Rewriting the rules for care of MDS and AML patients in the time of COVID-19
Publication date: Available online 20 April 2020Source: Leukemia Research ReportsAuthor(s): Azra Raza, Amer Assal, Abdullah M. Ali, Joseph G. Jurcic (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - April 21, 2020 Category: Hematology Source Type: research
Successful Treatment of Ocular Chronic Lymphocytic Leukemia with Ibrutinib: Case Report and Review of the Literature
Publication date: Available online 20 April 2020Source: Leukemia Research ReportsAuthor(s): Ayushi F Chauhan, Narine Viruni, T.Y. Alvin Liu, J Fernando Arevalo, Bruce D Cheson (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - April 21, 2020 Category: Hematology Source Type: research
Association between body mass index and insulin resistance in survivors of pediatric acute lymphoblastic leukemia
Publication date: Available online 19 April 2020Source: Leukemia Research ReportsAuthor(s): Gholamreza Bahoush, Pourya Salajegheh, Farzaneh Rohani (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - April 21, 2020 Category: Hematology Source Type: research
The sensitivity of the FLT3-ITD detection method is an important consideration when diagnosing acute myeloid leukemia
Publication date: Available online 19 April 2020Source: Leukemia Research ReportsAuthor(s): Masahiro Sakaguchi, Nana Nakajima, Hiroki Yamaguchi, Yuho Najima, Katsuhiro Shono, Atsushi Marumo, Ikuko Omori, Yusuke Fujiwara, Kazuki Terada, Shunsuke Yui, Satoshi Wakita, Miho Mitaya, Kunihito Arai, Tomoaki Kitano, Noriko Doki, Kazuteru Ohashi, Koiti Inokuchi (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - April 21, 2020 Category: Hematology Source Type: research
Hairy cell leukemia with CCND1/IGH fusion gene and BRAF V600E mutation
Publication date: Available online 17 March 2020Source: Leukemia Research ReportsAuthor(s): Zaid Abdel Rahman, Firas Muwalla, Liuyan Jiang, James Foran (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - March 18, 2020 Category: Hematology Source Type: research
The acquisition of trisomy 8 associated with Behçet's-like disease in myelodysplastic syndrome
Publication date: Available online 12 March 2020Source: Leukemia Research ReportsAuthor(s): Satoko Oka, Kazuo Ono, Masaharu Nohgawa (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - March 13, 2020 Category: Hematology Source Type: research
Molecular responses in e19a2 BCR-ABL1 chronic myeloid leukemia
Publication date: Available online 12 March 2020Source: Leukemia Research ReportsAuthor(s): Laura Kearney, Mireille Crampe, Eibhlin Conneally, Janusz Krawczyk, Senthil Kumar, Philip T. Murphy, Vitaliy Mykytiv, Mary-Frances Ryan, Stephen E. Langabeer (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - March 13, 2020 Category: Hematology Source Type: research
JAK2-negative acute monocytic leukemia with TET2 mutation in essential thrombocythemia with JAK2 mutation with literature review
Publication date: Available online 16 January 2020Source: Leukemia Research ReportsAuthor(s): Toshie Ogasawara, Kiyotaka Kawauchi, Takuya Ono, Kotaro Shide, Kazuya Shimoda, Naoki Mori, Hiroshi SakuraAbstractEssential thrombocythemia (ET) is an indolent myeloproliferative neoplasm (MPN) with a transformation to acute myeloid leukemia in <5% of patients. A 79-year-old man with JAK2V617F-positive ET exhibited leukocytosis with an increase in monoblastic cells, leading to a diagnosis of acute monoblastic and monocytic leukemia. Leukemic cells carried a TET2 mutation but not JAK2V617F mutation. We concluded that the TET2 mu...
