Synergistic findings from microbiological and evolutional analyses of virulence factors among pathogenic streptococcal species
ConclusionBacterial pathogens rapidly adapt to clinical intervention, such as antimicrobial agents and vaccination, via horizontal gene transfer, recombination, and/or natural point mutation. It is vital to continue development of innovative analysis methods to counter the mounting threats from evolving bacteria. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

Epigenetics and its implications for oral health
ConclusionEpigenetic mechanisms are highly sensitive and reversible, thereby offers significant potential for their use to develop novel diagnostic tools, pharmacotherapies and personalized based treatment care. However, there is lack of integrated approaches combining epigenomics with proteomics and genomics comparing the usefulness of epigenetic biomarkers in oral health research. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

Elevated concentrations of specific periodontopathic pathogens associated with severe periodontitis in Japanese patients with cardiovascular disease and concomitant obesity
ConclusionsPatients with CVD and concomitant obesity showed more severe periodontitis with increased concentrations of major periodontopathic bacteria than patients without obesity. These bacteria may cause deterioration of CVD and metabolic disorder. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

TGF-β autocrine signaling at secretory-stage enamel
ConclusionLatent TGF-β1 produced and secreted from secretory-stage ameloblasts is activated by MMP20, and the activated TGF-β1 maintains its activity by combining with amelogenin cleavage products processed by the same protease. TGF-β1 moves through the aqueous phase with the water-soluble 13 kDa amelogenin and binds to its receptor on the ameloblast surface, thereby inducing autocrine signaling. Once the ameloblasts differentiate and enter the maturation stage, TGF-β1 is degraded by KLK4, which is produced and secreted by maturation-stage ameloblasts, and loses its activity. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2018 Category: Biomedical Science Source Type: research

Epigenetics and its implications for oral health
Conclusion Epigenetic mechanisms are highly sensitive and reversible, thereby offers significant potential for their use to develop novel diagnostic tools, pharmacotherapies and personalized based treatment care. However, there is lack of integrated approaches combining epigenomics with proteomics and genomics comparing the usefulness of epigenetic biomarkers in oral health research. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 14, 2018 Category: Biomedical Science Source Type: research

Comparative gene expression profiles of dental follicle at different stages of periodontal development: Combined use of laser capture microdissection and microarray
Conclusions The delineation of the differential gene expressions between pre- and post-natal developmental stages of DF in vivo will increase the understanding of periodontal tissue development. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 14, 2018 Category: Biomedical Science Source Type: research

Donor –host tissue interaction in allogenic transplanted tooth germ with special reference to periodontal tissue
Conclusions The current tooth germ transplantation suggests that the PDL contains putative stem cells, which never proliferate during E15–17, and is composed of resident dental follicle-derived cells and other cell population. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 14, 2018 Category: Biomedical Science Source Type: research

Effects of salt taste disorder on behavior and lifespan in Drosophila melanogaster
Conclusions The results of this study suggest that although NaCl taste disorder results in reduced feeding and breeding behaviors in Drosophila, it does not impact lifespan. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 14, 2018 Category: Biomedical Science Source Type: research

Oral biosciences: The annual review 2017
Conclusion These reviews in the Journal of Oral Biosciences have inspired its readers to broaden their knowledge regarding the various aspects of oral biosciences. The current editorial review introduces these exciting review articles. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 14, 2018 Category: Biomedical Science Source Type: research

Synergistic findings from microbiological and evolutional analyses of virulence factors among pathogenic streptococcal species
Conclusion Bacterial pathogens rapidly adapt to clinical intervention, such as antimicrobial agents and vaccination, via horizontal gene transfer, recombination, and/or natural point mutation. It is vital to continue development of innovative analysis methods to counter the mounting threats from evolving bacteria. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 14, 2018 Category: Biomedical Science Source Type: research

Elevated concentrations of specific periodontopathic pathogens associated with severe periodontitis in Japanese patients with cardiovascular disease and concomitant obesity
Conclusions Patients with CVD and concomitant obesity showed more severe periodontitis with increased concentrations of major periodontopathic bacteria than patients without obesity. These bacteria may cause deterioration of CVD and metabolic disorder. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 14, 2018 Category: Biomedical Science Source Type: research

Roles of non-canonical Wnt signaling pathways in bone resorption
Conclusion Wnt5a and Wnt16 tightly regulate osteoclast differentiation and function in order to maintain bone mass under physiological conditions. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 14, 2018 Category: Biomedical Science Source Type: research

