Now, the Taller Die Earlier: The Curse of Cancer
This study estimates the relationship between height and mortality. Individuals in the National Health Interview Survey 1986, a nationally representative U.S. sample, are linked to death certificate data until December 31, 2006. We analyze this relationship in 14,440 men and 16,390 women aged 25+. We employ the Cox proportional hazards model, controlling for birthday and education. An additional inch increase in height is related to a hazard ratio of death from all causes that is 2.2% higher for men and 2.5% higher for women. The findings are robust to changing survival distributions, and further analyses indicate that the...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Sohn, K. Tags: Original Article Source Type: research

A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans
Human longevity and diseases are likely influenced by multiple interacting genes within a few biologically conserved pathways. Using long-lived smokers as a phenotype (n = 90)—a group whose survival may signify innate resilience—we conducted a genome-wide association study comparing them to smokers at ages 52–69 (n = 730). These results were used to conduct a functional interaction network and pathway analysis, to identify single nucleotide polymorphisms that collectively related to smokers’ longevity. We identified a set of 215 single nucleotide polymorphisms (all of which had p <5x10–3 in...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Levine, M. E., Crimmins, E. M. Tags: Original Article Source Type: research

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Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical Sciences Table of Contents
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Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Cover
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Biological Sciences Table of Contents
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Biological
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Motor Function Is Associated With Incident Disability in Older African Americans
Conclusions: Better motor function in older African Americans is associated with a decreased risk of developing disability. Moreover, the association of motor function and disability is stronger in individuals with better cognitive function. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Buchman, A. S., Wilson, R. S., Yu, L., Boyle, P. A., Bennett, D. A., Barnes, L. L. Tags: Research Article Source Type: research

Risk of Frailty in Elderly With COPD: A Population-Based Study
Conclusions: This population-based cohort study in elderly demonstrates that COPD is associated with frailty even after adjusting for shared risk factors. Our findings suggest that frailty—in addition to COPD severity and comorbidities—identifies those COPD participants at high risk of mortality. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Lahousse, L., Ziere, G., Verlinden, V. J. A., Zillikens, M. C., Uitterlinden, A. G., Rivadeneira, F., Tiemeier, H., Joos, G. F., Hofman, A., Ikram, M. A., Franco, O. H., Brusselle, G. G., Stricker, B. H. Tags: Research Article Source Type: research

Plasma Carotenoids Are Inversely Associated With Dementia Risk in an Elderly French Cohort
Conclusion: This large cohort of older participants suggests that maintaining higher concentrations of lutein in respect to plasma lipids may moderately decrease the risk of dementia and AD. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Feart, C., Letenneur, L., Helmer, C., Samieri, C., Schalch, W., Etheve, S., Delcourt, C., Dartigues, J.-F., Barberger-Gateau, P. Tags: Research Article Source Type: research

Plasma Klotho and Cognitive Decline in Older Adults: Findings From the InCHIANTI Study
Conclusions: Higher plasma klotho concentrations were associated with lower risk of meaningful decline and smaller average decline in MMSE. We did not observe such findings with Trails A and B, perhaps because they test executive function and motor skills, whereas MMSE measures global cognition. Future studies should investigate mechanisms through which klotho may affect domain-specific cognitive changes. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Shardell, M., Semba, R. D., Rosano, C., Kalyani, R. R., Bandinelli, S., Chia, C. W., Ferrucci, L. Tags: Research Article Source Type: research

Fatigue May Contribute to Reduced Physical Activity Among Older People: An Observational Study
Conclusions: Fatigue was associated with clinically important reductions in daily physical activity levels of older people. The findings show BMI, physical condition (in particular cardiorespiratory fitness), and comorbidity to be important factors in explaining the fatigue–physical activity association. Modification of these factors may facilitate increases in daily activity levels by lessening fatigue. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Egerton, T., Chastin, S. F. M., Stensvold, D., Helbostad, J. L. Tags: Research Article Source Type: research

Leg and Trunk Impairments Predict Participation in Life Roles in Older Adults: Results From Boston RISE
Conclusions: Leg speed, ankle ROM, and trunk extensor endurance are key physical impairments predicting participation in life roles in older adults. These results have implications for the development of exercise interventions to enhance participation. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Beauchamp, M. K., Jette, A. M., Ni, P., Latham, N. K., Ward, R. E., Kurlinski, L. A., Percac-Lima, S., Leveille, S. G., Bean, J. F. Tags: Research Article Source Type: research

Cost-effectiveness of the LIFE Physical Activity Intervention for Older Adults at Increased Risk for Mobility Disability
Conclusions: The PA intervention costs and QALYs gained are comparable to those found in other studies. The ICERS are less than many commonly recommended medical treatments. Implementing the intervention in non-research settings may reduce costs further. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - April 11, 2016 Category: Geriatrics Authors: Groessl, E. J., Kaplan, R. M., Castro Sweet, C. M., Church, T., Espeland, M. A., Gill, T. M., Glynn, N. W., King, A. C., Kritchevsky, S., Manini, T., McDermott, M. M., Reid, K. F., Rushing, J., Pahor, M., for the LIFE Study Group Tags: Research Article Source Type: research