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Gut microbiome ‐mediated modulation of hepatic cytochrome P450 and P‐glycoprotein: impact of butyrate and fructo‐oligosaccharide‐inulin
ConclusionThe expression of hepatic genes implicated in drug metabolism and transport displays sensitivity to the microbiome, microbiome ‐derived metabolites and a microbial‐targeted intervention. Our study may provide the impetus to explore microbiota‐targeted interventions in normalising host metabolic activity and reducing inter‐individual variability in drug pharmacokinetics. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 25, 2020 Category: Drugs & Pharmacology Authors: Jacinta Walsh, Cassandra E. Gheorghe, Joshua M. Lyte, Marcel Wouw, Marcus Boehme, Timothy G. Dinan, John F. Cryan, Brendan T. Griffin, Gerard Clarke, Niall P. Hyland Tags: Research Paper Source Type: research

Pharmacokinetics and in vivo distribution of optimized PLGA nanoparticles for pulmonary delivery of levofloxacin
ConclusionThe optimized formulation with desirability value 0.9612 showed mean particle size of 146 nm, MMAD of 4.40 μm and sustained the drug release up to 120 h in simulated lung fluid. Augmentation inCmax (1.71 ‐fold), AUC 0‐∞ (5.46‐fold), Mean Residence Time (6.64‐fold) and AUC/MIC (6.21‐fold) of LN through pulmonary route was found to significantly higher (P< 0.05) than levofloxacin (p. o.). (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 25, 2020 Category: Drugs & Pharmacology Authors: Sunny R. Shah, Hani R. Prajapati, Devang B. Sheth, Ekta M. Gondaliya, Amit J. Vyas, Moinuddin M. Soniwala, Jayant R. Chavda Tags: Research Paper Source Type: research

Green synthesis of gold nanoparticles by using Ferula persica Willd. gum essential oil: production, characterization and in vitro anti ‐cancer effects
ConclusionsFerula persica gum can be successfully used for green production of Au NPs. Au NPs showin vitro anti ‐cancer activity including cytotoxic, apoptotic and antiproliferative effects. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 20, 2020 Category: Drugs & Pharmacology Authors: Neda Hosseinzadeh, Tahoora Shomali, Saeid Hosseinzadeh, Fatemeh Raouf Fard, Maryam Pourmontaseri, Mehdi Fazeli Tags: Research Paper Source Type: research

A trimethoxy flavonoid isolated from stem extract of Tabebuia chrysantha suppresses angiogenesis in angiosarcoma
ConclusionThe isolated flavonoid named TMF fromT. chrysantha functions as specific regulators of target proteins of angiosarcoma. The STAT3 ‐MMP9 signalling may be used as an effective prognostic marker of angiosarcoma. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 19, 2020 Category: Drugs & Pharmacology Authors: Siva Prasad Panda, Uttam Prasad Panigrahy, DSNBK Prasanth, Uma Sankar Gorla, Chakravarthi Guntupalli, Deba Prasad Panda, Bikash Ranjan Jena Tags: Research Paper Source Type: research

Tectorigenin inhibits inflammation and pulmonary fibrosis in allergic asthma model of ovalbumin ‐sensitized guinea pigs
ConclusionsTectorigenin could inhibit pulmonary fibrosis and airway inflammation through TGF ‐β1/Smad signalling pathway and TLR4/NF‐κB signalling pathway. Therefore, tectorigenin might be a promising medicine to treat allergic asthma. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 19, 2020 Category: Drugs & Pharmacology Authors: Youpeng Wang, Weichao Jing, Wanying Qu, Zhiwei Liu, Di Zhang, Xiaoyu Qi, Lujia Liu Tags: Research Paper Source Type: research

Pharmacological screening of fenofibrate ‐loaded solid dispersion in fructose‐induced diabetic rat
ConclusionsThis newly formulated SDF would be a promising alternative for conventional fenofibrate in treating hyperlipidaemia. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 18, 2020 Category: Drugs & Pharmacology Authors: Milon Kumar Ghosh, Mir Imam Ibne Wahed, Rafiqul Islam Khan, Anwar Habib, Ranjan Kumar Barman Tags: Research Paper Source Type: research

Exploring the biotransformation of N ‐(2‐hydroxyphenyl)‐2‐propylpentanamide (an aryl valproic acid derivative) by CYP2C11, using in silico predictions and in vitro studies
ConclusionTherefore, rat liver CYP2C11 isoform is able to metabolize HO ‐AAVPA. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 18, 2020 Category: Drugs & Pharmacology Authors: Jessica Elena Mendieta ‐Wejebe, Arianna Silva‐Trujillo, Martiniano Bello, Humberto L. Mendoza‐Figueroa, Norma Lizeth Galindo‐Alvarez, Arnulfo Albores, Feliciano Tamay‐Cach, Martha Cecilia Rosales‐Hernández, Aurelio Romero‐Castro, J Tags: Research Paper Source Type: research

Drug repositioning: a brief overview
ConclusionThe history of great ‐repositioned drugs has given some solutions to various pathologies. Serendipity is not yet useful to find repositioning drugs. Drug repositioning is of growing interest. Nowadays, a more rational approach to the identification of drug candidates for repositioning is possible, especially using dat a mining. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 16, 2020 Category: Drugs & Pharmacology Authors: Jean ‐Pierre Jourdan, Ronan Bureau, Christophe Rochais, Patrick Dallemagne Tags: Review Source Type: research

Bioactive indanes: insight into the bioactivity of indane dimers related to the lead anti ‐inflammatory molecule PH46A
ConclusionsThe observed profile of cytokine modulation (IL ‐6/ TNF‐α, IL‐8) and inhibition of release of NO and 5‐LOX may contribute to thein vivo effects demonstrated by indane dimers and PH46A (1) in murine models of colitis. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 15, 2020 Category: Drugs & Pharmacology Authors: Kit Chan, Neil Frankish, Tao Zhang, Abdulilah Ece, Aoife Cannon, Jacintha O'Sullivan, Helen Sheridan Tags: Research Paper Source Type: research

Self ‐nanoemulsifying drug delivery system to improve transcorneal permeability of voriconazole: in‐vivo studies
ConclusionOur results suggest that SNEDDS is a promising carrier for voriconazole ocular delivery and this encourages further clinical studies. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 14, 2020 Category: Drugs & Pharmacology Authors: Bakoliarisoa Nivomalala Voahangy Rasoanirina, Mohamed Ali Lassoued, Karim Miladi, Zoarilala Razafindrakoto, Raja Cha âbane‐Banaoues, David Ramanitrahasimbola, Muriel Cornet, Souad Sfar Tags: Research Paper Source Type: research