The definition, diagnosis and management of mild hemophilia A: communication from the SSC of the ISTH
Journal of Thrombosis and Haemostasis, EarlyView. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 15, 2018 Category: Hematology Authors: M. Makris, J. Oldenburg, E. P. Mauser ‐Bunschoten, K. Peerlinck, G. Castaman, K. Fijnvandraat, For the subcommittee on Factor VIII, Factor IX and Rare Bleeding Disorders Tags: Recommendations and Guidelines Source Type: research

The antifibrinolytic and anti ‐inflammatory effects of multiple doses of oral tranexamic acid in total knee arthroplasty patients: a randomized controlled trial
ConclusionThe four ‐dose regimen yielded the maximum reductions in blood loss and inflammatory response, improved analgesia, and promoted early rehabilitation. Further studies are required to ensure that these findings are reproducible. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 15, 2018 Category: Hematology Authors: D. Wang, Z. ‐Y. Luo, Z.‐P. Yu, L.‐X. Liu, C. Chen, W.‐K. Meng, Q.‐P. Yu, F.‐X. Pei, Z.‐K. Zhou, W.‐N. Zeng Tags: Original Article Source Type: research

Performance of a recombinant fusion protein linking coagulation factor IX with recombinant albumin in one ‐stage clotting assays
ConclusionsrIX ‐FP activity can be accurately measured using OSC assays with the majority of commercial reagents. Actin® FS or kaolin ‐based reagents will likely lead to 50% underestimation in activity.This article is protected by copyright. All rights reserved. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 12, 2018 Category: Hematology Authors: Carsten Horn, Claude N égrier, Uwe Kalina, Wilfried Seifert, Kenneth D. Friedman Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Chronic liver injury drives non ‐traditional intrahepatic fibrin(ogen) cross‐linking via tissue transglutaminase
ConclusionsThese results indicate that neither traditional fibrin clots, formed by the thrombin:FXIIIa pathway, nor atypical TGM2 ‐cross‐linked fibrin(ogen) contribute to experimental CCl4‐induced liver fibrosis. Collectively, the results indicate that liver fibrosis occurs independently of intrahepatic fibrin(ogen) deposition.This article is protected by copyright. All rights reserved. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 11, 2018 Category: Hematology Authors: L.G. Poole, A. Pant, K.S. Baker, A.K. Kopec, H.M. Cline ‐Fedewa, S.E. Iismaa, M.J. Flick, J.P. Luyendyk Tags: Original Article ‐ Coagulation Source Type: research

Protease activated receptor ‐1 impedes prostate and intestinal tumor progression in mice: comment
This article is protected by copyright. All rights reserved. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 9, 2018 Category: Hematology Authors: C Arnold Spek, Cansu Tekin, Maarten F Bijlsma Tags: Letter ‐ to the Editor Source Type: research

Crosslinked clots formed independently of factor XIII and without fibrinogen ‐to‐fibrin conversion – is this a liver‐specific phenomenon?
This article is protected by copyright. All rights reserved. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 9, 2018 Category: Hematology Authors: Ton Lisman Tags: Commentary Source Type: research

Hemostatic abnormalities in patients with Ehlers –Danlos syndrome
ConclusionsOur results show that nearly half of patients with EDS have an abnormal BSS, which, in 90% of cases, appear, at least in part, to be attributable to platelet function abnormalities. Abnormalities of primary hemostasis may contribute to the risk of bleeding in patients with EDS. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 8, 2018 Category: Hematology Authors: A. Artoni, A. Bassotti, M. Abbattista, B. Marinelli, A. Lecchi, F. Gianniello, M. Clerici, P. Bucciarelli, S. La Marca, F. Peyvandi, I. Martinelli Tags: Original Article Source Type: research

Sulodexide in Venous Disease
Journal of Thrombosis and Haemostasis,Volume 0, Issue ja, -Not available-. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 5, 2018 Category: Hematology Authors: Brett J. Carroll, Gregory Piazza, Samuel Z. Goldhaber Source Type: research

Factor XII truncation accelerates activation in solution
Journal of Thrombosis and Haemostasis,Volume 0, Issue ja, -Not available-. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 5, 2018 Category: Hematology Authors: S. De Maat, C.C. Clark, M. Boertien, N. Parr, W. Sanrattana, Z.L.M. Hofman, C. Maas Source Type: research

A unique phenotype of acquired Glanzmann thrombasthenia due to non function ‐blocking anti‐αIIbβ3 autoantibodies
Journal of Thrombosis and Haemostasis,Volume 0, Issue ja, -Not available-. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 2, 2018 Category: Hematology Authors: Keigo Akuta, Hirokazu Kashiwagi, Toshiaki Yujiri, Nobuko Nishiura, Yoichiro Morikawa, Hisashi Kato, Shigenori Honda, Yuzuru Kanakura, Yoshiaki Tomiyama Source Type: research

Determining the minimal clinically important difference for the PEmbQoL questionnaire, a measure of pulmonary embolism ‐specific quality of life
Journal of Thrombosis and Haemostasis, EarlyView. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 2, 2018 Category: Hematology Authors: A. Akaberi, F. A. Klok, D. M. Cohn, A. Hirsch, J. Granton, S. R. Kahn Source Type: research

Issue Information
Journal of Thrombosis and Haemostasis,Volume 16, Issue 11, Page 1-3, November 2018. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 2, 2018 Category: Hematology Source Type: research

ISTH News and Updates: Renew Your Membership Today
Journal of Thrombosis and Haemostasis,Volume 16, Issue 11, Page 2354-2355, November 2018. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 2, 2018 Category: Hematology Source Type: research

Rapid determination of anticoagulating effects of dabigatran in whole blood with rotational thromboelastometry and a thrombin ‐based trigger
Journal of Thrombosis and Haemostasis, EarlyView. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - November 1, 2018 Category: Hematology Authors: V. Taune, M. Skeppholm, A. Ågren, G. Gryfelt, R. E. Malmström, A. Wikman, J. Van Ryn, H. Wallén Source Type: research

Keeping it clean: clot biofilm to wall out bacterial invasion
Journal of Thrombosis and Haemostasis, EarlyView. (Source: Journal of Thrombosis and Haemostasis)
Source: Journal of Thrombosis and Haemostasis - October 31, 2018 Category: Hematology Authors: J. W. Weisel, R. I. Litvinov Source Type: research