Long-term outcomes of hypofractionated stereotactic radiotherapy for refractory functional pituitary adenoma
ConclusionHSRT for refractory pituitary adenoma is well-tolerated with long-term local and biochemical control comparable with single-fraction SRS or IMRT. Prospective studies should evaluate whether HSRT provides non-inferior biochemical control and improved toxicity compared with single-fraction SRS. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - May 2, 2020 Category: Cancer & Oncology Source Type: research
Clinical outcomes and toxicity of proton radiotherapy for vestibular schwannomas: a systematic review
ConclusionIMRT is superior to 3D-CRT for bladder cancer and spares dose to bowel, rectum, and bladder with improved acute toxicity compared to published clinical literature. For boost treatment, daily full bladder volume and positioning are not always reproducible, supporting the need for CBCT for optimal localization of the primary bladder tumor. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - February 16, 2020 Category: Cancer & Oncology Source Type: research
The utilization patterns and comparative effectiveness of systemic therapy with high-dose thoracic radiotherapy or low-dose thoracic radiotherapy versus systemic therapy alone in newly diagnosed metastatic non-small cell lung cancer patients
ConclusionHD-RT utilization increased and was associated with improved OS versus ST alone or ST with low-dose RT. These findings are consistent with results from recently published randomized phase II studies. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - February 10, 2020 Category: Cancer & Oncology Source Type: research
The value of prostate-specific antigen monitoring during salvage radiotherapy: a retrospective study and systematic review with meta-analysis
ConclusionThese results need confirmation using prospective data before being applied to clinical practice and could help physician to choose the correct therapeutic strategy. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - January 28, 2020 Category: Cancer & Oncology Source Type: research
Outcome of surgery and radiotherapy for dermatofibrosarcoma protuberans: 5-year experience from two tertiary centers of eastern India
ConclusionCombined modality therapy with surgery and radiotherapy for cases of close or inadequate margin results in good local control with acceptable toxicity, in cases where re-surgery is not possible or not contemplated. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - January 16, 2020 Category: Cancer & Oncology Source Type: research
Intensity-modulated radiotherapy is superior to three-dimensional conformal radiotherapy in the trimodality management of muscle-invasive bladder cancer with daily cone beam computed tomography optimization
ConclusionIMRT is superior to 3D-CRT for bladder cancer and spares dose to bowel, rectum, and bladder with improved acute toxicity compared to published clinical literature. For boost treatment, daily full bladder volume and positioning are not always reproducible, supporting the need for CBCT for optimal localization of the primary bladder tumor. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - December 17, 2019 Category: Cancer & Oncology Source Type: research
Complications and toxicity of re-irradiation following total laryngectomy for laryngeal cancer
ConclusionPatients undergoing re-irradiation for recurrent laryngeal cancer have a poor prognosis with high risk of progression or recurrence. Re-irradiation may offer survival benefit at the expense of significant toxicities. The incidence of severe toxicity is high enough to warrant pretreatment counseling. Carotid blowout was seen in 15% of patients unrelated to cancer progression. Caution should be exercised in re-irradiated patients before instrumentation of the aerodigestive tract. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - December 12, 2019 Category: Cancer & Oncology Source Type: research
Temporalis muscle width as a measure of sarcopenia correlates with overall survival in patients with newly diagnosed glioblastoma
ConclusionOur results suggest sarcopenia and TMW correlate with GBM OS. Prospective validation of sarcopenia is needed to evaluate its potential in determining optimal patient treatment. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - December 12, 2019 Category: Cancer & Oncology Source Type: research
Delays in radiation therapy as a result of insurance peer-to-peer prior authorizations among lung cancer patients
ConclusionsPeer-to-peer reviews were strongly correlated with delay in RT treatment and planning. This insurance practice has additionally become more prevalent over time. A more streamlined process is needed to address this issue. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - December 9, 2019 Category: Cancer & Oncology Source Type: research
Patterns of relapse in older women diagnosed with estrogen receptor (ER) –positive early-stage breast cancer (BC) treated with lumpectomy without adjuvant endocrine therapy (ET)
ConclusionPatterns of relapse in older women with ER-positive early-stage BC note that local relapse is the most common site of failure. In this study, we also observed a low risk of distant relapse among patients not receiving ET. These observations on relapse patterns suggest that older women with early-stage BC may derive more benefit from adjuvant RT alone and be spared the potential side effects of ET. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 17, 2019 Category: Cancer & Oncology Source Type: research
Long-term clinical outcomes of 538 prostate carcinoma patients treated with combination high-dose-rate brachytherapy and external beam radiotherapy
ConclusionCombined HDR-B/EBRT for the treatment of clinically localized prostate cancer provides superb clinical outcomes with excellent 5-year bRFS, dMFS, OS, and late GI/GU toxicity rates. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - November 8, 2019 Category: Cancer & Oncology Source Type: research
Definitive chemoradiation followed by stereotactic body radiotherapy boost for inoperable endometrial cancer
ConclusionDefinitive chemoradiation with SBRT boost is safe and effective alternative when BB is not possible. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 24, 2019 Category: Cancer & Oncology Source Type: research
Dosimetric evaluation of the dose calculation accuracy of different algorithms for two different treatment techniques during whole breast irradiation
ConclusionWhen using the Eclipse TPS for breast cancer, AXB should be used instead of the AAA algorithm, bearing in mind that the AXB may still overestimate all OARs doses. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 22, 2019 Category: Cancer & Oncology Source Type: research
Thoracic radiotherapy for extensive-stage small-cell lung cancer: what is the optimal dose and timing?
AbstractSmall-cell lung cancer (SCLC) is a neuroendocrine tumor that represents about 12 –20% of all lung cancers. Most of the SCLC patients present with extensive-stage (ES) disease. Primary therapy for ES-SCLC is 4–6 cycles of platinum-based chemotherapy (CT) followed by prophylactic cranial irradiation (PCI) in selected cases. Although the response rate to CT is approximately 60– 70%, median survival times are very limited. The main problem of ES-SCLC patients after CT is intra-thoracic tumor recurrence since 75% of the patients had persisting intra-thoracic disease after CT, and approximately 90% of the patients ...
Source: Journal of Radiation Oncology - October 22, 2019 Category: Cancer & Oncology Source Type: research
Therapeutic value of postmastectomy radiation therapy for T1 –2 breast cancer with 1–3 positive lymph nodes
ConclusionsPMRT tended to improve LRR and disease-free survival. The omission of PMRT is carefully determined. (Source: Journal of Radiation Oncology)
Source: Journal of Radiation Oncology - October 15, 2019 Category: Cancer & Oncology Source Type: research
