Transcranial and pulsed focused ultrasound that activates brain can accelerate remyelination in a mouse model of multiple sclerosis
ConclusionMRI-guided focused ultrasound systems exist that can, in principle, deliver the ultrasound protocol we successfully tested here. In addition, MRI, as the clinical gold standard, can readily identify MS lesions. Given the relatively low intensity values of our ultrasound protocol – close to FDA limits – we anticipate that future success with this approach to MS therapy as tested using more realistic MS mouse models may one day translate to clinical trials that help address this devastating disease. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - December 10, 2018 Category: Radiology Source Type: research
Focused ultrasound for the treatment of bone metastases: effectiveness and feasibility
ConclusionsHIFU under MR-guidance seems to be an effective and safe procedure in the treatment of symptomatic bone lesions for patients suffering from metastatic disease. A significant decrease of patient pain was observed.Trial registrationNCT01091883. Registered 24 March 2010. Level of evidence: Level 3. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - November 30, 2018 Category: Radiology Source Type: research
Wedged gel pad for bowel manipulation during MR-guided high-intensity focused ultrasound therapy to treat uterine fibroids: a case report
ConclusionsOur preliminary experience suggests that the use of a wedged gel pad during MR-HIFU treatment could be an effective tool to manipulate the bowels in cases where the bladder and/or rectum filling is not sufficient to reposition the bowel loops. A wedged gel pad could also be used in other situations to achieve better treatment coverage to the uterine fibroid. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - November 28, 2018 Category: Radiology Source Type: research
The fine spatial and temporal control of ultrasonic neuromodulation is a necessary condition for discerning the accompanying subjective feelings, but is it sufficient?
(Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - November 23, 2018 Category: Radiology Source Type: research
MR thermometry-guided ultrasound hyperthermia of user-defined regions using the ExAblate prostate ablation array
ConclusionsWe have implemented a real-time MR thermometry-guided system for hyperthermia delivery within user-defined regions with the ExAblate prostate array and evaluated it in phantom experiments for different shapes and focal depths. Our results demonstrate the feasibility of using a commercially available endorectal FUS transducer to perform spatially-conformal hyperthermia therapy and could lead to a new set of exciting applications for these devices. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - August 13, 2018 Category: Radiology Source Type: research
Theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery
AbstractThis paper develops theory forbulk acoustic streaming in soft porous materials, with applications to biological tissue. The principal results of this paper are: (i) streaming equations for such porous media, which show interestingly significant differences from those that describe streaming in pure fluids; (ii) the Green functions obtained for these equations in isotropic, infinite media; and (iii) approximate evaluation of the sources in the streaming equations from acoustic wave forms often used, and the streaming velocities and particle trajectories resulting therefrom. People are now investigating acoustic enha...
Source: Journal of Therapeutic Ultrasound - August 2, 2018 Category: Radiology Source Type: research
A convenient, reliable, and fast acoustic pressure field measurement method for magnetic resonance-guided high-intensity focused ultrasound systems with phased array transducers
ConclusionsIn conclusion, our method offers a convenient, reliable, and fast acoustic pressure field characterization tool for MR-HIFU systems with phased array transducers. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - July 2, 2018 Category: Radiology Source Type: research
Effects of breast structure on high-intensity focused ultrasound focal error
ConclusionsThe obtained results demonstrated that the focal error observed during the breast cancer HIFU treatment is highly dependent on the structure of fibroglandular tissue. The optimal arrangement of the transducer to the target can be obtained by minimizing the local acoustic inhomogeneity before the breast cancer HIFU treatment. (Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - June 20, 2018 Category: Radiology Source Type: research
Meeting report: 2017 Winter School on Therapeutic Ultrasound
AbstractThe Winter School on Therapeutic Ultrasound held its biennial meeting at the Ecole de Physique des Houches in Les Houches, France from March 26-31, 2017. The program brought together a globally and scientifically diverse group of faculty, clinicians, and trainees with interest in elements of therapeutic ultrasound. The meeting agenda was composed of daily lectures on various topics of relevance, supplemented with evening seminars, excursions, and networking opportunities. In anticipation of the next edition of the Winter School expected in 2019, we are nearly reaching the half way point between offerings of this un...
Source: Journal of Therapeutic Ultrasound - June 6, 2018 Category: Radiology Source Type: research
Abstracts from the International Society for Therapeutic Ultrasound Conference 2017
(Source: Journal of Therapeutic Ultrasound)
Source: Journal of Therapeutic Ultrasound - May 15, 2018 Category: Radiology Source Type: research
