Journal of Pharmacy and Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Natural polyphenols prevent indomethacin ‐induced and diclofenac‐induced Caco‐2 cell death by reducing endoplasmic reticulum stress regardless of their direct reactive oxygen species scavenging capacity
ConclusionThe cytoprotective activity of polyphenols against NSAIDs ‐induced toxicity stemmed from either suppression of CHOP‐related ER and mitochondria stresses or other CHOP‐independent pathways, but not from the intrinsic ROS scavenging capacity. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - January 9, 2020 Category: Drugs & Pharmacology Authors: Cherdsak Boonyong, Nontima Vardhanabhuti, Suree Jianmongkol Tags: Research Paper Source Type: research

Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice
ConclusionsThese findings demonstrate that OSE has antihyperuricemic and nephroprotective effects on PO ‐induced HUA mice and those results indicate that OSE could be a safe and effective agent or functional ingredient for treating HUA. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - January 6, 2020 Category: Drugs & Pharmacology Authors: Wen ‐hao Xu, Han‐tao Wang, Ying Sun, Zhen‐cheng Xue, Ming‐li Liang, Wei‐ke Su Tags: Research Paper Source Type: research

Evaluating side ‐by‐side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine
ConclusionThe tested models were comparable; however, Caco ‐2 cell monolayers were considered too sensitive to be used to study drug supersaturation. Further studies are needed to evaluate the observed drug‐dependent effects of absorption on drug supersaturation. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 25, 2019 Category: Drugs & Pharmacology Authors: Jannik Nicklas Eliasen, Ragna Berthelsen, Anne Louise Slot, Anette M üllertz Tags: Research Paper Source Type: research

Beneficial effects of fish oil enriched in omega ‐3 fatty acids on the development and maintenance of neuropathic pain
ConclusionWe conclude that the fish oil enriched in omega ‐3 fatty acids administration relieves thermal hyperalgesia and mechanical allodynia effectively and also enhances the recovery process in rats with CCI of the sciatic nerve. These findings might contribute to new therapeutic approaches including omega‐3 fatty acids in neuropathic pain treatment . (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 25, 2019 Category: Drugs & Pharmacology Authors: Santiago R. Unda, Emilce A. Villegas, Mar ía Eugenia Toledo, Gabriela Asis Onell, Carlos H. Laino Tags: Research Paper Source Type: research

Chamuangone from Garcinia cowa leaves inhibits cell proliferation and migration and induces cell apoptosis in human cervical cancer in vitro
ConclusionsThe above results confirm the inhibitory effects of chamuangone on HeLa cell proliferation and cell migration. In addition, chamuangone also induces cell apoptosis in HeLa cells. These findings indicate that chamuangone is a compound that is a potential chemotherapeutic agent. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 24, 2019 Category: Drugs & Pharmacology Authors: Pirunrat Sae ‐Lim, Supaphorn Seetaha, Lueacha Tabtimmai, Prapasiri Suphakun, Duangnapa Kiriwan, Pharkphoom Panichayupakaranant, Kiattawee Choowongkomon Tags: Research Paper Source Type: research

Transport of trans ‐activator of transcription (TAT) peptide in tumour tissue model: evaluation of factors affecting the transport of TAT evidenced by flow cytometry
ConclusionWhile exploiting MCTS as tumour tissue model, older spheroids could be preferred to target penetration ‐resistant cells and mimic thein ‐vivo microenvironment. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 22, 2019 Category: Drugs & Pharmacology Authors: Aziz Ur Rahman, Shahzeb Khan, Munasib Khan Tags: Research Paper Source Type: research

7 ‐methoxyflavanone alleviates neuroinflammation in lipopolysaccharide‐stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO‐1 pathway
Conclusions7 ‐methoxyflavanone inhibited LPS‐stimulated TLR4/MyD88/MAPK signalling and activated Nrf2‐mediated transcription of antioxidant protein NQO‐1, showing antineuroinflammatory effect, so it is a potential neuroprotective agent. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 21, 2019 Category: Drugs & Pharmacology Authors: Zhao Qu, Yan Chen, Zhuo ‐Hui Luo, Xiao‐Ling Shen, Ying‐Jie Hu Tags: Research Paper Source Type: research

Population pharmacokinetics of cefuroxime and uptake into hip and spine bone of patients undergoing orthopaedic surgery
ConclusionEven if a majority of patients undergoing hip or spine surgery probably achieved adequate concentrations of cefuroxime, not all patients reached bone concentrations of cefuroxime above a recommended breakpoint for susceptible germs at the time of surgery. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 19, 2019 Category: Drugs & Pharmacology Authors: Ulrich Gergs, Lina Becker, Richard Okoniewski, Michael Weiss, Karl ‐Stefan Delank, Joachim Neumann Tags: Research Paper Source Type: research

Anaesthetic benefits of a ternary drug delivery system (Ropivacaine ‐in‐Cyclodextrin‐in‐Liposomes): in‐vitro and in‐vivo evaluation
ConclusionsThese results confirm the suitability of this double ‐carrier system in clinical practice, to decrease the toxicity and prolong the anaesthesia time evoked by RVC. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 19, 2019 Category: Drugs & Pharmacology Authors: Ana La ís Nascimento Vieira, Michelle Franz‐Montan, Luís Fernando Cabeça, Eneida de Paula Tags: Research Paper Source Type: research

Total triterpenes from the fruits of Chaenomeles speciosa (Sweet) Nakai protects against indomethacin ‐induced gastric mucosal injury: involvement of TFF1‐mediated EGF/EGFR and apoptotic pathways
ConclusionsOur present study demonstrated that TCS ’s gastroprotective effect was closely connected with boosting TFF1 expression, activating TFF1‐mediated EGF/EGFR pathway, thus restraining mitochondrial‐dependent apoptosis, which provided new insights into interpreting its underlying mechanism and promised to act as a candidate drug to treat gastric mucosal injury. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 19, 2019 Category: Drugs & Pharmacology Authors: Yuanyuan Zhang, Haiyan Xu, Haibo He, Xiaomei Li, Minlu Feng, Yumin He, Weijie Jiang, Junzhi Wang, Daoxiang Xu, Kun Zou Tags: Research Paper Source Type: research