Low Protein Intake in the Population: Low Risk of Kidney Function Decline but High Risk of Mortality
This population-based study investigated low protein intake, mortality, and kidney function decline. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - February 10, 2018 Category: Urology & Nephrology Authors: Massimo Cirillo, Pierpaolo Cavallo, Giancarlo Bilancio, Cinzia Lombardi, Oscar Terradura Vagnarelli, Martino Laurenzi Tags: Original Research Source Type: research

Does Low-Protein Diet Influence the Uremic Toxin Serum Levels From the Gut Microbiota in Nondialysis Chronic Kidney Disease Patients?
To evaluate the effects of low-protein diet (LPD) on uremic toxins and the gut microbiota profile in nondialysis chronic kidney disease (CKD) patients. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - February 10, 2018 Category: Urology & Nephrology Authors: Ana Paula Black, Juliana S. Anjos, Ludmila Cardozo, Fl ávia L. Carmo, Carla J. Dolenga, Lia S. Nakao, Dennis de Carvalho Ferreira, Alexandre Rosado, José Carlos Carraro Eduardo, Denise Mafra Tags: Research Brief Source Type: research

Low Protein Intake in the Population: Low Risk of Kidney Function Decline but High Risk of Mortality
This population-based study investigated low protein intake, mortality, and kidney function decline. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - February 10, 2018 Category: Urology & Nephrology Authors: Massimo Cirillo, Pierpaolo Cavallo, Giancarlo Bilancio, Cinzia Lombardi, Oscar Terradura Vagnarelli, Martino Laurenzi Tags: Original Research Source Type: research

Does Low-Protein Diet Influence the Uremic Toxin Serum Levels From the Gut Microbiota in Nondialysis Chronic Kidney Disease Patients?
To evaluate the effects of low-protein diet (LPD) on uremic toxins and the gut microbiota profile in nondialysis chronic kidney disease (CKD) patients. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - February 10, 2018 Category: Urology & Nephrology Authors: Ana Paula Black, Juliana S. Anjos, Ludmila Cardozo, Fl ávia L. Carmo, Carla J. Dolenga, Lia S. Nakao, Dennis de Carvalho Ferreira, Alexandre Rosado, José Carlos Carraro Eduardo, Denise Mafra Tags: Original Research Source Type: research

Postprandial Mineral Handling in Patients on Maintenance Hemodialysis
Patients on maintenance hemodialysis (HD) are unable to compensate for an enlarged mineral load with increased excretion of calcium and phosphate in the urine. Hence, excess calcium and phosphate must be neutralized by other mechanisms to avoid toxicity. The present study examined the acute handling of a mineral load in HD patients as compared with healthy subjects. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - February 8, 2018 Category: Urology & Nephrology Authors: Mark Reinhard, Jan Frystyk, Else Randers, Bo Martin Bibby, Per Ivarsen Tags: Original Research Source Type: research

Soluble Toll-like Receptor 4: A New Player in  Subclinical Inflammation and Malnutrition in Hemodialysis Patients
In this study, we describe the sTLR4 profile in regular HD patients. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - February 8, 2018 Category: Urology & Nephrology Authors: Pasquale Esposito, Edoardo La Porta, Maria Antonietta Grignano, Daniela Verzola, Samantha Milanesi, Francesca Ansaldo, Marilena Gregorini, Carmelo Libetta, Giacomo Garibotto, Teresa Rampino Tags: Original Research Source Type: research

Postprandial Mineral Handling in Patients on Maintenance Hemodialysis
Patients on maintenance hemodialysis (HD) are unable to compensate for an enlarged mineral load with increased excretion of calcium and phosphate in the urine. Hence, excess calcium and phosphate must be neutralized by other mechanisms to avoid toxicity. The present study examined the acute handling of a mineral load in HD patients as compared with healthy subjects. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - February 8, 2018 Category: Urology & Nephrology Authors: Mark Reinhard, Jan Frystyk, Else Randers, Bo Martin Bibby, Per Ivarsen Tags: Original Research Source Type: research

Soluble Toll-like Receptor 4: A New Player in  Subclinical Inflammation and Malnutrition in Hemodialysis Patients
In this study, we describe the sTLR4 profile in regular HD patients. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - February 8, 2018 Category: Urology & Nephrology Authors: Pasquale Esposito, Edoardo La Porta, Maria Antonietta Grignano, Daniela Verzola, Samantha Milanesi, Francesca Ansaldo, Marilena Gregorini, Carmelo Libetta, Giacomo Garibotto, Teresa Rampino Tags: Original Research Source Type: research

