Journals of Gerontology Series A: Biological Sciences and Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Medication Regimen Complexity and Number of Medications as Factors Associated With Unplanned Hospitalizations in Older People: A Population-based Cohort Study
Conclusions: There was no evidence that using a complex tool to assess regimen complexity was better at predicting unplanned hospitalization than number of medications. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Wimmer, B. C., Bell, J. S., Fastbom, J., Wiese, M. D., Johnell, K. Tags: Research Article Source Type: research

Multimorbidity Combinations and Disability in Older Adults
Conclusions: Clinicians stand to gain from a better understanding of which disease combinations are more and less disabling among older adults. Understanding how multimorbidity combinations relate to functional status is an important step towards reducing disability and sustaining independent living among older adults. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Quinones, A. R., Markwardt, S., Botoseneanu, A. Tags: Research Article Source Type: research

Circadian Characteristics of Older Adults and Aerobic Capacity
Conclusions. The biological clock seems to be enhanced in older participants with a higher level of physical capacity. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Dupont Rocher, S., Bessot, N., Sesboüe, B., Bulla, J., Davenne, D. Tags: Research Article Source Type: research

Associations of Computed Tomography-Based Trunk Muscle Size and Density With Balance and Falls in Older Adults
Conclusions. The results suggest that balance depends more on muscle quality than on the size of the muscle. The unexpected finding that larger muscle size was associated with increased postural sway and increased fall risk requires further investigation, but highlights the importance of factors besides muscle size in muscle function in older adults. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Anderson, D. E., Quinn, E., Parker, E., Allaire, B. T., Muir, J. W., Rubin, C. T., Magaziner, J., Hannan, M. T., Bouxsein, M. L., Kiel, D. P. Tags: Research Article Source Type: research

Brain MRI Volume Findings in Diabetic Adults With Albuminuria: The ACCORD-MIND Study
Conclusions: In this diabetic cohort, baseline albuminuria and persistent albuminuria were not independently associated with any significant differences in brain volume measurements compared with participants without albuminuria. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Barzilay, J. I., Morgan, T. M., Murray, A. M., Bryan, R. N., Williamson, J. D., Schnall, A., Launer, L. J. Tags: Research Article Source Type: research

Insulin-Like Growth Factor-1 Related to Disability Among Older Adults
Conclusions. Lower serum IGF-1 was independently related to disability among older adults. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Doi, T., Shimada, H., Makizako, H., Tsutsumimoto, K., Hotta, R., Nakakubo, S., Suzuki, T. Tags: Research Article Source Type: research

Energetics of Aging and Frailty: The FRADEA Study
Conclusion: Frailty status modulates the energy requirements of aging. Frail and prefrail older adults present lower eRMR than nonfrail adults. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Abizanda, P., Romero, L., Sanchez-Jurado, P. M., Ruano, T. F., Rios, S. S., Sanchez, M. F. Tags: Research Article Source Type: research

Stability and Change in Activities of Daily Living Among Older Mexican Americans
Conclusions. Substantial heterogeneity exists in changes in ADL disability over time among older Mexican Americans. Attempts at maintaining function may benefit from targeting reductions in comorbidities and acute health events associated with disability. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Howrey, B. T., Al Snih, S., Jana, K. K., Peek, M. K., Ottenbacher, K. J. Tags: Research Article Source Type: research

Hemoglobin, Anemia, and Cognitive Function: The Atherosclerosis Risk in Communities Study
Conclusions. There was a cross-sectional, but not prospective, nonlinear association between hemoglobin concentrations and cognitive function, although only associations of low levels of hemoglobin (anemia) were statistically significant. Subtypes of anemia had similar magnitudes of associations with cognition. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Schneider, A. L. C., Jonassaint, C., Sharrett, A. R., Mosley, T. H., Astor, B. C., Selvin, E., Coresh, J., Gottesman, R. F. Tags: Research Article Source Type: research

