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A trimethoxy flavonoid isolated from stem extract of Tabebuia chrysantha suppresses angiogenesis in angiosarcoma
ConclusionThe isolated flavonoid named TMF fromT. chrysantha functions as specific regulators of target proteins of angiosarcoma. The STAT3 ‐MMP9 signalling may be used as an effective prognostic marker of angiosarcoma. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Authors: Siva Prasad Panda, Uttam Prasad Panigrahy, DSNBK Prasanth, Uma Sankar Gorla, Chakravarthi Guntupalli, Deba Prasad Panda, Bikash Ranjan Jena Tags: Research Paper Source Type: research

Tectorigenin inhibits inflammation and pulmonary fibrosis in allergic asthma model of ovalbumin ‐sensitized guinea pigs
ConclusionsTectorigenin could inhibit pulmonary fibrosis and airway inflammation through TGF ‐β1/Smad signalling pathway and TLR4/NF‐κB signalling pathway. Therefore, tectorigenin might be a promising medicine to treat allergic asthma. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Authors: Youpeng Wang, Weichao Jing, Wanying Qu, Zhiwei Liu, Di Zhang, Xiaoyu Qi, Lujia Liu Tags: Research Paper Source Type: research

Exploring the biotransformation of N ‐(2‐hydroxyphenyl)‐2‐propylpentanamide (an aryl valproic acid derivative) by CYP2C11, using in silico predictions and in vitro studies
ConclusionTherefore, rat liver CYP2C11 isoform is able to metabolize HO ‐AAVPA. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Authors: Jessica Elena Mendieta ‐Wejebe, Arianna Silva‐Trujillo, Martiniano Bello, Humberto L. Mendoza‐Figueroa, Norma Lizeth Galindo‐Alvarez, Arnulfo Albores, Feliciano Tamay‐Cach, Martha Cecilia Rosales‐Hernández, Aurelio Romero‐Castro, J Tags: Research Paper Source Type: research

Corrigendum
Journal of Pharmacy and Pharmacology, Volume 72, Issue 7, Page 1000-1000, July 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Tags: Corrigendum Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 7, Page i-iv, July 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 7, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Arginase inhibitory properties of flavonoid compounds from the leaves of Mulberry (Morus alba, Moraceae)
ConclusionsThese results demonstrated the attractive ability ofM. alba to be a potential source for the discovery of new active products on vascular system. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Kamel Arraki, Perle Totoson, Rym Attia, Andy Zedet, Marc Pudlo, Chokri Messaoud, C éline Demougeot, Corine Girard Tags: Research Paper Source Type: research

Metabolomics coupled with integrative pharmacology reveals the therapeutic effect of l ‐borneolum against cerebral ischaemia in rats
ConclusionsThe therapeutic effect ofl‐borneolum on cerebral ischaemia might be associated with the regulation of energy metabolism, thermogenesis and bile secretion. These metabolic changes and the core target changes, as well as the metabolic‐target pathway network, help to elucidate the mechanisms governing the effect ofl‐borneolum on cerebral ischaemia. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Yinxiao Jiang, Jianxia Wen, Wenwen Zhang, Zhijie Ma, Congen Zhang, Jian Wang, Yao Dai, Qichao Hu, Zhibei Li, Xiao Ma Tags: Research Paper Source Type: research

Pharmacological characterization of the cardiovascular effect of Nibethione: ex vivo, in vivo and in silico studies
ConclusionsNibethione showedin vivo antihypertensive andex vivo vasorelaxant effects with implication of voltage ‐dependent L‐type Ca2+ channel blocking, and this may contribute to the research of novel antihypertensive drugs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Amanda S ánchez‐Recillas, Gabriel Navarrete‐Vázquez, Sergio Hidalgo‐Figueroa, Marcos Bonilla‐Hernández, Rolffy Ortiz‐Andrade, Maximiliano Ibarra‐Barajas, Víctor Yáñez‐Pérez, Juan Carlos Sánchez‐Salgado Tags: Research Paper Source Type: research

Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism
ConclusionsTripterygium wilfordii chronotoxicity was associated with diurnal variations in triptolide pharmacokinetics and circadian expression of hepatic Cyp3a11 regulated by circadian clock. Our findings may have implications for improving TW treatment outcome with a chronotherapeutic approach. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 31, 2020 Category: Drugs & Pharmacology Authors: Huan Zhao, Yongbin Tong, Danyi Lu, Baojian Wu Tags: Research Paper Source Type: research

Brassinin, a brassica ‐derived phytochemical, regulates monocyte‐to‐macrophage differentiation and inflammatory responses in human monocytes and murine macrophages
ConclusionsBrassinin suppressed monocyte ‐to‐macrophage differentiation and inflammatory responses by differentially regulating Nrf2 and NF‐κB signallings. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 21, 2020 Category: Drugs & Pharmacology Authors: Bobin Kang, Jisu Hwang, Hyeon ‐Son Choi Tags: Research Paper Source Type: research