Relationship between localization of proteoglycans and induction of neurotrophic factors in mouse dental pulp
Conclusions These data suggest that heparan sulfate proteoglycans, such as perlecan, enhance the expression of GDNF by facilitating FGF-induced Erk1/2 signaling in the subodontoblastic layer. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - October 16, 2016 Category: Biomedical Science Source Type: research

Unveiling a rhythmic regulatory mode hidden in developmental tissue growth by fluorescence live imaging-based mathematical modeling
Conclusion The scope of this review is to describe the experimental and theoretical evidence for cell cycle progression as a stochastic molecular and cellular process. In addition, we elucidate the rhythmic mode of tissue development that endows “biological robustness” for reproducible tissue development. Finally, we discuss the potential of the live imaging-based mathematical approach for understanding pathophysiological development in tissues. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - September 11, 2016 Category: Biomedical Science Source Type: research

Analysis of calcium, phosphorus, and carbon concentrations during developmental calcification of dentin and enamel in rat incisors using scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX)
Conclusions During tooth development, the initial dentin matrix may possess distinctive mineral characteristics as compared with other parts of dentin and predentin. Elemental composition of the mineral in enamel may change during late maturation. Our results are suggestive of degradation of organic components during developmental calcification in dentin and enamel. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - September 3, 2016 Category: Biomedical Science Source Type: research

Dentin sialophosphoprotein is a potentially latent bioactive protein in dentin
Conclusion The functions of DSPP for integrin-mediated signaling possibly arise from the proteolytic cleavage of the peptide bonds close to the RGD domain and induce reactionary dentinogenesis in vivo. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 27, 2016 Category: Biomedical Science Source Type: research

Cultivation strategies for growth of uncultivated bacteria
Conclusion Despite significant advances in recent years in methodologies for the cultivation of previously uncultivated bacteria, a substantial proportion remain to be cultured and efforts to devise high-throughput strategies should be a high priority. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 11, 2016 Category: Biomedical Science Source Type: research

Dentin sialophosphoprotein-derived proteins in porcine pulp and dentin – Gene expression and function
Conclusion DSP-only is expressed throughout odontoblast differentiation, while full-length DSPP is predominantly expressed by odontoblasts only after they have differentiated from mesenchymal cells. DPP and DSP rescued the loss of TGF-β1 activity. Type I collagen was infrequently bound to CF-hTGF-β1. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 6, 2016 Category: Biomedical Science Source Type: research

Proliferative activity of skeletal myoblast sheet by paracrine effects of mesenchymal stem cells
Conclusions This study demonstrated that the presence of MSCs could transiently enhance the proliferative activity of myoblasts, but that this enhancement is ultimately diminished due to contact inhibition. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 6, 2016 Category: Biomedical Science Source Type: research

New findings for dentin sialophosphoprotein studies: Applications of purified odontoblast-like cells derived from stem cells
Conclusion Mouse embryonic stem cells, mouse induced pluripotent stem cells, and α7+ human skeletal muscle stem cells can differentiate into odontoblast-like cells without an epithelial–mesenchymal transition, and are characterized by the signaling cascade underpinning odontoblastic differentiation, which may be useful for tooth regeneration and dentin sialophosphoprotein (DSPP) studies. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 6, 2016 Category: Biomedical Science Source Type: research

Degradation of bradykinin by a metalloendopeptidase from Streptococcus pyogenes
Conclusions S. pyogenes produces a cell-associated metalloendopeptidase that degrades bradykinin. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 6, 2016 Category: Biomedical Science Source Type: research

Fluorescence bioimaging of intracellular signaling and its clinical application
Conclusion Technologies that utilize fluorescent proteins, such as the biosensor presented here, should find increasing applications in clinical medicine. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 6, 2016 Category: Biomedical Science Source Type: research

