Journal of the American College of Cardiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Arrhythmogenic Right Ventricular Cardiomyopathy Better Tools for Detecting Early Disease and Progression ∗
(Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - November 15, 2016 Category: Cardiology Source Type: research

Right Ventricular Imaging and Computer Simulation for Electromechanical Substrate Characterization in Arrhythmogenic Right Ventricular Cardiomyopathy
ConclusionsDifferent ARVC stages were characterized by distinct RV deformation patterns, all of which could be reproduced by simulating different degrees of mechanical substrates. Subclinical and electrical staged ARVC subjects already showed signs of local mechanical abnormalities. Our novel approach could lead to earlier disease detection and, thereby, influence current definitions of electrical and subclinical ARVC stages. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - November 15, 2016 Category: Cardiology Source Type: research

Left Ventricular Noncompaction, or Is It? ∗
(Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - November 15, 2016 Category: Cardiology Source Type: research

Long-Term Prognostic Value of Cardiac  Magnetic Resonance in Left Ventricle Noncompaction A Prospective Multicenter Study
ConclusionsIn patients with LVNC evaluated by using CMR, the degree of LV trabeculation seems to have no prognostic impact over and above LV dilation, LV systolic dysfunction, and presence of LGE. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - November 15, 2016 Category: Cardiology Source Type: research

Left Ventricular Noncompaction Anatomical Phenotype or Distinct Cardiomyopathy?
BackgroundThere is considerable overlap between left ventricular noncompaction (LVNC) and other cardiomyopathies. LVNC has been reported in up to 40% of the general population, raising questions about whether it is a distinct pathological entity, a remodeling epiphenomenon, or merely an anatomical phenotype.ObjectivesThe authors determined the prevalence and predictors of LVNC in a healthy population using 4 cardiac magnetic resonance imaging diagnostic criteria.MethodsVolunteers>40 years of age (N  = 1,651) with no history of cardiovascular disease (CVD), a 10-year risk of CVD  (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - November 15, 2016 Category: Cardiology Source Type: research

Aortic Valve Surgery for Aortic Regurgitation The Threshold Is Falling ∗
(Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - November 15, 2016 Category: Cardiology Source Type: research

Long-Term Outcomes in Patients With  Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
This study sought to examine long-term outcomes in a contemporary group of patients with grade III+ chronic AR and preserved left ventricular ejection fraction (LVEF) and the value of aortic valve (AV) surgery on long-term survival. We also wanted to reassess the threshold of LV dimension, beyond which mortality significantly increases.MethodsThe authors studied 1,417 such patients (mean 54 ± 16 years of age, 75% men) seen between 2002 and 2010. Clinical data were obtained and Society of Thoracic Surgeons (STS) score was calculated. The primary endpoint was mortality.ResultsMean STS score was 5.5% ± 8%, and mean LVEF was...
Source: Journal of the American College of Cardiology - November 15, 2016 Category: Cardiology Source Type: research

Can TAVR Make Me Smarter?
(Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - November 15, 2016 Category: Cardiology Source Type: research

Serial Changes in Cognitive Function Following Transcatheter Aortic Valve Replacement
BackgroundData regarding the mid- to long-term cognitive trajectory of transcatheter aortic valve (TAVR) recipients are scarce.ObjectivesChanges in global cognition and specific cognitive domains up to 1 year post-TAVR were evaluated.MethodsFifty-one patients (median age 80.0 [interquartile range: 72.0 to 85.0] years; 37% women) underwent TAVR and prospective assessment of cognitive function using the Montreal Cognitive Assessment (MoCA) at baseline, short-term (30 days), and 1 year post-TAVR. Processing speed and executive cognitive functions were further evaluated with the digit-symbol substitution test (DSST), Trail Mak...
Source: Journal of the American College of Cardiology - November 15, 2016 Category: Cardiology Source Type: research

Correction
Bay és-Genís A, Villuendas R, Elosua R (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - November 15, 2016 Category: Cardiology Source Type: research

Correction
Jones TK, Rome JJ, Armstrong AK, Berger F, Hellenbrand WE, Cabalka AK, Benson LN, Balzer DT, Cheatham JP, Eicken A, McElhinney DB (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - November 15, 2016 Category: Cardiology Source Type: research

Reply Diagnostic Ultrasound Impulses Improve Microvascular Flow in Patients With STEMI Receiving Intravenous Microbubbles
We thank Dr. D ’Amario and colleagues for their interest in our recently published study and their intriguing preliminary findings with transthoracic diagnostic high mechanical index (HMI) ultrasound in the RIGENERA 2.0 (Recupero Dall'Infarto Miocardico Con G-CSF E Nuovi Esempi di Rigenerazione Avanzata, [NCT025 02747]).(1). In this trial, the authors have discovered that intermittent HMI ultrasound impulses with a standard diagnostic system (i.e., 33, Philips Healthcare, Bothel, Washington) during a lipid encapsulated microbubble infusion before granulocyte colony –stimulating factor (GCSF) injection resulted in great...
Source: Journal of the American College of Cardiology - October 25, 2016 Category: Cardiology Source Type: research

Diagnostic Ultrasound Impulses Improve Microvascular Flow in Patients With STEMI Receiving Intravenous Microbubbles
We read with interest the paper by Mathias et  al.(1), testing the hypothesis that the transthoracic high mechanical index impulses from ultrasound, used as a diagnostic tool to detect microvascular obstruction, may be used to improve the epicardial and microvascular flow in patients with acute ST-segment elevation myocardial infarction (STEMI). (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - October 25, 2016 Category: Cardiology Source Type: research

Reply Is Histamine H 2 Receptor a Real  Promising Target for Prevention or Treatment of Heart Failure?
We appreciate the thoughtful review of our work(1) by Dr. He and colleagues. Although salient, the lack of subgroup analyses by specific H2-receptor antagonists (H2RAs) is a limitation of our work imposed by the data structure and limited number of participants in individual drug subgroups in this cohort. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - October 25, 2016 Category: Cardiology Source Type: research

Is Histamine H 2 Receptor a Real Promising Target for Prevention or Treatment of Heart Failure?
The recently published research by Leary et  al.(1) in theJournal provided novel clinical evidence regarding the benefit effect of histamine H2 receptor antagonists (H2RAs) on heart failure (HF). We appreciate the long and hard effort the authors performed in this work, which, however, also brings up the following clinical issues. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - October 25, 2016 Category: Cardiology Source Type: research