Directing adipose derived stem cells into epidermal-like cells through epigenetic modifiers-based protocol
Objective: Adipose derived stem cells (ADSCs) have obtained the attention in skin regeneration and wound healing for their ease of isolation, and their abundance in adipose tissue. Stem cells differentiation into specific lineage requires to enhance or repress gene activation to alter cellular phenotype, metabolic state and function. Unfortunately, the differentiation process is not always efficient especially when targeted cells do not belong to the same lineage of the stem cell origin. Epigenetic modifications play a crucial role in guiding cell development and differentiation including DNA methylation and histone deacet...
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: Sallam Abdallah, Alexandra Lorenz, Moustafa Elmasry, Ahmed Elserafy Source Type: research

Histone deacetylase inhibitor alters adipose derived stem cells fate transition toward epidermal lineage
Objective: Histone acetylation is one of the epigenetic modifications which plays a crucial role in cell proliferation and differentiation. Induction of histone hyperacetylation modulates gene transcription which is responsible for directing the fate of stem cells. We applied a pharmacological approach for manipulating histone acetylation through the inhibition of histone deacetylases using Suberoylanilide hydroxamic acid (SAHA). Understanding the regulation of molecular mechanism will lead to potential therapeutic targets for various skin injuries. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: Sallam Abdallah, Mouna Tababi, Neserin Ali, Jing Wang, Wen Zhong, Moustafa Elmasry, Folke Sjoberg, Ahmed El-Serafi Source Type: research

Using artificial intelligence to write patient clinic letters: a study using chatgpt
Objectives Clinical letters are an important means of communication between healthcare providers and patients. The aim of this study was to assess the readability, factual correctness, and humanness of clinical letters generated by the ChatGPT chatbot, developed by OpenAI. To our knowledge, this is the first description of using artificial intelligence (AI) to generate clinical letters. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: Stephen R Ali, Thomas D Dobbs, Hayley A Hutchings, Iain S Whitaker Source Type: research

Hyperbaric oxygen treatment promotes axonal outgrowth
Objective: Hyperbaric oxygen (HBO) is a promising therapeutic approach to promote peripheral nerve regeneration. Underlying mechanisms of action are poorly understood resulting in inconsistent treatment protocols and unclear indications. The present study evaluated the effects of single or repeated HBO treatment alone or in combination with nerve growth factor (NGF) on PC12 cells. Cell proliferation, survival and differentiation (neurite outgrowth) were analyzed. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: Dominik Andr é-Lévigne, Margot Maytain, Rodrigue Pignel, Daniel Felix Kalbermatten, Srinivas Madduri Source Type: research

Breast implant illness
Introduction: Since the 1960s, there have been repeated speculations describing a correlation between breast implants and systemic diseases. Most studies up to now have neither been able to confirm nor refute this correlation. The problem still exists today and has been named “breast implant illness”. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: Bianca Baican, Z. Potente, Ch. Luther, K. Exner Source Type: research

Donor nerve selection in free gracilis muscle transfer; comparing cross-face nerve graft, motor nerve to the masseter and the dual innervation concenpt: a systematic review and meta-analysis of clinical outcomes
This study aimed to compare the clinical outcomes of different neurotization strategies for free gracilis muscle transfer (FGMT). (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: K. Can Bayezid, Marek Joukal, Erdem Karabulut, Jan Macek, Ludmila Moravcov á, Libor Streit Source Type: research

An elastic porous injectable scaffold enabling 3d shaping of autologous adipose tissue grafts and improving long-term volume retention
Introduction: Autologous adipose tissue (AAT) graft has been widely used for correcting soft-tissue defects and reconstructing soft-tissue volumes. However, variable cell death leads to unpredictable outcomes with graft volume retention varying between 25% and 80%. In addition, grafted AAT is liquid and fails to create 3D projected shapes, limiting clinical application. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: Gilles Bioley, Mariana Martins, Thomas Braschler, Thomas Di Mattia, Cristina Cudalbu, Am élie Béduer Source Type: research

Preliminary experience with volume assessment in breast asymmetries using external 3d printed sizers
Objective: Breast volume assessment is essential for surgical planning in patients with breast asymmetry. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: A Cavaliere, G Pezone, F D ’Andrea, F Schonauer Source Type: research

