Impact of Multi-Drug Sequential Therapy on Survival in Patients with Unresectable Hepatocellular Carcinoma
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 28, 2021 Category: Cancer & Oncology Source Type: research

Diffusion-Weighted Imaging Reflects Tumor Grading and Microvascular Invasion in Hepatocellular Carcinoma
Conclusion: ADCmin reflects tumor grading, and ADCmin andD predict MVI in HCC. Therefore, these DWI parameters should be estimated for every HCC lesion for pretreatment tumor stratification. ADCmean cannot predict tumor grading/MVI in HCC.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 27, 2021 Category: Cancer & Oncology Source Type: research

Comparison of Tenofovir and Entecavir in the Prevention of Hepatocellular Carcinoma Occurrence in Patients with Chronic Hepatitis B
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 18, 2021 Category: Cancer & Oncology Source Type: research

Laparoscopic Liver Resection versus Percutaneous Radiofrequency Ablation for Small Single Nodular Hepatocellular Carcinoma: Comparison of Treatment Outcomes
Conclusions: LLR can provide significantly better local tumor control than p-RFA for small single HCCs in subcapsular, perivascular, and anteroinferolateral liver portions and thus may be the preferred treatment option for these tumors.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 14, 2021 Category: Cancer & Oncology Source Type: research

Feasibility and Techniques of Securing 3D-Safety Margin in Superselective Transarterial Chemoembolization to Improve Local Tumor Control for Small Hepatocellular Carcinoma: An Intend-to-Treat Analysis
Conclusion: Superselective cTACE obtaining 3D-safety margin in small HCC was feasible with a high success rate by using 3D images, which could be tolerable and prevent local tumor recurrence.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 12, 2021 Category: Cancer & Oncology Source Type: research

Efficacy and Safety of Lenvatinib Therapy for Unresectable Hepatocellular Carcinoma in a Real-World Practice in Korea
Conclusion: Lenvatinib therapy showed a favorable efficacy and safety in a real-world practice. The REFLECT eligibility criteria and specific AEs could be one of the prognostic markers.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 8, 2021 Category: Cancer & Oncology Source Type: research

Clinical-Radiomic Analysis for Pretreatment Prediction of Objective Response to First Transarterial Chemoembolization in Hepatocellular Carcinoma
Conclusions: The CR model had an excellent performance in predicting the first TACE response in patients with intermediate-stage HCC and could provide a robust predictive tool to assist with the selection of patients for TACE.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 7, 2021 Category: Cancer & Oncology Source Type: research

Switching Monopolar No-Touch Radiofrequency Ablation Using Octopus Electrodes for Small Hepatocellular Carcinoma: A Randomized Clinical Trial
Conclusions: A switching monopolar no-touch RFA technique is a favorable treatment option and provides lower LTP after RFA compared with conventional RFA for small HCC.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - December 8, 2020 Category: Cancer & Oncology Source Type: research

Contents Vol. 9, 2020
Liver Cancer 2020;9:I –VIII (Source: Liver Cancer)
Source: Liver Cancer - December 1, 2020 Category: Cancer & Oncology Source Type: research

Acknowledgements to Reviewers
Liver Cancer 2020;9:791 –792 (Source: Liver Cancer)
Source: Liver Cancer - December 1, 2020 Category: Cancer & Oncology Source Type: research

APPLE News
Liver Cancer 2020;9:793 –794 (Source: Liver Cancer)
Source: Liver Cancer - December 1, 2020 Category: Cancer & Oncology Source Type: research

Recent Advances in Systemic Therapy for Hepatocellular Carcinoma in an Aging Society: 2020 Update
Systemic therapy for hepatocellular carcinoma (HCC) has changed markedly since the introduction of the molecular targeted agent sorafenib in 2007. Sorafenib increased the available treatment options for patients with extrahepatic spread and vascular invasion and improved survival in patients with advanced HCC; however, various shortcomings such as low response rates and relatively high toxicity (e.g., hand-foot skin reaction) prompted concerted efforts aimed at developing new molecular targeted agents to provide more treatment options and second-line agents for patients with disease progression or intolerance to sorafenib....
Source: Liver Cancer - November 17, 2020 Category: Cancer & Oncology Source Type: research

Impact of Extrahepatic Metastases on Overall Survival in Patients with Advanced Liver Dominant Hepatocellular Carcinoma: A Subanalysis of the SORAMIC Trial
Conclusions: This subanalysis of the SORAMIC trial suggests that in patients with liver-dominant advanced HCC, metastases to distant organs with the exception of pulmonary metastases do not in general exert a negative impact on patient prognosis. The choice of palliative treatment should incorporate a personalized analysis of the pattern of tumor distribution.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - November 11, 2020 Category: Cancer & Oncology Source Type: research

Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition)
Background: Primary liver cancer, around 90% are hepatocellular carcinoma in China, is the fourth most common malignancy and the second leading cause of tumor-related death, thereby posing a significant threat to the life and health of the Chinese people.Summary: Since the publication ofGuidelines for Diagnosis and Treatment of Primary Liver Cancer (2017 Edition) in 2018, additional high-quality evidence has emerged with relevance to the diagnosis, staging, and treatment of liver cancer in and outside China that requires the guidelines to be updated. The new edition(2019 Edition) was written by more than 70 experts in the ...
Source: Liver Cancer - November 11, 2020 Category: Cancer & Oncology Source Type: research

Lenvatinib-Transarterial Chemoembolization Sequential Therapy as an Effective Treatment at Progression during Lenvatinib Therapy for Advanced Hepatocellular Carcinoma
Conclusion: Oncological aggressiveness of HCC estimated by CT enhancement pattern was predictive of PPS after progression during lenvatinib. Successful subsequent treatment with lenvatinib-TACE sequential therapy may offer survival benefit regardless of CT enhancement pattern of HCC.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research