Selective Unidirectional Horizontal Saccadic Paralysis From Acute Ipsilateral Pontine Stroke
Conclusions: This case provides support for the concept that PPRF lesions in humans may selectively impair unidirectional horizontal saccades. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 25, 2017 Category: Opthalmology Tags: Clinical Observation Source Type: research

Reversible Edema-Like Changes Along the Optic Tract Following Pipeline-Assisted Coiling of a Large Anterior Communicating Artery Aneurysm
Abstract: Aneurysmal volume expansion after endovascular treatment is caused by intra-aneurysmal thrombosis in the early postembolization period. Although postembolization mass effect on cranial nerves and other adjacent structures has been previously reported, we are unaware of reports involving the anterior visual pathway. A 66-year-old woman with a 2-week history of blurred vision without headache was found to have a large, unruptured anterior communicating artery aneurysm. One month after endovascular treatment of the aneurysm with coiling and flow diversion, the patient developed decreased vision in her right eye and ...
Source: Journal of Neuro-Ophthalmology - May 25, 2017 Category: Opthalmology Tags: Clinical Observation Source Type: research

Short Follow-up Bias Confounds Estimates of the “Typical” Clinical Course of Susac Syndrome
Background: To evaluate the validity of the prevailing concept that Susac syndrome (SS), a rare microvasculopathy of the brain, retina, and inner ear, is a self-limiting disease. Methods: We performed a literature search to identify all cases of SS reported between 1973 and October 2015. If available, we determined their demographics, duration of follow-up, and the clinical course that was labeled as monocyclic or polycyclic. We attempted to determine the number of relapses and the relapse rate in patients with polycyclic disease. Results: Our literature search yielded 185 relevant publications reporting 405 cases of SS....
Source: Journal of Neuro-Ophthalmology - May 25, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Structural and Functional Analyses in Nonarteritic Anterior Ischemic Optic Neuropathy: Optical Coherence Tomography Angiography Study
Background: Retinal and optic disc perfusion in nonarteritic anterior ischemic optic neuropathy (NAION) is incompletely understood. Our aim was to investigate the characteristics of the microvascular structures at the peripapillary area and optic disc, and their associations with retinal structure and function in patients with NAION. Methods: We conducted a prospective, observational case series study. Thirty-four eyes, consisting of 15 NAION eyes and 19 normal eyes, were included. Optical coherence tomography (OCT) angiography was used to measure the vessel densities in the peripapillary superficial retina and whole-dept...
Source: Journal of Neuro-Ophthalmology - May 25, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Persistent Asymmetric Optic Disc Swelling After Long-Duration Space Flight: Implications for Pathogenesis
Conclusion: The persistent asymmetric findings noted above, coupled with the lumbar puncture opening pressures, suggest that prolonged microgravity exposure may have produced asymmetric pressure changes within the perioptic subarachnoid space. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 25, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Temporary Lumbar Drain as Treatment for Pediatric Fulminant Idiopathic Intracranial Hypertension
We present 2 patients in whom a temporary lumbar drain was successfully used in the management of medically undertreated pediatric FIIH, and circumvented the need for surgical intervention. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 25, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Transient Monocular Vision Loss on Awakening: A Benign Amaurotic Phenomenon
Conclusions: Evaluation was uniformly negative when patients described waking with isolated vision loss in 1 eye with subsequent resolution, usually in less than 15 minutes. The natural history seems benign with symptoms frequently remitting spontaneously. This visual phenomenon may represent an autoregulatory failure resulting in a supply/demand mismatch during low-light conditions. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 25, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Venous Sinus Stenting in Idiopathic Intracranial Hypertension: Results of a Prospective Trial
Conclusions: Stenting of VSS is safe and results in reduction of intracranial pressure in patients with IIH. This is associated with improvement in papilledema, RNFL thickness, VF parameters, and symptoms associated with intracranial hypertension. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 25, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Neuroendovascular Intervention: Evolving at the Intersection of Neurosurgery and Neuro-Ophthalmology
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - May 25, 2017 Category: Opthalmology Tags: Editorial Source Type: research