Kidney-Friendly Label Reading for Chronic Kidney Disease Shoppers
The education tool and article that follow are intended for use by chronic kidney disease (CKD) Stages 3 to 5 grocery shoppers. The article presents an overview of a handout intended to provide a nutrition education tool to assist CKD Stages 3 to 5 shoppers in shopping for kidney-friendly items. The handout may be used with CKD shopping tours and with CKD Stages 3 to 5 Medical Nutrition Therapy, in-center and home therapy dialysis. Because of the wide variation in nutrient needs for CKD Stages 3 to 5, the Kidney-Friendly Tips for Reading Food Labels for CKD shoppers is modifiable to be individualized for the specific needs...
Source: Journal of Renal Nutrition - December 15, 2017 Category: Urology & Nephrology Authors: Lois J. Hill, Amey J. Herald Tags: Patient Education Source Type: research

January Meeting Announcements
March 6-9, 2018 AKI& CRRT 2017 – The 23rd International Conference on Advances in Critical Care Nephrology, Manchester Grand Hyatt, San Diego, CA. Visit http://www.crrtonline.com/conference/ or call 858-272-1018. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - December 15, 2017 Category: Urology & Nephrology Tags: Announcements Source Type: research

Eating During Hemodialysis Treatment: A  Consensus Statement From the International Society of Renal Nutrition and Metabolism
Poor nutritional status and protein-energy wasting are common among maintenance dialysis patients and associated with unfavorable outcomes. Providing foods, meal trays, snack boxes, and/or oral nutritional supplements during hemodialysis can improve nutritional status and might also reduce inflammation, enhance health-related quality of life, boost patient satisfaction, and improve survival. Potential  challenges include postprandial hypotension and other hemodynamic instabilities, aspiration risk, gastrointestinal symptoms, hygiene issues, staff burden, reduced solute removal, and increased costs. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - December 15, 2017 Category: Urology & Nephrology Authors: Brandon M. Kistler, Debbie Benner, Jerrilynn D. Burrowes, Katrina L. Campbell, Denis Fouque, Giacomo Garibotto, Joel D. Kopple, Csaba P. Kovesdy, Connie M. Rhee, Alison Steiber, Peter Stenvinkel, Pieter ter Wee, Daniel Teta, Angela Y.M. Wang, Kamyar Kalan Tags: Review Article Source Type: research

Happy New Year
Welcome to 2018. Now that the holidays are over, I wish everyone a prosperous and productive 2018. One of the goals of the Council on Renal Nutrition (CRN) this year is to improve communication with our membership. It was recently brought to the CRN Executive Committees attention, by a number of members, they were not receiving timely communications from the National Kidney Foundation (NKF). It was discovered that the previous year NKF had done some upgrades to their IT systems. However, since the upgrades, some e-mails were failing to go through. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - December 15, 2017 Category: Urology & Nephrology Authors: Laura Holden Tags: Message From the Chairperson Source Type: research

Gut Endothelial Leakage of Endotoxin May Be the Source of Vascular Inflammation and Injury in CKD. How Can This Be Targeted?
The risk of cardiovascular events increases as glomerular filtration rate declines increasing as much as 35 fold in patients with Stage 5 chronic kidney disease (CKD).1 Despite the vast increase in risk in this population, biomarkers associated with risk in the general population, such as cholesterol level contribute little risk,2 while the primary biomarkers associated with increased risk are those linked to inflammation.3,4 One open question is identifying the causal pathway between inflammatory biomarkers, which themselves may simply provide evidence of inflammation and vascular injury. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - December 15, 2017 Category: Urology & Nephrology Authors: Niti Madan, George A. Kaysen Tags: Editorial Source Type: research

Masthead
(Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - December 15, 2017 Category: Urology & Nephrology Source Type: research

Editorial Board
(Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - December 15, 2017 Category: Urology & Nephrology Source Type: research

Table of Contents
(Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - December 15, 2017 Category: Urology & Nephrology Source Type: research

Guidelines for Contributing Authors
(Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - December 15, 2017 Category: Urology & Nephrology Source Type: research

