Journals of Gerontology Series A: Biological Sciences and Medical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats
The infrapatellar fat pad (IFP) secretes inflammatory mediators in osteoarthritic knees, but the effect of aging on IFP inflammation is unknown. We tested the hypothesis that aging increases basal and interleukin-1β (IL-1β)-stimulated IFP inflammation in 10-, 20-, and 30-month-old male F344BN F1-hybrid rats. IFPs were cultured ex vivo for 24 hours and treated ±1ng/mL IL-1β to simulate injury-induced inflammation. IFP inflammation was evaluated by measuring secreted cytokine concentrations and by quantitative expression of immunoregulatory and pro- and anti-adipogenic genes. With age, osteoarthritis pa...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Fu, Y., Huebner, J. L., Kraus, V. B., Griffin, T. M. Tags: Original Article Source Type: research

Association Between Circulating Osteogenic Progenitor Cells and Disability and Frailty in Older Persons: The Nepean Osteoporosis and Frailty Study
In conclusion, COP cells in the circulation decrease with age. Lower percentages of COP cells in late life are associated with prevalent frailty and disability. Further longitudinal studies are needed to understand COP cells as a risk stratifier, biomarker, or therapeutic target and to predict disability in frail older persons. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Gunawardene, P., Bermeo, S., Vidal, C., Al-Saedi, A., Chung, P., Boersma, D., Phu, S., Pokorski, I., Suriyaarachchi, P., Demontiero, O., Duque, G. Tags: Original Article Source Type: research

Responses of Dendritic Cells to TLR-4 Stimulation Are Maintained in the Elderly and Resist the Effects of CMV Infection Seen in the Young
Toll-like receptor 4 (TLR-4) plays a crucial role in the pathophysiology of several age-related diseases. Although poorer function of circulating myeloid dendritic cells (mDCs) has been reported in the elderly, data on TLR-4 function in these cells in older people are lacking. Here, we investigated TLR-4 functionality in the elderly by ex vivo analysis of cytokine production of mDCs in response to LPS in 39 younger (23–34 years) and 61 older (62–77 years) healthy people using flow cytometry. We matched these subjects for Cytomegalovirus (CMV)-serostatus because a latent infection with this ubiquitous herpesviru...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Authors: Janssen, N., Derhovanessian, E., Demuth, I., Arnaout, F., Steinhagen-Thiessen, E., Pawelec, G. Tags: Original Article Source Type: research

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Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical Sciences Table of Contents
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Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Medical
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Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Cover
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Biological Sciences Table of Contents
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Biological
(Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - August 8, 2016 Category: Geriatrics Tags: Cover / Standing Material Source Type: research

Methodology to Estimate the Longitudinal Average Attributable Fraction of Guideline-recommended Medications for Death in Older Adults With Multiple Chronic Conditions
Conclusions: Most cardiovascular medications were attributed independently to survival. The two cardiovascular conditions contributing independently to death were heart failure and atrial fibrillation. The medication effects were similar by age except for thiazides that had a significant contribution to survival in persons younger than 80 years. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Allore, H. G., Zhan, Y., Cohen, A. B., Tinetti, M. E., Trentalange, M., McAvay, G. Tags: Brief Report Source Type: research

Preliminary Evidence That Excitatory Transcranial Direct Current Stimulation Extends Time to Task Failure of a Sustained, Submaximal Muscular Contraction in Older Adults
Conclusions: These preliminary findings suggest that anodal transcranial direct current stimulation enhances time to task failure of a sustained, submaximal contraction in older adults by potentially increasing cortical excitability and/or influencing the perception of exertion. These results raise the question of whether interventions that acutely increase cortical excitability could enhance physical function and/or exercise-induced adaptations in older adults. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Oki, K., Mahato, N. K., Nakazawa, M., Amano, S., France, C. R., Russ, D. W., Clark, B. C. Tags: Brief Report Source Type: research

Continuous Monitoring of Turning Mobility and Its Association to Falls and Cognitive Function: A Pilot Study
Conclusions: Continuous monitoring of turning characteristics, while walking during daily activities, is feasible in older people. Turning characteristics during daily life appear to be more sensitive to fall risk than prescribed turning tasks. These findings suggest a slower, less variable, cautious turning strategy in elderly volunteers with a history of falls. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Mancini, M., Schlueter, H., El-Gohary, M., Mattek, N., Duncan, C., Kaye, J., Horak, F. B. Tags: Research Article Source Type: research

Sarcopenia Is Associated With Lower Skeletal Muscle Capillarization and Exercise Capacity in Older Adults
Conclusions: These findings suggest that low skeletal muscle capillarization is one factor that may contribute to sarcopenia and reduced exercise capacity in older adults by limiting diffusion of substrates, oxygen, hormones, and nutrients. Strategies to prevent the aging-related decline in skeletal muscle capillarization may help to prevent or slow the progression of sarcopenia and its associated functional declines in generally healthy older adults. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Prior, S. J., Ryan, A. S., Blumenthal, J. B., Watson, J. M., Katzel, L. I., Goldberg, A. P. Tags: Research Article Source Type: research

Gender Differences in the Combined Effects of Cardiovascular Disease and Osteoarthritis on Progression to Functional Impairment in Older Mexican Americans
Conclusions: Over time, the influence of COM on functional decline differs by specific combinations of COM and by gender. Aggregate COM scales obscure the biological and temporal heterogeneity in the effects of COM. Time-dependent-specific COMs better assess the development of impairment. Women experience a higher burden of functional impairment due to COM than men. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Haan, M. N., Lee, A., Odden, M. C., Aiello, A. E., To, T. M., Neuhaus, J. M. Tags: Research Article Source Type: research

Association of Motoric Cognitive Risk Syndrome With Brain Volumes: Results From the GAIT Study
Conclusions: The findings revealed similar cognitive profile in MCR and non-MCR participants, and MCR-related smaller global and regional gray matter volumes involving premotor and prefrontal cortices, suggesting that the MCR syndrome may predict cortical neurodegenerative dementia more than subcortical dementia. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - July 14, 2016 Category: Geriatrics Authors: Beauchet, O., Allali, G., Annweiler, C., Verghese, J. Tags: Research Article Source Type: research