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Regulation of breast cancer resistance protein and P ‐glycoprotein by ezrin, radixin and moesin in lung, intestinal and renal cancer cell lines
ConclusionsOur findings indicate that regulation of BCRP and P ‐gp functions by ERM proteins is organ‐specific. Thus, if the appropriate ERM protein(s) are functionally suppressed, accumulation of BCRP or P‐gp substrates in lung, intestine or kidney cancer tissue might be specifically increased. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Kentaro Yano, Chiaki Okabe, Kenta Fujii, Yuko Kato, Takuo Ogihara Tags: Research Paper Source Type: research

Preparation, characterization and preliminary pharmacokinetic study of pH ‐sensitive Hydroxyapatite/Zein nano‐drug delivery system for doxorubicin hydrochloride
ConclusionIn this study, HA/Zein ‐DOX NPs represented an antitumour drug delivery system for DOX in clinical tumour therapy with improved bioavailability and decreased cardiotoxicity. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Liqiong Zha, Beilei Wang, Jiajia Qian, Brock Fletcher, Caiyun Zhang, Qiannian Dong, Weidong Chen, Lufeng Hong Tags: Research Paper Source Type: research

Investigation of cell death mechanism and activity of esculetin ‐loaded PLGA nanoparticles on insulinoma cells in vitro
ConclusionsThe results revealed that esculetin is able to show its anti ‐tumor afficacy after loading to PLGA nano‐micelles and nano‐encapsulation intensifies its cytotoxic activityin vitro. Current study shows that esculetin and its nano formulations are promising agents in treatment of insulinoma. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Ayse Karatug Kacar, Fatemeh Bahadori, Serife Evrim Kepekci Tekkeli, Gulacti Topcu, Sehnaz Bolkent Tags: Research Paper Source Type: research

Anti ‐inflammatory potential of invasive sun corals (Scleractinia: Tubastraea spp.) from Brazil: alternative use for management?
ConclusionsThese species have potential pharmacological use, and considering their invasive nature, this study presents a potential alternative use, which may enhance the management of this biological invasion. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Raphael de Mello Carpes, Daniele Corr êa Fernandes, Marsen Garcia Pinto Coelho, Joel Christopher Creed, Beatriz Grosso Fleury, Simon John Garden, Israel Felzenszwalb Tags: Research Paper Source Type: research

Current trends in pharmacological approaches for treatment and management of acute pancreatitis – a review
AbstractObjectivesAcute pancreatitis (AP) is an inimical disorder associated with overall mortality rates between 10 ‐15%. It is a disorder of the exocrine pancreas which is characterized by local and systemic inflammatory responses primarily driven by oxidative stress and death of pancreatic acinar cells. The severity of AP ranges from mild pancreatic edema with complete recuperative possibilities to serious sy stemic inflammatory response resulting in peripancreatic/pancreatic necrosis, multiple organ failure, and death.Key findingsWe have retrieved the potential alternative approaches that are developed lately for eff...
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Vaishnavi Sundar, Keerthic Aswin Senthil Kumar, Venkatraman Manickam, Tamizhselvi Ramasamy Tags: Review Source Type: research

Quetiapine dose optimisation during gestation: a pharmacokinetic modelling study
ConclusionsQuetiapine doses in pregnancy should be increased to 500 –700 mg twice daily to counteract a concomitant increase in metabolic clearance, increase in volume of distribution and decrease in plasma protein binding. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Raj K. S. Badhan, Hannah Macfarlane Tags: Research Paper Source Type: research

MiRNA ‐7 enhances erlotinib sensitivity of glioblastoma cells by blocking the IRS‐1 and IRS‐2 expression
ConclusionsOur data propose that inhibition of IRS ‐1 and IRS‐2 by miRNA‐7 can effectively induce apoptosis and sensitize glioblastoma cell to EGFR‐TKIs. Therefore, miRNA‐7 may be a potential therapeutic target in patients with glioblastoma. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Vahab Alamdari ‐Palangi, Razieh Amini, Hadi Karami Tags: Research Paper Source Type: research

Cell ‐based, animal and H1 receptor binding studies relative to the sedative effects of ketotifen and norketotifen atropisomers
ConclusionThe lower sedative effect of SN in rodents is probably due to a combination of a lower uptake of N than K into the brain and less affinity of SN for CNS H1 receptors. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Feifei Feng, J. Paul Fawcett, Hu Zhang, Ian G. Tucker Tags: Research Paper Source Type: research

Brain ‐derived neurotrophic factor fused with a collagen‐binding domain inhibits neuroinflammation and promotes neurological recovery of traumatic brain injury mice via TrkB signalling
ConclusionsIn conclusion, CBD ‐BDNF can promote the anti‐inflammatory function of microglia and neurological recovery of TBI mice through TrkB signalling. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Rui Yin, Shufa Zhao, Caixia Qiu Tags: Research Paper Source Type: research

Meriolin1 induces cell cycle arrest, apoptosis, autophagy and targeting the Akt/MAPKs pathways in human neuroblastoma SH ‐SY5Y cells
ConclusionsMeriolin1 might be a promising therapeutic candidate for neuroblastoma. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Dan Su, Wenbin Wang, Xinyue Wu, Minyue Li, Xuelong Yan, Zhonghong Hua, Jiahui Liu, Zhiyu Zhu, Kun Hu, Jie Ren Tags: Research Paper Source Type: research

Gadolinium causes M1 and M2 microglial apoptosis after intracerebral haemorrhage and exerts acute neuroprotective effects
ConclusionsGadolinium induced M1 and M2 microglial apoptosis and exerted acute neuroprotective effects after ICH. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Masatoshi Ohnishi, Takao Kai, Yuki Shimizu, Yukino Yano, Yuui Urabe, Shunpei Tasaka, Marina Akagi, Yasunori Yamaguchi, Atsuko Inoue Tags: Research Paper Source Type: research

Standardized Xylocarpus moluccensis fruit fraction mitigates collagen ‐induced arthritis in mice by regulating immune response
ConclusionF018 may serve as a potential curative agent for arthritis. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Priya Gupta, Amit Kumar, Subhashis Pal, Sachin Kumar, Amit Lahiri, Jagavelu Kumaravelu, Naibedya Chattopadhyay, Madhu Dikshit, Manoj Kumar Barthwal Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 3, Page i-iv, March 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Increased risk of dizziness in human immunodeficiency virus ‐infected patients taking zidovudine and efavirenz combination: a Brazilian cohort study
ConclusionsThe results may contribute to clarify the dizziness occurrence dynamics in therapy with efavirenz and zidovudine by identifying susceptibilities and assisting in the choice of combined antiretroviral therapy. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 13, 2020 Category: Drugs & Pharmacology Authors: Josu é Jeyzon de Lima Soares Valeriano, Wlisses Henrique Veloso Carvalho‐Silva, Antônio Victor Campos Coelho, Ronald Rodrigues Moura, Luiz Cláudio Arraes, Lucas André Cavalcanti Brandão, Sergio Crovella, Rafael Lima Guimarães Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 3, Page i-iv, March 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - February 11, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research