Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials
ConclusionIn this pilot/phase II study, we learned: (1) radiosurgery using radiation doses based on our algorithm provides good local control with low toxicity. (2) Despite the relative commonality of brain metastases, patients with brain metastases are difficult to enroll on clinical trials. (3) A prospective study that encompasses all potentially important clinical variables that go into radiosurgery dose selection will require large amounts of patients. Our findings have important implications for future clinical trials of radiosurgery for brain metastases. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - January 14, 2019 Category: Cancer & Oncology Source Type: research
Five-year results of post-prostatectomy patients administered a hydrogel rectal spacer implant in conjunction with dose escalated external beam radiation therapy
ConclusionHydrogel rectal spacer implants in patients who previously had a prostatectomy is well tolerated long term with reduced incidence of GI and GU toxicities, and bRFS rates consistent with previous reports in the literature. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - December 18, 2018 Category: Cancer & Oncology Source Type: research
Ventricular violation increases the risk of leptomeningeal disease in cavity-directed radiosurgery treated patients
ConclusionsLMD incidence is relatively high in patients receiving postoperative cavity-directed SRS. Ventricular violation during surgery causes a significantly higher risk of LMD, and consideration of WBRT, greater SRS target volumes, or preoperative treatment in these patients may be warranted. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - December 18, 2018 Category: Cancer & Oncology Source Type: research
Clinical evidence for dose tolerance of the central nervous system in hypofractionated radiotherapy
ConclusionsEffective differences between single fraction SRS and conventional radiotherapy need to be better understood. The existing biological model might not be valid to predict the radiosurgical outcomes based on conventionally fractionated radiotherapy. However, application of the statistical dose response models of clinical SRS and SBRT outcomes data to selected current dose tolerance guidelines into simple tables can be a clinically useful resource. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - December 3, 2018 Category: Cancer & Oncology Source Type: research
Inter-fraction movements of the prostate and pelvic lymph nodes during IGRT
ConclusionLymph nodes and prostate were most mobile in the A-P direction, followed by the C-C and R-L directions. This movement should be taken into account when deciding the margins for the planning target volumes (PTV). (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 28, 2018 Category: Cancer & Oncology Source Type: research
Experience with hypofractionated stereotactic radiosurgery in a series of patients with skull base tumors
ConclusionsIn our series of patients, the high incidence of non-progression of tumors indicated that HSRS could be a therapeutic option in some cases of skull base lesions, mainly residuals or tumoral recurrences of pituitary adenomas, schwannomas, and meningiomas. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 22, 2018 Category: Cancer & Oncology Source Type: research
Relationship among different skin dose definitions in high-dose-rate (HDR) balloon breast brachytherapy
ConclusionThe presented relationships can be developed in each individual institution and convert one dosimetric index to another for different skin definitions. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 17, 2018 Category: Cancer & Oncology Source Type: research
Acute toxicities after volumetric modulated arc therapy for craniospinal irradiation in adults
ConclusionsVMAT radiation delivery is feasible and well tolerated in adult patients receiving CSI. The addition of adjuvant chemotherapy carries an increased risk for hematologic toxicity. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 15, 2018 Category: Cancer & Oncology Source Type: research
Evaluation of effectiveness of palliative radiotherapy for bone metastases: a prospective cohort study
ConclusionCompared to randomized trial populations, palliative radiotherapy in our unselected patients with bone metastases showed similar pain response rates (61%), with a reasonable duration of this effect. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 10, 2018 Category: Cancer & Oncology Source Type: research
A fiducial-less tracking method for radiation therapy of liver tumors by diaphragm disparity analysis part 2: validation study by using clinical data
ConclusionWe proposed and investigated the fiducial-less tracking method to follow tumor motion in the real-time under the influence of respiration. The study shows the feasibility of accurately predicting the tumor ’s position with the use of lung-diaphragm border’s information through available kV images without gold fiducial markers. This developed diaphragm disparity-analysis-based approach, verified with clinically accepted errors, has the potential to replace fiducial markers in clinical applications. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 18, 2018 Category: Cancer & Oncology Source Type: research
In memoriam: the legendary Dr. Luther Brady —founding ACRO president and founding JRO editor in chief
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - September 6, 2018 Category: Cancer & Oncology Source Type: research
The effects of treatment duration on outcomes of radiation treatment with high-dose-rate brachytherapy in the era of concurrent chemoradiation for cervical carcinoma
ConclusionsIn the present era of HDR-ICBT with CCRT, radiation treatment longer than 8 weeks does not appear to make a significant impact on clinical outcomes. This is a retrospective analysis. Further studies are warranted. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - September 1, 2018 Category: Cancer & Oncology Source Type: research
The albumin-bilirubin (ALBI) model in hepatocellular carcinoma (HCC) may better predict hepatic failure in patients with traditionally low-risk cirrhosis following definitive stereotactic body radiotherapy (SBRT)
ConclusionOur study indicates that the ALBI index more precisely predicted liver failure and survival in HCC following SBRT compared to CP scoring. Its application may help select the most ideal candidates for SBRT among the often heterogeneous CP-A population. Further study regarding precautionary measures such as functional treatment planning for ALBI-2 patients treated with liver SBRT may be warranted. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - September 1, 2018 Category: Cancer & Oncology Source Type: research
Factors predictive of neoadjuvant versus adjuvant chemoradiotherapy in locally advanced rectal cancer and the impact on overall survival
ConclusionsThe use of neoadjuvant chemoradiotherapy for locally advanced rectal cancer is possibly associated with an overall survival benefit compared to ACRT subject to the limitations of this analysis. Margin status affects survival greatly. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - September 1, 2018 Category: Cancer & Oncology Source Type: research
A phase II trial to determine the cosmetic outcomes and toxicity of 27 Gy in five-fraction accelerated partial breast irradiation: the ACCEL trial
ConclusionsThis trial will assess the cosmetic and normal tissue outcomes of external beam APBI delivered in 1 week for early-stage breast cancer.Trial registrationRegistration number: NCT02681107 (clinicaltrials.gov), registered February 2, 2016. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - September 1, 2018 Category: Cancer & Oncology Source Type: research
