Journal of Venomous Animals and Toxins including Tropical Diseases This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Samsum ant venom modulates the immune response and redox status at the acute toxic dose in vivo
Conclusion: Stimulation of PMNs by SAV leads to upregulation of MHC-II, CD 80, and CD 86, which plays critical roles in antigen presentation and consequently proliferation of T-cells. Subcutaneous route was more efficient than intraperitoneal by elevating MHC-II, CD80 and CD86 expression, disturbing oxidative stability and increasing lipogram concentration. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - December 3, 2019 Category: Tropical Medicine Source Type: research

The WHO strategy for prevention and control of snakebite envenoming: a sub-Saharan Africa plan
Abstract Snakebite is a critical public health issue in tropical countries, particularly in Africa, where 20% of snakebites globally occur. In 2017, the WHO added snakebite envenoming to the category A of neglected tropical diseases. In 2019, thanks to broad institutional and international NGO support, including strong mobilization of African experts and governments, WHO launched a strategy for prevention and control of snakebite envenoming with more ambitious goals. In sub-Saharan Africa, accessibility of antivenoms and symptomatic, adjuvant or replacement therapy is a priority. Several antivenoms are available but their ...
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - December 3, 2019 Category: Tropical Medicine Source Type: research

Unique heterologous fibrin biopolymer with hemostatic, adhesive, sealant, scaffold and drug delivery properties: a systematic review
Abstract Fibrin biopolymers, previously referred as “ fibrin glue ” or “ fibrin sealants ” , are natural biomaterials with diverse applications on health. They have hemostatic, adhesive, sealant, scaffold and drug delivery properties and have become widely used in medical and dental procedures. Historically, these biomaterials are produced from human fibrinogen and human or animal thrombin, and the possibility of transmission of infectious diseases by human blood is not ruled out. In the 1990s, to overcome this problem, a new heterologous biomaterial composed of a thrombin-like enzyme purified from Crotalus duriss...
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - November 12, 2019 Category: Tropical Medicine Source Type: research

Fibrin biopolymer as scaffold candidate to treat bone defects in rats
Conclusions: FBP proved to be an excellent scaffold candidate for bone repair therapies due to application ease and biocompatibility with synthetic calcium-based materials. The satisfactory results obtained by the association of FBP with MSCs may provide a more effective and less costly new approach for bone tissue engineering. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - November 5, 2019 Category: Tropical Medicine Source Type: research

Cytotoxic effects of Pseudocerastes persicus venom and its HPLC fractions on lung cancer cells
Conclusion: HPLC fraction 21 at low concentrations displayed promising anticancer properties with apoptosis induction in the lung cancer cells. This fraction may, therefore, be considered a promising candidate for further studies. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - September 16, 2019 Category: Tropical Medicine Source Type: research

Zika virus proteins at an atomic scale: how does structural biology help us to understand and develop vaccines and drugs against Zika virus infection?
Abstract In Brazil and in other tropical areas Zika virus infection was directly associated with clinical complications as microcephaly in newborn children whose mothers were infected during pregnancy and the Guillain-Barr é syndrome in adults. Recently, research has been focused on developing new vaccines and drug candidates against Zika virus infection since none of those are available. In order to contribute to vaccine and drug development efforts, it becomes important the understanding of the molecular basis of t he Zika virus recognition, infection and blockade. To this purpose, it is essential the structural determi...
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - August 29, 2019 Category: Tropical Medicine Source Type: research

Protein identification from the parotoid macrogland secretion of Duttaphrynus melanostictus
Conclusions: Proper sample preparation allowed the proteomic and de novo identification of different proteins in the D. melanostictus parotoid macrogland secretion. These results may increase the knowledge about the universe of molecules that compose amphibian skin secretion, as well as to understand their biological/physiological role in the granular gland. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - August 20, 2019 Category: Tropical Medicine Source Type: research

Antileishmanial activity and immunomodulatory effect of secosubamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae)
This study showed the antileishmanial activity of compounds 1 and 2 isolated from N. oppositifolia. Furthermore, compound 2 demonstrated an antileishmanial activity towards amastigotes associated to an immunomodulatory effect. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - August 20, 2019 Category: Tropical Medicine Source Type: research

Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system
Conclusion: The antinociceptive effect for PnTx4(5-5) was demonstrated against different rat pain models, i.e. induced by PGE2, carrageenan or glutamate. We suggest that the antinociceptive effect of PnTx4(5-5) may be related to an inhibitory activity on the glutamatergic system. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - August 13, 2019 Category: Tropical Medicine Source Type: research

Ethnomedicinal plants used for snakebite treatments in Ethiopia: a comprehensive overview
Abstract Traditional medicine plays an important role in the daily lives of people living in rural parts of Ethiopia. Despite the fact that Ethiopia has a long history of using traditional medicinal plants as an alternative medicine source, there is no checklist compiling these plants used for snakebite treatment. This review collected and compiled available knowledge on and practical usage of such plants in the country. A literature review on medicinal plants used to treat snakebites was conducted from 67 journal articles, PhD dissertation and MSc theses available online. Data that summarize scientific and folk names, adm...
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - August 6, 2019 Category: Tropical Medicine Source Type: research

BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation
Conclusions: BthTX-I induces apoptosis and autophagy in all breast cancer cell lines tested and also reduces CSC s subpopulation, which makes it a promising therapeutic alternative for breast cancer. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - July 30, 2019 Category: Tropical Medicine Source Type: research

Is the cat an important reservoir host for visceral leishmaniasis? A systematic review with meta-analysis
Abstract In recent years feline leishmanial infections (FLI) have been studied more than ever before in various parts of the world. However, evidence-based knowledge on FLI has remained unavailable. The main objectives of this study were to investigate the status of felines infected by Leishmania spp. worldwide. Data were extracted from 10 available databases over the period of 1982 to 2017. Overall, 78 articles fulfilled the inclusion criteria and were used for data extraction in this systematic review. The overall FLI prevalence by both serological and molecular methods was estimated at 10% (95% CI: 8%-14%). In Italy, bo...
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - June 11, 2019 Category: Tropical Medicine Source Type: research

Using prodigiosin against some gram-positive and gram-negative bacteria and Trypanosoma cruzi
Conclusions: This work demonstrates the potential usefulness of prodigiosin against some gram-positive and gram-negative bacteria and Trypanosoma cruzi although further studie s must be done in order to assess its value as a candidate molecule. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - June 3, 2019 Category: Tropical Medicine Source Type: research

Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
Abstract Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide toxins produce lethal effects on tumor cells by regulating the cell cycle, activating caspase pathway or inactivating mitochondria. Some of them also target the various types of ion channels (including voltage-gated calcium channels, voltage-gated sodium channels, and aci...
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - June 3, 2019 Category: Tropical Medicine Source Type: research

Divergences between the Brazilian national information systems for recording deaths from venomous animals
Conclusion: Comparative analysis of these databases permits identification of important differences between profiles presented by thes e systems, which have equal relevance for Brazil as a whole and for its regions. These differences may influence the construction of various scenarios. (Source: Journal of Venomous Animals and Toxins including Tropical Diseases)
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - May 21, 2019 Category: Tropical Medicine Source Type: research