Diet Quality of Chronic Kidney Disease Patients and the Impact of Nutritional Counseling
The aims of the study were to evaluate the quality of the diet of nondialysis-dependent patients with chronic kidney disease and to investigate the impact of dietary counseling in the quality of the diet of these patients. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - December 6, 2017 Category: Urology & Nephrology Authors: Andr éia Silva Fernandes, Christiane Ishikawa Ramos, Fabiana Baggio Nerbass, Lilian Cuppari Tags: Original Research Source Type: research

Effects of Oral Nutritional Supplements on Mortality, Missed Dialysis Treatments, and Nutritional Markers in Hemodialysis Patients
Protein-energy wasting is common in end-stage renal disease patients undergoing dialysis and is strongly associated with mortality and adverse outcomes. Intradialytic oral nutritional supplements (ONS) reduce risk of mortality in these patients. Large studies characterizing the impact of ONS on other outcomes are lacking. We assessed the associations between administration of ONS and clinical and nutritional outcomes. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - December 5, 2017 Category: Urology & Nephrology Authors: Debbie Benner, Steven M. Brunelli, Becky Brosch, Jane Wheeler, Allen R. Nissenson Tags: Original Research Source Type: research

Alkaline Diet and Metabolic Acidosis: Practical Approaches to the Nutritional Management of Chronic Kidney Disease
The kidneys play an extremely important role in maintaining the body acid –base balance by excreting nonvolatile acids and regenerating and reabsorbing bicarbonate in the kidney tubules. As the individual loses their kidney function, renal excretion of nonvolatile acid produced by metabolism of the diet is impaired, resulting in low-grade metabolic acidosis. With this i n mind, it is relevant to better understand the dietary aspects related to the acid–base balance in chronic kidney disease metabolic acidosis and try to provide possible strategies for the nutritional management of these cases. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - December 5, 2017 Category: Urology & Nephrology Authors: Larissa Rodrigues Neto Ang éloco, Gabriela Cristina Arces de Souza, Elen Almeida Romão, Paula Garcia Chiarello Tags: Practical Aspects Source Type: research

Effects of Oral Nutritional Supplements on Mortality, Missed Dialysis Treatments, and Nutritional Markers in Hemodialysis Patients
Protein-energy wasting is common in end-stage renal disease patients undergoing dialysis and is strongly associated with mortality and adverse outcomes. Intradialytic oral nutritional supplements (ONS) reduce risk of mortality in these patients. Large studies characterizing the impact of ONS on other outcomes are lacking. We assessed the associations between administration of ONS and clinical and nutritional outcomes. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - December 5, 2017 Category: Urology & Nephrology Authors: Debbie Benner, Steven M. Brunelli, Becky Brosch, Jane Wheeler, Allen R. Nissenson Tags: Original Research Source Type: research

Alkaline Diet and Metabolic Acidosis: Practical Approaches to the Nutritional Management of Chronic Kidney Disease
The kidneys play an extremely important role in maintaining the body acid –base balance by excreting nonvolatile acids and regenerating and reabsorbing bicarbonate in the kidney tubules. As the individual loses their kidney function, renal excretion of nonvolatile acid produced by metabolism of the diet is impaired, resulting in low-grade metabolic acidosis. With this i n mind, it is relevant to better understand the dietary aspects related to the acid–base balance in chronic kidney disease metabolic acidosis and try to provide possible strategies for the nutritional management of these cases. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - December 5, 2017 Category: Urology & Nephrology Authors: Larissa Rodrigues Neto Ang éloco, Gabriela Cristina Arces de Souza, Elen Almeida Romão, Paula Garcia Chiarello Tags: Practical Aspects Source Type: research

Different Dietary Patterns and New-Onset Diabetes Mellitus After Kidney Transplantation: A Cross-Sectional Study
To verify the association of dietary patterns and dietary components with new-onset diabetes mellitus after transplantation (NODAT). (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - November 21, 2017 Category: Urology & Nephrology Authors: Analaura Centenaro, Elis F. Pedrollo, Bruna B. Nicoletto, Roberto C. Manfro, Luiz Felipe S. Gon çalves, Cristiane B. Leitão, Gabriela C. Souza Tags: Original Research Source Type: research