Orthodontic tooth movement and HMGB1
Conclusion Orthodontic force modulates HMGB1 expression in PDL fibroblasts, and HMGB1 is an accessory regulator of bone resorption and bone formation during OTM. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 14, 2018 Category: Biomedical Science Source Type: research

The temporospatial pattern of energy metabolism coordinates the interactions between the bones and other organ systems
Conclusion Studies on the connections between bones and other organ systems indicate the possible existence of a temporospatial pattern of energy metabolism through the cellular biorhythm and migration. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - November 23, 2017 Category: Biomedical Science Source Type: research

Expression of N-cadherin and cell surface molecules in the taste buds of mouse circumvallate papillae
Conclusions Our study indicated that N-cadherins are expressed in type II and III taste cells. Taken together with results from previous studies, we propose that N-cadherins might play a functional role in the establishment of nerve terminal connections. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - September 21, 2017 Category: Biomedical Science Source Type: research

Evaluation of shear bond strength between PEEK and resin-based luting material
Conclusions This study found that the bond strength between PEEK and resin-based luting materials was not adequate for clinical use of PEEK. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - September 21, 2017 Category: Biomedical Science Source Type: research

Dentin hypersensitivity and emerging concepts for treatments
Conclusion The ideal treatment for dentin hypersensitivity should restore the original impermeability of the dentinal tubules. A novel way to treat dentin hypersensitivity is the regeneration of tubular dentin to overcome microleakage. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - September 8, 2017 Category: Biomedical Science Source Type: research

Oral immunization with Porphyromonas gingivalis outer membrane protein and CpG oligodeoxynucleotides attenuates P. gingivalis-accelerated atherosclerosis and inflammation
Conclusions These results suggest that oral administration of 40k-OMP plus CpG ODN may be an effective vaccine for the prevention of accelerated atherosclerosis caused by P. gingivalis infection. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - August 12, 2017 Category: Biomedical Science Source Type: research

Cytoskeleton, intercellular junctions, planar cell polarity, and cell movement in amelogenesis
Conclusion One core PCP protein, VANGL2, is proposed to be a key molecule determining the direction of ameloblast movement. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 27, 2017 Category: Biomedical Science Source Type: research

A review of chitosan's effect on oral biofilms: Perspectives from the tube to the mouth
Conclusion Currently, the body of work on chitosan and the oral cavity ranges from planktonic studies in vitro to biofilm control/removal studies in vivo. With a wide range of topics available for analysis, this review provides a working understanding of chitosan's role in the control and management of oral biofilms. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 25, 2017 Category: Biomedical Science Source Type: research

Dynamic expression of nectins in enamel organs of mouse incisors
Conclusion These results indicate that nectins show graded and overlapping distribution in mouse incisors. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 8, 2017 Category: Biomedical Science Source Type: research

Structural characterization of endogenous peroxidase activity in human, rat, hamster, and Suncus murinus salivary glands
Conclusion The technique proposed here may result in novel applications for DAB-based histochemistry. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 8, 2017 Category: Biomedical Science Source Type: research

Quantification of dental plaque in oral cavity was enabled by a novel algorithm of image processing
Conclusions We successfully developed a novel method, designated “plaque volume ratio,” to quantify the plaque accurately from photographic image data. Our findings indicated that this method may be useful for the evaluation of the amount of plaque on the surfaces of not only teeth but also dental materials in the oral cavity. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 6, 2017 Category: Biomedical Science Source Type: research

Role of an Autoinducer-2-like Molecule from Veillonella tobetsuensis in Streptococcus gordonii Biofilm Formation
Conclusions These results suggest that an AI-2-like molecule from V. tobetsuensis is a potential inhibitor of the development of S. gordonii biofilms and could be used for the prevention of early-stage oral biofilm formation. However, the V. tobetsuensis factors that promote the development of S. gordonii biofilms will need to be explored in future studies. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 1, 2017 Category: Biomedical Science Source Type: research

Circadian Clock and Bone Biology
Conclusion This review focuses on the latest knowledge on the molecular mechanisms of biological clocks and their roles in bone biology, indicating the potential of this clock system in the treatment of bone disorders. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - July 1, 2017 Category: Biomedical Science Source Type: research

Positional and ultrastructural changes in peripheral pulp capillaries correlate with the active phase of dentin deposition and mineralization in rat molars
Conclusions These results indicate that the positional and ultrastructural changes in peripheral capillaries correlate with the active phase of dentin deposition and mineralization. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 23, 2017 Category: Biomedical Science Source Type: research

