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Thrombus radiomics in patients with anterior circulation acute ischemic stroke undergoing endovascular treatment
Conclusions TR describing thrombus volume and texture were associated with more attempts to successful reperfusion. Compared with models using CV and MTM, TR had no added value for predicting procedural and functional outcome. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: van Voorst, H., Bruggeman, A. A. E., Yang, W., Andriessen, J., Welberg, E., Dutra, B. G., Konduri, P. R., Arrarte Terreros, N., Hoving, J. W., Tolhuisen, M. L., Kappelhof, M., Brouwer, J., Boodt, N., van Kranendonk, K. R., Koopman, M. S., Hund, H. M., Kri Tags: Ischemic stroke Source Type: research

Contrast conservation measures during the global iohexol contrast shortage crisis did not affect stroke thrombectomy outcomes
Conclusions Modifying stroke workflow to adapt to the current global shortage in iohexol is feasible. Using diluted iohexol (50% contrast mixed with 50% heparinized saline) did not affect MT outcomes. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Almallouhi, E., Sattur, M., Lajthia, O., Kicielinski, K. P., Holmstedt, C., Lena, J. R., Al Kasab, S., Spiotta, A. M. Tags: Ischemic stroke Source Type: research

Augmentation of perfusion with simultaneous vasodilator and inotropic agents in experimental acute middle cerebral artery occlusion: a pilot study
Conclusion Results suggest that perfusion can be augmented in ischemic stroke with norepinephrine and hydralazine. Perfusion augmentation depends on degree of collateralization and territory in question, with some evidence of vascular steal. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Liu, M., Saadat, N., Jeong, Y. I., Roth, S., Niekrasz, M., Carroll, T., Christoforidis, G. A. Tags: Ischemic stroke Source Type: research

Thrombus imaging characteristics within acute ischemic stroke: similarities and interdependence
Conclusions Thrombus imaging characteristics are significantly intercorrelated – strong correlations should be considered in future predictive modeling studies. Clustering analysis showed there are no distinct thrombus archetypes – novel treatments should consider this thrombus variability. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Arrarte Terreros, N., Bruggeman, A. A., Kappelhof, M., Tolhuisen, M. L., Brouwer, J., Hoving, J. W., Konduri, P. R., van Kranendonk, K. R., Dutra, B. G., Alves, H. C., Dippel, D. W., van Zwam, W. H., Beenen, L. F., Yo, L. S., van Bavel, E., Majoie, C. B., Tags: Open access, Ischemic stroke Source Type: research

Influence of time metrics on the treatment effect of intravenous alteplase prior to endovascular treatment in MR CLEAN-NO IV
Conclusion In MR CLEAN-NO IV, the effect of IVT prior to EVT was not modified by OTR, OTN, DTG or NTG times. Our results do not support the use of these metrics to guide IVT treatment decisions prior to EVT in comprehensive stroke centres. Trial registration number ISRCTN80619088. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Rinkel, L. A., Treurniet, K. M., Kappelhof, M., LeCouffe, N. E., Bruggeman, A. A. E., Nieboer, D., van Zwam, W. H., Uyttenboogaart, M., Dippel, D. W. J., Emmer, B. J., Roos, Y. B. W. E. M., Majoie, C. B. L. M., Coutinho, J. M., on behalf of the MR CLEAN-N Tags: Ischemic stroke Source Type: research

Stroke imaging modality for endovascular therapy in the extended window: systematic review and meta-analysis
Conclusions Our study suggests that, in anterior circulation LVO, the rates of functional independence may be similar when patients are selected using ADVI or NCCT for EVT in the extended time window. A simplified triage protocol does not seem to increase mortality or sICH. Protocol registration number (PROSPERO ID: CRD42021236092). (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Sequeiros, J. M., Rodriguez-Calienes, A., Chavez-Malpartida, S. S., Moran-Marinos, C., Alvarado-Gamarra, G., Malaga, M., Quincho-Lopez, A., Hernadez-Fernandez, W., Pacheco-Barrios, K., Ortega-Gutierrez, S., Hoit, D., Arthur, A. S., Alexandrov, A. V., Alva Tags: Ischemic stroke Source Type: research

In-stent restenosis after vertebral artery origin stenosis stenting: a nomogram for risk assessment
Conclusions A nomogram and a risk evaluation table were developed with good predictive ability for in-stent restenosis among patients with VAOS, which could serve as a practical approach for individualized risk evaluation. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Yang, K., Fang, S., Zhang, X., Wang, T., Feng, Y., Jiao, L., Yan, Y. Tags: Ischemic stroke Source Type: research

Gene expression profiles of ischemic stroke clots retrieved by mechanical thrombectomy are associated with disease etiology
Conclusions Expression profiles of stroke clots were identified between stroke etiologies and reflected different biologic responses. Cryptogenic thrombi may be related to multiple etiologies. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Tutino, V. M., Fricano, S., Chien, A., Patel, T. R., Monteiro, A., Rai, H. H., Dmytriw, A. A., Chaves, L. D., Waqas, M., Levy, E. I., Poppenberg, K. E., Siddiqui, A. H. Tags: Ischemic stroke Source Type: research