Effect of Change in Fluid Status Evaluated by Bioimpedance Techniques on Body Composition in Hemodialysis Patients
This prospective study uses calf bioimpedance spectroscopy (cBIS) to guide the attainment of dry weight (DWcBIS) in chronic hemodialysis (HD) patients. The primary aim of this study was to evaluate whether body composition is altered when fluid status is reduced to DWcBIS. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - November 20, 2017 Category: Urology & Nephrology Authors: Samer R. Abbas, Stephan Thijssen, Erik L. Penne, Jochen G. Raimann, Li Liu, Murat H. Sipahioglu, Eric Seibert, Yuedong Wang, Yuqi Chen, Qingqing Xiao, Nathan W. Levin, Peter Kotanko, Fansan Zhu Tags: Original Research Source Type: research

Frailty and the Quality of Life in Hemodialysis Patients: The Importance of Waist Circumference
Frailty among the end-stage renal disease (ESRD) population is highly prevalent and has been associated with mortality. Little is known about the relation of different aspects of body composition, a modifiable risk factor, with the risk of frailty in ESRD population. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - November 20, 2017 Category: Urology & Nephrology Authors: Nazanin Noori, Arti Sharma Parpia, Rajiv Lakhani, Sabrina Janes, Marc B. Goldstein Tags: Original Research Source Type: research

Effect of Change in Fluid Status Evaluated by Bioimpedance Techniques on Body Composition in Hemodialysis Patients
This prospective study uses calf bioimpedance spectroscopy (cBIS) to guide the attainment of dry weight (DWcBIS) in chronic hemodialysis (HD) patients. The primary aim of this study was to evaluate whether body composition is altered when fluid status is reduced to DWcBIS. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - November 20, 2017 Category: Urology & Nephrology Authors: Samer R. Abbas, Stephan Thijssen, Erik L. Penne, Jochen G. Raimann, Li Liu, Murat H. Sipahioglu, Eric Seibert, Yuedong Wang, Yuqi Chen, Qingqing Xiao, Nathan W. Levin, Peter Kotanko, Fansan Zhu Tags: Original Research Source Type: research

Fatty Acids in Nephrotic Syndrome and Chronic Kidney Disease
The role of fatty acids (FAs) in inflammation and in the related chronic diseases has been demonstrated. However, there is a lack of consistent and agreed knowledge about the role of FA profile and renal physiology and pathology, most articles focusing on the effect of polyunsaturated FAs supplementation, without considering the impact of basal FA metabolism on the efficacy of the supplementation. Here, we have summarized the specific literature concerning the assessment of circulating FA in 2 renal diseases, namely nephrotic syndrome and chronic kidney disease, also under hemodialytic treatment, and have received the most...
Source: Journal of Renal Nutrition - November 16, 2017 Category: Urology & Nephrology Authors: Stefano Turolo, Alberto Edefonti, Marie Louise Syren, Franca Marangoni, William Morello, Carlo Agostoni, Giovanni Montini Tags: Review Article Source Type: research

Novel Equations for Estimating Lean Body Mass in Patients With Chronic Kidney Disease
Simplified methods to estimate lean body mass (LBM), an important nutritional measure representing muscle mass and somatic protein, are lacking in nondialyzed patients with chronic kidney disease (CKD). We developed and tested 2 reliable equations for estimation of LBM in daily clinical practice. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - November 15, 2017 Category: Urology & Nephrology Authors: Xue Tian, Yuan Chen, Zhi-Kai Yang, Zhen Qu, Jie Dong Tags: Original Research Source Type: research

Patient Experiences of Dietary Management in Chronic Kidney Disease: A Focus Group Study
This study aimed to describe the experiences of patients with managing dietary recommendations, including their perspectives on the potential to use telehealth to support dietary management in CKD. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - November 14, 2017 Category: Urology & Nephrology Authors: Jaimon T. Kelly, Katrina L. Campbell, Tammy Hoffmann, Dianne P. Reidlinger Tags: Original Research Source Type: research

The Myth of Water and Salt: From Aquaretics to Tenapanor
The impact of water intake has been studied in several renal diseases. For example, increasing water intake is useful to prevent primary and secondary nephrolithiasis. In autosomal dominant polycystic kidney disease, arginine vasopressin (AVP) is involved in the progression of the disease, and water intake could play a therapeutic role by inhibiting the synthesis of AVP, but its efficacy is still controversial. Conversely, the use of aquaretics, which are antagonists of AVP V2 receptors, results in the reduction of the increase rate of total kidney volume with a slower decline of glomerular filtration rate. (Source: Journa...
Source: Journal of Renal Nutrition - November 14, 2017 Category: Urology & Nephrology Authors: Luca Visconti, Valeria Cernaro, Sebastiano Calimeri, Antonio Lacquaniti, Francesca De Gregorio, Carlo Alberto Ricciardi, Viviana Lacava, Domenico Santoro, Michele Buemi Tags: Review Article Source Type: research

