Multidisciplinary Taiwan Consensus Recommendations for the Use of DEBDOX-TACE in Hepatocellular Carcinoma Treatment
Transarterial chemoembolization (TACE) is the first-line treatment in patients with unresectable hepatocellular carcinoma (HCC). In recent years, there has been increasing clinical evidence that drug-eluting beads provide a combined ischemic and cytotoxic effect that may be superior to conventional TACE, with low systemic toxicity. The therapeutic value of TACE performed using the embolic microsphere DC Bead loaded with doxorubicin (drug-eluting bead doxorubicin [DEBDOX]) has been shown by several randomized controlled trials. Since Lencioni et al. [Cardiovasc Intervent Radiol 2012; 35: 980 –985] published the first wide...
Source: Liver Cancer - March 29, 2018 Category: Cancer & Oncology Source Type: research

A Phase I/Randomized Phase II Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of Nintedanib versus Sorafenib in Asian Patients with Advanced Hepatocellular Carcinoma
Conclusions: Nintedanib showed numerically similar efficacy to sorafenib for CIR TTP and OS in Asian patients with advanced HCC and adequate liver function. AEs were generally manageable.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - March 15, 2018 Category: Cancer & Oncology Source Type: research

The Prognosis of Single Large Hepatocellular Carcinoma Was Distinct from Barcelona Clinic Liver Cancer Stage A or B: The Role of Albumin-Bilirubin Grade
Conclusion: Patients in the SLHCC group had an overall survival rate intermediate to those of the BCLC-A and BCLC-B groups. It is suggested that the SLHCC group could be classified as occupying a different stage from the BCLC stages A and B. The ALBI grade could help to stratify SLHCC into a different prognostic group. However, the results need to be validated externally in other regions of the world.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - March 14, 2018 Category: Cancer & Oncology Source Type: research

Effectiveness of Particle Radiotherapy in Various Stages of Hepatocellular Carcinoma: A Pilot Study
Conclusions: The local control rates after PRT were sufficiently high compared to TACE or sorafenib. Thus, PRT should be adopted for patients with difficult-to-treat HCC in the early and intermediate stages.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - March 14, 2018 Category: Cancer & Oncology Source Type: research

Long-Term Prognostic Factors after Hepatic Resection for Hepatitis C Virus-Related Hepatocellular Carcinoma, with a Special Reference to Viral Status
Conclusion: The prognostic factors varied according to the duration after hepatic resection for HCV-related HCC. Tumor-related factors were unfavorable prognostic factors in the early postoperative period, whereas SVR and good liver function were favorable prognostic factors at 10 and 15 years postoperatively. Achievement of SVR with IFN therapy is essential for long-term ( ≥15 years) survival after hepatic resection for HCV-related HCC.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - March 14, 2018 Category: Cancer & Oncology Source Type: research

APPLE News
Liver Cancer 2018;7:120 –120 (Source: Liver Cancer)
Source: Liver Cancer - March 12, 2018 Category: Cancer & Oncology Source Type: research

The APPLE Association President's Message
Liver Cancer 2018;7:121 –121 (Source: Liver Cancer)
Source: Liver Cancer - March 12, 2018 Category: Cancer & Oncology Source Type: research

Immune Gene Expression Profile in Hepatocellular Carcinoma and Surrounding Tissue Predicts Time to Tumor Recurrence
Conclusions: Immune gene expression profiles predictive of TTR could be identified both in HCC and in adjacent cirrhotic tissues. Longer TTR was associated with overexpression in T tissue and downregulation in NT tissue of the immune response and of inflammation-related genes.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - March 7, 2018 Category: Cancer & Oncology Source Type: research

Liver Transplantation for Intermediate-Stage Hepatocellular Carcinoma
In conclusion, outcomes after LT for intermediate-stage HCC are more favorable if patients meet our extended criteria.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - March 1, 2018 Category: Cancer & Oncology Source Type: research

Risk of de novo Hepatocellular Carcinoma after HCV Treatment with Direct-Acting Antivirals
Conclusion: The de novo HCC rates did not differ between the DAA-treated patients and those who received IFN. Achievement of SVR is of utmost importance for HCC prevention.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - March 1, 2018 Category: Cancer & Oncology Source Type: research

Lenvatinib May Drastically Change the Treatment Landscape of Hepatocellular Carcinoma
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - February 15, 2018 Category: Cancer & Oncology Source Type: research

Combination Cancer Immunotherapy in Hepatocellular Carcinoma
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - January 31, 2018 Category: Cancer & Oncology Source Type: research

Hong Kong Consensus Statements for the Management of Unresectable Hepatocellular Carcinoma
Background: Hepatocellular carcinoma (HCC) is highly prevalent in Hong Kong due to the high prevalence of chronic hepatitis B infection. Liver cancer is the fourth most common cancer and the third most common cause of cancer death. Due to the high case load, there is a high level of local expertise in treating HCC, and the full spectrum of treatment modalities is available. This document summarizes how these modalities should be used based on the latest evidence.Summary: In 2 meetings held in early 2017, a multidisciplinary group of Hong Kong clinicians, including liver surgeons, interventional radiologists, clinical oncol...
Source: Liver Cancer - January 25, 2018 Category: Cancer & Oncology Source Type: research

Liver Stiffness Measured by Two-Dimensional Shear-Wave Elastography: Prognostic Value after Radiofrequency Ablation for Hepatocellular Carcinoma
Purpose: To evaluate the prognostic value of liver stiffness (LS) measured using two-dimensional (2D) shear-wave elastography (SWE) in patients with hepatocellular carcinoma (HCC) treated by radiofrequency ablation (RFA).Methods: The Institutional Review Board approved this retrospective study and informed consent was obtained from all patients. A total of 134 patients with up to 3 HCCs ≤5 cm who had undergone pre-procedural 2D-SWE prior to RFA treatment between January 2012 and December 2013 were enrolled. LS values were measured using real-time 2D-SWE before RFA on the procedural day. After a mean follow-up of 33.8 ± ...
Source: Liver Cancer - January 11, 2018 Category: Cancer & Oncology Source Type: research

Patient Selection for Transarterial Chemoembolization in Hepatocellular Carcinoma: Importance of Benefit/Risk Assessment
Background: Liver cancer is the second most common cause of cancer-related death, with hepatocellular carcinoma (HCC) accounting for most primary liver cancers and most commonly arising from a history of advanced chronic liver disease. Among the available therapies, transarterial chemoembolization (TACE) is the most widely utilized and is considered the first-line treatment recommended for patients staged as intermediate HCC (Barcelona Clinic Liver Cancer stage B). If applied correctly, TACE can produce survival benefits without adversely affecting hepatic functional reserve. Summary: The aim of this nonsystematic review i...
Source: Liver Cancer - January 11, 2018 Category: Cancer & Oncology Source Type: research