Using a qPCR device to screen for modulators of ABC transporter activity: A step-by-step protocol
Publication date: Available online 28 May 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Luisa Möhle, Barbora Schwarzová, Markus Krohn, Sven Marcel Stefan, Jens Pahnke (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 30, 2020 Category: Drugs & Pharmacology Source Type: research

The application of electrophysiological methods to characterize AMPA receptors in dissociated adult rat and non-human primate cerebellar neurons for use in neuronal safety pharmacology assessments of the central nervous system
Publication date: Available online 25 May 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Loïs S. Miraucourt, Michael V. Accardi, Karen E. Asin, Michael K. Pugsley, Michael J. Curtis, Simon Authier (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 25, 2020 Category: Drugs & Pharmacology Source Type: research

Unraveling the mechanism and the risk behind seizure liability of lead compounds in a neuroscience project
Publication date: Available online 22 May 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Annie Delaunois, Michael V. Accardi, Véronique André, Simon Authier, François Bouzom, Simon Hebeisen, Yves Lamberty, Faiza Laredj, Karine Leclercq, Anne-Gaëlle Letombe, Marie-Luce Rosseels, Chiara Carla Rospo, Marie-Christine Tordeur, Jean-Pierre Valentin, Martyn Wood (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 22, 2020 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: May–June 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 103Author(s): (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 21, 2020 Category: Drugs & Pharmacology Source Type: research

Combined cSLO-OCT imaging as a tool in preclinical ocular toxicity testing: A comparison to standard in-vivo and pathology methods
Publication date: Available online 12 May 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Petr Soukup, Barbara Lenz, Bernd Altmann, Solveig Badillo, Elke-Astrid Atzpodien, Simon A. Pot (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 13, 2020 Category: Drugs & Pharmacology Source Type: research

A capillary electrophoresis based approach for the identification of anti-drug antibodies against camelid VHH biologics (Nanobodies®)
Publication date: Available online 7 May 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Derek Wiswell, Divas Neupane, Minchao Chen, Edward P. Bowman, Douglas Linn, Anandi Sawant, Alissa Chackerian, Shuli Zhang, Enrique Escandón (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 7, 2020 Category: Drugs & Pharmacology Source Type: research

Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs
Publication date: Available online 30 April 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Yevgeniya E. Koshman, Amanda S. Wilsey, Brandan M. Bird, Aimee L. Endemann, Sabine Sadilek, Jessica Treadway, Ruth L. Martin, James S. Polakowski, Gary A. Gintant, Scott W. Mittelstadt (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 1, 2020 Category: Drugs & Pharmacology Source Type: research

Comprehensive analysis of cardiac function, blood biomarkers and histopathology for milrinone-induced cardiotoxicity in cynomolgus monkeys
Publication date: Available online 28 April 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Katsuyoshi Chiba, Tomomichi Ishizaka, Yu Yoshimatsu, Kei Mikamoto, Yu Maeda, Takuma Iguchi, Makoto Shirai, Takashi Yamaguchi, Koichi Goto, Ken Sakurai, Satoshi Tamai, Hiroko Kataoka, Miki Hasegawa, Kazuhiko Mori (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - April 28, 2020 Category: Drugs & Pharmacology Source Type: research

A practical guide to secondary pharmacology in drug discovery
Publication date: Available online 14 April 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Stephen Jenkinson, Friedemann Schmidt, Lyn Rosenbrier Ribeiro, Annie Delaunois, Jean-Pierre Valentin (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - April 15, 2020 Category: Drugs & Pharmacology Source Type: research

RNA interference-mediated silencing of Kv7.2 in rat dorsal root ganglion neurons abolishes the anti-nociceptive effect of a selective channel opener
Publication date: Available online 8 April 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Markus Valdor, Anke Wagner, Heike Fischer, Viola Röhrs, Wolfgang Schröder, Gregor Bahrenberg, André Welbers, Henry Fechner, Jens Kurreck, Thomas M. Tzschentke, Thomas Christoph (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

Host cell proteins induce inflammation and immunogenicity as adjuvants in an integrated analysis of in vivo and in vitro assay systems
Publication date: Available online 8 April 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Kyohei Yasuno, Eri Hamamura-Yasuno, Daisuke Nishimiya, Masako Soma, Masako Imaoka, Kiyonori Kai, Kazuhiko Mori (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: March–April 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 102Author(s): (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - March 12, 2020 Category: Drugs & Pharmacology Source Type: research

Insights into toxicology, safety pharmacology, and drug dependence testing: The performance and predictive values of nonclinical tests
Publication date: Available online 12 March 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): J.D. Suarez-Torres, C.E. Ciangherotti, F.A. Jimenez-Orozco (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - March 12, 2020 Category: Drugs & Pharmacology Source Type: research

Stability of ceftolozane in human plasma and dried blood spots: Implications for transport and storage
Publication date: Available online 12 March 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Jens Martens-Lobenhoffer, Matthias Hinderhofer, Uwe Tröger, Stefanie M. Bode-Böger (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - March 12, 2020 Category: Drugs & Pharmacology Source Type: research

Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative
Publication date: Available online 24 February 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Jamie K. DaSilva, Laura Breidenbach, Tracy Deats, Dingzhou Li, Kimberly Treinen, Theo Dinklo, Sophie Kervyn, Greet Teuns, Martin Traebert, Katja Hempel (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - February 25, 2020 Category: Drugs & Pharmacology Source Type: research