Black holes in the brain and spine: A dark disease
This article emphasizes the importance of recognizing its classical neuroimaging findings distinct from other disorders. (Source: Journal of Pediatric Neurosciences)
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Bhanudeep Singanamalla Sumeet Dhawan Arushi Gahlot Saini Paramjeet Singh Naveen Sankhyan Source Type: research
Miller Fisher variant of Guillain & #8211;Barr & #233; syndrome in a child
We describe the case of a 7-year-old boy who presented with diplopia, speech difficulty, dysphagia, gait disturbance, and difficulty in eyeball movements since 5 days. On examination, the child was having ataxia, areflexia, ophthalmoplegia, drooling of saliva, dysphonia, and absent gag reflex. MFS and brain stem encephalitis were kept as the differential diagnoses. The patient improved gradually over 3 weeks, following a treatment with intravenous immunoglobulin. (Source: Journal of Pediatric Neurosciences)
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Sushant S Mane Umesh Nagesh Vaijinath T Sathe Jyothi Janadhanan Source Type: research
An unusual presentation of Menkes disease masquerading as a leukodystrophy with macrocephaly
Conclusion: This case exemplifies a rare presentation of Menkes disease, simulating a leukodystrophy with macrocephaly. Tortuosity of cerebral blood vessels is an important finding, which can help in differentiating Menkes disease from white matter disorders. (Source: Journal of Pediatric Neurosciences)
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Anshula Tayal Aman Elwadhi Suvasini Sharma Bijoy Patra Source Type: research
A case of deep cerebral venous thrombosis presenting like acute necrotizing encephalopathy
We report a case of 2½-year-old child who presented like acute necrotizing encephalopathy but on further investigations was found to be having deep cerebral vein thrombosis. (Source: Journal of Pediatric Neurosciences)
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Sachin Dangi Namita Gwasikoti Source Type: research
Reports of a conus cauda tumor with holocord syrinx in an adolescent girl
We report a case highlighting these findings. Case Report: A 16-year-old adolescent presented critically ill with respiratory failure due to severe pneumonia. Evaluation showed fungal pneumonia with secondary bacterial infection. On recovery, she had nasal regurgitation and required nasogastric tube feeding. Examination showed palatal and left vocal cord palsy. Neuroimaging of brain showed conus cauda tumor with syringobulbia and holocord multiseptate syrinx extending from medulla to filum terminale with lipoma. Histopathology examination showed myxopapillary ependymoma. She improved with excision and postoperative radioth...
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Smriti Sinha Prathibha Shankar Ashwini Pelala Nayan Baba Rathika Damodar Shenoy Source Type: research
Myelopathy in two brothers with respiratory chain disorder & #8211;severe complex 1 deficiency with atlantoaxial dislocation and long spinal arachnoid cyst: A new unreported association
Sadanandavalli Retnaswami Chandra, Hansashree Padmanabha, Manisha Gupta, Nupur Pruthi, Gayathri Narayanappa, Rita ChristopherJournal of Pediatric Neurosciences 2020 15(1):45-50Billion of years ago bacteria is believed to have entered a eukaryotic cell and converted to mitochondria. The respiratory chain present in it supplies ATP to all cells and therefore the diseases can have any phenotype. Diagnosis may be difficult to confirm by the conventional methods including genetics. Two brothers born to consanguineous parents had global delay, mild visual impairment and drooping of eyelids since birth in the elder child and dysm...
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Sadanandavalli Retnaswami Chandra Hansashree Padmanabha Manisha Gupta Nupur Pruthi Gayathri Narayanappa Rita Christopher Source Type: research
A case of split notochord syndrome with left congenital diaphragmatic hernia: A rare association
Pradyumna PanJournal of Pediatric Neurosciences 2020 15(1):42-44Split notochord syndrome is a rare neural tube malformation involving the brain, spinal cord, and vertebral column. In nearly half of the cases, the malformation also involves the gastrointestinal tract in the form of a dorsal neurenteric fistula and imperforate anus. In the literature, less than 50 cases have been reported. To the best of my knowledge, this is the first reported case associated with a left congenital diaphragmatic hernia. (Source: Journal of Pediatric Neurosciences)
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Pradyumna Pan Source Type: research
Multiple tubercular brain abscesses with obstructive hydrocephalus in an immunocompetent child: A case report
Ipsita K Sahoo, Amit K Satapathy, Joseph JohnJournal of Pediatric Neurosciences 2020 15(1):38-41Tubercular brain abscesses are rare manifestations in children, and very few cases have been reported till date. It is characterized by an encapsulated collection of pus, containing viable tubercular bacilli. Antitubercular treatment (ATT) is the mainstay of treatment along with surgical drainage or aspiration or excision of the abscess. We hereby report a case of a 15-month-old child with multiple tubercular brain abscesses with obstructive hydrocephalus, managed with ATT and ventriculoperitoneal shunt. (Source: Journal of Pediatric Neurosciences)
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Ipsita K Sahoo Amit K Satapathy Joseph John Source Type: research
Acute hydrocephalus in a case of mumps meningoencephalitis: A rare occurrence
Anish Mehta, Rohan Mahale, Kiran Khanapure, Anirudh T Jagannatha, Purushottam Acharya, Rangasetty SrinivasaJournal of Pediatric Neurosciences 2020 15(1):34-37Mumps is an acute viral illness, which presents with glandular and/or nervous system involvement. The most common central nervous system manifestations of mumps include aseptic meningitis and meningoencephalitis. Mumps meningoencephalitis, which is characterized by fever, vomiting, nuchal rigidity, and altered sensorium, usually develops at least 3–10 days after mumps parotitis. Acute hydrocephalus secondary to mumps meningoencephalitis is rare. Here we r...
