Journal of Pharmacological Sciences 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Retrograde signaling via axonal transport through signaling endosomes
Publication date: Available online 17 October 2019Source: Journal of Pharmacological SciencesAuthor(s): Naoya YamashitaAbstractNeurons extend axons far from cell bodies, and retrograde communications from distal axons to cell bodies and/or dendrites play critical roles in the development and maintenance of neuronal circuits. In neurotrophin signaling, the retrograde axonal transport of endosomes containing active ligand-receptor complexes from distal axons to somatodendrite compartments mediates retrograde signaling. However, the generality and specificity of these endosome-based transportations called “signaling endosom...
Source: Journal of Pharmacological Sciences - October 17, 2019 Category: Drugs & Pharmacology Source Type: research
A novel free radical scavenger, NSP-116, ameliorated the brain injury in both ischemic and hemorrhagic stroke models
Publication date: Available online 15 October 2019Source: Journal of Pharmacological SciencesAuthor(s): Takahiko Imai, Sena Iwata, Daisuke Miyo, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki HaraAbstractReperfusion injury is a serious problem in ischemic stroke therapy, which leads to neuronal damage and intracranial hemorrhage (ICH). A novel free radical scavenger, NSP-116, has anti-oxidative effect and may ameliorate reperfusion injury. The purpose of this study was to investigate the effects of NSP-116 on both ischemic and hemorrhagic stroke models.First, we assessed whether NSP-116 has protective effects in vitro. Pr...
Source: Journal of Pharmacological Sciences - October 16, 2019 Category: Drugs & Pharmacology Source Type: research
Role of Rac1 in augmented endothelin-1-induced bronchial contraction in airway hyperresponsive mice
Publication date: Available online 10 October 2019Source: Journal of Pharmacological SciencesAuthor(s): Yuki Kai, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Junzo Kamei, Hiroyasu SakaiAbstractIt has recently been exhibited that Rac1 expression is increased in the bronchial tissue of a murine model with repeated antigen-challenged airway hyperresponsiveness (AHR). In the present study, the role of Rac1 in endothelin-1 (ET-1)-induced bronchial contraction and myosin light chain (MLC) phosphorylation was examined in AHR mice. Enhanced reactions in AHR mice were prevented by the Rac1 inhibitor NSC23766. These findings sug...
Source: Journal of Pharmacological Sciences - October 11, 2019 Category: Drugs & Pharmacology Source Type: research
A novel rat model of contrast-induced nephropathy based on dehydration
ConclusionsA novel CIN rat model based on dehydration and iohexol exposure was established and validated to assist in understanding and preventing CIN. (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - September 29, 2019 Category: Drugs & Pharmacology Source Type: research
Puerarin prevents progression of experimental hypoxia-induced pulmonary hypertension via inhibition of autophagy
In this study, we explored the effects of puerarin in a hypoxic pulmonary hypertension (PH) rat model using immunohistochemistry, and morphometric analyses of right ventricle. In addition, cell counting kit 8 assay, western blotting and flow cytometry were employed to test cell proliferation in PASMCs, and then autophagy was tested with mRFP-GFP-LC3 fluorescence microscopy and western blot. We found that puerarin could alleviate hypoxia-induced PH in rats and improved pulmonary histopathology, and also reduced the expression of autophagy markers in vivo and in vitro. Moreover, puerarin also ameliorated hypoxia-induced PASM...
Source: Journal of Pharmacological Sciences - September 29, 2019 Category: Drugs & Pharmacology Source Type: research
Therapeutic targeting of mitochondrial ROS ameliorates murine model of volume overload cardiomyopathy
Publication date: Available online 28 September 2019Source: Journal of Pharmacological SciencesAuthor(s): Kenichi Okamura, Yu Nakagama, Norihiko Takeda, Katsura Soma, Tatsuyuki Sato, Takayuki Isagawa, Yasutoshi Kido, Masaya Sakamoto, Ichiro Manabe, Yasutaka Hirata, Issei Komuro, Minoru OnoAbstractConcomitant heart failure is associated with poor clinical outcome in dialysis patients. The arteriovenous shunt, created as vascular access for hemodialysis, increases ventricular volume-overload, predisposing patients to developing cardiac dysfunction. The integral function of mitochondrial respiration is critically important fo...
Source: Journal of Pharmacological Sciences - September 29, 2019 Category: Drugs & Pharmacology Source Type: research
P53-Induced Reduction of Lipid Peroxidation Supports Brain Microvascular Endothelium Integrity
In conclusion, P53 supports BBB integrity, at least in part, by reducing lipid peroxidation. (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - September 29, 2019 Category: Drugs & Pharmacology Source Type: research
Activation of adenosine A2A but not A2B receptors is involved in uridine adenosine tetraphosphate-induced porcine coronary smooth muscle relaxation
Publication date: Available online 27 September 2019Source: Journal of Pharmacological SciencesAuthor(s): Changyan Sun, Tong Jiao, Daphne Merkus, Dirk J. Duncker, S. Jamal Mustafa, Zhichao ZhouAbstractActivation of both adenosine A2A and A2B receptors (A2BR) contributes to coronary vasodilation. We previously demonstrated that uridine adenosine tetraphosphate (Up4A) is a novel vasodilator in the porcine coronary microcirculation, acting mainly on A2AR in smooth muscle cells (SMC). We further investigated whether activation of A2BR is involved in Up4A-mediated coronary SMC relaxation. Both A2AR and A2BR may stimulate H2O2 p...
