Collagen nanofiber anisotropy induces myotube differentiation and acetylcholine receptor clustering
Abstract To create musculoskeletal tissue scaffolds for functional integration into host tissue, myotubes must be properly aligned with native tissue and spur the formation of neuromuscular junctions (NMJs). However, our understanding of myoblast differentiation in response to structural alignment is incomplete. To examine how substrate anisotropy mediates myotube differentiation, we studied C2C12 myoblasts grown on aligned collagen substrates in the presence or absence of agrin. Myoblasts grown on microfluidically patterned collagen substrates demonstrated increased multinucleated myotubes and nicotinic acetylcholine rece...
Source: Journal of Tissue Engineering and Regenerative Medicine - December 21, 2017 Category: Biotechnology Authors: Frank H. Kung, David Sillitti, Anil B. Shrirao, David I. Shreiber, Bonnie L. Firestein Tags: RESEARCH ARTICLE Source Type: research

Construction of a Vascularized Hydrogel for Cardiac Tissue Formation in a Porcine Model
We presented results on technical feasibility and challenges of grafting vascularized centimeter‐sized human cardiac construct that may spur novel approaches in cardiac tissue replacement strategy. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 21, 2017 Category: Biotechnology Authors: K.P. Myu Mai Ja, Kee Pah Lim, Allen Chen, Sherwin Ting, Shi Qi Li, Nicole Tee, Chrishan Ramachandra, Ashish Mehta, Philip Wong, Steve Oh, Winston Shim Tags: RESEARCH ARTICLE Source Type: research

Meniscus ECM ‐functionalised hydrogels containing infrapatellar fat pad‐derived stem cells for bioprinting of regionally defined meniscal tissue
The objective of this study was to develop a range of ECM‐functionalised bioinks suitable for 3D bioprinting of meniscal tissue. To this end, alginate hydrogels were functionalised with ECM derived from the inner and outer regions of the meniscus and loaded with infrapatellar fat pad‐derived stem cells. In the absence of exogenously supplied growth factors, inner meniscus ECM promoted chondrogenesis of fat pad‐derived stem cells, whereas outer meniscus ECM promoted a more elongated cell morphology and the development of a more fibroblastic phenotype. With exogenous growth factors supplementation, a more fibrogenic ph...
Source: Journal of Tissue Engineering and Regenerative Medicine - December 19, 2017 Category: Biotechnology Authors: S. Romanazzo, S. Vedicherla, C. Moran, D.J. Kelly Tags: RESEARCH ARTICLE Source Type: research

Improving the biological function of decellularized heart valves through integration of protein tethering and three ‐dimensional cell seeding in a bioreactor
Journal of Tissue Engineering and Regenerative Medicine, EarlyView. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 18, 2017 Category: Biotechnology Source Type: research

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Journal of Tissue Engineering and Regenerative Medicine, Ahead of Print. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 18, 2017 Category: Biotechnology Source Type: research

In vivo implantation of a tissue engineered stem cell seeded hemi ‐laryngeal replacement maintains airway, phonation, and swallowing in pigs
Journal of Tissue Engineering and Regenerative Medicine, EarlyView. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 17, 2017 Category: Biotechnology Source Type: research

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Journal of Tissue Engineering and Regenerative Medicine, Ahead of Print. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 17, 2017 Category: Biotechnology Source Type: research

Issue Information
No abstract is available for this article. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 15, 2017 Category: Biotechnology Tags: Issue Information Source Type: research

Cover Image, Volume 11, Issue 12
The cover image, by Karan Gulati et al., is based on the Research Article Anodized 3D—printed titanium implants with dual micro‐ and nano‐scale topography promote interaction with human osteoblasts and osteocyte‐like cells, DOI: 10.1002/term.2239. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 15, 2017 Category: Biotechnology Authors: Karan Gulati, Matthew Prideaux, Masakazu Kogawa, Luis Lima ‐Marques, Gerald J. Atkins, David M. Findlay, Dusan Losic Tags: Cover Image Source Type: research

Decellularized bovine cotyledons may serve as biological scaffolds with preserved vascular arrangement
Journal of Tissue Engineering and Regenerative Medicine, EarlyView. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 13, 2017 Category: Biotechnology Source Type: research

Cell yield, chondrogenic potential, and regenerated cartilage type of chondrocytes derived from ear, nasoseptal, and costal cartilage
Journal of Tissue Engineering and Regenerative Medicine, EarlyView. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 13, 2017 Category: Biotechnology Source Type: research

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Journal of Tissue Engineering and Regenerative Medicine, Ahead of Print. (Source: Journal of Tissue Engineering and Regenerative Medicine)
Source: Journal of Tissue Engineering and Regenerative Medicine - December 13, 2017 Category: Biotechnology Source Type: research

Cell yield, chondrogenic potential, and regenerated cartilage type of chondrocytes derived from ear, nasoseptal, and costal cartilage
Abstract Functional reconstruction of large cartilage defects in subcutaneous sites remains clinically challenging because of limited donor cartilage. Tissue engineering is a promising and widely accepted strategy for cartilage regeneration. To date, however, this strategy has not achieved a significant breakthrough in clinical translation owing to a lack of detailed preclinical data on cell yield and functionality of clinically applicable chondrocytes. To address this issue, the current study investigated the initial cell yield, proliferative potential, chondrogenic capacity, and regenerated cartilage type of human chondr...
Source: Journal of Tissue Engineering and Regenerative Medicine - December 13, 2017 Category: Biotechnology Authors: Aijuan He, Huitang Xia, Kaiyan Xiao, Tingting Wang, Yu Liu, Jixin Xue, Dan Li, Shengjian Tang, Fangjun Liu, Xiaoyun Wang, Wenjie Zhang, Wei Liu, Yilin Cao, Guangdong Zhou Tags: RESEARCH ARTICLE Source Type: research