On behalf of the North American Neuro-Ophthalmology Society, the editorial office of the Journal of Neuro-Ophthalmology acknowledge with gratitude our reviewers who volunteered their time in 2016.
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Acknowledgement of Reviewers Source Type: research

Neuro-Ophthalmology in Portugal
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Worldwide Neuro-Opthalmology Source Type: research

Dyschromatopsia in Multiple Sclerosis Patients: A Marker of Subclinical Involvement?: Response
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Dyschromatopsia in Multiple Sclerosis Patients: A Marker of Subclinical Involvement?: Comment
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Nonarteritic Ischemic Optic Neuropathy Associated With Clomiphene Citrate Use
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Invasive Aspergillosis Mimicking Sphenoid Wing Meningioma
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Nonarteritic Anterior Ischemic Optic Neuropathy and Erectile Dysfunction Drugs: Is There an Elephant in the Bedroom?
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Literature Commentary.
In this issue of Journal of Neuro-Ophthalmology, M. Tariq Bhatti, MD and Mark L. Moster, MD, will discuss the following 6 articles: 1. Lee YC, Wang JH, Huang TL, Tsai RK. Increased risk of stroke in patients with nonarteritic anterior ischemic optic neuropathy: a nationwide retrospective cohort study. Am J Ophthalmol. 2016;170:183-189. 2. Ray JG, Vermeulen MJ, Bharatha A, Montanera WJ, Park AL. Association between MRI exposure during pregnancy and fetal and childhood outcomes. JAMA. 2016;316:952-961. 3. Kilduff CL, Casswell EJ, Salam T, Hersh D, Ortiz-Perez S, Ezra D. Use of alleviating maneuvers for periocular facial d...
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Literature Commentary: PDF Only Source Type: research

Cerebellar Control of Eye Movements
Conclusions: The cerebellum guarantees the precision of ocular movements to optimize visual performance and occupies a central role in all classes of eye movements both in real-time control and in long-term calibration and learning (i.e., adaptation). (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research

Are Anemia and Hypotension Causally Related to Perioperative Ischemic Optic Neuropathy?
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Point Counter-Point Source Type: research

Ipsilateral Ophthalmic and Cerebral Infarctions After Cosmetic Polylactic Acid Injection Into the Forehead
Abstract: A 55-year-old woman developed no light perception vision in her right eye 5 days after an injection of polylactic acid cosmetic filler into her right forehead. Diffuse corneal edema and anterior chamber inflammation prohibited any view to the posterior segment to identify the cause of her profound vision loss. MRI of the orbits with diffusion-weighted imaging showed hyperintensity of the right optic nerve with signal reduction on apparent diffusion coefficient mapping, consistent with ischemia. Our patient also was found to have acute infarctions in the distribution of the right anterior cerebral artery on MRI of...
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Photo Essay Source Type: research

A Giant Tumefactive Virchow-Robin Space: A Rare Cause of a Homonymous Quadrantanopia
Abstract: A 53-year-old woman was found to have a left inferior homonymous quadrantanopia. Brain MRI disclosed a giant Virchow–Robin space compressing the right optic tract. After fenestration of this cystic lesion, most of the visual field loss resolved. Giant Virchow–Robin spaces may cause homonymous field defects which, with appropriate management, may improve. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Photo Essay Source Type: research

IgG4 Disease: Is It or Isn't It?
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Clinical-Pathological Case Study Source Type: research

Diagnosis and Management of Mitochondrial Neuro-Ophthalmologic Disorders: Translating Scientific Advances Into the Clinic
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Bench to Bedside Source Type: research

Harnessing the Power of Genetic Engineering for Patients With Mitochondrial Eye Diseases
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Bench to Bedside Source Type: research

