Profiling of seizurogenic liability compounds using high-throughput human iPSC–derived neuronal 3D cultures
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Carsten Andersen, Steven Dea, Ryan Gordon, Kendra Prum, Oivin Guicherit, Fabian Zanella, Cassiano Carromeu, Blake Anson (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Correlation between MTHFR c.677C > T, MTHFR c.1298 A > C, ABCB1 c.3435C > T and GGH c.452C > T polymorphisms and methotrexate therapeutic outcome of rheumatoid arthritis in West Algerian
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Wafaa Boughrara, Meriem Aberkane, Elisabeth Aberkane, Abdallah Boudjema (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

L-Citrulline as translational safety biomarker for the small intestine—An update
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Sven Jäckel, Barbara Emde, Valentina Lai, Stefan Weigt, Bettina Hanschke, Lena Kasper, Anindya Siddharta, Jürgen Hellmann, Stephanie Czasch, Anja Knippel, Michael W. Schmitt (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation and comparison of continuous glucose monitoring solutions in felines
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Kyle P. O'Donohue, Jill A. Dalton, Margaret M. McComb (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Surgical techniques for implantation of continuous glucose telemetry implants in felines
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Kyle P. O'Donohue, Jill A. Dalton, Eric J. Herrmann (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

NSAID-induced gastrointestinal injury: Reduction of gastric and exacerbation of enteric lesions by omeprazole and ranitidine in rats
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): George P. Thomas, Brian Klatt, Jennifer Shenise, Maura Boyarsky, Charles Spainhour (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Large intestine motility in the rodent—How does it measure up?
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Kate Voss, Jeanine Bussier, Aldo Coppi, Tyler Ardrey, Kristen Ford, Cassie James, Michelle Waines, Bethani Woods, Brian M. Roche (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Can safety pharmacology studies support the assessment of immune-related adverse events?
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Michael K. Pugsley, Eric Martel (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Use of the ZDF rat to model dietary fat induced hypercoagulability is limited by progressive and fatal nephropathy
Publication date: Available online 27 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Michael K. Pugsley, Marjory B. Brooks, Cindy E. Fishman, Paula Katavolos, Alan Y. Chiang, Stanley T. Parish, Albert E. Schultze, Jennifer B. Pierson (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 27, 2020 Category: Drugs & Pharmacology Source Type: research

Determination of the alcohol biomarker phosphatidylethanol 16:0/18:1 and 33 compounds from eight different drug classes in whole blood by LC-MS/MS
Publication date: Available online 24 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Benedicte Jørgenrud, Eline Skadberg, Julio de Carvalho Ponce, Håvard Furuhaugen, Thomas Berg (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 24, 2020 Category: Drugs & Pharmacology Source Type: research

Use of computed tomography to assess subcutaneous drug dispersion with recombinant human hyaluronidase PH20 in a swine model
Publication date: Available online 22 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Robert J. Connor, Darin M. Taverna, Karla Thrall, Michael J. LaBarre, David W. Kang (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 23, 2020 Category: Drugs & Pharmacology Source Type: research

Δ9-tetrahydrocannabinol: Drug discrimination abuse liability testing in female Lister Hooded rats: Trials, tribulations and triumphs
Publication date: Available online 21 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): S.S. Rowton, B.A. Rocha, I.E. Porter (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 21, 2020 Category: Drugs & Pharmacology Source Type: research

Caenorhabditis elegans as a possible model to screen anti-Alzheimer's therapeutics
Publication date: Available online 20 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Deepraj Paul, Sandhya Chipurupalli, Antony Justin, Kalpana Raja, Suresh K. Mohankumar (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 20, 2020 Category: Drugs & Pharmacology Source Type: research

Experimental model of congestive heart failure induced by transverse aortic constriction in BALB/c mice
Publication date: Available online 20 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Shahid Tannu, John Allocco, Melissa Yarde, Pancras Wong, Xiuying Ma (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 20, 2020 Category: Drugs & Pharmacology Source Type: research

Simultaneous determination of barbiturates, phenytoin and topiramate in hair by LC-MS/MS and application to real samples
Publication date: Available online 19 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Jihyun Kim, Junghyun Kim, Hyesun Yum, Moonhee Jang, Jongsook Rhee, Sangki Lee, Sang Beom Han (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 19, 2020 Category: Drugs & Pharmacology Source Type: research