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Losartan and azelastine either alone or in combination as modulators for endothelial dysfunction and platelets activation in diabetic hyperlipidemic rats
ConclusionsBoth drug categories may be expressed as suitable therapeutic tools for atherosclerotic complications either alone or along with other hypolipidemic drugs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Mohamed M. Elseweidy, Gehad M. Elnagar, Marwa M.Elsawy, Abdelmoneim A. Ali, Nabila Zein Tags: Research Paper Source Type: research

Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors
ConclusionsCollectively, we would suggest that geniposide may potentially be utilized as an adjunct to existing thiazide and thiazide ‐like diuretics to control hypertension, mainly through inhibiting the activation of the WNK signalling pathway mediated by the estrogen receptor. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Yang Fu, Pei ‐pei Yuan, Yan‐gang Cao, Ying‐ying Ke, Qi Zhang, Ying Hou, Yan‐li Zhang, Wei‐sheng Feng, Xiao‐ke Zheng Tags: Research Paper Source Type: research

Recombinant ling zhi ‐8 enhances Tregs function to restore glycemic control in streptozocin‐induced diabetic rats
ConclusionsThese data suggest that rLZ ‐8 can antagonize STZ‐induced T1D, and its mechanism may be related to inhibit inflammation and enhance Tregs generation. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Authors: Hongyu Xiao, Zhi Fang, Xueling He, Ping Ding, Yongkai Cao, Shamyuen Chan, Shaozhen Hou, Jian Liang Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 12, Page i-iv, December 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - November 3, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 11, Page i-iv, November 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - October 5, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

The hepatoprotective effect and mechanism of lotus leaf on liver injury induced by Genkwa Flos
ConclusionsThis study could be a meaningful investigation to provide mechanistic insights into the hepatoprotective effect of lotus leaf and further lay a theoretical basis for the clinical application of lotus leaf. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 25, 2020 Category: Drugs & Pharmacology Authors: Zhipeng Wang, Panpan Zhao, Yuanyuan Zhang, Shan Shi, Xiaohui Chen Tags: Research Paper Source Type: research

Umbelliprenin relieves paclitaxel ‐induced neuropathy
ConclusionsUmbelliprenin alleviated neuropathic pain, and decreased serum IL ‐6 levels and oxidative stress. UMB deserves further investigations, especially in clinical settings. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 14, 2020 Category: Drugs & Pharmacology Authors: Jafar Shahraki, Ramin Rezaee, Sabereh Mohammadzehi Kenar, Samaneh Setoodeh Nezhad, Gholamreza Bagheri, Hosseinali Jahantigh, Konstantinos Tsarouhas, Mahmoud Hashemzaei Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 10, Page i-iv, October 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 9, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Catechol protects against iron ‐mediated oxidative brain injury by restoring antioxidative metabolic pathways; and modulation of purinergic and cholinergic enzymes activities
ConclusionThese results suggest the neuroprotective effects of catechol in iron ‐mediated oxidative brain injury. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 8, 2020 Category: Drugs & Pharmacology Authors: Veronica F. Salau, Ochuko L. Erukainure, Neil A. Koorbanally, Md. Shahidul Islam Tags: Research Paper Source Type: research

Shikonin ameliorates experimental autoimmune encephalomyelitis (EAE) via immunomodulatory, anti ‐apoptotic and antioxidative activity
ConclusionsThis study emphasized the immune ‐modulatory and antioxidative effects of shikonin, which may have an important healing effect on the severity of EAE. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 5, 2020 Category: Drugs & Pharmacology Authors: Mehrdad Nasrollahzadeh Sabet, Sajjad Biglari, Hamid Reza Khorram Khorshid, Emran Esmaeilzadeh Tags: Research Paper Source Type: research

Losartan and azelastine either alone or in combination as modulators for endothelial dysfunction and platelets activation in diabetic hyperlipidemic rats
ConclusionsBoth drug categories may be expressed as suitable therapeutic tools for atherosclerotic complications either alone or along with other hypolipidemic drugs. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 2, 2020 Category: Drugs & Pharmacology Authors: Mohamed M. Elseweidy, Gehad M. Elnagar, Marwa M.Elsawy, Abdelmoneim A. Ali, Nabila Zein Tags: Research Paper Source Type: research

Therapeutic effects of a çaí seed extract on hepatic steatosis in high‐fat diet‐induced obesity in male mice: a comparative effect with rosuvastatin
ConclusionsThe therapeutic effect of ASE was similar to that of rosuvastatin in reducing dyslipidemia and hepatic steatosis but was better in reducing oxidative damage and hyperglycaemia. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 26, 2020 Category: Drugs & Pharmacology Authors: Thamires Barros Tavares, Izabelle Barcellos Santos, Graziele Freitas Bem, Dayane Teixeira Ognibene, Ana Paula Machado Rocha, Roberto Soares Moura, Angela de Castro Resende, Julio Beltrame Daleprane, Cristiane Aguiar Costa Tags: Research Paper Source Type: research

Pinoresinol ‐4‐O‐β‐D‐glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo
ConclusionsPinoresinol ‐4‐O‐β‐D‐glucopyranoside is a natural entity combating oxidative stress, hepatic damage and diabetes. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 26, 2020 Category: Drugs & Pharmacology Authors: Fadia S. Youssef, Mohamed L. Ashour, Hesham A. El ‐Beshbishy, Alaaeldin Ahmed Hamza, Abdel Nasser B. Singab, Michael Wink Tags: Research Paper Source Type: research

Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti ‐inflammatory agent and as adjuvant in psoriasis therapy
ConclusionsThe results demonstrated the relevant therapeutic and marketing potentials of INFLATIV, which is likely to be further evaluated in clinical trials for drug registration process with regulatory agencies. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 25, 2020 Category: Drugs & Pharmacology Authors: N ícolas de Castro Campos Pinto, Mariana de Souza Ferreira Maciel, Nathalia dos Santos Rezende, Ana Paula do Nascimento Duque, Renata de Freitas Mendes, Jucélia Barbosa Silva, Monique de Rezende Evangelista, Luana Cahon Monteiro, Josiane Mello S Tags: Research Paper Source Type: research

Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors
ConclusionsCollectively, we would suggest that geniposide may potentially be utilized as an adjunct to existing thiazide and thiazide ‐like diuretics to control hypertension, mainly through inhibiting the activation of the WNK signalling pathway mediated by the estrogen receptor. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 23, 2020 Category: Drugs & Pharmacology Authors: Yang Fu, Pei ‐pei Yuan, Yan‐gang Cao, Ying‐ying Ke, Qi Zhang, Ying Hou, Yan‐li Zhang, Wei‐sheng Feng, Xiao‐ke Zheng Tags: Research Paper Source Type: research