Utilization of mechanistic modelling and simulation to analyze fenspiride proarrhythmic potency–role of physiological and other non-drug related parameters
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Sebastian Polak, Jeremy Craven, Mitra Abbasi, Mark Holbrook (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Cardiovascular effects of adenosine transporter (ENT1) inhibition in various preclinical animal models
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Chris Regan, Pierre Morissette, Hillary Regan, Kevin Fitzgerald, Jeff Travis, Frederick Sannajust (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Quantitative PK/PD analysis demonstrates reduced sensitivity for sedation translation from rats to humans
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Karen Tse, Pär Nordell (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Relationship between occurrence of atorvastatin induced muscle adverse effects, serum vitamin D and low-density lipoprotein-cholesterol levels: A cross sectional observational study
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Harmanjit Singh, Harsheen Kaur Manaise, Jagjit Singh, Jeet Ram Kashyap, Ravi Rohilla, Shivani Jaswal, Rajiv Kumar, C.S. Gautam (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

The use of emerging safety biomarkers in nonclinical and clinical safety assessment—the current and future state: An IQ DruSafe industry survey
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Tanja S. Zabka, John Burkhardt, Dominique Brees, Jean-Charles Gautier, Warren E. Glaab, Magali R. Guffroy, Joanna Harding, Eric McDuffie, Lila Ramaia, William J. Reagan, Albert E. Schultze, James Smith, Deidre A. Dalmas (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Use of human induced pluripotent stem cell-derived engineered cardiac tissues to predict cardiotoxic responses to a chemotherapeutic agent
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Roozbeh Aschar-Sobbi, Nicole Feric, Isabella Pallotta, Rishabh Singh, Danielle R. Bogdanowicz, Marietta Gustilo, Krista M. Durney, Michael P. Graziano (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

A new method to assess a unique mechanism of drug targeting sodium channels involved in pain
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): James Kramer, Caiyun Wu, Zhiqi Liu, Yuri A. Kuryshev (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Electrophysiological evaluation of LUHMES cells as model of human dopaminergic neurons
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Udo Kraushaar, Dominik Loser, Timm Danker, Clemens Moeller, Marcel Leist (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Assessment of cardiorespiratory function using telemetric jacket in rodents
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Timothé Flenet, Hervé Barret, Elodie Chastel, Abdelhaq Momtaz, Charles Eynard, Christophe Boixel (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Individual QTc drift correction by core body temperature in the Göttingen minipig
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Elisa Estaca Banon, Kate Read, Karim Melliti (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

A cardiovascular assessment following a single oral (gavage) dose of digoxin and verapamil in conscious, dual pressure radiotelemetry-instrumented male Sprague-Dawley rats
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Margaret White, Brian M. Roche, Michelle Waines, Bethani Woods, Velu Karicheti, John B. Ross (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Utility of heart rate variability analysis in telemetrized cynomolgus monkeys
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Tsuyoshi Uchino, Hikaru Fukuda, Masaaki Ban, Tatsuya Jikuzono (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Comparison of ECG parameters in beagle dog from stand-alone safety pharmacology and repeat dose toxicology studies
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Xinchao Xia, Rui Wu, Shanshan An, Rui Li, Sue McPherson (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Cardiovascular and respiratory (impedance) by digital telemetry monitoring in cynomolgus monkeys, Beagle dogs and Göttingen minipigs
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Emmanuel Boulay, Elissa Gazaille, Marjorie Demers, Isabelle Reeves, Said Maghezzi, Simon Authier (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Strain differences in respiratory, body temperature, and locomotor activity responses to amphetamine and morphine in Sprague Dawley and Wistar Han rats
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Jonelle R. May, Kyle P. O'Donohue, Anson L. Phillips, Jill A. Dalton, Theodore J. Baird (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research