Journal of Pharmacological Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Tacrolimus, a calcineurin inhibitor, promotes capsaicin-induced colonic pain in mice
Publication date: Available online 25 February 2020Source: Journal of Pharmacological SciencesAuthor(s): Kazuki Matsui, Yuka Terada, Maho Tsubota, Fumiko Sekiguchi, Atsufumi Kawabata (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - February 25, 2020 Category: Drugs & Pharmacology Source Type: research

The role of nitric oxide in small intestine differs between a single and a consecutive administration of methotrexate to rats
Publication date: Available online 20 February 2020Source: Journal of Pharmacological SciencesAuthor(s): Saki Shiga, Takuji Machida, Takumi Yanada, Maiko Machida, Masahiko Hirafuji, Kenji IizukaAbstractThe role of nitric oxide (NO) on intestinal mucosal injury induced by single or consecutive administration of methotrexate was investigated in a rodent model. Rats received methotrexate intraperitoneally either as a single administration (50 mg/kg) or as a consecutive administration (12.5 mg/kg/day) for 4 days. NG-nitro-L-arginine methyl ester (L-NAME) was given subcutaneously to inhibit NO synthase (NOS). Ninety-six hours a...
Source: Journal of Pharmacological Sciences - February 21, 2020 Category: Drugs & Pharmacology Source Type: research

Sensitivity of inhalation anesthetics isoflurane and sevoflurane for the drug-induced QT-interval prolongation in guinea pigs
Publication date: Available online 21 February 2020Source: Journal of Pharmacological SciencesAuthor(s): Yoshinobu Nagasawa, Kaori Sakai, Rui Kurimoto, Satoshi Kawakami, Megumi Aimoto, Akira TakaharaAbstractWe investigated effects of isoflurane and sevoflurane on sparfloxacin-induced QT-interval prolongation in guinea pigs under the monitoring of electrocardiogram and monophasic action potential (MAP), which was compared with that of halothane or non-inhaled anesthetics ketamine/xylazine. Intravenous administration of sparfloxacin at 3 and 10 mg/kg prolonged the QT interval and MAP duration together with bradycardic action...
Source: Journal of Pharmacological Sciences - February 21, 2020 Category: Drugs & Pharmacology Source Type: research

Dihydrocapsaicin-induced angiogenesis and improved functional recovery after cerebral ischemia and reperfusion in a rat model
This study investigated the long-term effects of dihydrocapsaicin (DHC)-induced angiogenesis and improved functional outcomes in cerebral ischemia and reperfusion (I/R) rats. Middle cerebral artery occlusion was induced in I/R rats for 2 h, followed by reperfusion. The animals were divided into three groups: sham, I/R + vehicle, and I/R + DHC (10 mg/kg body weight). Fourteen days after I/R injury, the DHC-treated I/R rats had decreased neurological deficit scores, infarct volume, and brain morphology changes. DHC-induced angiogenesis significantly increased the expression of angiogenic factor proteins, such as hypoxia indu...
Source: Journal of Pharmacological Sciences - February 15, 2020 Category: Drugs & Pharmacology Source Type: research

Protective effect of Clinopodium chinense (Benth.) O. Kuntze against abnormal uterine bleeding in female rats
ConclusionsTEC showed beneficial effects on treating AUB by reducing metrorrhagia volume, inhibiting the inflammatory response and promoting the repair of the endometrium. Additionally, TEC also showed great haemostatic potential in AUB. (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - February 13, 2020 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: March 2020Source: Journal of Pharmacological Sciences, Volume 142, Issue 3Author(s): (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - February 11, 2020 Category: Drugs & Pharmacology Source Type: research

Characterization of microminipig as a laboratory animal for pharmacological study by analyzing bepridil-induced cardiovascular responses
Publication date: Available online 4 February 2020Source: Journal of Pharmacological SciencesAuthor(s): Yoshio Nunoi, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Takeshi Wada, Hiroko Izumi-Nakaseko, Akio Matsumoto, Yoshinori Watanabe, Atsushi SugiyamaAbstractSince microminipig is becoming attractive model for various cardiac electropharmacological applications, which may meet consideration of 3Rs. We characterized microminipigs by analyzing how multi-ionic channel inhibitor bepridil may affect their in situ hearts in comparison with dogs. Bepridil in doses of 0.3 and 3.0 mg/kg were intravenously admi...
Source: Journal of Pharmacological Sciences - February 5, 2020 Category: Drugs & Pharmacology Source Type: research

Ellagic acid attenuates liver toxicity induced by valproic acid in rats
Publication date: Available online 29 January 2020Source: Journal of Pharmacological SciencesAuthor(s): Mohammed Elyamany, Noha F. Abdelkader, Amany M. Gad, Naglaa Assaf, Hala M. Fawzy, Wesam H. ElesawyAbstractValproic acid is a commonly used drug for many psychiatric disorders, particularly for epilepsy. However, it has been reported that its use is associated with possible side effects including hepatotoxicity.The present study investigated the hepatoprotective effect of ellagic acid against valproic acid-induced hepatotoxicity in rats.Ellagic acid (60 mg/kg/day; p.o) was treated for one week, followed by concomitant inj...
Source: Journal of Pharmacological Sciences - January 29, 2020 Category: Drugs & Pharmacology Source Type: research