Source: Leukemia Research Reports - January 17, 2020 Category: Hematology Source Type: research
Publisher's Note
Publication date: 2019Source: Leukemia Research Reports, Volume 12Author(s): (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - December 4, 2019 Category: Hematology Source Type: research
Association of genes arid5b, cebpe and folate pathway with acute lymphoblastic leukemia in a population from the brazilian amazon region
Publication date: Available online 27 November 2019Source: Leukemia Research ReportsAuthor(s): Darlen Cardoso de Carvalho, Alayde Vieira Wanderley, Fernando Augusto Rodrigues Mello, André Mauricio Ribeiro dos Santos, Luciana Pereira Colares Leitão, Tatiane Piedade de Souza, Amanda de Nazaré Cohen Lima de Castro, Leandro Lopes de Magalhães, Marianne Rodrigues Fernandes, João Augusto Nunes de Carvalho, André Salim Khayat, Sidney Santos, Paulo Pimentel de Assumpção, Ney Pereira Carneiro dos SantosAbstractAcute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility t...
Source: Leukemia Research Reports - November 27, 2019 Category: Hematology Source Type: research
Rate of Differentiation Syndrome in Patients Based on Timing of Initial All-Trans Retinoic Acid Administration
Publication date: Available online 27 November 2019Source: Leukemia Research ReportsAuthor(s): Mary Nauffal, Lillian Werner, Jian Ni, Richard M. Stone, Daniel J. DeAngelo, Anne M. McDonnellAbstractAll-trans-retinoic acid (ATRA) is the standard of care for the management of acute promyelocytic leukemia. (APL), but can be associated with differentiation syndrome (DS). Over a seven-year period, we sought to determine the impact of ATRA initiation time on the development of DS. ATRA administration time had no impact on DS occurrence (p=0.13), APL risk (p=0.28) or regimen received (p=0.1). Patients with higher mean body mass in...
Source: Leukemia Research Reports - November 27, 2019 Category: Hematology Source Type: research
Laryngeal mucous membrane plasmacytosis with 15 year follow-up: case report and literature review
We present a case of MMP with over 15 years of clinical follow-up, emphasizing the relatively benign clinical course of this disorder. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - November 27, 2019 Category: Hematology Source Type: research
Mutations of FLT3 receptor affect its surface glycosylation, intracellular localization, and downstream signaling
Publication date: Available online 27 November 2019Source: Leukemia Research ReportsAuthor(s): Shinichiro TakahashiAbstractThis review describes the effects of FLT3 mutations that alter its intracellular localization and modify its glycosylation, leading to differences in downstream signaling pathways. The most common type of FLT3 mutation, internal tandem duplication (FLT3-ITD), leads to localization in the endoplasmic reticulum and constitutive strong activation of STAT5. In contrast, the ligand-activated FLT3-wild type is mainly expressed on the cell surface and activates MAP kinases. Based on these backgrounds, several...
Source: Leukemia Research Reports - November 27, 2019 Category: Hematology Source Type: research
Inotuzumab ozogamicin as chemotherapy-sparing salvage in a 67-year-old man with primary refractory B-cell acute lymphoblastic leukemia with high-risk genomic features
Publication date: Available online 26 November 2019Source: Leukemia Research ReportsAuthor(s): Xiaochuan Yang, Filiz Sen, Mark B. GeyerAbstractOlder adults with acute lymphoblastic leukemia (ALL) continue to have a poor prognosis, in part due to greater chemotherapy-related toxicities. We herein report a 67-year-old man with Philadelphia chromosome (Ph)-negative B-cell ALL, who exhibited refractoriness to 3 different regimens of induction chemotherapy and experienced multiple complications including intracranial bleeding and respiratory failure, who achieved minimal residual disease (MRD)-negative complete response (CR) af...
Source: Leukemia Research Reports - November 26, 2019 Category: Hematology Source Type: research
Genotypic and Phenotypic Evolution in a Patient with Chronic Myelomonocytic Leukemia
Publication date: Available online 5 October 2019Source: Leukemia Research ReportsAuthor(s): Klaus Geissler, Eva Jäger, Michael GurbiszAbstractThe correlation of molecular and phenotypic evolution in individual patients with chronic myelomonocytic leukemia (CMML) is poorly investigated. The longitudinal follow up of a CMML patient for more than 10 years illustrates that the emergence of clones harboring mutations in TET2, SRSF2, RUNX1, MPL, NRAS, and finally in multiple genes, respectively, was mirrored by thrombocytopenia, thrombocytosis, myeloproliferation and transformation into acute myeloid leukemia. Moreover, molecu...
Source: Leukemia Research Reports - October 6, 2019 Category: Hematology Source Type: research