VAMP4 and its cognate SNAREs are required for maintaining the ribbon structure of the Golgi apparatus
Conclusion Our findings suggest that VAMP4 and its cognate SNAREs are required for maintaining the Golgi ribbon structure by balancing membrane transport between the endosome and TGN. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 10, 2017 Category: Biomedical Science Source Type: research

Binding properties between human sweet receptor and sweet-inhibitor, gymnemic acids
Conclusion Gymnemic acids inhibit sweet responses in humans through an interaction between the glucuronosyl group of gymnemic acids and the transmembrane domain of hTAS1R3. Our molecular model provides a foundation for the development of taste modifiers. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 10, 2017 Category: Biomedical Science Source Type: research

Novel function of Porphyromonas gingivalis gingipains in the PI3K/Akt signaling pathway
Conclusion This review describes the biological characterization of gingipains, which inactivate PI3K and Akt, and disorder the PI3K/Akt signaling pathway. Hence, gingipains may decrease cellular physiological functions, eventually disrupting the gingival epithelium and causing development of periodontal diseases. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - June 1, 2017 Category: Biomedical Science Source Type: research

The W9 peptide directly stimulates osteoblast differentiation via RANKL signaling
Conclusions The W9 peptide inhibited RANKL-mediated osteoclast formation in osteoblasts. It also directly stimulated osteoblast differentiation, both via RANKL signaling-mediated autocrine factors, and alternative mechanisms. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 25, 2017 Category: Biomedical Science Source Type: research

Scardovia wiggsiae and its potential role as a caries pathogen
Conclusion S. wiggsiae was associated with advanced and initial caries, is acid tolerant and produces acid to low pH at initial neutral and low pH conditions. In combination with S. mutans, S. wiggsiae was detected in caries in an animal model. Together, these data suggest that S. wiggsiae has many of the characteristics consistent with its being a caries-associated species. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 24, 2017 Category: Biomedical Science Source Type: research

Bone Quality Characteristics Obtained by Fourier Transform Infrared and Raman Spectroscopic Imaging
Conclusion The PO4 3- bands in the FTIR spectra were affected by changes in calcium phosphate composition rather than by changes in crystal size. Thus, FTIR is more suitable for the evaluation of mineral maturity than crystallinity; Raman spectroscopy is more sensitive to crystallinity than FTIR. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - May 14, 2017 Category: Biomedical Science Source Type: research

Phospholipase C-related catalytically inactive protein-knockout mice exhibit uncoupling protein 1 upregulation in adipose tissues following chronic cold exposure
Conclusion Prip-KO mice exhibit greater ability to consume lipids as an energy source, indicating that PRIP modulates of systemic energy expenditure. Our findings provide increased understanding of PRIP-mediated non-shivering thermogenic mechanisms and offers important insights for the treatment and control of obesity. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 13, 2017 Category: Biomedical Science Source Type: research

Molecular mechanisms for activation of mutant activin receptor-like kinase 2 in fibrodysplasia ossificans progressiva
Conclusion BMP type II receptor-dependent phosphorylation of ALK2 mutants in response to ligand binding is important for the activation of BMP signaling in FOP. Therefore, the use of anti-activin A compounds would be a novel treatment approach for FOP. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 13, 2017 Category: Biomedical Science Source Type: research

Overexpression of Sp7 in odontoblasts results in dentinogenesis imperfecta due to the inhibition of odontoblast maturation
Conclusions These results indicate that sustained Sp7 expression in differentiated odontoblasts inhibits odontoblast maturation and reduces the expression of dentin matrix proteins; however, it fails to induce the transdifferentiation of odontoblasts into osteoblasts, which occurs in Runx2 transgenic mice. Therefore, Sp7 expression needs to be down-regulated to an appropriate level for odontoblast maturation. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - April 5, 2017 Category: Biomedical Science Source Type: research

Regulation of hemodynamics in major salivary glands by parasympathetic vasodilation
Conclusion Glandular hemodynamics in the submandibular, parotid, and sublingual glands are regulated by different parasympathetic vasodilator mechanisms, which may functionally contribute to the differences in secretion among the major salivary glands. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 28, 2017 Category: Biomedical Science Source Type: research

Differentiation capacity and maintenance of dental pulp stem/progenitor cells in the process of pulpal healing following tooth injuries
Conclusion Host and recipient interactions that occur with allografts disturb the maintenance of putative stem/progenitor cells, resulting in the disappearance of these cell types. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - March 22, 2017 Category: Biomedical Science Source Type: research

