Free Fibular Flap Neomandible Density Changes in a Previously Irradiated Tissue Bed
Microvascular fibula free flaps have become the gold standard for mandibular reconstruction. Various indications for maxillofacial reconstruction via microvascular fibula free flaps include benign tumors/cysts (ameloblastomas, odontogenic keratocysts, dentigerous cysts), osteoradionecrosis, and trauma. Our study set out to analyze the bone density of a microvascular fibula free flap neomandible reconstruction. Previous studies have evaluated these bone density changes; however, no study has compared the density changes of fibula reconstructions due to benign indications versus previously irradiated tissue beds. (Source: Jo...
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Jeremiah D'Anna, Andrew Salama, David Hirsch, Denis Knobel Source Type: research

Developing Novel Therapeutics for Oral Cancer Leveraging Drosophila Models
The prevalence of oral squamous cell carcinoma (OSCC) has been increasing worldwide. Surgical resection and chemoradiotherapy are the main OSCC treatments currently, but their effectiveness is limited. One of their major problems is the decline in patients ’ quality of life due to oral dysfunction caused by the extensive resection and oral mucositis. Although targeted therapies have emerged for treating OSCC and have improved the patients’ survival rate, these therapies also cause severe side effects that hamper completion of the regimens. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Taku Kimura, Masahiro Sonoshita, Yoshimasa Kitagawa Source Type: research

Tumor Microenvironment Modulation by Cetuximab and its Contribution to Subsequent Immune-Checkpoint Inhibition Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
Current clinical and observational evidence supports the EXTREME regimen as 1 of the standards of care for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) followed by the administration of immune checkpoint inhibitors (ICIs). In addition to the inhibition of the endothelial growth factor receptor (EGFR) pathway, cetuximab-mediated EGFR blockade has been shown to modulate tumor microenvironment (TME) characteristics, such as antibody-dependent cellular cytotoxicity (ADCC) activity, cytotoxic T-lymphocyte (CTL) infiltration into the tumor, anti-angiogenesis activity, and cytokine secre...
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Kohei Okuyama, Tomofumi Naruse, Souichi Yanamoto Source Type: research

Identifying Great Auricular Nerve via Bony Landmarks: A Cadaver Study
Great Auricular Nerve (GAN) is the most commonly sacrificed nerve during rhydectomies due to anatomical variation and lack of a reliable landmark.1 Even though quality of life does not decrease, surgeons should strive to avoid iatrogenic injury to the nerve. The aim of this study is to utilize 2 bony landmarks for the GAN to determine which if there is a reliable, bony anatomical landmark during surgery, specifically calculating the ratio at which the angle of the mandible (gonion) and tip of the mastoid process bisect GAN. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: May Lin, Dale A. Baur, Guneet Singh Source Type: research

Obstructive Sleep Apnea in Young Adults Undergoing Orthognathic Surgery: Impact on Length of Stay and Hospital Admission Costs
Length of hospital stay (LOS) significantly affects costs and is a frequently employed metric for quality of care. Obstructive sleep apnea (OSA) has been demonstrated to elevate the risk of postoperative complications and prolong LOS in patients undergoing orthognathic surgery. However, previous studies have predominantly focused on OSA patients amongst older adults and those with underlying comorbidities. A paucity of data exists regarding younger patients with OSA undergoing orthognathic surgery. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Samuel Daley, Syed Abbas Raza, Hunter Martin, Andrew Salama Tags: Obstructive Sleep Apnea (OSA) Source Type: research

OSA as a Consideration in Upper Jaw Surgery
Segmental LeFort I osteotomy is useful for the management of transverse and vertical maxillary discrepancies. However, some patients in need of orthognathic surgery may also have risk factors for obstructive sleep apnea (OSA) in which clinicians must be conscious about how surgery will affect the soft palate, the most commonly involved area of obstruction (77.9%).1 Furthermore, in patients who need palatal expansion and maxillary advancement for the purpose of increasing airway volume and treating OSA, it is important to consider whether the segmental LeFort I osteotomy will provide similar advancement of the palate compar...
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Vania Firmalino, Thomas Kim, Joshua A. Stone, Stanley Y. Liu Source Type: research

Three-Dimensional Airway Changes and AHI Reduction Following Maxillomandibular Advancement and Genioglossus Advancement in Patients with Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a common disorder characterized by repeated airway obstruction throughout the night. Sequela of untreated and long standing OSA includes increase in all-cause mortality, cardiovascular disease, such pulmonary/systemic hypertension or cardiac arrhythmias, cerebrovascular events, cognitive impairment, diabetes, and overall decrease in quality of life. Therefore, treatment is strongly recommended. Maxillomandibular advancement (MMA) and genioglossus advancement (GA) have been shown to improve or eliminate OSA, as it leads to an increase in posterior airway volume and, therefore, decreased airw...
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Mina Boulos, Daniel I. Taub Source Type: research

