Journals of Gerontology Series A: Biological Sciences and Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Mifepristone Reduces Food Palatability and Affects Drosophila Feeding and Lifespan
The Drosophila GeneSwitch system facilitates the spatial and temporal control of gene expression through dietary supplementation of mifepristone (RU486). Because experimental and control groups differ only by treatment with RU486, confounding results from using flies of different genetic backgrounds are eliminated, making GeneSwitch especially useful in studies of aging. However, the effect of RU486 itself on longevity has not been well characterized, particularly in relation to nutritional states known to affect lifespan. Here, we show that RU486 has dose- and diet-dependent effects on longevity in both sexes. On low nutr...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Yamada, R., Deshpande, S. A., Keebaugh, E. S., Ehrlich, M. R., Soto Obando, A., Ja, W. W. Tags: Original Article Source Type: research

Reduced Oxidative Burst by Primed Neutrophils in the Elderly Individuals Is Associated With Increased Levels of the CD16bright/CD62Ldim Immunosuppressive Subset
The aim of our study was to analyze polymorphonuclear neutrophil (PMN) functions in elderly individuals compared with those in healthy young participants, directly in whole blood to avoid issues with data interpretation related to cell isolation procedures. Despite the presence of increased circulating levels of proinflammatory cytokines, resting PMNs from the elderly individuals were not activated as shown by normal CD62L and CD11b expression at the PMN surface and normal constitutive reactive oxygen species (ROS) production. However, suboptimal stimulation induced modulations of CD62L and CD11b expression, which positive...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Sauce, D., Dong, Y., Campillo-Gimenez, L., Casulli, S., Bayard, C., Autran, B., Boddaert, J., Appay, V., Elbim, C. Tags: Original Article Source Type: research

Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344xBrown Norway Female Rat
Age-associated changes in cardiac structure and function, together with estrogen loss, contribute to the progression of heart failure with preserved ejection fraction in older women. To investigate the effects of aging and estrogen loss on the development of its precursor, asymptomatic left ventricular diastolic dysfunction, echocardiograms were performed in 10 middle-aged (20 months) and 30 old-aged (30 months) female Fischer344xBrown-Norway rats, 4 and 8 weeks after ovariectomy (OVX) and sham procedures (gonads left intact). The cardioprotective potential of administering chronic G1, the selective agonist to the new G-pr...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Alencar, A. K., da Silva, J. S., Lin, M., Silva, A. M., Sun, X., Ferrario, C. M., Cheng, C., Sudo, R. T., Zapata-Sudo, G., Wang, H., Groban, L. Tags: Original Article Source Type: research

Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans
Aging is marked by a collapse of protein homeostasis and deterioration of adaptive stress responses that often lead to disease. During aging, the induction of stress responses decline along with protein quality control. Here, we have shown that the ability to mount an adaptive response by pretreatment with minor oxidative stress is abrogated in aged Caenorhabditis elegans. We have identified a defect in SKN-1 signaling sensitivity during aging and have also found an aging-related increase in basal proteasome expression and in vitro activity, however, adaptation of the 20S proteasome in response to stress is lost in old ani...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Raynes, R., Juarez, C., Pomatto, L. C. D., Sieburth, D., Davies, K. J. A. Tags: Original Article Source Type: research

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Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical Sciences Table of Contents
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Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Cover
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Biological Sciences Table of Contents
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Biological
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Response to Letter From De Alfieri et al.: Biological Resilience of Elderly Hospitalized Patients
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Whitson, H. E., Duan-Porter, W., Schmader, K., Morey, M., Cohen, H. J., Colon-Emeric, C. Tags: Letter to the Editor Source Type: research

Biologic Resilience of Elderly Hospitalized Patients
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: De Alfieri, W., Borgogni, T., Costanzo, S., Nistico, F. Tags: Letter to the Editor Source Type: research

Association Between Sleep Characteristics and Incident Dementia Accounting for Baseline Cognitive Status: A Prospective Population-Based Study
Conclusions: Short and extended TIB and delayed rising among older adults predicted increased dementia incidence in the following 17 years. The pattern of findings suggests that extended TIB and late rising represent prodromal features whereas short TIB appeared to be a risk factor for dementia. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Bokenberger, K., Ström, P., Dahl Aslan, A. K., Johansson, A. L. V., Gatz, M., Pedersen, N. L., Akerstedt, T. Tags: Research Article Source Type: research

Associations Between Arthritis and Change in Physical Function in U.S. Retirees
Conclusions: Arthritis was associated with a greater prevalence of physical function limitations. Preventing limitations caused by arthritis is a key strategy to prevent disability in retirees. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Baker, N. A., Barbour, K. E., Helmick, C. G., Zack, M. M., Al Snih, S. Tags: Research Article Source Type: research

The Relationship Between Cognitive Functioning and the JNC-8 Guidelines for Hypertension in Older Adults
Conclusions: Persons with BP ≥150 mmHg show a faster global cognitive decline and transition to MCI than those with lower BP readings. However, the poor cognitive performance in the attention and executive functioning domains for the 140–149 mmHg group indicates the need for further research evaluating the newer recommended cutoff. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - December 13, 2016 Category: Geriatrics Authors: Goldstein, F. C., Hajjar, I. M., Dunn, C. B., Levey, A. I., Wharton, W. Tags: Research Article Source Type: research