Evaluating improvements in cardiac dosimetry in breast radiotherapy and comparison of cardiac sparing techniques
ConclusionCardiac doses were lower following the 2013 publication of Darby et al. due to greater use of cardiac sparing techniques. Overall, the average MHD was< 1 Gy and< 2 Gy for right and left breast cancers, respectively, with lower doses achieved using DIBH and prone positioning as cardiac sparing techniques. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 10, 2019 Category: Cancer & Oncology Source Type: research
Impact of choice of dose calculation algorithm on PTV and OAR doses in lung SBRT
ConclusionKnowing the strengths and limitations of clinical treatment planning system allows more consistent and accurate dose comparison for patients enrolled in protocol studies. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 29, 2019 Category: Cancer & Oncology Source Type: research
Patterns of utilization and comparative efficacy of altered fractionation and concurrent chemoradiation for treatment for T2N0M0 glottic carcinoma
ConclusionsHypofractionation gave superior survival than standard fractionation for glottic T2N0M0 tumors. Its use varies among treatment centers but is increasing with time. Chemoradiation gave a lower therapeutic ratio: more than 30% greater acute toxicity without improvement of survival; yet, its use is growing over time. More explicit guidelines are needed. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 11, 2019 Category: Cancer & Oncology Source Type: research
Assessment of the alpha/beta ratio of the optic pathway to adjust hypofractionated stereotactic radiosurgery regimens for perioptic lesions
ConclusionCompared to single-fraction SRS, a significant intrinsic benefit from hypofractionation can be achieved, not only for perioptic malignant tumors, but for benign lesions as well, because of the very low alpha/beta ratio of the optic system of 1.03 Gy. An increased single fraction equivalent dose of up to 10% for perioptic meningiomas and of more than 25% for malignant tumors can be reached with optimized hypofractionated stereotactic radiosurgery schedules. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - August 9, 2019 Category: Cancer & Oncology Source Type: research
Letter to the Editor concerning “Re-irradiation in gynaecological cancers, present experiences and future hopes”
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 9, 2019 Category: Cancer & Oncology Source Type: research
Challenges in the re-irradiation of locally advanced head and neck cancers: outcomes and toxicities
ConclusionRe-irradiation with IMRT for locally advanced HN recurrences either definitively or after salvage surgery is feasible, but treatment-related toxicity remains significant. Patients who received surgery as a component of their initial treatment and those with more advanced stage disease may be more difficult to salvage with re-irradiation. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 8, 2019 Category: Cancer & Oncology Source Type: research
Stereotactic body radiotherapy versus conventional radiotherapy for early-stage small cell lung cancer
ConclusionPatients with T1-2N0M0 SCLC treated with SBRT regimens incorporating chemotherapy had comparable outcomes with those treated with concurrent chemoradiotherapy using standard fractionation. Treatment paradigms for T1-2N0M0 SCLC incorporating SBRT warrant further exploration and should incorporate chemotherapy. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 3, 2019 Category: Cancer & Oncology Source Type: research
Quantitative assessment of the efficacy of two different treatment plan optimization algorithms in treating tumors in locations of high heterogeneity
ConclusionsThe analysis for the lung, liver, and H&N cases indicated that both planning systems are equivocal for the majority of parameters measured, with a few differentiating trends. In H&N plans, Pinnacle showed improved parotid sparing but inferior performance in calculated GI values. Liver plans showed superiority of Raystation in GI computations, but the most notable differences were in the lung plans where Pinnacle spared the spinal cord significantly more in contrast to Raystation ’s performance but also delivered significantly more dose to the esophagus. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - July 2, 2019 Category: Cancer & Oncology Source Type: research
Salvage radiation therapy following radical prostatectomy in Stockholm County in 2008 –2016
ConclusionsPatients who started SRT at PSA < 0.28 ng/ml had the best 5-year bPFS of 58%. Median pre-SRT PSA was 0.28 ng/l (0.2–0.45) indicating the good standard of salvage radiotherapy process from patient referral to start of radiotherapy in Stockholm County. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 21, 2019 Category: Cancer & Oncology Source Type: research
The systemic immunostimulatory effects of radiation therapy producing overall tumor control through the abscopal effect
ConclusionTogether, the clinical outcomes from published reports suggest that localized radiation therapy is capable of inducing abscopal effects in a wide variety of malignant tumors. With the advent of novel immunotherapies, the potential for immune activation by radiation defines a novel role for radiation therapy in the treatment of systemic disease. A clinical consideration of the abscopal effects produced by radiation therapy could lead to a revolutionary change in the current management of patients including radiation treatment strategies and immunotherapies for various malignant tumors. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 18, 2019 Category: Cancer & Oncology Source Type: research
The proceedings of the radiation oncology summit: acro 2019
(Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - June 12, 2019 Category: Cancer & Oncology Source Type: research
Neoadjuvant chemotherapy and high-dose radiation using intensity-modulated radiotherapy followed by rectal sparing TEM for distal rectal cancer
ConclusionsHigh-dose IMRT and chemotherapy followed by FTLE to treat distal rectal cancers are well tolerated and effective. FTLE may improve outcomes and minimize complications in appropriately selected patients. Randomized clinical trials are needed to compare it with standard surgery. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 29, 2019 Category: Cancer & Oncology Source Type: research
A risk model for lung complication combining radiation therapy and chronic obstructive pulmonary disease
ConclusionsCOPD status was not associated with survival or radiation pneumonitis. Age was the dominant factor in survival, and total lung V20 was associated with risk of RP. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 27, 2019 Category: Cancer & Oncology Source Type: research
Effect of intermittent low-dose irradiation on the radiotherapy efficiency for MDA-MB-231 human breast adenocarcinoma cell line
ConclusionLDIR may result in HRS through a concurrent increase of apoptosis and a significant decrease in cell viability. The therapeutic effects of this approach should be further investigated in animal models. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 24, 2019 Category: Cancer & Oncology Source Type: research
Fast in situ image reconstruction for proton radiography
ConclusionWe have demonstrated, through computer simulations of proton irradiation of a pediatric head phantom using the newly built pRad detector and image reconstruction software, that high-quality proton radiographs can be generated for patient alignment and verification of water equivalent thickness of the patient before each treatment. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 24, 2019 Category: Cancer & Oncology Source Type: research
