Y5 receptor signalling counteracts the anorectic effects of PYY3 ‐36 in diet‐induced obese mice
Abstract
Peptide YY 3‐36 (PYY3‐36) is known as a critical satiety factor that reduces food intake both in rodents and humans. Although the anorexic effect of PYY3‐36 is assumed to be mediated mainly by the Y2 receptor, the involvement of other Y‐receptors in this process has never been conclusively resolved. Amongst them, the Y5 receptor (Y5R) is the most likely candidate to also be a target for PYY3‐36, which is considered to counteract the anorectic effects of Y2R activation. In the present study, we show that short‐term treatment of diet‐induced obese wild‐type (WT) and Y5R knockout mice (Y5KO) with PYY3...
Source: Journal of Neuroendocrinology - October 22, 2017 Category: Endocrinology Authors: Y. ‐C. Shi, C. K. Ip, F. Reed, D. A. Sarruf, B. S. Wulff, H. Herzog Tags: ORIGINAL ARTICLE Source Type: research
Short ‐term high‐fat diet increases the presence of astrocytes in the hypothalamus of C57BL6 mice without altering leptin sensitivity
Diet‐induced obesity is associated with hypothalamic inflammation and this phenomenon has been proposed to explain leptin resistance. In the present study, we used a short‐term high‐fat diet (HFD) paradigm for 10 days and analysed the cellular and physiological responses to leptin administration in C57BL6 mice. In parallel, we performed glial fibrillary acidic protein immunostaining to measure the presence of astrocytes in the arcuate nucleus of the hypothalamus (ARH) after 10 days and 20 weeks of HFD. Interestingly, the results obtained demonstrate that the presence of star‐like astrocytes is significantly incr...
Source: Journal of Neuroendocrinology - October 22, 2017 Category: Endocrinology Authors: E. Balland, M. A. Cowley Tags: ORIGINAL ARTICLE Source Type: research
The regulation and role of carbohydrate response element ‐binding protein in metabolic homeostasis and disease
The transcription factor carbohydrate response element‐binding protein (ChREBP) is a member of the basic helix‐loop‐helix leucine zipper transcription factor family. Under high‐glucose conditions, it has a role in regulating the expression of key genes involved in various pathways, including glycolysis, gluconeogenesis and lipogenesis. It does this by forming a tetrameric complex made up of two ChREBP/Mlx heterodimers, which enables it to bind to the carbohydrate response element (ChoRE) in the promoter region of its target genes to regulate transcription. Because ChREBP plays a key role in glucose signalling and m...
Source: Journal of Neuroendocrinology - October 22, 2017 Category: Endocrinology Authors: T. Jois, M. W. Sleeman Tags: REVIEW ARTICLE Source Type: research
Note
(Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - October 22, 2017 Category: Endocrinology Tags: Note Source Type: research
A focus on reward in anorexia nervosa through the lens of the activity ‐based anorexia rodent model
Abstract
Patients suffering anorexia nervosa (AN) become anhedonic, unable or unwilling to derive normal pleasures and tend to avoid rewarding outcomes, most profoundly in food intake. The activity‐based anorexia model recapitulates many of the pathophysiological and behavioural hallmarks of the human condition, including a reduction in food intake, excessive exercise, dramatic weight loss, loss of reproductive cycles, hypothermia and anhedonia, and therefore it allows investigation into the underlying neurobiology of anorexia nervosa. The use of this model has directed attention to disruptions in central reward neurocir...
Source: Journal of Neuroendocrinology - October 22, 2017 Category: Endocrinology Authors: C. J. Foldi, L. K. Milton, B. J. Oldfield Tags: REVIEW ARTICLE Source Type: research
Neuroendocrine mechanisms underlying bariatric surgery: Insights from human studies and animal models
Obesity has reached epidemic proportions and, to date, bariatric surgery remains the only effective treatment for morbid obesity in terms of its capacity to achieve durable weight loss. Bariatric surgery procedures, including Roux‐en‐Y gastric bypass (RYGB), adjustable gastric banding (AGB) and sleeve gastrectomy (SG), have been the primary procedures conducted over the past decade, with SG increasing in popularity over the past 5 years at the expense of both RYGB and AGB. Although these procedures were initially proposed to function via restrictive or malabsorptive mechanisms, it is now clear that profound physiologi...
Source: Journal of Neuroendocrinology - October 22, 2017 Category: Endocrinology Authors: A. Stefanidis, B. J. Oldfield Tags: REVIEW ARTICLE Source Type: research
Issue Information
(Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - October 22, 2017 Category: Endocrinology Tags: Issue Information Source Type: research
Diversity of oxytocin neurons: beyond magno ‐ and parvocellular cell types?
Journal of Neuroendocrinology,Volume 0, Issue ja, -Not available-. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - October 12, 2017 Category: Endocrinology Authors: Ferdinand Althammer
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Valery Grinevich Source Type: research
Steroids, Stress, and the Gut Microbiome ‐Brain Axis
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - October 12, 2017 Category: Endocrinology Authors: Marc J. Tetel, Geert J. de Vries, Roberto C. Melcangi, GianCarlo Panzica, Siobhain M. O'Mahony Tags: Review Article Source Type: research
Diversity of oxytocin neurons: beyond magno ‐ and parvocellular cell types?
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - October 12, 2017 Category: Endocrinology Authors: Ferdinand Althammer, Valery Grinevich Tags: Review Article Source Type: research
Stress ‐related cortisol responsivity modulates prospective memory
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - October 10, 2017 Category: Endocrinology Authors: Katharina Glienke, Martina Piefke Tags: Original Article Source Type: research
Expression of isotocin is male ‐specifically upregulated by gonadal androgen in the medaka brain
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - October 10, 2017 Category: Endocrinology Authors: Junpei Yamashita, Yukika Kawabata, Kataaki Okubo Tags: Original Article Source Type: research
ZENK Induction in the Zebra Finch Brain by Song: Relationship to Hemisphere, Rhythm, Estradiol, and Sex
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - October 6, 2017 Category: Endocrinology Authors: Jennifer Lampen, Devin J. McAuley, Soo ‐Eun Chang, Juli Wade Tags: Original Article Source Type: research
Neonatal overfeeding by small ‐litter rearing sensitizes hippocampal microglial responses to immune challenge: reversal with neonatal repeated injections of saline as well as minocycline
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - October 6, 2017 Category: Endocrinology Authors: Simone N. De Luca, Ilvana Ziko, Kshitija Dhuna, Luba Sominsky, Mary Tolcos, Leanne Stokes, Sarah J. Spencer Tags: Original Article Source Type: research
Effects of GABA active steroids in the female brain with focus on the premenstrual dysphoric disorder
In conclusion, the underlying studies of this review provide evidence that allopregnanolone is the provoking factor behind the negative mood symptoms in PMDD and that isoallopregnanolone could ameliorate the symptoms due to its ability to antagonize the allopregnanolone effect on the GABAA receptor.
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - October 1, 2017 Category: Endocrinology Authors: Marie Bixo, Maja Johansson, Erika Timby, Louise Michalski, Torbj örn Bäckström Tags: Review Article Source Type: research