Paraneoplastic Optic Neuropathy Associated With Purkinje Cell Antibody-2 in a Patient With Small Cell Lung Cancer
We describe a case of a 57-year-old woman with bilateral vision loss with the characteristic features of CRMP-5 PON including bilateral optic disc edema and vitreous cells. However, she was negative for anti-CRMP-5 including a negative Western blot on two occasions, but positive for Purkinje Cell Antibody (PCA)-2. Although paraneoplastic antibodies are more predictive of an underlying cancer than a specific syndrome, previously PON has not been associated with PCA-2. Based on this observation, we recommend that the workup should include PCA-2 antibodies in patients who present with bilateral optic neuropathy and vitreous c...
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Clinical Observation Source Type: research

Tumoral Presentation of Homonymous Hemianopia and Prosopagnosia in Cerebral Amyloid Angiopathy–Related Inflammation
We report a 73-year-old woman with an extensive cancer history who presented with tumor-like lesions and symptoms of homonymous hemianopia and prosopagnosia. Found to have cerebral amyloid angiopathy–related inflammation proven by brain biopsy, she was treated successfully with immunosuppression. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Clinical Observation Source Type: research

Epstein–Barr Virus Neuroretinitis in a Lung Transplant Patient
We describe a unique case of a patient who developed severe bilateral EBV neuroretinitis after solid organ transplant. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Clinical Observation Source Type: research

Re-Treatment With Ethambutol After Toxic Optic Neuropathy
We describe a patient who developed optic neuropathy attributed to ethambutol, recovered fully after drug withdrawal, and tolerated a 14-month long re-treatment 10 years later without developing recurrent optic neuropathy. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Diagnosing Light Chain Amyloidosis on Temporal Artery Biopsies for Suspected Giant Cell Arteritis
We report 2 such cases where initial symptoms and signs were identical to and mistaken for those of giant cell arteritis, associated with polymyalgia rheumatica. Neither patient responded to high-dose corticosteroids; instead, their temporal artery biopsies revealed amyloid deposits and other investigations confirmed a diagnosis of systemic AL amyloidosis. Review of the literature reveals similar cases of diagnostic confusion spanning 75 years. We have summarized the findings and learning points from cases reported in the past 30 years and highlight the need for increased awareness and investigation of this underrecognized...
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Ciliary Body/Iris Appositioning Producing Mechanical Pupillary Defects in Carotid-Cavernous Sinus Fistula: An Overlooked Pathophysiologic Mechanism
Conclusions: Where there are acute elevations in orbital venous pressure causing ciliary body effusion, changes in visual acuity and pupillary abnormalities can be produced by mechanical effects. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Detection of Thyroid Abnormalities in Aquaporin-4 Antibody–Seropositive Optic Neuritis Patients
Conclusion: A high prevalence of ATAs and HT was found in AQP4-Ab+ ON patients, and AQP4-Ab+ patients with HT exhibited worse visual outcomes than non-HT patients. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Spectrum of Magnetic Resonance Imaging Features in Unilateral Optic Tract Dysfunction
Conclusions: Neuroradiologists aware of unilateral optic tract dysfunction but not of its side detected extrinsic (neighborhood) MRI abnormalities in most cases but did not appreciate that these extrinsic features sometimes included compression of the optic tract. MRI abnormalities intrinsic to the optic tract were entirely overlooked during independent review, being recognized only in a consensus conference with clinician authors. Neuroradiologists are more likely to detect MRI abnormalities pertinent to optic tract dysfunction once they have more complete clinical information and with higher resolution imaging, especiall...
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Invited Commentary: Form Versus Function: A State of Disunion?
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Invited Commentary: Ganglion Cell Complex Measurement in Compressive Optic Neuropathy
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Ganglion Cell Complex Loss in Chiasmal Compression by Brain Tumors
Background: Patterns of ganglion cell complex (GCC) loss detected by optical coherence tomography provide an objective measure of optic nerve injury. These patterns aid in early diagnosis and localization of chiasmal lesions. Methods: Twenty-three patients with chiasmal compression seen between 2010 and 2015 were imaged with the Cirrus high-definition optical coherence tomography macular cube 512 × 128, retinal nerve fiber layer (RNFL) scan protocols and automated (30-2 Humphrey) visual fields (VFs). Age-matched controls were included for comparison. Generalized estimating equations were performed comparing RNFL and...
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Original Contribution Source Type: research