Source: Journal of Pharmacological Sciences - September 28, 2019 Category: Drugs & Pharmacology Source Type: research
Editorial Board
Publication date: July 2019Source: Journal of Pharmacological Sciences, Volume 140, Issue 3Author(s): (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - September 25, 2019 Category: Drugs & Pharmacology Source Type: research
Pharmacological β-adrenoceptor blockade can augment torsadogenic action of IKr inhibitor: Comparison of proarrhythmic effects of d-sotalol and dl-sotalol in the chronic atrioventricular block dogs
Publication date: Available online 24 September 2019Source: Journal of Pharmacological SciencesAuthor(s): Ai Goto, Mihoko Hagiwara-Nagasawa, Koki Chiba, Ryuichi Kambayashi, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Akio Matsumoto, Yasunari Kanda, Atsushi SugiyamaAbstractInformation is still limited whether β-blockade may augment or attenuate the onset of torsade de pointes in patients with IKr inhibitor-induced labile repolarization process. We compared the proarrhythmic effects of d-sotalol with those of dl-sotalol using the chronic atrioventricular block dogs, since d- and l-isomers share a similar blocking action on IKr but...
Source: Journal of Pharmacological Sciences - September 25, 2019 Category: Drugs & Pharmacology Source Type: research
Overexpression of microRNA-21 mediates Ang II-induced renal fibrosis by activating the TGF-β1/Smad3 pathway via suppressing PPARα
Publication date: Available online 23 September 2019Source: Journal of Pharmacological SciencesAuthor(s): Huiyan Lv, Xin Li, Qi Wu, Lirong HaoAbstractAngiotensin II (Ang II) is an important profibrotic factor, and the tumor-promoting microRNA miR-21 was recently linked to fibrotic disorders. We aimed to investigate whether and how miR-21 mediates Ang II-induced renal fibrosis. In renal tubular epithelial cells, Ang II upregulated miR-21 and fibrosis-related indicators but decreased PPARα expression. miR-21 overexpression promoted PPARα downregulation, activated the TGF-β1/Smad3 pathway and induced fibrogenesis, while mi...
Source: Journal of Pharmacological Sciences - September 25, 2019 Category: Drugs & Pharmacology Source Type: research
Involvement of l-Lactate in Hippocampal Dysfunction of Type I Diabetes
Publication date: Available online 13 September 2019Source: Journal of Pharmacological SciencesAuthor(s): Riho Kobayashi, Junya Maruoka, Hiroaki Norimoto, Yuji Ikegaya, Kazuhiko Kume, Masahiro OhsawaAbstractHippocampal neurons play a crucial role in memory formation. Accumulating evidence raises the possibility that hippocampal sharp-wave ripples (SW-Rs) are involved in memory consolidation. Here, we examined in an animal model of diabetes and found the amplitude of SW-Rs in diabetic mice were smaller than control group and were rescued by acute application of L-lactate, a major neural energy source. The cognitive impairme...
Source: Journal of Pharmacological Sciences - September 13, 2019 Category: Drugs & Pharmacology Source Type: research
Overexpression of the gene product of ocular albinism 1 (GPR143/OA1) but not its mutant forms inhibit neurite outgrowth in PC12 cells
Publication date: Available online 11 September 2019Source: Journal of Pharmacological SciencesAuthor(s): Daiki Masukawa, Kaisei Yamada, Yoshio GoshimaAbstractNeurite outgrowth is a complex differentiation process regulated by external and/or internal mechanisms. Among external mechanisms, G-protein coupled receptors (GPCRs) have been implicated in this process, but the pathways involved are not fully understood. L-3,4-dihydroxyphenylalanine (L-DOPA) is considered to be inert by itself, and to relieve Parkinson’s disease through its conversion to dopamine. We have proposed that L-DOPA acts as a neurotransmitter. GPR143, ...
Source: Journal of Pharmacological Sciences - September 11, 2019 Category: Drugs & Pharmacology Source Type: research
Nitric oxide plays a critical role in methotrexate-induced hyperplasia of enterochromaffin cells containing 5-hydroxytryptamine in rat small intestine
Publication date: Available online 10 September 2019Source: Journal of Pharmacological SciencesAuthor(s): Yuho Takano, Megumi Hirano, Takuji Machida, Yusuke Obara, Naoya Hamaue, Kana Fujita, Masafumi Taniguchi, Tomoko Endo, Saki Shiga, Maiko Machida, Kenji Iizuka, Masahiko HirafujiAbstractThe role of nitric oxide (NO) in the changes in enterochromaffin cells and ileal 5-hydroxytryptamine (5-HT) content induced by a single i.p. administration of methotrexate was investigated in rats. Methotrexate significantly increased inducible NO synthase (iNOS) mRNA and protein expressions in the intestinal tissue at 96 h. Methotrexate ...
Source: Journal of Pharmacological Sciences - September 11, 2019 Category: Drugs & Pharmacology Source Type: research
Effects of 2′-3′-dihydroxy-4′,6′-dimethoxychalcone derived from green perilla on auricle thickness in chronic contact dermatitis model mice
Publication date: Available online 28 August 2019Source: Journal of Pharmacological SciencesAuthor(s): Yuki Takada-Takatori, Yuka Takeda, Risa Imai, Yasuhiko Izumi, Akinori Akaike, Katsuharu Tsuchida, Toshiaki KumeAbstractOxidative stress has been implicated in the pathogenesis of allergic contact dermatitis. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway, an in vivo antioxidant system, induces antioxidant enzymes. In our previous studies, we isolated 2ʹ,3ʹ-dihydroxy-4ʹ,6ʹ-dimethoxychalcone (DDC) from green perilla and identified it as a novel activator of the Nrf2-AR...
Source: Journal of Pharmacological Sciences - September 5, 2019 Category: Drugs & Pharmacology Source Type: research
