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Endovascular treatment for acute ischemic stroke in patients with tandem lesion in the anterior circulation: analysis from the METRICS study
Conclusion Patients with TL did not differ from those with SO in outcomes after EVT. TL patients with prior IVT had more complete recanalization and mRS 0–2 and IVT was found to be a predictor of good outcome after EVT. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Sanak, D., Kocher, M., Zapletalova, J., Cihlar, F., Czerny, D., Cernik, D., Duras, P., Fiksa, J., Husty, J., Jurak, L., Kovar, M., Lacman, J., Padr, R., Prochazka, P., Raupach, J., Reiser, M., Rohan, V., Roubec, M., Sova, J., Sercl, M., Skorna, M., Simune Tags: Ischemic stroke Source Type: research

Mildly elevated INR is associated with worse outcomes following mechanical thrombectomy for acute ischemic stroke
Conclusion In patients with stroke treated with MT, mildly elevated INR is associated with worse clinical outcomes after recanalization and may worsen the mortality risk of hemorrhagic transformations. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Chen, H., Ahmad, G., Colasurdo, M., Yarbrough, K., Schrier, C., Phipps, M. S., Cronin, C. A., Mehndiratta, P., Cole, J. W., Wozniak, M., Miller, T. R., Gandhi, D., Jindal, G., Chaturvedi, S. Tags: Ischemic stroke Source Type: research

Impact of aspiration catheter size on clinical outcomes in aspiration thrombectomy
Conclusions Larger aspiration catheters are associated with a higher rate of FPE, final recanalization with only an aspiration catheter, and in cases with rescue modalities, though with a higher rate of hemorrhagic complications. These findings confirm that aspiration catheter size functions as a variable in aspiration thrombectomy, which should be considered in future study and trial design. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Schartz, D., Ellens, N., Kohli, G. S., Rahmani, R., Akkipeddi, S. M. K., Colby, G. P., Hui, F., Bhalla, T., Mattingly, T., Bender, M. T. Tags: Ischemic stroke Source Type: research

Time to treatment with bridging intravenous alteplase before endovascular treatment:subanalysis of the randomized controlled SWIFT-DIRECT trial
Conclusions We found no evidence that the effect of bridging IVT on functional independence is modified by overall or in-hospital treatment delays. Considering its low power, this subgroup analysis could have missed a clinically important effect, and exploratory analysis of secondary clinical outcomes indicated a potentially favorable effect of IVT with shorter in-hospital delays. Heterogeneity of the IVT effect size before MT should be further analyzed in individual patient meta-analysis of comparable trials. Trial registration number URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03192332 (Source: Journal o...
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Meinel, T. R., Kaesmacher, J., Buetikofer, L., Strbian, D., Eker, O. F., Cognard, C., Mordasini, P., Deppeler, S., Mendes Pereira, V., Albucher, J. F., Darcourt, J., Bourcier, R., Guillon, B., Papagiannaki, C., Costentin, G., Sibolt, G., Räty, S., Tags: Open access, Ischemic stroke Source Type: research

Multicenter investigation of technical and clinical outcomes after thrombectomy for distal vessel occlusion by frontline technique
Conclusions Outcomes following EVT for DVO are comparable to LVO with similar results between techniques. Techniques may exhibit different futility metrics; stent retriever thrombectomy was influenced by attempts whereas aspiration was more dependent on procedure time. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Alawieh, A. M., Chalhoub, R. M., Al Kasab, S., Jabbour, P., Psychogios, M.-N., Starke, R. M., Arthur, A. S., Fargen, K. M., De Leacy, R., Kan, P., Dumont, T. M., Rai, A., Crosa, R. J., Maier, I., Goyal, N., Wolfe, S. Q., Cawley, C. M., Mocco, J., Tjoumaka Tags: Ischemic stroke Source Type: research

Long-term effect of field triage on times to endovascular treatment for emergent large vessel occlusion
Conclusions Comparing adjacent states over time, the implementation of severity-based field triage significantly reduced time to EVT. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Jayaraman, M. V., Baird, G., Oueidat, K., Paolucci, G., Haas, R. A., Torabi, R., Moldovan, K., Rhodes, J., Potvin, J., Alexander-Scott, N., Yaghi, S., Madsen, T., Furie, K., McTaggart, R. A. Tags: Ischemic stroke Source Type: research

Thrombus radiomics in patients with anterior circulation acute ischemic stroke undergoing endovascular treatment
Conclusions TR describing thrombus volume and texture were associated with more attempts to successful reperfusion. Compared with models using CV and MTM, TR had no added value for predicting procedural and functional outcome. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: van Voorst, H., Bruggeman, A. A. E., Yang, W., Andriessen, J., Welberg, E., Dutra, B. G., Konduri, P. R., Arrarte Terreros, N., Hoving, J. W., Tolhuisen, M. L., Kappelhof, M., Brouwer, J., Boodt, N., van Kranendonk, K. R., Koopman, M. S., Hund, H. M., Kri Tags: Ischemic stroke Source Type: research

