Journal of Pharmacological Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Interactions between rat cortico-striatal slice cultures and neutrophil-like HL60 cells under thrombin challenge: Toward elucidation of pathological events in intracerebral hemorrhage
Publication date: Available online 28 December 2019Source: Journal of Pharmacological SciencesAuthor(s): Daisuke Noda, Yuki Kurauchi, Akinori Hisatsune, Takahiro Seki, Hiroshi KatsukiAbstractNeutrophils constitute the major population of infiltrating leukocytes after stroke including intracerebral hemorrhage (ICH), and these cells may exhibit pro-inflammatory and anti-inflammatory phenotypes depending on the external stimuli. Here we constructed an experimental system to evaluate how the properties of neutrophils were influenced by the injured brain tissues. HL60 cells differentiated into neutrophils were added to the cult...
Source: Journal of Pharmacological Sciences - January 7, 2020 Category: Drugs & Pharmacology Source Type: research

Carvacrol inhibits the neuronal voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.3, Nav1.7, and Nav1.8 expressed in Xenopus oocytes with different potencies
Publication date: Available online 7 January 2020Source: Journal of Pharmacological SciencesAuthor(s): Takafumi Horishita, Yuichi Ogata, Reiko Horishita, Ryo Fukui, Kuniaki Moriwaki, Susumu Ueno, Nobuyuki Yanagihara, Yasuhito Uezono, Yuka Sudo, Kouichiro MinamiAbstractCarvacrol is the predominant monoterpene in essential oils from many aromatic plants. Several animal studies showing analgesic effects of carvacrol indicate potential of carvacrol as a new medication for patients with refractory pain. Voltage-gated sodium channels (Nav) are thought to have crucial roles in the development of inflammatory and neuropathic pain,...
Source: Journal of Pharmacological Sciences - January 7, 2020 Category: Drugs & Pharmacology Source Type: research

Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes
Publication date: Available online 7 January 2020Source: Journal of Pharmacological SciencesAuthor(s): Ai Goto, Kengo Sakamoto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Akio Matsumoto, Atsushi SugiyamaAbstractIt has been difficult to experimentally reproduce synergistic effects of ketoconazole on terfenadine-induced torsade de pointes. We assessed proarrhythmic effects of terfenadine (30 mg/kg, p.o.) with/without ketoconazole (100 mg/kg, p.o.) pretreatment using the chronic atrioventricular block cynomolgus monkeys with repeated-measured design (n=4). Terfenadine with k...
Source: Journal of Pharmacological Sciences - January 7, 2020 Category: Drugs & Pharmacology Source Type: research

A Potent antiarrhythmic drug N-methyl berbamine extends the action potential through inhibiting both calcium and potassium currents
In conclusion, N-MB is a potent and natural antiarrhythmic multitarget drug that may elicit its antiarrhythmic effect through blocking both Ca2+ and K+ channel currents.Graphical abstract (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - January 1, 2020 Category: Drugs & Pharmacology Source Type: research

Interactions between rat cortico-striatal slice cultures and neutrophil-like HL60 cells under thrombin challenge: toward elucidation of pathological events in intracerebral hemorrhage
Publication date: Available online 28 December 2019Source: Journal of Pharmacological SciencesAuthor(s): Daisuke Noda, Yuki Kurauchi, Akinori Hisatsune, Takahiro Seki, Hiroshi KatsukiAbstractNeutrophils constitute the major population of infiltrating leukocytes after stroke including intracerebral hemorrhage (ICH), and these cells may exhibit pro-inflammatory and anti-inflammatory phenotypes depending on the external stimuli. Here we constructed an experimental system to evaluate how the properties of neutrophils were influenced by the injured brain tissues. HL60 cells differentiated into neutrophils were added to the cult...
Source: Journal of Pharmacological Sciences - December 29, 2019 Category: Drugs & Pharmacology Source Type: research

The angiotensin II receptor-neprilysin inhibitor LCZ696 attenuates the progression of proteinuria in type 2 diabetic rats
We examined the effects of the angiotensin receptor-neprilysin inhibitor LCZ696 on overt proteinuria and renal injury in type 2 diabetic Otsuka-Long- Evans-Tokushima-Fatty (OLETF) rats. Aged OLETF rats were also treated with either valsartan or valsartan plus hydralazine for comparison. LCZ696 caused greater attenuation of the progression of proteinuria than either valsartan alone or valsartan combined with hydralazine. Reduced glomerular injury and tubulointerstitial fibrosis were also observed in LCZ696-treated rats. Moreover, LCZ696 prevented increases in blood urea nitrogen (BUN) and creatinine levels. These data sugge...
Source: Journal of Pharmacological Sciences - December 18, 2019 Category: Drugs & Pharmacology Source Type: research

Direct in vitro and in vivo demonstration of muscarinic receptor binding by the novel radioligand, [3H]5-hydroxymethyltolterodine, in the bladder and other tissues of rats
Publication date: Available online 11 December 2019Source: Journal of Pharmacological SciencesAuthor(s): Shizuo Yamada, Shiori Kuraoka, Yoshihiko Ito, Satomi Kagota, Kazumasa Shinozuka, Satomi OnoueAbstractIn vitro and in vivo binding sites of [3H]-labeled 5-hydroxymethyltolterodine (5-HMT), a new radioligand for labeling muscarinic receptors in rat tissues were characterized. Specific [3H]5-HMT binding in rat tissues was saturable and of high affinity in each tissue. The dissociation constant (Kd) was significantly lower in bladder and heart than in submaxillary gland. Significant levels of in vivo specific [3H]5-HMT b...
Source: Journal of Pharmacological Sciences - December 18, 2019 Category: Drugs & Pharmacology Source Type: research

