular, perivascular, and anteroinferolateral liver portions and thus may be the preferred treatment option for these tumors.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 14, 2021 Category: Cancer & Oncology Source Type: research

Feasibility and Techniques of Securing 3D-Safety Margin in Superselective Transarterial Chemoembolization to Improve Local Tumor Control for Small Hepatocellular Carcinoma: An Intend-to-Treat Analysis
Conclusion: Superselective cTACE obtaining 3D-safety margin in small HCC was feasible with a high success rate by using 3D images, which could be tolerable and prevent local tumor recurrence.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 12, 2021 Category: Cancer & Oncology Source Type: research

Efficacy and Safety of Lenvatinib Therapy for Unresectable Hepatocellular Carcinoma in a Real-World Practice in Korea
Conclusion: Lenvatinib therapy showed a favorable efficacy and safety in a real-world practice. The REFLECT eligibility criteria and specific AEs could be one of the prognostic markers.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 8, 2021 Category: Cancer & Oncology Source Type: research