Metalloproteases and CCN2/CTGF in dentin –pulp complex repair
Conclusion In this review, we summarize novel roles for metalloproteases, particularly MMP-3 and BMP-1, in dentin–pulp complex repair, with particular emphasis on the effects of CCN2/CTGF expression during regulation of cell migration and tertiary dentinogenesis. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 18, 2016 Category: Biomedical Science Source Type: research

Cell –extracellular matrix interactions in oral tumorigenesis: Roles of podoplanin and CD44 and modulation of Hippo pathway
Conclusion Signaling pathways initiated by adhesion molecule-mediated crosstalk between tumor cells and extracellular matrices play important roles in driving and maintaining tumor-specific tissue architecture and contributing to tumor survival, growth, and metastasis. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 18, 2016 Category: Biomedical Science Source Type: research

Bridging the gap: A regulator of NF- κB linking inflammation and cancer
Conclusion Here, we briefly summarize the known contact points between inflammation and cancer, including oral cancers, and put into context the identification of κB-Ras proteins as molecular link between two independent pathways important for tumor growth. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 18, 2016 Category: Biomedical Science Source Type: research

The downward spiral of periodontitis and diabetes in Alzheimer ׳s disease: Extending healthy life expectancy through oral health
Conclusion Effective management of periodontitis may contribute to prevention of AD, as periodontitis is both treatable and preventable. Therefore, brain health, which includes oral health as a contributing factor, is a promising strategy for achieving healthy life expectancy. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 18, 2016 Category: Biomedical Science Source Type: research

Dental plaque as a biofilm and a microbial community —Implications for treatment
Conclusion An appreciation of ecological principles can lead to new strategies for treatment by identifying and removing the factors that drive dysbiosis, while actively supporting the growth of the natural oral microbiota. Also, the beneficial activities of the resident oral microbiota are retained and the risk of dysbiosis is reduced. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 18, 2016 Category: Biomedical Science Source Type: research

Chronic obstructive pulmonary disease and periodontitis  – unwinding their linking mechanisms
Conclusion The present article briefly reviews the interlinking mechanisms between the two diseases, starting with the role of periodontal pathogens, innate immunity, and, ultimately, imbalances in oxidative stress and the protease–antiprotease system. Although epidemiological evidence provides no clear association between these two diseases, the striking commonalities should not be overlooked. Hence, future research should be targeted to this area in order to obtain constructive information. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 18, 2016 Category: Biomedical Science Source Type: research

Morphological comparison of the enamel –dentine junction and outer enamel surface of molars using a micro-computed tomography technique
Conclusion A detailed comparison of EDJ and OES using µCT will contribute to our understanding of the phylogenetic relationships among fossil records and evolutionary changes in dental characteristics from the developmental perspective. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 18, 2016 Category: Biomedical Science Source Type: research

Fine-tuning between BMP and NF- κB pathways regulates osteoblastic bone formation
Conclusion p65 inhibits BMP2-induced osteoblastic bone formation by interfering with DNA binding of the Smad complex via an interaction with Smad4. Thus, targeting the association between p65 and Smad4 may help promote bone regeneration in the treatment of bone diseases. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 18, 2016 Category: Biomedical Science Source Type: research

Interferon- β produced by osteocytes may negatively regulate osteoclastogenesis
Conclusion We found that osteocytes secrete IFN-β as an inhibitory factor of osteoclastogenesis. Our findings provide a new insight into the mechanisms underlying the osteocytic regulation of bone remodeling. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 18, 2016 Category: Biomedical Science Source Type: research

Three-dimensional imaging of internal tooth structures: applications in dental education
Conclusion Non-invasive, three-dimensional imaging techniques, in particular the various modalities of computed tomography, have ushered in a new era of endodontic studies. Owing to their digital nature, the results derived from these techniques can not only be easily analyzed and distributed but also be rapidly integrated into the teaching materials. Recent studies as well as the data shown in the present contribution suggest that digital educational materials lead to an improved understanding of the complex anatomy of human teeth. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 10, 2016 Category: Biomedical Science Source Type: research

