In silico classifier for early screening of drug-induced torsadogenic risk
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Jordi Llopis Lorente, Jordi Cano García, Julio Gomis-Tena Dolz, Lucía Romero Pérez, Ferran Sanz Carreras, Manuel Pastor Maeso, Beatriz Trénor Gomis, Javier Saiz Rodriguez (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Machine learning for six forms of cardiotoxicity prediction
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Polina Mamoshina, Alfonso Bueno-Orovio, Blanca Rodriguez (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Simultaneous assessment of drug-induced effects on contractility and electrophysiology using human in silico trials
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Francesca Margara, Elisa Passini, Francesc Levrero-Florencio, Alfonso Bueno-Orovio, Blanca Rodriguez (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Combining an in silico pro-arrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Pierre Morissette, Sebastian Polak, Anne Chain, Jin Zhai, Jeffrey Travis, Kevin Fitzgerald, Patrick Fanelli, Elisa Passini, Blanca Rodriguez, Frederick Sannajust, Chris Regan (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Human in silico drug trials with a novel human ventricular electrophysiology model
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Elisa Passini, Jakub Tomek, Xin Zhou, Alfonso Bueno-Orovio, Blanca Rodriguez (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Use of the comprehensive in vitro proarrhythmia assay and in silico modeling to investigate the safety profile of bisphenol analogues
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Rafael Jaimes, Damon McCullough, Luther Swift, Marissa Reilly, Morgan Burke, Jordi Llopis Lorente, Beatriz Trénor Gomis, Javier Saiz Rodriguez, Jiansong Sheng, Nikki G. Posnack (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

IC50 evaluation is critically dependent on the protocol used for measurement
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Julio Gomis-Tena Dolz, Brandon M. Brown, Jordi Cano García, Beatriz Trenor, Pei-Chi Yang, Javier Saiz Rodriguez, Colleen E. Clancy, Lucia Romero (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Novel human Purkinje electrophysiology model for drug safety and efficacy mechanistic investigations
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Cristian Trovato, Elisa Passini, Norbert Nagy, Andras Varro, Najah Abi-Gerges, Andre Ghetti, Paul E. Miller, Stefano Severi, Blanca Rodriguez (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

uHeart: A beating heart-on-chip platform for on-line recording of functional 3D cardiac microtissues' electrical activity
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Roberta Visone, Simona Marzorati, Valeria Perego, Paola Occhetta, Enrico Pesenti, Marco Rasponi (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

The database for in silico cardiac risk prediction tools
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Barbara Wiśniowska, Zofia Tylutki, Sebastian Polak (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Machine learning and multiresolution wavelet decomposition to improve automated cardiac arrhythmia detection and classification
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): David Delafontaine, Olga Domanova, Christophe Bleunven, Sylvain Bernasconi (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Impact of housing conditions on cardiovascular parameters in telemetry-implanted cynomolgus monkeys
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Abdel-Ilah El Amrani, Stephane Loriot, Francine El Amrani-Callens, Marie-Eve Duclos, Pramila Singh, Roy Forster (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Acute toxicity evaluation of polypropylene and polystyrene microplastics in Sprague Dawley (SD) rats after oral administration
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Jin Sik-Kim (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

Complementary in vitro safety pharmacology profiling aids risk management
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Amber Ko, Jin-Jye Feng, Heng-Hsu Lin (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research

The carbon source in the culture media modulates the cardiotoxic effects of doxorubicin on human stem cell-derived cardiomyocytes
Publication date: September 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 105Author(s): Carlos A. Obejero-Paz, Tiffany Snow, Servane Lachize, Peter Hawryluk, Shushant Jain, Andrew Bruening-Wright (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 2, 2020 Category: Drugs & Pharmacology Source Type: research