Liver hydrolysate improves depressive-like behavior in olfactory bulbectomized mice: Involvement of hippocampal neurogenesis through the AMPK/BDNF/CREB pathway
Publication date: Available online 25 January 2020Source: Journal of Pharmacological SciencesAuthor(s): Osamu Nakagawasai, Kotaro Yamada, Takayo Odaira, Kohei Takahashi, Wataru Nemoto, Wakana Sakuma, Miharu Wakou, Jia-Rong Lin, Koichi Tan-NoAbstractRecently, we has reported that AMPK activator has antidepressant effect. Previous our study suggested that liver hydrolysate (LH) activated adenosine monophosphate-activated protein kinase (AMPK) in periphery. However, the effect of LH on depression is unclear. Therefore, we examines whether LH has antidepressant effect on olfactory bulbectomized (OBX) mice. OBX mice showed depr...
Source: Journal of Pharmacological Sciences - January 25, 2020 Category: Drugs & Pharmacology Source Type: research

Dermatophagoides pteronyssinus-induced pro-inflammatory responses mediated via STAT3 and NF-kappaB signaling pathways in human bronchial epithelial cells – Inhibitory effects of Lafoensia pacari and ellagic acid
Publication date: Available online 22 January 2020Source: Journal of Pharmacological SciencesAuthor(s): Ana Letícia Júlio de Souza, Aline Beatriz Mahler Pereira, Jhony Robison de Oliveira, Luciana Santos Ramalho, Henrique Ismarsi de Souza, Altina Lacerda Nascimento, Mohib Uddin, Paulo Sérgio Pereira, David Nascimento Silva Teixeira, Paulo Roberto da Silva, Deijanira Alves de Albuquerque, Lucia Helena Faccioli, Alexandre de Paula RogérioAbstractThe house dust mite allergen Dermatophagoides pteronyssinus (Der p) is a major driver of allergic asthma. Studies from our group demonstrated anti-eosinophlic effects of ethanoli...
Source: Journal of Pharmacological Sciences - January 22, 2020 Category: Drugs & Pharmacology Source Type: research

Comparison of the Anti-Colitis Activities of Qing Dai/Indigo Naturalis Constituents in Mice
This study investigates the effects of QD on murine dextran sulfate sodium salt-induced colitis. Oral administration of QD protected the animals from colitis as manifested by weight loss, diarrhea, and rectal bleeding. QD was distinguishingly more effective than 5-aminosalicylate. Focused microarray analysis of genes expressed in the distal colon suggested that QD influences the inflammatory pathway. Anti-inflammatory activity of QD was confirmed by the suppression of nitric oxide (NO) production in response to interleukin-1β in cultured hepatocytes. Some of the constituents in QD, such as tryptanthrin (TRYP) and indigo, ...
Source: Journal of Pharmacological Sciences - January 22, 2020 Category: Drugs & Pharmacology Source Type: research

Negative impact of anesthesia with midazolam, sufentanil, and propofol used in pediatric flexible bronchoscopy on the tracheal ciliary beat frequency in guinea pigs
Publication date: Available online 22 January 2020Source: Journal of Pharmacological SciencesAuthor(s): Marta Joskova, Peter Durdik, Martina Sutovska, Marian Grendar, Dusan Koniar, Libor Hargas, Peter Banovcin, Sona FranovaAbstractThere is no direct evidence for the exact cilia-inhibitory effects of opioids, which are generally used to achieve general anesthesia in combination with other anesthetic drugs. These are the reasons, why we analysed direct concentration-dependent or systemic effects of anesthetics (propofol, sufentanil, and midazolam) at a recommended doses administered individually or simultaneously on the trac...
Source: Journal of Pharmacological Sciences - January 22, 2020 Category: Drugs & Pharmacology Source Type: research

Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes
Publication date: Available online 7 January 2020Source: Journal of Pharmacological SciencesAuthor(s): Ai Goto, Kengo Sakamoto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Akio Matsumoto, Atsushi SugiyamaAbstractIt has been difficult to experimentally reproduce synergistic effects of ketoconazole on terfenadine-induced torsade de pointes. We assessed proarrhythmic effects of terfenadine (30 mg/kg, p.o.) with/without ketoconazole (100 mg/kg, p.o.) pretreatment using the chronic atrioventricular block cynomolgus monkeys with repeated-measured design (n = 4). Terfenadine ...
Source: Journal of Pharmacological Sciences - January 16, 2020 Category: Drugs & Pharmacology Source Type: research

Thrombomodulin induces anti-inflammatory effects by inhibiting the rolling adhesion of leukocytes in vivo
Publication date: Available online 14 January 2020Source: Journal of Pharmacological SciencesAuthor(s): Shino Nishizawa, Junichi Kikuta, Shigeto Seno, Masahiro Kajiki, Ryuichi Tsujita, Hiroki Mizuno, Takao Sudo, Tomoka Ao, Hideo Matsuda, Masaru IshiiAbstractThrombomodulin (TM) is an integral membrane protein expressed on the surface of vascular endothelial cells that suppresses blood coagulation. Recent studies have shown that TM exhibits anti-inflammatory effects by inhibiting leukocyte recruitment. However, the actual modes of action of TM in vivo remain unclear. Here, we describe the pharmacological effects of recombina...
Source: Journal of Pharmacological Sciences - January 16, 2020 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: February 2020Source: Journal of Pharmacological Sciences, Volume 142, Issue 2Author(s): (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - January 15, 2020 Category: Drugs & Pharmacology Source Type: research