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Anish Mehta Rohan Mahale Kiran Khanapure Anirudh T Jagannatha Purushottam Acharya Rangasetty Srinivasa Source Type: research
Electroclinical findings of SYNJ1 epileptic encephalopathy
Conclusion: This is a newly described early-onset epileptic encephalopathy secondary to a critical reduction of the dual phosphatase activity of SYNJ. Clinical features include early-onset intractable focal, myoclonic seizures, infantile spasms, and hypotonia progressing to spastic quadriparesis, opisthotonus, dystonia, profound developmental delay, and a progressive neurodegenerative course. Brain magnetic resonance imaging is usually normal. Electroencephalography shows diffuse slowing with multifocal epileptiform discharges or modified hypsarrhythmia. These findings further expand the clinical spectrum of synaptic dysre...
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Debopam Samanta Kapil Arya Source Type: research
A rare case of sphenoid encephalocoele presenting with fifth cranial nerve involvement
Rohit Wadikhaye, Vamsi Krishna Yerramneni, Thirumal Yerragunta, Neeraj SharmaJournal of Pediatric Neurosciences 2020 15(1):25-28A 14-year-old girl presented with chronic headache, recurrent episodes of vomiting, fever, and two episodes of generalized tonic clonic seizure in the past 2 months. Neuroimaging revealed herniation of the brain along with the dura through a defect in the left greater wing of the sphenoid. Left pterional craniotomy was carried out. Herniation of the dural sac along with its contents through the bony defect in the greater sphenoid wing was identified lateral to the V2 nerve passing through the fora...
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Rohit Wadikhaye Vamsi Krishna Yerramneni Thirumal Yerragunta Neeraj Sharma Source Type: research
Prevalence of vitamin B12 deficiency in West syndrome: A retrospective chart review
Conclusion: In this limited cross-sectional study, vitamin B12 was deficient in 7.7% of children with West syndrome with lack of reduction in frequency of spasm on B12 supplementation. (Source: Journal of Pediatric Neurosciences)
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Manjeet Singh Mohit Bansal Jaya S Kaushik Source Type: research
Intravenous levetiracetam for treatment of seizures in term and preterm neonates
Conclusion: Our data suggest that levetiracetam may be a safe and effective treatment for neonatal seizures, which are unresponsive to phenobarbital. (Source: Journal of Pediatric Neurosciences)
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Pakize Karaoglu Semra H & #305;z Bur & #231;in & #304; & #351;can Ay & #351;e & #304; Polat M & #252;ge Ayano & #287;lu Nuray Duman Ulu & #231; Yis & #807; & #8217; Source Type: research
Auditory and visual P300 responses in early cognitive assessment of children and adolescents with epilepsy
Conclusion: Visual and auditory P300 latencies have an important role in the evaluation of early cognitive dysfunctions in children with epilepsy. P300 potentials are not influenced by antiepileptic treatment, whereas the type of epilepsy alters them (Source: Journal of Pediatric Neurosciences)
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Sangeeta Gupta Arun Prasad Ramji Singh Gaurav Gupta Source Type: research
Relation between febrile seizure recurrence and hyponatremia in children: A single-center trial
Conclusion: Although the results did not show that the lower level of serum sodium increased the risk of seizure recurrence during the next 24h in febrile illness, lower serum sodium concentration was more common in FS groups. (Source: Journal of Pediatric Neurosciences)
Source: Journal of Pediatric Neurosciences - March 18, 2020 Category: Neuroscience Authors: Mohammad Reza Navaeifar Ali Abbaskhanian Akram Farmanbarborji Source Type: research
