MicroRNAs for the Prediction of Early Response to Sorafenib Treatment in Human Hepatocellular Carcinoma
Background: Several studies suggest the role of circulating microRNAs (miRNAs) as biomarkers of hepatocellular carcinoma (HCC). However, the serum miRNA profile associated with the response to sorafenib remains to be elucidated. The aim of this study was to clarify the specific miRNAs in serum that could predict the early response of HCC to sorafenib treatment.Summary: Analyzing the sera from 16 HCC patients, we selected five miRNAs that showed differences in serum levels between patients with and without tumor responses among 179 known secretory miRNAs by using locked nucleic acid probe-based quantitative PCR. Through fur...
Source: Liver Cancer - December 18, 2016 Category: Cancer & Oncology Source Type: research

Commentary on the Paper “Anatomical Study of the Caudate Lobe with Special Reference to the Portal Venous and Biliary Branches Using Corrosion Liver Casts and Clinical Application” by Kumon
Liver Cancer 2017;6:171-172 (Source: Liver Cancer)
Source: Liver Cancer - December 18, 2016 Category: Cancer & Oncology Source Type: research

Molecular Targeted Agents for Hepatocellular Carcinoma: Current Status and Future Perspectives
Liver Cancer 2017;6:101-112 (Source: Liver Cancer)
Source: Liver Cancer - December 14, 2016 Category: Cancer & Oncology Source Type: research

New Perspectives in the Treatment of Colorectal Metastases
Background: In recent years, the management of metastatic colorectal cancer has become more aggressive and more multidisciplinary. New treatment options have been proposed in addition to the standard approach of resection of liver metastases and chemotherapy.Summary:Selected patients with synchronous limited peritoneal and liver disease (peritoneal cancer index (Source: Liver Cancer)
Source: Liver Cancer - November 28, 2016 Category: Cancer & Oncology Source Type: research

Surgery of Colorectal Liver Metastases: Pushing the Limits
Background:The recent advent of more effective chemotherapy and the development of surgical procedures have expanded the pool of resectable patients with colorectal liver metastases (CLM). Two-stage hepatectomy (TSH), associated liver partition and portal vein ligation for staged hepatectomy (ALPPS), and ultrasound-guided enhanced one-stage hepatectomy (e-OSH) are the surgical solutions proposed for these patients, but the range of indications for these procedures vary from institution to institution.Summary:The advantages and disadvantages of each approach are herein discussed. Patients who drop out between the staged ope...
Source: Liver Cancer - November 28, 2016 Category: Cancer & Oncology Source Type: research