Genetic Polymorphisms of UDP-Glucuronosyltransferases and Susceptibility to Antituberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis
CONCLUSIONS: The polymorphisms of UGT1A1 rs3755319, UGT2B7 rs7662029, and UGT2B7 rs7439366 were significantly associated with AT-DILI susceptibility. However, this conclusion should be interpreted with caution due to the low number of studies and the relatively small sample size.PMID:37868740 | PMC:PMC10586897 | DOI:10.1155/2023/5044451 (Source: Journal of Tropical Medicine)
Source: Journal of Tropical Medicine - October 23, 2023 Category: Tropical Medicine Authors: Xinyu Chen Zhuolu Hao Nannan Wang Jia Zhu Honggang Yi Shaowen Tang Source Type: research

Inhibition of Autophagy in Heat-Stressed Sperm of Adult Mice: A Possible Role of Catsper1, 2 Channel Proteins
CONCLUSION: In this study, following heat stress, the decrease in CatSper protein distribution may lead to the structural disorder of CatSper channels, which could strongly affect autophagic activity. Also, disruption of spermatogenesis and sperm parameters may be the consequence of decreased autophagy activity.PMID:37850157 | PMC:PMC10578978 | DOI:10.1155/2023/6890815 (Source: Journal of Tropical Medicine)
Source: Journal of Tropical Medicine - October 18, 2023 Category: Tropical Medicine Authors: Malihe Soltani Majid Rahmati Mohammad Reza Nikravesh Shahin Saeedi Nejat Mahdi Jalali Source Type: research

Efficiency of Automated Viral RNA Purification for Pediatric Studies of Dengue and Zika in Hyperendemic Areas
J Trop Med. 2023 Sep 30;2023:1576481. doi: 10.1155/2023/1576481. eCollection 2023.ABSTRACTThe isolation of nucleic acids is a critical and limiting step for molecular assays, which prompted the arrival in Colombia of automated purification instruments during the SARS-CoV-2 pandemic. The local application of this technology in the study of tropical diseases, such as dengue and zika, is beginning to be tested. We evaluated the efficiency of the automated extraction of viral RNA for studies of pediatric dengue and zika. Clinical samples of children with dengue that were well characterized through RNA isolation by silica colum...
Source: Journal of Tropical Medicine - October 9, 2023 Category: Tropical Medicine Authors: Sandra L Delgado Piedad M Perilla Doris M Salgado Mar ía Clemencia Rojas Carlos F Narv áez Source Type: research

Assessment of Intestinal Parasites and Its Associated Factors among Fruits and Vegetables Collected from Local Markets of Bule Hora Town, Southeast Ethiopia
CONCLUSIONS: The results of this study show that eating vegetables that are raw in the study area carries a potentially significant risk of contracting parasitic illnesses. Therefore, the appropriate bodies should make an effort to lower the rate of product contamination with intestinal parasites by educating vendors and the general public.PMID:37781133 | PMC:PMC10539081 | DOI:10.1155/2023/1861919 (Source: Journal of Tropical Medicine)
Source: Journal of Tropical Medicine - October 2, 2023 Category: Tropical Medicine Authors: Tibeso Gemechu Jemal Bona Alqeer Aliyo Wako Dedecha Girma Ashenafi Source Type: research