How to Prevent Renal Cachexia? A Clinical Randomized Pilot Study Testing Oral Supplemental Nutrition in Hemodialysis Patients With and Without Human Immunodeficiency Virus Infection
End-stage renal disease associates with catabolism and sarcopenia. Hypothetically, peroral supplemental nutrition over 6  months prevents catabolism in hemodialysis patients. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - November 14, 2017 Category: Urology & Nephrology Authors: Michael Zilles, Christoph Betz, Oliver Jung, Stefan Gauer, Renate Hammerstingl, Astrid W ächtershäuser, Thomas J. Vogl, Helmut Geiger, Aida Asbe-Vollkopf, Rainer U. Pliquett Tags: Original Research Source Type: research

Visceral Adiposity Index as a Predictor of Chronic Kidney Disease in a Relatively Healthy Population in Taiwan
Abdominal obesity is an independent risk factor for cardiovascular disease and chronic kidney disease (CKD). Visceral adiposity index (VAI), a simple formula representing visceral adipose dysfunction, has already been proven to have a strong correlation with various cardiometabolic disorders. Limited studies are available regarding the relationship between VAI and renal function decline. Therefore, the purpose of this study was to evaluate the relationship between VAI and renal function and to estimate the risk of chronic kidney disease in a relatively healthy adult population in Taiwan. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - November 14, 2017 Category: Urology & Nephrology Authors: Yi-Chuan Chen, Shih-Han Lai, Yi-Wen Tsai, Shy-Shin Chang Tags: Original Research Source Type: research

Patient Experiences of Dietary Management in Chronic Kidney Disease: A Focus Group Study
This study aimed to describe the experiences of patients with managing dietary recommendations, including their perspectives on the potential to use telehealth to support dietary management in CKD. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - November 14, 2017 Category: Urology & Nephrology Authors: Jaimon T. Kelly, Katrina L. Campbell, Tammy Hoffmann, Dianne P. Reidlinger Tags: Original Research Source Type: research

The Impact of Additives on the Phosphorus, Potassium, and Sodium Content of Commonly Consumed Meat, Poultry, and Fish Products Among Patients With Chronic Kidney Disease
This study aimed to determine the impact of food additives on the chemically analyzed content of phosphorus, potassium, sodium, and protein in commonly consumed meat, poultry, and fish products (MPFs). (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - November 14, 2017 Category: Urology & Nephrology Authors: Arti Sharma Parpia, Mary L'Abb é, Marc Goldstein, Joanne Arcand, Bernadene Magnuson, Pauline Darling Tags: Original Research Source Type: research

Development of Kidney Transplant Fibrosis Is Inversely Associated With Plasma Marine Fatty Acid Level
We assessed associations between plasma levels of polyunsaturated fatty acids (PUFAs) and degree of inflammation and interstitial fibrosis in transplanted kidneys. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - November 14, 2017 Category: Urology & Nephrology Authors: Ivar A. Eide, Christina D örje, My Svensson, Trond Jenssen, Clara Hammarstrøm, Helge Scott, Kristian S. Bjerve, Jeppe H. Christensen, Erik B. Schmidt, Anders Hartmann, Anders Åsberg, Anna V. Reisæter, Finn P. Reinholt Tags: Original Research Source Type: research

The Associations of Endotoxemia With Systemic Inflammation, Endothelial Activation, and Cardiovascular Outcome in Kidney Transplantation
This study investigated the associations of endotoxemia with inflammation, endothelial activation, and 5-year cardiovascular events in KTRs. Determinants of endotoxemia were also explored. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - October 28, 2017 Category: Urology & Nephrology Authors: Winnie Chan, Jos A. Bosch, Anna C. Phillips, Shui Hao Chin, Adaikala Antonysunil, Nicholas Inston, Sue Moore, Okdeep Kaur, Philip G. McTernan, Richard Borrows Tags: Original Research Source Type: research

