Contents Vol. 9, 2020
Liver Cancer 2020;9:I –VIII (Source: Liver Cancer)
Source: Liver Cancer - December 1, 2020 Category: Cancer & Oncology Source Type: research

Acknowledgements to Reviewers
Liver Cancer 2020;9:791 –792 (Source: Liver Cancer)
Source: Liver Cancer - December 1, 2020 Category: Cancer & Oncology Source Type: research

APPLE News
Liver Cancer 2020;9:793 –794 (Source: Liver Cancer)
Source: Liver Cancer - December 1, 2020 Category: Cancer & Oncology Source Type: research

Recent Advances in Systemic Therapy for Hepatocellular Carcinoma in an Aging Society: 2020 Update
Systemic therapy for hepatocellular carcinoma (HCC) has changed markedly since the introduction of the molecular targeted agent sorafenib in 2007. Sorafenib increased the available treatment options for patients with extrahepatic spread and vascular invasion and improved survival in patients with advanced HCC; however, various shortcomings such as low response rates and relatively high toxicity (e.g., hand-foot skin reaction) prompted concerted efforts aimed at developing new molecular targeted agents to provide more treatment options and second-line agents for patients with disease progression or intolerance to sorafenib....
Source: Liver Cancer - November 17, 2020 Category: Cancer & Oncology Source Type: research

Impact of Extrahepatic Metastases on Overall Survival in Patients with Advanced Liver Dominant Hepatocellular Carcinoma: A Subanalysis of the SORAMIC Trial
Conclusions: This subanalysis of the SORAMIC trial suggests that in patients with liver-dominant advanced HCC, metastases to distant organs with the exception of pulmonary metastases do not in general exert a negative impact on patient prognosis. The choice of palliative treatment should incorporate a personalized analysis of the pattern of tumor distribution.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - November 11, 2020 Category: Cancer & Oncology Source Type: research

Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition)
Background: Primary liver cancer, around 90% are hepatocellular carcinoma in China, is the fourth most common malignancy and the second leading cause of tumor-related death, thereby posing a significant threat to the life and health of the Chinese people.Summary: Since the publication ofGuidelines for Diagnosis and Treatment of Primary Liver Cancer (2017 Edition) in 2018, additional high-quality evidence has emerged with relevance to the diagnosis, staging, and treatment of liver cancer in and outside China that requires the guidelines to be updated. The new edition(2019 Edition) was written by more than 70 experts in the ...
Source: Liver Cancer - November 11, 2020 Category: Cancer & Oncology Source Type: research

Lenvatinib-Transarterial Chemoembolization Sequential Therapy as an Effective Treatment at Progression during Lenvatinib Therapy for Advanced Hepatocellular Carcinoma
Conclusion: Oncological aggressiveness of HCC estimated by CT enhancement pattern was predictive of PPS after progression during lenvatinib. Successful subsequent treatment with lenvatinib-TACE sequential therapy may offer survival benefit regardless of CT enhancement pattern of HCC.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

The Real Impact of Bridging or Downstaging on Survival Outcomes after Liver Transplantation for Hepatocellular Carcinoma
Conclusions: The impact of bridging therapy on survival outcomes is limited in patients with early-stage HCC, whereas OPTN T1 or T2 with progression provides worse prognosis. OPTN T3 should undergo LT after successful downstaging, and OPTN T3 with successful downstaging allows for acceptable long-term posttransplant outcomes.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - October 28, 2020 Category: Cancer & Oncology Source Type: research

Surveillance for Hepatocellular Carcinoma Also Improves Survival of Incidentally Detected Intrahepatic Cholangiocarcinoma Arisen in Liver Cirrhosis
Conclusions: Cirrhotic patients have different clinical presentation and outcomes of ICC according to their surveillance status. In our series, ICC in cirrhosis was not associated with worse OS. Cirrhosis itself should not discourage either surgical or non-surgical treatments.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - October 28, 2020 Category: Cancer & Oncology Source Type: research

Limited Impact of Anti-PD-1/PD-L1 Monotherapy for Hepatocellular Carcinoma
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - October 26, 2020 Category: Cancer & Oncology Source Type: research

Clinico-Radio-Pathological and Molecular Features of Hepatocellular Carcinomas with Keratin 19 Expression
Hepatocellular carcinoma (HCC) is a heterogeneous neoplasm, both from the molecular and histomorphological aspects. One example of heterogeneity is the expression of keratin 19 (K19) in a subset (4 –28%) of HCCs. The presence of K19 expression in HCCs has important clinical implications, as K19-positive HCCs have been associated with aggressive tumor biology and poor prognosis. Histomorphologically, K19-positive HCCs demonstrate a more infiltrative appearance, poor histological differentiati on, more frequent vascular invasion, and more intratumoral fibrous stroma than K19-negative conventional HCCs. From the molecular a...
Source: Liver Cancer - October 23, 2020 Category: Cancer & Oncology Source Type: research

EZ-ALBI Score for Predicting Hepatocellular Carcinoma Prognosis
Conclusions: The EZ-ALBI score, EZ-ALBI grade, and EZ-ALBI-T grade are useful, simple scores, which might replace the conventional ALBI score in the future.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - October 23, 2020 Category: Cancer & Oncology Source Type: research

APPLE News
Liver Cancer 2020;9:627 –628 (Source: Liver Cancer)
Source: Liver Cancer - September 18, 2020 Category: Cancer & Oncology Source Type: research

Reply to the Letter “Microvascular Invasion as a Prognostic Predictor in Hepatocellular Carcinoma: How Accurate Is It?”
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: research

Microvascular Invasion as a Prognostic Predictor in Hepatocellular Carcinoma: How Accurate Is It?
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - September 8, 2020 Category: Cancer & Oncology Source Type: research