Endothelial Cell Transplantation in Tumors Restores Normal Vasculature, Reduces Tumor Hypoxia, and Suppresses Tumor Outgrowth
Conclusion Reconstruction of tumor blood vessels to their normal state alleviated hypoxic conditions and improved the efficiency of drug delivery; the present approach provides a useful model for the development of new cancer therapies. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 10, 2016 Category: Biomedical Science Source Type: research

Interferon-β produced by osteocytes may negatively regulate osteoclastogenesis
Conclusion We found that osteocytes secrete IFN-β as an inhibitory factor of osteoclastogenesis. Our findings provide a new insight into the mechanisms underlying the osteocytic regulation of bone remodeling. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 27, 2016 Category: Biomedical Science Source Type: research

Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination
This study examined the effect of OSCC-derived exosomes on angiogenesis and lymphangiogenesis, closely related with hematogenous and lymphatic metastasis, respectively. Our data demonstrated that OSCC-derived exosomes stimulated the expression of VEGFs and their receptors, essential regulators of angiogenesis and lymphangiogenesis, in human lymphatic endothelial cells but not in human vein endothelial cells. These results suggest that specific exosomes have differential tropism toward a certain cell type, defining the modality of metastasis. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 25, 2016 Category: Biomedical Science Source Type: research

Analytical Methods and Interpretation of Variation in Tooth Morphology
Conclusion Over the past few decades, the morphological data of teeth have been analyzed on the basis of tooth morphology itself as well as from an anthropological perspective. Morphologists should intensify their exchange with molecular biologists and evaluate tooth morphogenesis as well as the genetic basis of tooth structure. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 30, 2016 Category: Biomedical Science Source Type: research

Integration of olfactory and gustatory chemosignals in the insular cortex
Conclusion Several studies, including fMRI analyses in human and animal studies, suggest that the IC directly integrates olfactory and gustatory chemical signals. In particular, our study raises the possibility that the AI plays an important role in integrating olfactory and gustatory signals. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 8, 2016 Category: Biomedical Science Source Type: research

Fine-tuning between BMP and NF-κB pathways regulates osteoblastic bone formation
Conclusion p65 inhibits BMP2-induced osteoblastic bone formation by interfering with DNA binding of the Smad complex via an interaction with Smad4. Thus, targeting the association between p65 and Smad4 may help promote bone regeneration in the treatment of bone diseases. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 1, 2016 Category: Biomedical Science Source Type: research

Cortico-muscular communication for motor control of the tongue in humans: a review
Conclusion This review provides a detailed description of the functional connection between the bilateral cortex and each side of the tongue during sustained tongue movements in humans, using CMC analyses. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 27, 2016 Category: Biomedical Science Source Type: research

Biphasic activation of nuclear factor-kappa B in chondrocyte death induced by interleukin-1beta: The expression of inducible nitric oxide synthase and phagocyte-type NADPH oxidase through immediate and monocarboxylate transporter-1-mediated late-phase activation of nuclear factor-kappa B
Conclusion We found that MCT-1 contributed to the expression of NOX-2 via late-phase activation of nuclear factor κB in a ROS-dependent manner in cells exposed to IL-1β. Hence, MCT-1 could be a potential target for the treatment of degenerative joint diseases. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 24, 2016 Category: Biomedical Science Source Type: research

Morphological comparison of the enamel–dentine junction and outer enamel surface of molars using a micro-computed tomography technique
Conclusion A detailed comparison of EDJ and OES using µCT will contribute to our understanding of the phylogenetic relationships among fossil records and evolutionary changes in dental characteristics from the developmental perspective. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 24, 2016 Category: Biomedical Science Source Type: research

Mechanistic insight into the aberrant silencing of the keratin 13 gene in oral squamous cell carcinoma cells
Conclusion Identification of epigenetic alterations underlying OSCC will be useful for the development of epigenetic biomarkers for diagnosis and prognosis and the discovery of novel therapeutic targets for OSCC. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 30, 2016 Category: Biomedical Science Source Type: research

