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Age is not associated with intracranial haemorrhage in patients with mild traumatic brain injury and oral anticoagulation
Patients admitted to emergency departments with traumatic brain injury (TBI) are commonly being treated with oral anticoagulants. In contrast to patients without anticoagulant medication, no guidelines, scores... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - June 1, 2016 Category: Research Authors: Thomas C. Sauter, Stephan Ziegenhorn, Sufian S. Ahmad, Wolf E. Hautz, Meret E. Ricklin, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Dominik G. Haider and Aristomenis K. Exadaktylos Source Type: research

Investigation of SLA4A3 as a candidate gene for human retinal disease
SLC4A3 has been shown to cause retinal degeneration in a genetically engineered knockout mouse, and in a naturally occurring form of canine progressive retinal atrophy considered to be th... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - May 23, 2016 Category: Research Authors: Louise M. Downs, Andrew R. Webster, Anthony T. Moore, Michel Michaelides, Robin R. Ali, Alison J. Hardcastle and Cathryn S. Mellersh Source Type: research

Noise trauma and systemic application of the selective glucocorticoid receptor modulator compound A
Selective glucocorticoid receptor modulators (SEGRMs) comprise a novel class of drugs promising both reduced side effects and similar pharmacological potency relative to glucocorticoids, which presently serve ... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - May 11, 2016 Category: Research Authors: Lukas D. Landegger, Clemens Honeder, Chengjing Zhu, Hanna Schöpper, Elisabeth Engleder, Franz Gabor, Wolfgang Gstoettner and Christoph Arnoldner Source Type: research

Intracerebroventricular injections of dronabinol, a cannabinoid receptor agonist, does not attenuate serotonin-induced apnea in Sprague-Dawley rats
Evidence suggests that vagal nerve activity may play a role in sleep apnea induction. In anesthetized rats, dronabinol, a cannabinoid (CB) receptor agonist, injected into the nodose ganglia attenuates reflex a... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - May 2, 2016 Category: Research Authors: Michael W. Calik and David W. Carley Source Type: research

Tlr2 deficiency does not limit the development of left ventricular hypertrophy in a model of transverse aortic constriction induced pressure overload
Toll-like receptors (TLRs) are involved in a variety of cardiovascular disorders, including septic cardiomyopathy, ischemia/reperfusion, heart failure, and cardiac hypertrophy. Previous research revealed that ... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - April 25, 2016 Category: Research Authors: Tippaporn Bualeong, Sied Kebir, Dorothea Hof, Lina Goelz, Mathias Graewe, Stefan Felix Ehrentraut, Pascal Knuefermann, Georg Baumgarten, Rainer Meyer and Heidi Ehrentraut Source Type: research

Endothelial, platelet, and macrophage microparticle levels do not change acutely following transcatheter aortic valve replacement
Patients with severe aortic stenosis have increased levels of prothrombotic and proinflammatory microparticles (MP), and MPs actively regulate pathological processes that lead to atherothrombotic cardiovascula... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - April 11, 2016 Category: Research Authors: Julio F. Marchini, Ayumi Aurea Miyakawa, Flavio Tarasoutchi, José Eduardo Krieger, Pedro Lemos and Kevin Croce Source Type: research

Targeted drugs and Psycho-oncological intervention for breast cancer patients
Personalized medicine is a new field based on molecular biology and genomics in which targeted tumor therapies are administered to patients. Psycho-oncology is a complementary approach that considers social an... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - April 1, 2016 Category: Research Authors: Flavio D’Abramo, Ute Goerling and Cecilia Guastadisegni Source Type: research

Topical ocular dexamethasone decreases intraocular pressure and body weight in rats
Recently, topical dexamethasone-induced ocular hypertension and a consequent loss of retinal ganglion cells (RGCs) have been described in mice. This has been proposed as a model of steroid-induced glaucoma. In... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 12, 2016 Category: Research Authors: Kota Sato, Koji M. Nishiguchi, Kazuichi Maruyama, Satoru Moritoh, Kosuke Fujita, Yoshikazu Ikuta, Hitoshi Kasai and Toru Nakazawa Source Type: research

Comparison of serological methods with PCR-based methods for the diagnosis of community-acquired pneumonia caused by atypical bacteria
The diagnosis of community-acquired pneumonia (CAP) caused by Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydophila pneumoniae is traditionally based on cultures and serology, which have special requir... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - March 2, 2016 Category: Research Authors: Mariana Herrera, Yudy Alexandra Aguilar, Zulma Vanessa Rueda, Carlos Muskus and Lázaro Agustín Vélez Source Type: research

Thanks to all those who reviewed for Journal of Negative Results in BioMedicine in 2015
A peer-reviewed journal would not survive without the generous time and insightful comments of the reviewers, whose efforts often go unrecognized. Although final decisions are always editorial, they are greatl... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - February 17, 2016 Category: Research Authors: Bjorn R. Olsen and Dirk Mielenz Source Type: research

ADAMTS-18 in the host tissues exerts little effect on breast tumor progress in a murine 4T1 breast cancer model
In this study, we aimed to identify a novel extracellular proteinase ADAMTS-18 that could be a potential tumor suppressor gene. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - February 3, 2016 Category: Research Authors: Min Liu, Tiantian Lu, Fang Jing, Suying Dang and Wei Zhang Source Type: research

Use of Diuretics is not associated with mortality in patients admitted to the emergency department: results from a cross-sectional study
Patients with diuretic therapy are at risk for drug-induced adverse reactions. It is unknown if presence of diuretic therapy at hospital emergency room admission is associated with mortality. (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - February 1, 2016 Category: Research Authors: Dominik G. Haider, Gregor Lindner, Michael Wolzt, Alexander Benedikt Leichtle, Georg-Martin Fiedler, Thomas C. Sauter, Valentin Fuhrmann and Aristomenis K. Exadaktylos Source Type: research

Mobile phone use and risk for intracranial tumors
Mobile phone use has been discussed over the last few decades with increased risk for intracranial tumors. The majority of studies have been conducted on gliomas and meningiomas. Although some case-control stu... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 23, 2015 Category: Research Authors: George A. Alexiou and Chrissa Sioka Source Type: research

Substrate stiffness effect and chromosome missegregation in hIPS cells
Ensuring genetic stability in pluripotent stem cell (PSC) cultures is essential for the development of successful cell therapies. Although most instances lead to failed experiments and go unreported in the lit... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 18, 2015 Category: Research Authors: Suehelay Acevedo-Acevedo and Wendy C. Crone Source Type: research

Effects of omega-3 fatty acids on arterial stiffness in patients with hypertension: a randomized pilot study
Omega–3 fatty acids prevent cardiovascular disease (CVD) events in patients with myocardial infarction or heart failure. Benefits in patients without overt CVD have not been demonstrated, though most studies d... (Source: Journal of Negative Results in BioMedicine)
Source: Journal of Negative Results in BioMedicine - December 2, 2015 Category: Research Authors: Mori J. Krantz, Edward P. Havranek, Rocio I. Pereira, Brenda Beaty, Philip S. Mehler and Carlin S. Long Source Type: research