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Acacetin inhibits Streptococcus pneumoniae virulence by targeting pneumolysin
ConclusionsTaken together, the results presented in this study indicated that acacetin inhibited the pore ‐forming activity of PLY and reduced the virulence ofS. pneumoniae in vivo andin vitro, which may provide a leading compound for the treatment ofS. pneumoniae infection. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 9, 2020 Category: Drugs & Pharmacology Authors: Shufang Li, Qianghua Lv, Xiaodi Sun, Tianzhong Tang, Xuming Deng, Yunhou Yin, Li Li Tags: Research Paper Source Type: research

Issue Information
Journal of Pharmacy and Pharmacology, Volume 72, Issue 6, Page i-iv, June 2020. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 4, 2020 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

A comparative study on pharmacokinetics and tissue distribution of 5 ‐hydroxy‐4‐methoxycanthin‐6‐one and its metabolite in normal and dextran sodium sulfate‐induced colitis rats by HPLC‐MS/MS
ConclusionsThese results contributed to further illuminate the ADME process of PQ ‐A in different status and were prospected to be the reference to the clinical application of similar medicines in pathological states. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 2, 2020 Category: Drugs & Pharmacology Authors: Fangle Liu, Qiuyu Zhang, Chaozhan Lin, Yufeng Yao, Meiqi Wang, Changhui Liu, Chenchen Zhu Tags: Research Paper Source Type: research

Cassia tora extract alleviates A β1–42 aggregation processes in vitro and protects against aluminium‐induced neurodegeneration in rats
ConclusionsAltogether, our results reveal that methanol extract ofC. tora is able to prevent typical AD ‐related events and therefore stands as a promising mild and natural anti‐AD multitarget compound. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - May 2, 2020 Category: Drugs & Pharmacology Authors: Sunil K. Ravi, Ramesh B. Narasingappa, Ravi Mundagaru, Talakatta K. Girish, Bruno Vincent Tags: Research Paper Source Type: research

Tropisetron improves pancreas function and increases insulin synthesis and secretion in the STZ ‐induced diabetic rats: involvement of UCP2/ZnT8 pathway
ConclusionsThis effect might be partly related to the modulated UCP2/ZnT8 signal pathway and improved oxidative stress ‐induced damage. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 28, 2020 Category: Drugs & Pharmacology Authors: Roya Naderi, Alireza Shirpoor, Mahrokh Samadi, Bagher Pourheydar, Azam Moslehi Tags: Research Paper Source Type: research

Pharmacokinetic, bioavailability and tissue distribution study of astilbin in rats
ConclusionsThe oral absolute bioavailability of astilbin is poor because of the low permeability and solubility. Both oral absorption and clearance of astilbin in rats are rapid after oral administration. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 27, 2020 Category: Drugs & Pharmacology Authors: Meiyun Shi, Mengyao Xu, Lei Yin Tags: Research Paper Source Type: research

Precision dosing ‐based optimisation of paroxetine during pregnancy for poor and ultrarapid CYP2D6 metabolisers: a virtual clinical trial pharmacokinetics study
ConclusionsFor all phenotypes studied, there was a requirement for daily doses in excess of the standard 20 mg dose throughout gestation. For EM, a dose of 30 mg daily in trimester 1 followed by 40 mg daily in trimesters 2 and 3 is suggested to be optimal. For poor metabolisers (PM), a 20 mg daily dose in trimester 1 followed by 30 mg daily in trimesters 2 and 3 is suggested to be optimal. For UM, a 40 mg daily dose throughout gestation is suggested to be optimal. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 27, 2020 Category: Drugs & Pharmacology Authors: Aminah Almurjan, Hannah Macfarlane, Raj K. S. Badhan Tags: Research Paper Source Type: research

Release rate determination from in situ gel forming PLGA implant: a novel ‘shape‐controlled basket in tube’ method
ConclusionsThe developed ‘shape‐controlled basket in tube’ method can provide the most reproducible release profiles by minimizing implant adhesion to the release vessels or movement without sacrificing full contact between the release medium and the implant surface. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 26, 2020 Category: Drugs & Pharmacology Authors: Qiangnan Zhang, Reza Fassihi Tags: Research Paper Source Type: research