Altered Serum n-6 Polyunsaturated Fatty Acid Profile and Risks of Mortality and Cardiovascular Events in a Cohort of Hemodialysis Patients
Alterations in the balance between serum n-3 and n-6 polyunsaturated fatty acids (PUFAs) is predictive of cardiovascular  events among hemodialysis patients, although little is known about the serum ratio of n-6 arachidonic acid (AA) to n-6 dihomo-γ-linoleic acid (DGLA) in renal failure. We hypothesized that AA/DGLA ratio is altered in hemodialysis patients resulting in poor clinical outcomes. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - October 28, 2017 Category: Urology & Nephrology Authors: Yukinobu Kuwamura, Tetsuo Shoji, Yujiro Okute, Yuko Yamazaki, Koka Motoyama, Tomoaki Morioka, Katsuhito Mori, Shinya Fukumoto, Yoshihiro Tsujimoto, Atsushi Shioi, Masanori Emoto, Masaaki Inaba Tags: Original Research Source Type: research

Probiotic Soy Milk: A Call to Action
In a recently published clinical trial, Ghiasvand R et  al1 have shown that the 8-week consumption of 200 mL/day probiotic soy milk fortified with Lactobacillus plantarum A7 may exert favorable changes on biomarkers of oxidative stress in patients with type 2 diabetes and concomitant diabetic kidney disease (DKD). (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - October 28, 2017 Category: Urology & Nephrology Authors: Leonardo Spatola, Salvatore Badalamenti, Marco Dauriz Tags: Letter to the Editor Source Type: research

Proceedings of the Ninth International Congress of Uremia Research and Toxicity
We are pleased to provide the readers of the Journal of Renal Nutrition with the Proceedings of the Ninth International Congress of Uremia Research and Toxicity which was organized by Professor Alejandro Trevino Becerra and held in Guadalajara, Mexico, on March 17-19, 2016. The Congress was sponsored by the International Society of Uremia Research and Toxicity. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - October 20, 2017 Category: Urology & Nephrology Authors: Shaul G. Massry, Alejandro Trevino Becerra Tags: ICURT Proceedings Source Type: research

A History of Uremia Research
The history of uremia research begins with the discovery of urea and the subsequent association of elevated blood urea levels with the kidney disease described by Richard Bright, a well told story that needs no recounting. What this article highlights is how clinical and laboratory studies of urea launched the analysis of body fluids, first of urine and then of blood, that would beget organic chemistry, paved the way for the study of renal function and the use of urea clearance to determine “renal efficiency,” provided for the initial classification of kidney disease, and clarified the concepts of diffusion and...
Source: Journal of Renal Nutrition - October 20, 2017 Category: Urology & Nephrology Authors: Garabed Eknoyan Tags: ICURT Proceedings Source Type: research

Sister Earth, Our Common Home: Toward a Sustainable, Planet Friendly Approach to Dialysis, a Paradigm of High Technology Medicine
In our high-technology, highly polluted world, medicine plays an important role balancing saving lives with the expenses of growing amounts of waste products, not only biologically dangerous (the potentially “contaminated” or “hazardous” waste) but also potentially harmful for the planet (nonrecyclable, plastic waste). Dialysis, the prototype of high-technology medicine, is central to these problems, as the present treatment of about 2 million patients produces an enormous quantity of waste (co nsidering hazardous waste only about 2 kg per session, with 160 sessions per year, that is 320&n...
Source: Journal of Renal Nutrition - October 20, 2017 Category: Urology & Nephrology Authors: Giorgina Barbara Piccoli, David Mery Tags: ICURT Proceedings Source Type: research

Skin Blood Flow and Vascular Endothelium Function in Uremia
Prevalence of dermatological disorder in patients with end-stage kidney disease is estimated as 50% to 100% in various studies. Some of the skin lesions are specific for the diseases causing chronic kidney disease (CKD), some are associated with CKD, and still others are the dermatological manifestation of uremia. Microangiopathy was also found in both arterioles and venule in the skin biopsy of “normal looking” skin in patients with end-stage kidney disease. In a cross-sectional study in patients on dialysis, we measured skin blood flow (SBF) using laser Doppler device in a standardized way at various areas of...
Source: Journal of Renal Nutrition - October 20, 2017 Category: Urology & Nephrology Authors: Miroslaw J. Smogorzewski Tags: ICURT Proceedings Source Type: research

