An Ecological Study of the Association between Air Pollution and Hepatocellular Carcinoma Incidence in Texas
Introduction: Primary liver cancer is a significant cause of cancer-related death in both the United States and the world at large. Hepatocellular carcinoma comprises 90% of these primary liver cancers and has numerous known etiologies. Evaluation of these identified etiologies and other traditional risk factors cannot explain the high incidence rates of hepatocellular carcinoma in Texas. Texas is home to the second largest petrochemical industry and agricultural industry in the nation; industrial activity and exposure to pathogenic chemicals have never been assessed as potential links to the state's increased incidence ra...
Source: Liver Cancer - August 28, 2017 Category: Cancer & Oncology Source Type: research

Sorafenib versus Hepatic Arterial Infusion Chemotherapy as Initial Treatment for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombosis
Conclusion: For the treatment of HCC with Vp3/Vp4, it is desirable to initially use LFP and then immediately change to sorafenib if no response is obtained.Liver Cancer 2017;6:275-286 (Source: Liver Cancer)
Source: Liver Cancer - August 28, 2017 Category: Cancer & Oncology Source Type: research

Lenvatinib in Advanced Hepatocellular Carcinoma
Liver Cancer 2017;6:253-263 (Source: Liver Cancer)
Source: Liver Cancer - August 28, 2017 Category: Cancer & Oncology Source Type: research

Title Page / Table of Contents
Liver Cancer 2017;6(suppl 1):I-IV (Source: Liver Cancer)
Source: Liver Cancer - July 13, 2017 Category: Cancer & Oncology Source Type: research

The 8th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2017). The Art & Science of Conquering Liver Cancer. Singapore, July 14-16, 2017: Abstracts
Liver Cancer 2017;6(suppl 1):1-71 (Source: Liver Cancer)
Source: Liver Cancer - July 13, 2017 Category: Cancer & Oncology Source Type: research

Information of APPLE 2017
Liver Cancer 2017;6:252 (Source: Liver Cancer)
Source: Liver Cancer - June 6, 2017 Category: Cancer & Oncology Source Type: research

The APPLE Association President's Message
Liver Cancer 2017;6:251 (Source: Liver Cancer)
Source: Liver Cancer - June 6, 2017 Category: Cancer & Oncology Source Type: research

Apple News
Liver Cancer 2017;6:250 (Source: Liver Cancer)
Source: Liver Cancer - June 6, 2017 Category: Cancer & Oncology Source Type: research

Beneficial Effect of Maintaining Hepatic Reserve during Chemotherapy on the Outcomes of Patients with Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) usually develops in chronically damaged liver. We investigated hepatic reserves during chemotherapy of patients with advanced HCC and compensated liver function to evaluate the effect on patients' outcomes of maintaining hepatic reserve after chemotherapy. We retrospectively reviewed the medical records of 190 patients with Child-Pugh A with advanced HCC who were treated with sorafenib or hepatic arterial infusion chemotherapy (HAIC). We investigated the Child-Pugh score and albumin-bilirubin grade for hepatic reserve, and evaluated the effect of the change in Child-Pugh scores on patients' o...
Source: Liver Cancer - May 16, 2017 Category: Cancer & Oncology Source Type: research

The Overall Survival of Patients with Hepatocellular Carcinoma Correlates with the Newly Defined Time to Progression after Transarterial Chemoembolization
Conclusions: There was a moderate correlation between the TTTP and OS of patients with HCC after TACE therapy, where the patients with short TTTP represented short OS, indicating that TTTP is an alternative parameter for survival analysis of HCC patients with BCLC stage B tumors who undergo TACE.Liver Cancer 2017;6:227-235 (Source: Liver Cancer)
Source: Liver Cancer - May 9, 2017 Category: Cancer & Oncology Source Type: research

Adoption of Sorafenib for the Treatment of Advanced-Stage Hepatocellular Carcinoma in Oncology Practices in the United States
Conclusions: Sorafenib has not been widely adopted into oncology practice since FDA approval for advanced HCC. Few factors apart from Child-Pugh score and race/ethnicity predict sorafenib use in clinical practice, although sorafenib treatment is associated with a lower risk of death.Liver Cancer 2017;6:216-226 (Source: Liver Cancer)
Source: Liver Cancer - April 27, 2017 Category: Cancer & Oncology Source Type: research

How to Differentiate Borderline Hepatic Nodules in Hepatocarcinogenesis: Emphasis on Imaging Diagnosis
This article discusses radiological and pathological characteristics of these borderline hepatic nodules and offers an understanding of multistep hepatocarcinogenesis by focusing on the descriptions of the imaging changes in the progression of DN and early HCC. Detection and accurate diagnosis of borderline hepatic nodules are still a challenge with contrast enhanced ultrasonography, CT, and MRI with extracellular contrast agents. However, gadoxetic acid-enhanced MRI may be useful for improving the diagnosis of these borderline nodules.Key Messages: Since there is a net effect of incomplete neoangiogenesis and decreased po...
Source: Liver Cancer - March 8, 2017 Category: Cancer & Oncology Source Type: research

Albumin-Bilirubin (ALBI) Grade as Part of the Evidence-Based Clinical Practice Guideline for HCC of the Japan Society of Hepatology: A Comparison with the Liver Damage and Child-Pugh Classifications
Aim/Background: The purpose of this study was to evaluate the validity of 3 classifications for assessing liver function, the liver damage and Child-Pugh classifications and the newly proposed albumin-bilirubin (ALBI) grade, in order to examine the feasibility of evaluating hepatic function using ALBI grade with the hepatocellular carcinoma (HCC) treatment algorithm used in Japan.Methods: We analyzed the medical records of 3,495 Japanese HCC patients admitted from 2000 to 2015, which were comprised of 1,580 patients hospitalized in the Ehime Prefecture area and used as a training cohort (Ehime group), and 1,915 others who ...
Source: Liver Cancer - March 8, 2017 Category: Cancer & Oncology Source Type: research

Albumin-Bilirubin Grade and Hepatocellular Carcinoma Treatment Algorithm
Liver Cancer 2017;6:185-188 (Source: Liver Cancer)
Source: Liver Cancer - March 8, 2017 Category: Cancer & Oncology Source Type: research

A New Era of Systemic Therapy for Hepatocellular Carcinoma with Regorafenib and Lenvatinib
Liver Cancer 2017;6:177-184 (Source: Liver Cancer)
Source: Liver Cancer - March 8, 2017 Category: Cancer & Oncology Source Type: research