CBCT Analysis of the Descending Palatine Canal for LeFort I Osteotomy
The most significant morbidity from maxillary orthognathic surgery is blood loss. Since avascular necrosis may occur as a result of blood loss, the descending palatine artery (DPA) should be preserved whenever possible.1 This requires a clear understanding of the anatomic position of the descending palatine canal (DPC). Studies have delineated the position of DPA by measuring the piriform rim-to-DPC distance (PDC). However, the clinical applicability of the data is limited due to variability in the method of measurement and subject characteristics. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Steven Licht, Michael Miloro, Michael D. Han Tags: Orthognathic Surgery Source Type: research

The Change of the Hyoid Bone Position After Orthognathic Surgery Using 3-Dimensional Computed Tomography in Mandibular Prognathism
Many studies have been reported on the hyoid bone, which are thought to affect the stability of the dentition and the mandible after orthognathic surgery. Most of these studies are mainly conducted using cephalometric radiographs, but the overlap and difference in magnification makes it difficult to evaluate accurately and there was a possibility of error due to flat analysis. The 3-dimensional computed tomography has recently been widely used in orthodontic patients for diagnosis, treatment plan, surgical indicators, evaluation of surgical results, and follow-up studies. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Young Long Park, Min-Woo Kang, Taeyeong Kim, Jae-Young Kim, Jong-Ki Huh Source Type: research

Hardware Failure after Orthognathic Surgery
The likelihood of hardware failure following orthognathic surgery depends on various factors such as the type and location of the hardware, the patient's age and health, and adherence to postoperative instructions. This project aims to investigate hardware failure associated with commonly performed orthognathic procedures at the University of Cincinnati Medical Center (UCMC) from 2008 to 2020. We specifically focused on Bilateral Sagittal Split Mandibular Osteotomy (BSSO), Lefort I maxillary Osteotomy, and Genioplasty. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Soroush Samimi, Deepak Krishnan Source Type: research

Does Removal of Third Molars at the Time of Sagittal Split Osteotomy Impact Intraoperative Complications? A Retrospective Review from a Single Institution and Single Surgeon from 2015 - 2021
The sagittal split osteotomy (SSO) is a predictable and reliable procedure to correct dentofacial deformities of the mandible. First performed by Obwegeser, there have been many modifications to the procedure. The decision to simultaneously remove mandibular third molars at the time of SSO has been debated in the literature1 and within clinical practice, with evidence supporting both sides. In addition, de Souza et al meta-analysis of 19 articles showed no statistical difference in unfavorable fractures or neurosensory disturbances in those that had third molars removed simultaneously with SSO. (Source: Journal of Oral and...
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Tyler Horton, Timothy A. Turvey, Michelle Chen, Grant Egnatz, Matthew Lowe Source Type: research

Relationship Between Temporal and Masseter Muscle Status and Skeletal Patterns With Facial Asymmetry
Facial morphology is the result of complex integration between genetics and epigenetics. Based on the theory of the functional matrix, the bones do not grow but are grown and regulated by the surrounding soft tissues. Each mandibular unit is related to a different functional matrix, such as the angular unit and the masseter and medial pterygoid muscle, and the coronoid unit and the temporalis muscle. Among the masticatory muscles, the masseter and temporalis muscles not only play roles in regulating the growth pattern, but also serve as reliable structures for diagnosis of temporomandibular disorder (TMD). (Source: Journal...
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Chaeyeon Lee, Minwoo Kang, Taeyeong Kim, Jae-Young Kim, Jong-Ki Huh Source Type: research

Do Changes in Orthognathic Surgery Reimbursement Affect the Volume of Procedures Performed at an Academic Medical Center?
Previous literature has described declining reimbursement rates for orthognathic surgery leading to surgical volume reduction and sparking discussion about the future of these procedures.1 Many patients are now referred to academic medical centers, away from private practices, which may cause these centers to become havens for orthognathic surgery.2 We aimed to review the orthognathic surgical volume at an academic medical center over a 13-year period, and to determine correlations between the average charges and collections with the volume of these procedures performed per year. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Andrew J. Deek, Devin Clegg, Caleb Blackburn, Patricia N.E. Roberson, J. Franklin Murchison, Christopher A. Scott, Tyler Holley, Jack E. Gotcher Source Type: research

An Acoustic Speech Analysis of Patients Before and After Orthognathic Surgical Intervention Using Praat
Orthognathic surgery along with orthodontic treatment can be used to correct for dental malocclusion in patients with concomitant maxillo-mandibular skeletal deformities. Prior studies have shown favorable postoperative speech changes following corrective orthognathic surgery with non-cleft patients. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Odai Abushanab Source Type: research

Alveolar Bone Change After the Decompensation of Maxillary and Mandibular Anterior Teeth in Surgical Skeletal Class III Patients
This study aimed to evaluate the alveolar bone change of maxillary and mandibular anterior teeth in skeletal Class III patients who had orthognathic surgery. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 1, 2023 Category: ENT & OMF Authors: Junghoon Kim, Seok-Young Kim Source Type: research