New functions of lysosomes in bone cells
Conclusion RAB27A participates in bone resorption by LROs in osteoclasts. In addition, lysosomal biogenesis modulated by TFEB is necessary for osteoblastic differentiation. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - February 2, 2017 Category: Biomedical Science Source Type: research

Determinants for selective transport of exogenously expressed cargo proteins into regulated and constitutive secretory pathways
Conclusion In order to study the sorting mechanism for secretory proteins, some evaluation of the cells’ ability to synthesize, transport, and store the proteins is required. The HaloTag method has proved promising for the quantification of transportation in the two pathways. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 25, 2017 Category: Biomedical Science Source Type: research

Japanese workers with long leisure time have deteriorated periodontal condition: A cross-sectional study
Conclusions Subjects with long leisure time showed aggregated periodontal condition consistent with increased serum antibody against periodontal bacteria compared to subjects with short free time. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 24, 2017 Category: Biomedical Science Source Type: research

Premotoneuronal inputs to early developing trigeminal motoneurons
Conclusions These results suggested that, similar to P1–5 motoneurons, both P9–12 motoneurons received convergent inputs from the SupV, IntV, and PrV; however, the input–output gains of some of the premotor neurons decreased. These synaptic input changes may contribute to the proper development of chewing. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - January 24, 2017 Category: Biomedical Science Source Type: research

Oral Biosciences: The annual review 2016
Conclusion These published reviews in the Journal of Oral Biosciences have inspired the readers of the Journal to broaden their knowledge regarding the various aspects of oral biosciences. The current editorial review introduces these exciting review articles. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 15, 2016 Category: Biomedical Science Source Type: research

Involvement of microglia and astroglia in modulation of the orofacial motor functions in rats with neuropathic pain
Conclusion The results observed in our studies suggest the involvement of microglia and astroglia in the alteration of orofacial motor activity during neuropathic pain. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 5, 2016 Category: Biomedical Science Source Type: research

Bioactive peptides hidden in human salivary proteins
Conclusion Human salivary proteins have the ability to generate bioactive peptides upon proteolytic cleavage. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 5, 2016 Category: Biomedical Science Source Type: research

Biological application of focus ion beam-scanning electron microscopy (FIB-SEM) to the imaging of cartilaginous fibrils and osteoblastic cytoplasmic processes
Conclusion Taken together, these data suggest that FIB-SEM imaging of serial bone sections may facilitate new insights on the ultrastructure of cartilage and bone tissues. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - December 5, 2016 Category: Biomedical Science Source Type: research

Fibroblasts and macrophages: Key players in the head and neck cancer microenvironment
Conclusion CAFs can promote HNSCC progression through direct contact and/or paracrine signaling. Interactions between HNSCC cells and CAFs stimulate expression of various growth factors, cytokines, chemokines, MMPs, and periostin. TAMs in HNSCC upregulate the production of IL-1β, IL-10, and MIP-3α/CCL20, which are involved in tumorigenic processes. Graphical abstract (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - November 25, 2016 Category: Biomedical Science Source Type: research

Porphyromonas gingivalis promotes low-density lipoprotein oxidation and atherosclerosis
Conclusions These results suggest that Pg promotes LDL oxidation and contributes to atheroma development. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - November 11, 2016 Category: Biomedical Science Source Type: research

Aneuploidy of a murine immortalized endothelial cell line, MS1
Conclusion MS1 cells are aneuploid and activate H2AX to a greater extent than NECs do. MS1 cells resemble TECs in terms of the proliferative phenotype and aneuploidy. Thus, MS1 may be a good cell line for studies on the relation between chromosomal instability and a DDR in nonmalignant cells. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - November 5, 2016 Category: Biomedical Science Source Type: research

The small GTPase, Rab27, and its effectors and regulators participate in granule exocytosis by parotid acinar cells
Conclusion Exocytosis occurs via a Rab27 GDP/GTP cycling mechanism in parotid acinar cells. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - November 4, 2016 Category: Biomedical Science Source Type: research

Evaluation of a new mouse model for studying dental pulpal responses to GaAlAs laser irradiation
Conclusions The current output energy induced apoptosis in the affected dental pulp, followed by active cell proliferation, resulting in tertiary dentin formation. This is the first report regarding laser irradiation of teeth in an in vivo mouse model. This model could enable further understanding of the function of certain proteins, including transcriptional factors. (Source: Journal of Oral Biosciences)
Source: Journal of Oral Biosciences - October 29, 2016 Category: Biomedical Science Source Type: research