Associations of Serum Tumor Biomarkers with Integrated Genomic and Clinical Characteristics of Hepatocellular Carcinoma
Conclusions: Serum AFP, AFP-L3, and DCP levels can help predict variants in the genetic profile of HCC, especially forTP53 andCTNNB1. These findings may facilitate development of an evidence-based approach to treatment.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - September 22, 2021 Category: Cancer & Oncology Source Type: research

Tenofovir Is Superior to Entecavir on Tertiary Prevention for BCLC Stage 0/A Hepatocellular Carcinoma after Curative Resection
Conclusions: TDF therapy is associated with a significantly lower risk of HCC recurrence, especially of late recurrence, than ETV therapy among patients who undergo curative hepatectomy for HBV-related early-stage HCC.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - September 21, 2021 Category: Cancer & Oncology Source Type: research

Immune Checkpoint Inhibitors: The Emerging Cornerstone in Cholangiocarcinoma Therapy?
Background: Cholangiocarcinoma (CCA) encompasses a heterogeneous group of malignant tumors with dismal prognosis and increasing incidence worldwide. Both late diagnosis due to the lack of early symptoms and the refractory nature of these tumors seriously compromise patients ’ welfare and outcomes.Summary: During the last decade, immunotherapy and, more specifically, modulation of immune checkpoints-mediated signaling pathways have been under the spotlight in the field of oncology, emerging as a potential therapeutic approach for the treatment of several cancers, including CCA. Generally, high expression levels of immune ...
Source: Liver Cancer - September 21, 2021 Category: Cancer & Oncology Source Type: research

Evolutionary Learning-Derived Clinical-Radiomic Models for Predicting Early Recurrence of Hepatocellular Carcinoma after Resection
Conclusion: The GARSL models using both clinical and radiomic features significantly improved the accuracy to predict early recurrence of HCC after surgical resection, which was significantly better than other well-known machine learning-derived models and currently available clinical models.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - September 20, 2021 Category: Cancer & Oncology Source Type: research

Postresection Period-Specific Hazard of Recurrence as a Framework for Surveillance Strategy in Patients with Hepatocellular Carcinoma: A Multicenter Outcome Study
Conclusions: Our chronological and morphological insights into recurrence after resection of primary HCCs may help implement an optimal intensity of surveillance for recurrence.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - September 17, 2021 Category: Cancer & Oncology Source Type: research

Adjuvant Immunotherapy after Curative Treatment for Hepatocellular Carcinoma
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - September 6, 2021 Category: Cancer & Oncology Source Type: research

Phase II Trial of the Combination of Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma with Tumor Mutation Profiling
Conclusions: The combination of temsirolimus and sorafenib demonstrated acceptable safety but did not achieve the target threshold for efficacy in this phase II study. Tumor NGS including the presence ofmTOR pathway mutations was not associated with treatment response in an exploratory subgroup analysis.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - September 6, 2021 Category: Cancer & Oncology Source Type: research

Adjuvant Radiotherapy for Extrahepatic Cholangiocarcinoma: A Quality Assessment-Based Meta-Analysis
Conclusions: ART was shown to improve OS in all studies and in those selected for their reliable comparability.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - August 26, 2021 Category: Cancer & Oncology Source Type: research

The Prognostic Impact of Tumor Differentiation on Recurrence and Survival after Resection of Hepatocellular Carcinoma Is Dependent on Tumor Size
Conclusions: Por HCC measuring ≥2 cm was associated with early recurrence. Hence, it had negative effects on OS. After surgery, patients with Por HCC measuring ≥5 cm should be cautiously monitored for early extrahepatic recurrence. These findings will help physicians devise treatment strategies for patients with HCC.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - August 24, 2021 Category: Cancer & Oncology Source Type: research

Higher Enhancement Intrahepatic Nodules on the Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI as a Poor Responsive Marker of Anti-PD-1/PD-L1 Monotherapy for Unresectable Hepatocellular Carcinoma
Conclusion: The TTnP on HCC nodules with higher enhancement and the median PFS in patients who carried higher enhancement intrahepatic HCC nodules were significantly shorter than those in hypointense HCC nodules with anti-PD-1/PD-L1 monotherapy. The intensity of the nodule on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI is a promising imaging biomarker for predicting unfavorable response with anti-PD-1/PD-L1 monotherapy in patients with HCC.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - August 19, 2021 Category: Cancer & Oncology Source Type: research

Use of Antibiotics during Immune Checkpoint Inhibitor Treatment Is Associated with Lower Survival in Hepatocellular Carcinoma
Conclusions: Concurrent antibiotic use during immunotherapy was associated with higher mortality in patients with advanced HCC. Further studies should examine the role of gut dysbiosis on responses to ICI.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - August 18, 2021 Category: Cancer & Oncology Source Type: research

Redefining Tumor Burden in Patients with Intermediate-Stage Hepatocellular Carcinoma: The Seven-Eleven Criteria
Conclusion: Conventional definitions of tumor burden were not optimal for patients with intermediate HCC. The new 7 –11 criteria had the best discriminative power in predicting radiologic response and survival in patients with intermediate-stage HCC undergoing TACE.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 22, 2021 Category: Cancer & Oncology Source Type: research

APPLE News
Liver Cancer 2021;10:396 –398 (Source: Liver Cancer)
Source: Liver Cancer - July 20, 2021 Category: Cancer & Oncology Source Type: research

Twenty Years of Radiation Therapy of Unresectable Intrahepatic Cholangiocarinoma: Internal or External? A Systematic Review and Meta-Analysis
Conclusions: Both EBRT and SIRT were safe and effective in treating unresectable iCCA. However, available evidence was highly heterogeneous regarding patient population, limiting fair comparison between 2 radiation modalities. Future high-quality comparative studies are warranted.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 19, 2021 Category: Cancer & Oncology Source Type: research

Baseline Liver Function and Subsequent Outcomes in the Phase 3 REFLECT Study of Patients with Unresectable Hepatocellular Carcinoma
Conclusions: Better liver function at baseline, as measured by ALBI grade or CPS, may be prognostic for better survival outcomes in patients with uHCC undergoing treatment with lenvatinib or sorafenib.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 15, 2021 Category: Cancer & Oncology Source Type: research