Contrast conservation measures during the global iohexol contrast shortage crisis did not affect stroke thrombectomy outcomes
Conclusions Modifying stroke workflow to adapt to the current global shortage in iohexol is feasible. Using diluted iohexol (50% contrast mixed with 50% heparinized saline) did not affect MT outcomes. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Almallouhi, E., Sattur, M., Lajthia, O., Kicielinski, K. P., Holmstedt, C., Lena, J. R., Al Kasab, S., Spiotta, A. M. Tags: Ischemic stroke Source Type: research

Augmentation of perfusion with simultaneous vasodilator and inotropic agents in experimental acute middle cerebral artery occlusion: a pilot study
Conclusion Results suggest that perfusion can be augmented in ischemic stroke with norepinephrine and hydralazine. Perfusion augmentation depends on degree of collateralization and territory in question, with some evidence of vascular steal. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Liu, M., Saadat, N., Jeong, Y. I., Roth, S., Niekrasz, M., Carroll, T., Christoforidis, G. A. Tags: Ischemic stroke Source Type: research

Thrombus imaging characteristics within acute ischemic stroke: similarities and interdependence
Conclusions Thrombus imaging characteristics are significantly intercorrelated – strong correlations should be considered in future predictive modeling studies. Clustering analysis showed there are no distinct thrombus archetypes – novel treatments should consider this thrombus variability. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Arrarte Terreros, N., Bruggeman, A. A., Kappelhof, M., Tolhuisen, M. L., Brouwer, J., Hoving, J. W., Konduri, P. R., van Kranendonk, K. R., Dutra, B. G., Alves, H. C., Dippel, D. W., van Zwam, W. H., Beenen, L. F., Yo, L. S., van Bavel, E., Majoie, C. B., Tags: Open access, Ischemic stroke Source Type: research

Influence of time metrics on the treatment effect of intravenous alteplase prior to endovascular treatment in MR CLEAN-NO IV
Conclusion In MR CLEAN-NO IV, the effect of IVT prior to EVT was not modified by OTR, OTN, DTG or NTG times. Our results do not support the use of these metrics to guide IVT treatment decisions prior to EVT in comprehensive stroke centres. Trial registration number ISRCTN80619088. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Rinkel, L. A., Treurniet, K. M., Kappelhof, M., LeCouffe, N. E., Bruggeman, A. A. E., Nieboer, D., van Zwam, W. H., Uyttenboogaart, M., Dippel, D. W. J., Emmer, B. J., Roos, Y. B. W. E. M., Majoie, C. B. L. M., Coutinho, J. M., on behalf of the MR CLEAN-N Tags: Ischemic stroke Source Type: research

Stroke imaging modality for endovascular therapy in the extended window: systematic review and meta-analysis
Conclusions Our study suggests that, in anterior circulation LVO, the rates of functional independence may be similar when patients are selected using ADVI or NCCT for EVT in the extended time window. A simplified triage protocol does not seem to increase mortality or sICH. Protocol registration number (PROSPERO ID: CRD42021236092). (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Sequeiros, J. M., Rodriguez-Calienes, A., Chavez-Malpartida, S. S., Moran-Marinos, C., Alvarado-Gamarra, G., Malaga, M., Quincho-Lopez, A., Hernadez-Fernandez, W., Pacheco-Barrios, K., Ortega-Gutierrez, S., Hoit, D., Arthur, A. S., Alexandrov, A. V., Alva Tags: Ischemic stroke Source Type: research

In-stent restenosis after vertebral artery origin stenosis stenting: a nomogram for risk assessment
Conclusions A nomogram and a risk evaluation table were developed with good predictive ability for in-stent restenosis among patients with VAOS, which could serve as a practical approach for individualized risk evaluation. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Yang, K., Fang, S., Zhang, X., Wang, T., Feng, Y., Jiao, L., Yan, Y. Tags: Ischemic stroke Source Type: research

Gene expression profiles of ischemic stroke clots retrieved by mechanical thrombectomy are associated with disease etiology
Conclusions Expression profiles of stroke clots were identified between stroke etiologies and reflected different biologic responses. Cryptogenic thrombi may be related to multiple etiologies. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Tutino, V. M., Fricano, S., Chien, A., Patel, T. R., Monteiro, A., Rai, H. H., Dmytriw, A. A., Chaves, L. D., Waqas, M., Levy, E. I., Poppenberg, K. E., Siddiqui, A. H. Tags: Ischemic stroke Source Type: research

Persistent perfusion abnormalities at day 1 correspond to different clinical trajectories after stroke
Conclusion ASL hypoperfusion within the infarct and the surrounding tissue was associated with poor outcome. A more comprehensive view of the mechanisms in the hypoperfused surrounding tissue could help to design new therapeutic approaches during and after reperfusion therapies. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Rosso, C., Belkacem, S., Amor-Sahli, M., Clarencon, F., Leger, A., Baronnet, F., Dormont, D., Alamowitch, S., Lehericy, S., Samson, Y. Tags: Ischemic stroke Source Type: research