Rho-associated protein kinase and cyclophilin A are involved in inorganic phosphate-induced calcification signaling in vascular smooth muscle cells
We examined the involvement of the ROCK-CypA axis in VSMC calcification induced by inorganic phosphate (Pi), a potent cell mineralization initiator. We found that Pi stimulated ROCK activity, CypA secretion, extracellular signal-regulated protein kinase (ERK) 1/2 phosphorylation, and runt-related transcription factor 2 expression, resulting in calcium accumulation in rat aortic smooth muscle cells (RASMCs). The ROCK inhibitor Y-27632 significantly suppressed Pi-induced CypA secretion, ERK1/2 phosphorylation, and calcium accumulation. Recombinant CypA was found to be associated with increased calcium accumulation in RASMCs....
Source: Journal of Pharmacological Sciences - December 18, 2019 Category: Drugs & Pharmacology Source Type: research

Mechanisms of endothelium-dependent vasorelaxation induced by procyanidin B2 in venous bypass graft
Publication date: Available online 11 December 2019Source: Journal of Pharmacological SciencesAuthor(s): Goran Jankovic, Marija Marinko, Predrag Milojevic, Ivan Stojanovic, Dragoslav Nenezic, Vladimir Kanjuh, Qin Yang, Guo-Wei He, Aleksandra NovakovicAbstractCardioprotective abilities of procyanidins, might, at least in part, attribute to their vasodilator properties. The present study was undertaken to assess the vasorelaxant effect of procyanidin B2 on isolated human saphenous vein (HSV) and its underlying mechanisms. Procyanidin B2 relaxed phenylephrine-induced contraction of HSV rings in concentration-dependent manner....
Source: Journal of Pharmacological Sciences - December 11, 2019 Category: Drugs & Pharmacology Source Type: research

Direct in vitro and in vivo demonstration of muscarinic receptor binding by the novel radioligand, [3H]5-hydroxymethyltolterodine, in the bladder and other tissues of rats
Publication date: Available online 11 December 2019Source: Journal of Pharmacological SciencesAuthor(s): Shizuo Yamada, Shiori Kuraoka, Yoshihiko Ito, Satomi Kagota, Kazumasa Shinozuka, Satomi OnoueAbstractIn vitro and in vivo binding sites of [3H]-labeled 5-hydroxymethyltolterodine (5-HMT), a new radioligand for labeling muscarinic receptors in rat tissues were characterized. Specific [3H]5-HMT binding in rat tissues was saturable and of high affinity in each tissue. The dissociation constant (Kd) was significantly lower in bladder and heart than in submaxillary gland. Significant levels of in vivo specific [3H]5-HMT bind...
Source: Journal of Pharmacological Sciences - December 11, 2019 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: January 2020Source: Journal of Pharmacological Sciences, Volume 142, Issue 1Author(s): (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - December 10, 2019 Category: Drugs & Pharmacology Source Type: research

A simple method using anesthetics to test effects of sleep-inducing substances in mice
Publication date: Available online 6 December 2019Source: Journal of Pharmacological SciencesAuthor(s): Hiroki Murai, Hiroto Suzuki, Hirochi Tanji, Tomoki Kimura, Yoshinori IbaAbstractWe investigated the effects of sleep-inducing agents with different mechanisms of action on the loss of the righting reflex induced by isoflurane or a mixture of medetomidine, midazolam, and butorphanol (MMB), followed by atipamezole reversal. Chlorpromazine and brotizolam delayed recovery from both types of anesthesia, whereas the melatonin receptor agonist ramelteon had no effect. The orexin receptor antagonist suvorexant delayed recovery f...
Source: Journal of Pharmacological Sciences - December 6, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of orally active hypoxia inducible factor alpha prolyl hydroxylase inhibitor, FG4592 on renal fibrogenic potential in mouse unilateral ureteral obstruction model
Publication date: Available online 6 December 2019Source: Journal of Pharmacological SciencesAuthor(s): Kazuya Kabei, Yu Tateishi, Masayuki Shiota, Mayuko Osada-Oka, Shunji Nishide, Junji Uchida, Tatsuya Nakatani, Shinji Matsunaga, Takehiro Yamaguchi, Shuhei Tomita, Katsuyuki MiuraAbstractOrally active hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors that stabilize HIF protein and stimulate the production of erythropoietin have been approved to treat renal anemia. Our previous report suggested that HIF-1α dependent fibrogenic mechanisms are operating at the early onset of renal fibrosis and its contribution de...
Source: Journal of Pharmacological Sciences - December 6, 2019 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: December 2019Source: Journal of Pharmacological Sciences, Volume 141, Issue 4Author(s): (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - November 30, 2019 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: November 2019Source: Journal of Pharmacological Sciences, Volume 141, Issue 3Author(s): (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - November 29, 2019 Category: Drugs & Pharmacology Source Type: research