The Burden and Trends of Primary Liver Cancer Caused by Specific Etiologies from 1990 to 2017 at the Global, Regional, National, Age, and Sex Level Results from the Global Burden of Disease Study 2017
Conclusions: The global incidence is still rising and the causes have national, regional, or population specificities. More targeted prevention strategies must be developed for the different etiologic types in order to reduce liver cancer burden.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 23, 2020 Category: Cancer & Oncology Source Type: research

Analyses of Intermediate-Stage Hepatocellular Carcinoma Patients Receiving Transarterial Chemoembolization prior to Designing Clinical Trials
Conclusions: Our results demonstrate the basis for selecting a population that would not benefit from TACE and setting DRR ≥3 months or ≥6 months as alternative endpoints when designing clinical trials comparing TACE and ICIs.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 22, 2020 Category: Cancer & Oncology Source Type: research

Changes in Background Liver Function in Patients with Hepatocellular Carcinoma over 30 Years: Comparison of Child-Pugh Classification and Albumin Bilirubin Grade
Conclusions: CPC is not suitable for assessing patients with recently diagnosed HCC and good remnant hepatic function. In such patients with HCC, the prognosis can be stratified by ALBI grade rather than CPC.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 16, 2020 Category: Cancer & Oncology Source Type: research

Liver Injury in COVID-19: Caution and Management
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 14, 2020 Category: Cancer & Oncology Source Type: research

Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice
Conclusion: DR suppressed steatosis-associated hepatic tumorigenesis in HCVcpTg mice, mainly due to attenuation of pathways involved in inflammation, cellular stress, cell proliferation, insulin signaling, and senescence. These findings support the notion that persistent 30% reduction of daily food intake is beneficial for preventing steatosis-associated hepatocarcinogenesis caused by HCV core protein.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - July 10, 2020 Category: Cancer & Oncology Source Type: research

A Paradigm Change in the Treatment Strategy for Hepatocellular Carcinoma
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - June 29, 2020 Category: Cancer & Oncology Source Type: research

APPLE News
Liver Cancer 2020;9:365 –366 (Source: Liver Cancer)
Source: Liver Cancer - June 15, 2020 Category: Cancer & Oncology Source Type: research

The Era of the Hepatic Oncologist
Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - June 3, 2020 Category: Cancer & Oncology Source Type: research

Publisher's Note
Liver Cancer 2020;9:231 (Source: Liver Cancer)
Source: Liver Cancer - June 3, 2020 Category: Cancer & Oncology Source Type: research

Better Efficacy of Ramucirumab in Japanese Patients than in the Global Population with Unresectable Hepatocellular Carcinoma
Liver Cancer 2020;9:232 –244 (Source: Liver Cancer)
Source: Liver Cancer - May 29, 2020 Category: Cancer & Oncology Source Type: research

A Changing Paradigm for the Treatment of Intermediate-Stage Hepatocellular Carcinoma: Asia-Pacific Primary Liver Cancer Expert Consensus Statements
The Asia-Pacific Primary Liver Cancer Expert (APPLE) Consensus Statement on the treatment strategy for patients with intermediate-stage hepatocellular carcinoma (HCC) was established on August 31, 2019, in Sapporo, Hokkaido during the 10th Annual APPLE Meeting. This manuscript summarizes the international consensus statements developed at APPLE 2019. Transarterial chemoembolization (TACE) is the only guideline-recommended global standard of care for intermediate-stage HCC. However, not all patients benefit from TACE because intermediate-stage HCC is a heterogeneous disease in terms of tumor burden and liver function. Ten i...
Source: Liver Cancer - May 13, 2020 Category: Cancer & Oncology Source Type: research

Mortality after Transplantation for Hepatocellular Carcinoma: A Study from the European Liver Transplant Registry
Conclusions: Using PS calibration, we showed that HCC in non-cirrhotic liver has similar overall mortality, but higher HCC-specific mortality. This may be a result of a more aggressive cancer form in the non-cirrhotic liver as higher mortality could not be explained by tumour characteristics or other prognostic variables.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - May 12, 2020 Category: Cancer & Oncology Source Type: research

Tenofovir Treatment Has Lower Risk of Hepatocellular Carcinoma than Entecavir Treatment in Patients with Chronic Hepatitis B: A Systematic Review and Meta-Analysis
Conclusions: Evidence to date suggests that TDF treatment is associated with significantly fewer cases of HCC when compared to ETV.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - May 5, 2020 Category: Cancer & Oncology Source Type: research

Potential of Lenvatinib for an Expanded Indication from the REFLECT Trial in Patients with Advanced Hepatocellular Carcinoma
Conclusion: Lenvatinib had potential benefits for patients with advanced HCC with second- or later-line therapies and a high burden of intrahepatic lesions. Dose modification should be paid increased attention among patients with poor liver function, such as Child-Pugh class B patients.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - May 5, 2020 Category: Cancer & Oncology Source Type: research

Irradiation-Related Lymphopenia for Bone Metastasis from Hepatocellular Carcinoma
Conclusion: TRL was observed in patients receiving RT for bone metastasis from HCC, and it was associated with poor survival. The percentage of active bone marrow within the RT field significantly affected TRL development. The results suggest that a new strategy is required to prevent TRL.Liver Cancer (Source: Liver Cancer)
Source: Liver Cancer - June 21, 2019 Category: Cancer & Oncology Source Type: research