The Leaky Gut and Altered Microbiome in Chronic Kidney Disease
Chronic kidney disease results in disruption of the intestinal epithelial barrier as well as profound changes in the gut microbial flora. These events are largely mediated by (1) heavy influx of circulating urea to the gut lumen and (2) dietary restrictions of foods containing high fiber (such as fruits and vegetable) and symbiotic organisms (such as yogurt and cheese) imposed to mitigate hyperkalemia and hyperphosphatemia. Collectively, these factors promote systemic inflammation and cardiovascular morbidity by mediating microbial dysbiosis, disruption of the intestinal epithelial barrier, and translocation of endotoxin, ...
Source: Journal of Renal Nutrition - October 20, 2017 Category: Urology & Nephrology Authors: Wei Ling Lau, Nosratola D. Vaziri Tags: ICURT Proceedings Source Type: research

Long-term Adverse Events Associated With Acute Kidney Injury
Acute kidney injury (AKI) occurs in approximately 10% to 15% of hospital-admitted patients and is associated with in-hospital mortality of 50% in patients requiring renal replacement therapy. Recently, multiple observational studies have demonstrated that patients who survive AKI have significant long-term consequences including cardiovascular events, progression to advanced-stage chronic kidney disease (CKD), and mortality. A direct link between AKI and CKD is provided by studies that demonstrate that some patients with normal renal function who develop AKI requiring dialysis never recover. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - October 20, 2017 Category: Urology & Nephrology Authors: Manisha Singh, Nithin Karakala, Sudhir V. Shah Tags: ICURT Proceedings Source Type: research

Unacylated Ghrelin: A Novel Regulator of Muscle Intermediate Metabolism With Potential Beneficial Effects in Chronic Kidney Disease
In patients with chronic kidney disease (CKD), malnutrition with loss of skeletal muscle mass has a negative impact on morbidity and mortality. Emerging evidence indicates that a cluster of oxidative stress, inflammation, and insulin resistance directly contributes to skeletal muscle catabolism by favoring protein breakdown over synthesis. Ghrelin is a gastric hormone discovered and initially studied in its acylated orexigenic form. More recently, a role of unacylated ghrelin (UnAG) has been described to reduce skeletal muscle mitochondrial reactive oxygen species generation, inflammation, and insulin resistance both in ex...
Source: Journal of Renal Nutrition - October 20, 2017 Category: Urology & Nephrology Authors: Gianluca Gortan Cappellari, Michela Zanetti, Pierandrea Vinci, Gianfranco Guarnieri, Rocco Barazzoni Tags: ICURT Proceedings Source Type: research

Cystic Fibrosis: A Risk Condition for Renal Disease
Cystic fibrosis (CF) is the most common autosomal recessive disease affecting the Caucasian population, with a birth incidence ranging between 1:2,500 and 1:1,800. It is caused by mutations in the CF transmembrane regulator gene which is localized on 7 chromosomes. Renal disease is reported as a relatively rare complication in adult patient with CF. We evaluated proteinuria and chronic renal failure (CRF) in a population of patients with CF. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - October 20, 2017 Category: Urology & Nephrology Authors: Domenico Santoro, Adele Postorino, Cristina Lucanto, Stefano Costa, Simona Cristadoro, Salvatore Pellegrino, Giovanni Conti, Michele Buemi, Giuseppe Magazz ù, Guido Bellinghieri Tags: ICURT Proceedings Source Type: research

ADAM17, a New Player in the Pathogenesis of Chronic Kidney Disease –Mineral and Bone Disorder
The triad composed by α-Klotho, fibroblast growth factor-23, and its receptor are involved in the pathogenesis of chronic kidney disease–mineral and bone disorder. A disintegrin and metalloproteinase 17 (ADAM17) is a metalloproteinase causing the proteolytic shedding of α-Klotho from the cell membrane, and its role i n chronic kidney disease–mineral and bone disorder is not yet known. We studied the circulating levels of the above-mentioned mediators in patients with secondary hyperparathyroidism due to uremia, compared to control subjects, as well as in patients with primary hyperparathyroidism. (S...
Source: Journal of Renal Nutrition - October 20, 2017 Category: Urology & Nephrology Authors: Alessandra F. Perna, Alessandra Pizza, Annarita Di Nunzio, Rocco Bellantone, Marco Raffaelli, Tommaso Cicchella, Giovanni Conzo, Luigi Santini, Miriam Zacchia, Francesco Trepiccione, Diego Ingrosso Tags: ICURT Proceedings Source Type: research