Cognitive Aging Trajectories and Burdens of Disability, Hospitalization and Nursing Home Admission Among Community-living Older Persons
Conclusions. Community-living older persons follow distinct cognitive aging trajectories and experience increasing burdens of disability, hospitalization, and nursing home placement as they age, with greater burdens for those on a declining cognitive trajectory. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Han, L., Gill, T. M., Jones, B. L., Allore, H. G. Tags: Research Article Source Type: research

Effects of Mobility and Cognition on Risk of Mortality in Women in Late Life: A Prospective Study
Conclusions: Among women late in life, 5-year mortality risk was substantially increased among women with deficits in mobility even after accounting for cognition and traditional prognostic indicators. Similarly, deficits in cognition were associated with increased 5-year mortality despite consideration of mobility and conventional risk factors. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Ensrud, K. E., Lui, L.-Y., Paudel, M. L., Schousboe, J. T., Kats, A. M., Cauley, J. A., McCulloch, C. E., Yaffe, K., Cawthon, P. M., Hillier, T. A., Taylor, B. C., for the Study of Osteoporotic Fractures (SOF) Tags: Research Article Source Type: research

The Expression Changes of Inflammasomes in the Aging Rat Kidneys
In this study, for the first time, we systematically investigated the role of the inflammasomes and the inflammatory responses activated by inflammasomes during kidney aging. We found that during kidney aging, the expression levels of the molecules associated with the activation of inflammasomes, including toll-like receptor-4 and interleukin-1 receptor (IL-1R), were significantly increased; their downstream signaling pathway molecule interleukin-1 receptor-associated kinase-4 (IRAK4) was markedly activated (Phospho-IRAK4 was obviously increased); the nuclear factor-B (NF-B) signaling pathway was activated (the activated N...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Song, F., Ma, Y., Bai, X.-Y., Chen, X. Tags: Original Article Source Type: research

Heritability and Genome-Wide Association Analyses of Human Gait Suggest Contribution of Common Variants
In conclusion, human gait has highly heritable components that are explained by common genetic variation, which are partly attributed to height and weight. Collaborative efforts are needed to identify robust single variant associations for the heritable parameters. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Adams, H. H. H., Verlinden, V. J. A., Callisaya, M. L., van Duijn, C. M., Hofman, A., Thomson, R., Uitterlinden, A. G., Vernooij, M. W., van der Geest, J. N., Srikanth, V., Ikram, M. A. Tags: Original Article Source Type: research

Acute Treatment of Resveratrol Alleviates Doxorubicin-Induced Myotoxicity in Aged Skeletal Muscle Through SIRT1-Dependent Mechanisms
Study of the exacerbating effects of chemotherapeutics, such as doxorubicin, on the impairment of insulin metabolic signaling in aged skeletal muscle is very limited. Here, we tested the hypothesis that activation of sirtuin 1 deacetylase activity by resveratrol would prevent the disruption of insulin signaling and augmentation of catabolic markers induced by doxorubicin in aged skeletal muscle. Two- and 10-month-old senescence-accelerated mice (prone 8) were randomized to receive saline, doxorubicin, doxorubicin and resveratrol, or a combination of doxorubicin, resveratrol, and sirtinol or EX527. Doxorubicin reduced the s...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Sin, T. K., Tam, B. T., Yu, A. P., Yip, S. P., Yung, B. Y., Chan, L. W., Wong, C. S., Rudd, J. A., Siu, P. M. Tags: Original Article Source Type: research

Resveratrol Decreases TXNIP mRNA and Protein Nuclear Expressions With an Arterial Function Improvement in Old Mice
In conclusion, we demonstrated that resveratrol helped to restore several aging impaired processes in old mice, with a decrease of aortic TXNIP mRNA and protein nuclear expressions. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 11, 2016 Category: Geriatrics Authors: Bedarida, T., Baron, S., Vibert, F., Ayer, A., Henrion, D., Thioulouse, E., Marchiol, C., Beaudeux, J.-L., Cottart, C.-H., Nivet-Antoine, V. Tags: Original Article Source Type: research