Migration modulation following soluble il-6 receptor treatment for normal human dermal fibroblasts and adipose- derived stem cells 2d cultures
Introduction: Interleukin-6 (Il-6) is a key player in wound healing, through its dual pro and anti-inflammatory role depending on the intracellular signaling pathway. In vivo setups, cells can express gp130 and IL-6 can act as a proinflammatory cytokine through soluble IL-6 receptor present within the microenvironment. The aim of this study was to evaluate phenotype modulation following soluble IL-6 receptor treatment on fibroblasts and adipose-derived stem cells. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: Alina Chelmu ș, Kirsten Riches-Suman, Ajay L. Mahajan, M. Julie Thornton Source Type: research

Nasal morphological changes due to maxillary advancement surgery: should we consider while doing rhinoplasty?
Objectives: Because of close relationship between the soft tissues in nasolabial region and maxilla, changing the maxilla position with orthognathic surgery leads to the changes in shape and functions of nose. The aim of this study is cephalometric evaluation of morphological changes in the 3-dimensional structure and the projection of nose after maxillary advancement surgery. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: Sare Demirta ş, Sergen Karataş, Ahmet Rıfat Doğramacı, Gökçe Yıldıran, Zekeriya Tosun Source Type: research

Evaluation of a guided nerve repair using multi-lumen aligned nanofibrilar collagen scaffold in a rabbit model
Objective: When coaptation in large peripheral nerve defects can be challenging, autologous nerve grafts or various biomaterials can be used with different advantages. The aim of our study is to examine different biomaterials based on multi-lumen aligned nanofibrillar collagen scaffolds (BB) in nerve regeneration. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: Dimitrios Dionyssiou, Georgios Farmakis, Athanasios Tychalas, Chryssa Bekiari, Angeliki Cheva, Efterpi Demiri Source Type: research

A prospecive dual-centre intra-individual controlled study for the treatment of burns comparing dermis graft with split- thickness skin auto-graft
Objective: To investigate if donor site morbidity (healing time and cosmesis) could be reduced by a novel, modified split thickness skin grafting (STSG) technique using a dermal component in the STSG procedure. The secondary objective was to examine the effects of this procedure on the recipient site of the (dermal) graft compared to STSG. The STSG technique has been used for 150 years in surgery with limited improvements. Its drawbacks are well known and relate to donor site morbidity and recipient site cosmetic shortcomings (mesh patterns, wound contracture, and scarring). (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: Sinan Dogan, Moustafa Elmasry, Ahmed T. El-Serafi, Folke Sj öberg, Jyrki Vuola, Esko Kankuri, Marina Perdiki Grigoriadi, Jussi Valtonen, Islam Abdelrahman, Ingrid Steinvall, Matilda Karlsson, Pia Olofsson, Andrew Lindford Source Type: research

Modified flexor digitorum superficialis slip flap techn İque as alternative to double-loop tendon graft in a4 pulley reconstruction
Introduction: In digital A4 pulley reconstruction, double loop repair around the middle phalanx with autologous tendon grafts is one of the most preferred methods. However, for this, an autologous tendon graft needs to be taken from a distant location. The aim of this study is to compare the pulley reconstruction performed with the 'Modified Flexor Digitorum Superficialis (FDS) slip flap method', which might be good alternative to classical techniques and eliminates the need for tendon grafts from distant regions, with the classical loop technique. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: O ğuz Eker, Gökçe Yıldıran, Zekeriya Tosun Source Type: research

Towards an advanced therapeutic medicinal product, autologous keratinocytes in solution for difficult-to-heal skin wounds
Objective: Keratinocytes-based therapy represents a potential solution for patients with difficult-to-heal skin wounds, which is considered as an advanced therapy medicinal product by the European Medicines Agency (EMA). We aimed at achieving a protocol for complete, EMA compliant, workflow. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: Ahmed Elserafi, Cathrine Lagerwall, Hady Shahin, Sallam Abdallah, Ingrid Steinvall, Folke Sj öberg, Moustafa Elmasry Source Type: research

Cell-based skin grafting
Objective: The cell-based skin grafting (CBSG) has been developed as a state-of-art approach for skin regeneration. The aim is to provide autologous cells, isolated from a skin biopsy, as a regenerative solution for patients suffering from severe skin loss or difficult-to-heal skin wounds. The technique involves the collaboration of the surgical team with cell biologists to conduct the isolation of the skin cells and the application of cell suspension to the wound inside the operation room, in a 3-hour procedure. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - December 1, 2023 Category: Cosmetic Surgery Authors: Ahmed Elserafi, Matilda Karlsson, Moustafa Elmasry Source Type: research