The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes
Publication date: Available online 18 November 2015 Source:Journal of Oral Biosciences Author(s): Tomoyo Kawakubo-Yasukochi, Masahiko Morioka, Yoshikazu Hayashi, Takuya Nishinakagawa, Mai Hazekawa, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima Emerging evidence indicates that cancer-derived exosomes increase the tumorigenic potential of tumor cells by reprogramming the cells associated with the tumor microenvironment. Our aim was to examine the cross talk via exosomes between two oral squamous cell carcinoma (OSCC) clones from the same patient. Our data showed that exosomes derived from highly metastatic SQUU...
Source: Journal of Oral Biosciences - January 28, 2016 Category: Biomedical Science Source Type: research

Effect of Brazilian green propolis on oral pathogens and human periodontal fibroblasts
Conclusions These results suggest that BGP has antibacterial properties but is not significantly cytotoxic to periodontal fibroblasts. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 28, 2016 Category: Biomedical Science Source Type: research

Oral biosciences: The annual review 2015
Conclusion These reviews published in the Journal of Oral Biosciences have inspired the readers of the journal to broaden their knowledge regarding various aspects of oral biosciences. The current editorial review introduces these exciting review articles. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 28, 2016 Category: Biomedical Science Source Type: research

Profiling subgingival microbiota of plaque biofilms in the elderly
Conclusions This study suggests that an increase in P. gingivalis and T. forsythia may be associated with periodontitis in the elderly, and we have identified characteristic pathogenic fimA genotypes that target this vulnerable group. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 28, 2016 Category: Biomedical Science Source Type: research

Streptococcus mutans biofilm formation is dependent on extracellular DNA in primary low pH conditions
Conclusions Insoluble glucan-independent biofilm formation by S. mutans was significantly influenced by increasing eDNA in primary low pH culture conditions. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 28, 2016 Category: Biomedical Science Source Type: research

A novel method for visualization of the inferior alveolar nerve for clinical and educational purposes
Publication date: Available online 6 January 2016 Source:Journal of Oral Biosciences Author(s): Joe Iwanaga, Tsuyoshi Saga, Yoko Tabira, Koichi Watanabe, Koh-ichi Yamaki The detailed nervous system in the mandibular bone cannot be observed on computed tomography. Dental professionals need to understand the running route of the inferior alveolar nerve and can do so by using gross anatomical dissection. However, the nervous system is difficult to dissect and visualize clearly because it is surrounded by a hard cortical plate. To develop an educational material for dental professionals, we visualized the inferior alveo...
Source: Journal of Oral Biosciences - January 28, 2016 Category: Biomedical Science Source Type: research

The function of glucagon-like peptide-1 in the mouse peripheral taste system
Conclusion GLP-1 released from taste cells may be involved in transmission of sweet and lipid signals, thereby impacting animals׳ feeding behavior in response to these important nutrient factors. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - October 11, 2015 Category: Biomedical Science Source Type: research

Chronic obstructive pulmonary disease and periodontitis – unwinding their linking mechanisms
Conclusion The present article briefly reviews the interlinking mechanisms between the two diseases, starting with the role of periodontal pathogens, innate immunity, and, ultimately, imbalances in oxidative stress and the protease–antiprotease system. Although epidemiological evidence provides no clear association between these two diseases, the striking commonalities should not be overlooked. Hence, future research should be targeted to this area in order to obtain constructive information. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - October 9, 2015 Category: Biomedical Science Source Type: research

Chronic obstructive pulmonary disease and periodontitis- unwinding their linking mechanisms
Conclusion The present article briefly reviews the interlinking mechanisms between the two diseases, starting with the role of periodontal pathogens, innate immunity, and, ultimately, imbalances in oxidative stress and the protease-antiprotease system. Although epidemiological evidence provides no clear association between these two diseases, the striking commonalities should not be overlooked. Hence, future research should be targeted to this area in order to obtain constructive information. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - October 4, 2015 Category: Biomedical Science Source Type: research