Swelling of the Optic Nerve Head: A Backstage View of a Staging Scheme
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Perspective Source Type: research

New Treatments in Neuro-Ophthalmology: The Role for Evidence
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 17, 2017 Category: Opthalmology Tags: Editorial Source Type: research

Neuro-Ophthalmology by Judit Somlai and Tibor Kovacs
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - December 1, 2016 Category: Opthalmology Tags: Books Received Source Type: research

Neuro-Ophthalmology by Judit Somia and Tibor Kovacs
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - December 1, 2016 Category: Opthalmology Tags: Books Received Source Type: research

Neuro-Ophthalmology
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - November 18, 2016 Category: Opthalmology Tags: Books Received Source Type: research

Food and Drug Administration Adverse Event Reports of Retinal Vascular Occlusions Associated With Phosphodiesterase Type 5 Inhibitor Use
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - November 18, 2016 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Temporal Arteritis With Arteritic Anterior Ischemic Optic Neuropathy is Bilateral Until Proven Otherwise: Response
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - November 18, 2016 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Giant Cell Arteritis With Arteritic Anterior Ischemic Optic Neuropathy Is Bilateral Until Proven Otherwise
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - November 18, 2016 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Literature Commentary
In this issue of Journal of Neuro-Ophthalmology, Tariq Bhatti, MD and Mark Moster, MD, will discuss the following 6 articles: 1. Granet DB, Hodgson N, Godfrey KJ, Ventura R, Kikkawa DO, Levi L, Kinori M. Chemodenervation of extraocular muscles with botulinum toxin in thyroid eye disease. Graefes Arch Clin Exp Ophthalmol. 2016;254:999–1003. 2. Sanders DB, Wolfe GI, Benatar M, Evoli A, Gilhus NE, Illa I, Kuntz N, Massey JM, Melms A, Murai H, Nicolle M, Palace J, Richman DP, Verschuuren J, Narayanaswami P. International consensus guidance for management of myasthenia gravis: executive summary. Neurology. 2016;87:419...
Source: Journal of Neuro-Ophthalmology - November 18, 2016 Category: Opthalmology Tags: Literature Commentary Source Type: research

Optic Gliomas: Past, Present, and Future
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - November 18, 2016 Category: Opthalmology Tags: Jacobson Lecture Source Type: research

Optical Coherence Tomography Should Be Used Routinely to Monitor Patients With Idiopathic Intracranial Hypertension
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - November 18, 2016 Category: Opthalmology Tags: Point Counter-Point Source Type: research

An 82-Year-Old Man With Diplopia
No abstract available (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - November 18, 2016 Category: Opthalmology Tags: Clinical-Pathological Case Study Source Type: research

Retrolaminar Migration of Intraocular Silicone Oil
Conclusion: Greater awareness on the part of treating physicians, systematic study of at-risk populations, and advances in imaging technology will allow further insight into this phenomenon. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - November 18, 2016 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research

Avoiding Clinical Misinterpretation and Artifacts of Optical Coherence Tomography Analysis of the Optic Nerve, Retinal Nerve Fiber Layer, and Ganglion Cell Layer
Conclusions: While OCT is invaluable in diagnosing optic nerve disease, we need to be cognizant of the artifacts that can occur with OCT. Failure to recognize some of these artifacts can lead to misdiagnoses and inappropriate investigations. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - November 18, 2016 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research

Congenital Tonic Pupils Associated With Congenital Central Hypoventilation Syndrome and Hirschsprung Disease
We describe a rare association of tonic pupils, congenital central hypoventilation syndrome, and Hirschsprung disease in a newborn with a mutation in the PHOX2B gene, a key regulator of neural crest cells. Hirschsprung disease is characterized by the congenital absence of neural crest–derived intrinsic ganglion cells. Tonic pupils may result from an abnormality of the ciliary ganglion, another structure of neural crest origin. The close association of these conditions in this child suggests a common abnormality in neural crest migration and differentiation. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - November 18, 2016 Category: Opthalmology Tags: Clinical Observation Source Type: research