Horner Syndrome in Giant Cell Arteritis: Case Series and Review of the Literature
Conclusions:
This case series describes 2 patients with new diagnosis of GCA and concurrent Horner syndrome, with new diagnosis of likely nuclear/fascicular fourth nerve palsy in one patient and skew deviation in the other. In both patients, vasculitis presumptively affected vertebral arteries and their branches supplying the first-order sympathetic neurons in the brainstem. Considering the severe complication of permanent vision loss in GCA, this diagnosis should be considered in older patients presenting with concurrent new onset of Horner syndrome. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - August 28, 2022 Category: Opthalmology Tags: Original Contribution Source Type: research
Expert Consensus on the Use of Teprotumumab for the Management of Thyroid Eye Disease Using a Modified-Delphi Approach
Background:
Teprotumumab is the first treatment for thyroid eye disease (TED), a debilitating autoinflammatory condition, approved by the Food and Drug Administration in the United States, which reduces proptosis and improves quality of life. In the absence of guidelines, clinical recommendations were developed for using teprotumumab in patients with TED in the United States.
Methods:
A 3-round modified-Delphi panel was conducted between October 2020 and February 2021 with experts in the management of patients with TED. Key areas regarding the use of teprotumumab were investigated, including eligible patient pop...
Source: Journal of Neuro-Ophthalmology - August 28, 2022 Category: Opthalmology Tags: Original Contribution Source Type: research
Prevalence of Macular Microcystoid Lacunae in Autosomal Dominant Optic Atrophy Assessed With Adaptive Optics
Conclusion:
In ADOA, macular microcystoid lacunae were found in 23% of the study participants and tended to be present in younger participants with moderate visual acuity reduction and a smaller nerve fiber layer volume. Further studies are needed to investigate whether cavities left by dead ganglion cells are predictors of decrease in visual function. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - August 28, 2022 Category: Opthalmology Tags: Original Contribution Source Type: research
Increased Incidence of Pseudotumor Cerebri Syndrome Among Users of Tetracycline Antibiotics
Conclusions:
Although a causative link between tetracycline use and pseudotumor cerebri has yet to be firmly established, our study suggests that the incidence of pseudotumor cerebri among tetracycline users is significantly higher than the incidence of IIH in the general population. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - August 28, 2022 Category: Opthalmology Tags: Original Contribution Source Type: research
The Impact of Leber Hereditary Optic Neuropathy on the Quality of Life of Patients and Their Relatives: A Qualitative Study
Conclusions:
The impact of LHON extends beyond vision-related activity limitations. Addressing the psychosocial impact of LHON and helping patients and their relatives adapt and cope with vision loss are vital. As part of this, an accurate and timely diagnosis is important to enable early intervention. Further investigation of specific unmet needs is required. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - August 28, 2022 Category: Opthalmology Tags: Original Contribution Source Type: research
Ganglion Cell Layer Thickness Variance Using SPECTRALIS Optical Coherence Tomography
Conclusions:
Our model found a predictable threshold of 0.07 mm3 or less for SPECTRALIS OCT mean GCL volume variance, which did not significantly change with eye registration in eyes without macular pathology. Clinicians may also consider a threshold of 0.04 mm3 when determining stable vs progressive changes in mean GCL volume using this device. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - August 28, 2022 Category: Opthalmology Tags: Original Contribution Source Type: research
Long-Term Visual Prognosis in Patients With Aquaporin-4-Immunoglobulin G–Positive Neuromyelitis Optica Spectrum Disorder
Conclusions:
Our results indicate that the severity of ON rather than the number of recurrences might be critical for the visual prognosis of patients with AQP4-IgG–positive NMOSD. Rapid treatment within 3 days may improve visual outcomes, and a younger age at onset may have better visual outcomes. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - August 28, 2022 Category: Opthalmology Tags: Original Contribution Source Type: research
Comparison of 1.5 Tesla and 3.0 Tesla Magnetic Resonance Imaging in the Evaluation of Acute Demyelinating Optic Neuritis
Background:
Optic neuritis (ON) is the most common optic neuropathy in young adults. MRI is reported to have a high sensitivity for ON. Higher signal strengths of MRI may enhance resolution and lead to better detection of ON. We sought to compare the sensitivity of 3.0 Tesla (T) MRI to that of 1.5 T MRI in detecting acute demyelinating ON.
Methods:
A retrospective chart review was performed on patients with a clinical diagnosis of optic neuritis at Mayo Clinic Health System from January 2010 to April 2020. Among 1,850 patients identified, 126 patients met the eligibility criteria. Exclusion criteria comprised qu...
Source: Journal of Neuro-Ophthalmology - August 28, 2022 Category: Opthalmology Tags: Original Contribution Source Type: research
The Treatment of Myelin Oligodendrocyte Glycoprotein Antibody Disease: A State-of-the-Art Review
Conclusions:
While acute MOGAD attacks are usually treated with high-dose IV corticosteroids, longer oral corticosteroid tapers may prevent rapid relapse. Multiple long-term treatment strategies are being employed in recurrent MOGAD, with IVIg is emerging as probably the most effective therapy. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - August 28, 2022 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research
Real-World Translation of Artificial Intelligence in Neuro-Ophthalmology: The Challenges of Making an Artificial Intelligence System Applicable to Clinical Practice
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - August 28, 2022 Category: Opthalmology Tags: Editorial Source Type: research
Gazing Into the Crystal Ball Photo Essay: Response
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 27, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research
Comments on a Case Entitled “Gazing Into the Crystal Ball”
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 27, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research
Reply to Should Tocilizumab Be Used Routinely in New Patients With a Diagnosis of Giant Cell Arteritis?
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 27, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research
Comments on Tocilicizumab Use in Giant Cell Arteritis
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 27, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research
Pellegrini et al—“Reply to: Paracentral Acute Middle Maculopathy as a Manifestation of Giant Cell Arteritis”: Response
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 27, 2022 Category: Opthalmology Tags: Letters to the Editor Source Type: research