Combining prebiotics and probiotics to develop novel synbiotics that suppress oral pathogens
Conclusion The present study indicates that prebiotics and probiotics can potentially be developed into novel synbiotics against oral pathogens in future. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - September 5, 2015 Category: Biomedical Science Source Type: research

Chemokine CXCL14 is a multistep tumor suppressor
Conclusion These data indicate that CXCL14 expressed at high levels does not have severe side effects, and, thus, we propose CXCL14 as a promising molecular target for cancer suppression/prevention. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - September 5, 2015 Category: Biomedical Science Source Type: research

Dental plaque as a biofilm and a microbial community—Implications for treatment
Conclusion An appreciation of ecological principles can lead to new strategies for treatment by identifying and removing the factors that drive dysbiosis, while actively supporting the growth of the natural oral microbiota. Also, the beneficial activities of the resident oral microbiota are retained and the risk of dysbiosis is reduced. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 22, 2015 Category: Biomedical Science Source Type: research

Dental plaque as a biofilm and a microbial community – implications for treatment
Conclusion An appreciation of ecological principles can lead to new strategies for treatment by identifying and removing the factors that drive dysbiosis, while actively supporting the growth of the natural oral microbiota. Also, the beneficial activities of the resident oral microbiota are retained and the risk of dysbiosis is reduced. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 19, 2015 Category: Biomedical Science Source Type: research

Biomaterial properties of titanium in dentistry
Conclusion This review presents an overview of the properties of titanium that are vital for its use in implant dentistry. From a restorative perspective, interaction between implant restoration metals, intra-oral fluorides and pH may cause titanium to corrode. Therefore, in order to avoid the resulting deleterious effects, an understanding of these interactions is important for long-term prognosis of implant restorations. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 15, 2015 Category: Biomedical Science Source Type: research

Review: Biomaterial properties of titanium in dentistry
Conclusion This review presents an overview of the properties of titanium that are vital for its use in implant dentistry. From a restorative perspective, interaction between implant restoration metals, intra-oral fluorides and pH may cause titanium to corrode. Therefore, in order to avoid the resulting deleterious effects, an understanding of these interactions is important for long-term prognosis of implant restorations. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 12, 2015 Category: Biomedical Science Source Type: research

Alterations of the oral microbiota and oral clinical findings in dry mouth
Conclusion In order to treat the various dry mouth-associated health concerns, an understanding of the qualitative alterations of the oral microbiota occurring in dry mouth and appropriate prophylaxis of oral disease are required. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 23, 2015 Category: Biomedical Science Source Type: research

The sonic hedgehog signaling pathway and the development of pharyngeal arch Derivatives in Haplochromis piceatus, a Lake Victoria cichlid
Conclusions These results suggest that the shh pathway is important for the development of pharyngeal arch derivatives such as teeth, premaxilla, operculum, and gill filaments in H. piceatus. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 18, 2015 Category: Biomedical Science Source Type: research

GLP-1R expression in the major salivary glands of rats
Conclusions This is the first time that GLP-1R expression has been detected in rat PG, SMG, and SLG. Our findings provide new insights into the effects of GLP-1 and GLP-1R in the major salivary glands of rats. Furthermore, our results indicate a new role for GLP-1 in salivary secretion, and potentially a new pathway for glucose metabolism. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 18, 2015 Category: Biomedical Science Source Type: research

Regulation of transcriptional network system during bone and cartilage development
Conclusion Recent advances in our knowledge about transcriptional network systems contributed to understanding the molecular underpinnings of regulation and pathological disease mechanisms in bone and cartilage. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 13, 2015 Category: Biomedical Science Source Type: research

Inhibition of bone morphogenetic protein-induced osteoblast differentiation
Conclusion In addition to BMP-3, NF-κB, and TLE3, numerous inhibitors suppress BMP-induced osteoblast differentiation. Therefore, a precise understanding of mechanisms underlying the inhibition of osteoblast differentiation may help develop novel methods for treating bone-related diseases or for the tissue engineering of the bone. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 7, 2015 Category: Biomedical Science Source Type: research