Persistent perfusion abnormalities at day 1 correspond to different clinical trajectories after stroke
Conclusion ASL hypoperfusion within the infarct and the surrounding tissue was associated with poor outcome. A more comprehensive view of the mechanisms in the hypoperfused surrounding tissue could help to design new therapeutic approaches during and after reperfusion therapies. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Rosso, C., Belkacem, S., Amor-Sahli, M., Clarencon, F., Leger, A., Baronnet, F., Dormont, D., Alamowitch, S., Lehericy, S., Samson, Y. Tags: Ischemic stroke Source Type: research

Direct to angiosuite strategy versus standard workflow triage for endovascular therapy: systematic review and meta-analysis
Conclusion Patients undergoing the DTAS strategy had a significant reduction in door-to-puncture and door-to-reperfusion times. This resulted in an increased rate of early neurological and 90-day functional recovery without compromising safety in LVO patients undergoing endovascular thrombectomy. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Galecio-Castillo, M., Vivanco-Suarez, J., Zevallos, C. B., Dajles, A., Weng, J., Farooqui, M., Ribo, M., Jovin, T. G., Ortega-Gutierrez, S. Tags: Ischemic stroke Source Type: research

Predictors and outcome of early neurological deterioration after endovascular thrombectomy: a secondary analysis of the DIRECT-MT trial
Conclusions Postoperative END is associated with adverse functional outcome. Several non-modifiable and modifiable factors can predict END and support future treatment decision-making to improve the potential utility of endovascular thrombectomy. Trial registration number DIRECT-MT ClinicalTrials.gov NCT03469206. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Zhang, M., Xing, P., Tang, J., Shi, L., Yang, P., Zhang, Y., Zhang, L., Peng, Y., Liu, S., Zhang, L., Fu, J., Liu, J., On behalf of the DIRECT-MT Investigators, Liu, Deng, Hong, Ke, Lou, Yin, Wang, Chen, Xu, Li, Wei, Li, Zhu, Sun, Liang, Wang, Wang, Peng, Tags: Ischemic stroke Source Type: research

Preprocedural determination of an occlusion pathomechanism in endovascular treatment of acute stroke: a machine learning-based decision
Conclusions An ML-PM could accurately determine an occlusion pathomechanism with common preprocedural findings. A decision flowchart consisting of the four most influential findings was clinically applicable and superior to single common preprocedural findings for determining an occlusion pathomechanism. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Baek, J.-H., Kim, B. M., Kim, D. J., Heo, J. H., Nam, H. S., Kim, Y. D., Rho, M. H., Chung, P.-W., Won, Y. S., Chung, Y. Tags: Ischemic stroke Source Type: research

Introduction
This online supplement is the first of three featuring previously accepted manuscripts focusing on ischemic stroke. The last decade has witnessed a revolution in the endovascular management of acute ischemic stroke. Device improvement, better-constructed prospective trials, and refinements in endovascular techniques have sparked this revolution. However, critical issues still need to be addressed. Specifically, the importance of pre-thrombectomy imaging, medium-sized vessel thromboses, patient access to capable treatment centers, management of intracranial atherosclerosis, and posterior circulation disease are subjects of ...
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Albuquerque, F. C. Tags: Editorial Source Type: research

Author index
Abdalkader Mohamad, A78Abdulla Fatema, A71Abecassis Isaac Josh, A10Abla Adib, A10Abud Daniel, A40Abud Thiago, A40Achutegui Maider Iza, A34Adam Dmytriw, A56Agosti Edoardo, A44, A58Agripnidis Thibault, A14Ahmad Saima, A63Ahn Hong Suk, A45Akermane Valda, A28Akkari Fouad Georges, A58Akkurt Burak, A42Al-Nidawai Firas, A71Al-Salihi Mohammed Maan, A79Al-Sewaidi Yosef, A62Alaraj Ali, A10Alessandro Pedicelli, A72Algin Oktay, A84Alhabli Ibrahim, A2Almendra Luciano, A77Alsarraf Lamiya, A23Althaus Katharina, A67Altikes Mario, A47Alves Marta, A42Amans Matthew, A83Ambrogi Cesare, A30Ameer Hassan, A56Amin-Hanjani Sepideh, A10Amsalem Yaak...
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Tags: Author index Source Type: research

P183/344 Real-time quantitative radial force measurements of WEB devices
ConclusionThis study could play a significant role in WEB-assisted aneurysm embolization. In light of our findings, we can say that for aneurysms larger than their diameter, or if a spherical device is not planned to be used, it seems more appropriate to choose a device with a diameter of 2 mm larger than the aneurysm diameter.Disclosure of Interestnothing to disclose (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Algin, O., Kutbay, U. Tags: 3.3 OTHER - Miscellaneous Source Type: research