Impacts of COVID-19 on Liver Cancers: During and after the Pandemic
Background: The pandemic of coronavirus disease 2019 (COVID-19) has diverted resources from healthcare services for patients with chronic medical illness such as cancer. COVID-19 also causes organ dysfunction, complicating cancer treatment. In most countries with an outbreak of COVID-19, modifications of cancer management have been adopted to accommodate the crisis and minimize the exposure of cancer patients to the infection. In countries where COVID-19 numbers are subsiding, medical teams should also be prepared to resume normal practices gradually. Here, we aim to review the literature on the impact of COVID-19 on patie...
Source: Liver Cancer - September 1, 2020 Category: Cancer & Oncology Source Type: research

Gd-EOB-DTPA-MRI Could Predict WNT/ β-Catenin Mutation and Resistance to Immune Checkpoint Inhibitor Therapy in Hepatocellular Carcinoma
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - August 20, 2020 Category: Cancer & Oncology Source Type: research

Sequencing Systemic Therapy Pathways for Advanced Hepatocellular Carcinoma: A Cost Effectiveness Analysis
Conclusions: The most cost-effective strategy was 1st-line tyrosine kinase inhibitor therapy followed by 2nd-line immunotherapy. All pathways exceeded a commonly accepted WTP of USD 100 –150,000/QALY. Our preliminary results warrant further studies to best inform real-world practices.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - August 12, 2020 Category: Cancer & Oncology Source Type: research

A Comparison of Biannual Two-Phase Low-Dose Liver CT and US for HCC Surveillance in a Group at High Risk of HCC Development
Conclusions: Patients with a risk index ≥2.33 showed a high annual incidence of HCC development in our study, and two-phase LDCT showed significantly higher sensitivity and specificity for HCC detection than US.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - August 6, 2020 Category: Cancer & Oncology Source Type: research

APPLE News
Liver Cancer 2020;9:477 –478 (Source: Liver Cancer)
Source: Liver Cancer - August 5, 2020 Category: Cancer & Oncology Source Type: research

Real-World Efficacy and Safety of Lenvatinib in Korean Patients with Advanced Hepatocellular Carcinoma: A Multicenter Retrospective Analysis
Conclusions: In this real-world study, lenvatinib was found to be well tolerated and effective in more heterogeneous HCC patient populations.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 29, 2020 Category: Cancer & Oncology Source Type: research

Hepatic Arterial Infusion Chemotherapy versus Sorafenib in Patients with Advanced Hepatocellular Carcinoma
Conclusion: HAIC is a potential front-line treatment choice in a subpopulation of patients with advanced HCC with MVI but without EHM.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 24, 2020 Category: Cancer & Oncology Source Type: research

The Burden and Trends of Primary Liver Cancer Caused by Specific Etiologies from 1990 to 2017 at the Global, Regional, National, Age, and Sex Level Results from the Global Burden of Disease Study 2017
Conclusions: The global incidence is still rising and the causes have national, regional, or population specificities. More targeted prevention strategies must be developed for the different etiologic types in order to reduce liver cancer burden.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Analyses of Intermediate-Stage Hepatocellular Carcinoma Patients Receiving Transarterial Chemoembolization prior to Designing Clinical Trials
Conclusions: Our results demonstrate the basis for selecting a population that would not benefit from TACE and setting DRR ≥3 months or ≥6 months as alternative endpoints when designing clinical trials comparing TACE and ICIs.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 22, 2020 Category: Cancer & Oncology Source Type: research

Changes in Background Liver Function in Patients with Hepatocellular Carcinoma over 30 Years: Comparison of Child-Pugh Classification and Albumin Bilirubin Grade
Conclusions: CPC is not suitable for assessing patients with recently diagnosed HCC and good remnant hepatic function. In such patients with HCC, the prognosis can be stratified by ALBI grade rather than CPC.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 16, 2020 Category: Cancer & Oncology Source Type: research

Liver Injury in COVID-19: Caution and Management
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 14, 2020 Category: Cancer & Oncology Source Type: research

Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice
Conclusion: DR suppressed steatosis-associated hepatic tumorigenesis in HCVcpTg mice, mainly due to attenuation of pathways involved in inflammation, cellular stress, cell proliferation, insulin signaling, and senescence. These findings support the notion that persistent 30% reduction of daily food intake is beneficial for preventing steatosis-associated hepatocarcinogenesis caused by HCV core protein.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 10, 2020 Category: Cancer & Oncology Source Type: research

A Paradigm Change in the Treatment Strategy for Hepatocellular Carcinoma
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - June 29, 2020 Category: Cancer & Oncology Source Type: research

APPLE News
Liver Cancer 2020;9:365 –366 (Source: Liver Cancer)
Source: Liver Cancer - June 15, 2020 Category: Cancer & Oncology Source Type: research

The Era of the Hepatic Oncologist
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - June 3, 2020 Category: Cancer & Oncology Source Type: research