Anesthesia-induced Recognition Deficit Is Improved in Postnatally Gonadectomized Male Rats
Conclusions: The absence of testosterone does not block cell death after anesthesia in specific brain regions of interest; however, does provide some neuroprotection as evidenced by the improved cognitive test performance during adulthood. These findings suggest that testosterone may be mechanistically involved in the sex-specific effects of anesthetic injury on the developing brain by extending the vulnerable period in male rats. (Source: Journal of Neurosurgical Anesthesiology)
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Laboratory Investigation Source Type: research

Management of Endovascular Treatment for Acute Ischemic Stroke During the COVID-19 Pandemic at a Single Institution in Beijing, China: A Brief Report
Background: The coronavirus disease (COVID-19) pandemic is currently a major challenge for health care systems around the world. For a time-sensitive emergency such as acute ischemic stroke (AIS), streamlined workflow times are essential to ensure good clinical outcomes. Methods: The aim of this single-center, retrospective, observational study was to describe changes in stroke workflow patterns and clinical care during the COVID-19 pandemic. Data from AIS patients undergoing emergent endovascular treatment (EVT) between 23 January and 8 April 2020 were retrospectively collected and compared with data from patie...
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Short Reports Source Type: research

Anesthesia During Positive-pressure Myelogram: A New Role for Cerebral Oximetry
Background: Positive-pressure myelogram (PPM) is an emerging radiologic study used to localize spinal dural defects. During PPM, cerebrospinal fluid pressure (CSFp) is increased by injecting saline with contrast into the cerebrospinal fluid. This has the potential to increase intracranial pressure and compromise cerebral perfusion. Methods: We performed a retrospective chart review and analysis of 11 patients. The aim was to describe the periprocedural anesthetic management of patients undergoing PPM. Results: All patients underwent PPM with general anesthesia and intra-arterial blood pressure and near-in...
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Short Reports Source Type: research

The Incidence and Magnitude of Cerebral Desaturation in Traumatic Brain Injury: An Observational Cohort Study
The objective of this study was to determine the incidence and severity of regional cerebral oxygen (rSO2) desaturation (rSO2 (Source: Journal of Neurosurgical Anesthesiology)
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Short Reports Source Type: research

Ischemia-modified Albumin as a Biomarker for Prediction of Poor Outcome in Patients With Traumatic Brain Injury: An Observational Cohort Study
Background: Biomarkers can assist in outcome prediction and therapeutic decision making after traumatic brain injury (TBI). The aim of this study was to evaluate the role of ischemia-modified albumin (IMA) in the prediction of mortality in patients with TBI. Methods: In this observational study IMA was measured on admission to intensive care unit (D0) and 24 hours later (D1) in a cohort of patients with mixed TBI severity. The primary outcome was the correlation between IMA and 28-day mortality. Secondary outcomes included the incidence of elevated IMA, and the correlation between the severity of TBI and IMA, an...
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Short Reports Source Type: research

Early Postoperative Outcomes of Normal Pressure Hydrocephalus: Results of a Service Evaluation
Conclusions: Early postoperative outcomes of NPH patients are good after both ventriculoperitoneal shunt insertion and lumbar drainage. This evaluation provides initial evidence on the utility of the C-POMS as a service evaluation tool in the standardized assessment postoperative outcomes in neurosurgery patients. (Source: Journal of Neurosurgical Anesthesiology)
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Clinical Investigations Source Type: research

Scalp Block Is Associated With Improved Recurrence Profiles in Patients Undergoing Primary Glioma Resection Surgery
Conclusions: The study results suggest that the scalp block improves the recurrence profiles of patients receiving primary glioma resection. (Source: Journal of Neurosurgical Anesthesiology)
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Clinical Investigations Source Type: research

A Bolus Dose of Ketamine Reduces the Amplitude of the Transcranial Electrical Motor-evoked Potential: A Randomized, Double-blinded, Placebo-controlled Study
Background: A low-dose bolus or infusion of ketamine does not affect transcranial electrical motor-evoked potential (MEP) amplitude, but a dose ≥1 mg/kg may reduce MEP amplitude. We conducted a randomized, double-blinded, placebo-controlled study to evaluate the effect of ketamine (1 mg/kg) on transcranial electrical MEP. Methods: Twenty female patients (aged 12 to 18 y) with adolescent idiopathic scoliosis scheduled to undergo posterior spinal fusion were randomly allocated to receive ketamine or saline. General anesthesia was induced and maintained with continuous infusions of propofol and remifentanil...
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Clinical Investigations Source Type: research

Recent Preoperative Concussion and Postoperative Complications: A Retrospective Matched-cohort Study
Conclusions: There were no differences in intraoperative and postoperative outcomes in patients with recent concussion compared with unexposed patients. Before correction for multiple comparisons, several potential targets for further investigation are identified. Well-powered studies are warranted. (Source: Journal of Neurosurgical Anesthesiology)
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Clinical Investigations Source Type: research

Postoperative Nausea and Vomiting After Craniotomy: An Evidence-based Review of General Considerations, Risk Factors, and Management
One of the most common and distressing symptoms after craniotomy is postoperative nausea and vomiting (PONV). PONV could generate delayed postanesthesia care and hospitalization discharge, lower patient satisfaction, and an increase in overall hospitalization costs. The incidence of reported PONV after craniotomy is 22% to 70% without prophylaxis, and a multimodal regimen of medication has been recommended. We conducted a comprehensive literature review of the clinical evidence related to PONV prevention and management after craniotomy. All clinical trials in adult populations relevant to PONV after craniotomy available in...
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Review Articles Source Type: research

Neurosurgical Interventions for Neurotrauma in the Obstetric Population: A Systematic Review
Trauma requiring neurosurgical intervention in the obstetric population is rare. Provision of care must include consideration for both maternal and fetal well-being, and conflicts may arise. Management strategies to reduce elevated maternal intracranial pressure (ICP) and provide adequate surgical exposure, for example, may compromise uteroplacental perfusion. There is scarce literature to guide anesthetic care and few resources summarizing management of these uncommon cases. We conducted a systematic literature search for English publications of neurosurgical interventions on obstetric patients following trauma. We search...
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Review Articles Source Type: research

Treatment of Subarachnoid Hemorrhage-associated Delayed Cerebral Ischemia With Milrinone: A Review and Proposal
Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage continues to be associated with high levels of morbidity and mortality. This complication had long been thought to occur secondary to severe cerebral vasospasm, but expert opinion now favors a multifactorial etiology, opening the possibility of new therapies. To date, no definitive treatment option for DCI has been recommended as standard of care, highlighting a need for further research into potential therapies. Milrinone has been identified as a promising therapeutic agent for DCI, possessing a mechanism of action for the reversal of cerebral va...
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Review Articles Source Type: research

Twitter Journal Clubs in Perioperative Neuroscience: Opportunities and Challenges
No abstract available (Source: Journal of Neurosurgical Anesthesiology)
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Editorials Source Type: research

Delayed Cerebral Ischemia: Is Prevention Better Than Treatment?
No abstract available (Source: Journal of Neurosurgical Anesthesiology)
Source: Journal of Neurosurgical Anesthesiology - June 18, 2021 Category: Anesthesiology Tags: Editorials Source Type: research

Intraoperative Magnetic Resonance Imaging–induced Oropharyngeal Thermal Injury in a Patient With Acromegaly
No abstract available (Source: Journal of Neurosurgical Anesthesiology)
Source: Journal of Neurosurgical Anesthesiology - March 11, 2021 Category: Anesthesiology Tags: Correspondence Source Type: research